JP2010530218A5 - - Google Patents
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- JP2010530218A5 JP2010530218A5 JP2010510480A JP2010510480A JP2010530218A5 JP 2010530218 A5 JP2010530218 A5 JP 2010530218A5 JP 2010510480 A JP2010510480 A JP 2010510480A JP 2010510480 A JP2010510480 A JP 2010510480A JP 2010530218 A5 JP2010530218 A5 JP 2010530218A5
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 claims 23
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 23
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 17
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 17
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 5
- 206010016654 Fibrosis Diseases 0.000 claims 4
- 230000004761 fibrosis Effects 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 241000251468 Actinopterygii Species 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 238000008157 ELISA kit Methods 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000288906 Primates Species 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 150000002430 hydrocarbons Chemical group 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical group CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 101000800130 Bos taurus Thyroglobulin Proteins 0.000 claims 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 206010019668 Hepatic fibrosis Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010028594 Myocardial fibrosis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 241000237988 Patellidae Species 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
- 208000003589 Spider Bites Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 101710162629 Trypsin inhibitor Proteins 0.000 claims 1
- 229940122618 Trypsin inhibitor Drugs 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 210000001742 aqueous humor Anatomy 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 229940098773 bovine serum albumin Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002500 effect on skin Effects 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 108060003552 hemocyanin Proteins 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 239000012508 resin bead Substances 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000002753 trypsin inhibitor Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
- 230000037314 wound repair Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94096407P | 2007-05-30 | 2007-05-30 | |
| US60/940,964 | 2007-05-30 | ||
| PCT/US2008/065045 WO2008150841A1 (en) | 2007-05-30 | 2008-05-29 | Compositions and methods for binding lysophosphatidic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014232393A Division JP2015096507A (ja) | 2007-05-30 | 2014-11-17 | リゾホスファチジン酸結合のための組成物と方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530218A JP2010530218A (ja) | 2010-09-09 |
| JP2010530218A5 true JP2010530218A5 (enExample) | 2011-08-04 |
| JP5989299B2 JP5989299B2 (ja) | 2016-09-07 |
Family
ID=40094082
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510480A Active JP5989299B2 (ja) | 2007-05-30 | 2008-05-29 | リゾホスファチジン酸結合のための組成物と方法 |
| JP2014232393A Pending JP2015096507A (ja) | 2007-05-30 | 2014-11-17 | リゾホスファチジン酸結合のための組成物と方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014232393A Pending JP2015096507A (ja) | 2007-05-30 | 2014-11-17 | リゾホスファチジン酸結合のための組成物と方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8158124B2 (enExample) |
| EP (1) | EP2164992B1 (enExample) |
| JP (2) | JP5989299B2 (enExample) |
| AU (1) | AU2008260135A1 (enExample) |
| CA (1) | CA2724432A1 (enExample) |
| DK (1) | DK2164992T3 (enExample) |
| ES (1) | ES2585702T3 (enExample) |
| LT (1) | LT2164992T (enExample) |
| WO (1) | WO2008150841A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9274129B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Methods and reagents for detecting bioactive lipids |
| US20080138334A1 (en) * | 2006-05-31 | 2008-06-12 | Sabbadini Roger A | Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same |
| US8796429B2 (en) | 2006-05-31 | 2014-08-05 | Lpath, Inc. | Bioactive lipid derivatives, and methods of making and using same |
| US9274130B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
| AU2008260135A1 (en) * | 2007-05-30 | 2008-12-11 | Lpath, Inc. | Compositions and methods for binding lysophosphatidic acid |
| US20110064744A1 (en) * | 2007-05-30 | 2011-03-17 | Sabbadini Roger A | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
| WO2009134776A2 (en) | 2008-04-29 | 2009-11-05 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| US8372888B2 (en) * | 2008-04-29 | 2013-02-12 | Enzo Therapeutics, Inc. | Sphingosine kinase type 1 inhibitors, compositions and processes for using same |
| RU2010153580A (ru) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двумя вариабельными доменами и их применение |
| NZ589436A (en) | 2008-06-03 | 2012-12-21 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| RU2011104348A (ru) | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение |
| US8629247B2 (en) | 2009-04-14 | 2014-01-14 | Proscan Rx Pharma Inc. | Antibodies against prostate specific membrane antigen |
| EP2419446A4 (en) * | 2009-04-17 | 2013-01-23 | Lpath Inc | HUMANIZED ANTIBODY COMPOSITIONS AND METHOD FOR BINDING LYSOPHOSPHACIDIC ACID |
| US20110076269A1 (en) * | 2009-06-24 | 2011-03-31 | Pebay Alice Marie | Methods of increasing neuronal differentiation using antibodies to lysophosphatidic acid |
| WO2011081214A1 (ja) * | 2009-12-28 | 2011-07-07 | 国立大学法人東京大学 | オートタキシン測定による肝線維化の検査方法および検査薬 |
| US20110212088A1 (en) * | 2010-02-26 | 2011-09-01 | Sabbadini Roger A | Anti-paf antibodies |
| US20120034631A1 (en) * | 2010-06-11 | 2012-02-09 | Wojciak Jonathan Michael | Anti-lysophospholipid antibody design using antibody structures |
| US20120014946A1 (en) * | 2010-07-14 | 2012-01-19 | Sabbadini Roger A | Prevention and treatment of pain using monoclonal antibodies and antibody fragments to lysophosphatidic acid |
| MX341579B (es) | 2010-08-03 | 2016-08-25 | Abbvie Inc * | Inmunoglobulinas de dominio variable doble y usos de las mismas. |
| CA2809433A1 (en) | 2010-08-26 | 2012-03-01 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| CA2844580A1 (en) * | 2011-08-09 | 2013-02-14 | Lpath, Inc. | Stem cell therapy using inhibitors of lysophosphatidic acid |
| BR112014015851A2 (pt) | 2011-12-30 | 2019-09-24 | Abbvie Inc | proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17 |
| CA2865428A1 (en) * | 2012-02-29 | 2013-09-06 | Lpath, Inc. | Methods and kits for detecting and diagnosing neurotrauma |
| DE102012021222B4 (de) * | 2012-10-27 | 2015-02-05 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung einer nanoporösen Schicht auf einem Substrat |
| BR112015009961B1 (pt) | 2012-11-01 | 2020-10-20 | Abbvie Inc. | proteína de ligação capaz de se ligar a dll4 e vegf, bem como composição que a compreende como composição que a compreende |
| WO2014144280A2 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1β AND / OR IL-17 |
| WO2016025879A1 (en) * | 2014-08-15 | 2016-02-18 | Indiana University Research And Technology Corporation | Treatment of cystic diseases |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| US9724057B2 (en) * | 2015-06-30 | 2017-08-08 | Toshiba Medical Systems Corporation | Magnetic field actuation of detectors in a computed tomography scanner |
| JP6889432B2 (ja) * | 2016-04-28 | 2021-06-18 | 学校法人甲南学園 | 樹脂固定ペプチド |
| EP3796935A4 (en) | 2018-05-23 | 2022-03-16 | The Jackson Laboratory | ANTI-OX40 ANTIBODIES AND METHODS OF USE |
| ES2736045A1 (es) * | 2018-06-21 | 2019-12-23 | Univ Cadiz | Metodos para el diagnostico y/o tratamiento de enfermedades neurodegenerativas |
| CN113827605B (zh) * | 2021-08-27 | 2023-06-09 | 上海市肺科医院 | 甘油磷酸胆碱在制备预防和治疗结核病药物中的应用 |
| EP4408468A4 (en) * | 2021-09-28 | 2025-07-02 | Frontaim Biomedicines Inc | MULTIPLE FORMATS OF MOLECULAR COMPLEXES |
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| CA2492092A1 (en) * | 2002-06-28 | 2004-01-08 | Greg Winter | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
| US7459285B2 (en) | 2002-12-10 | 2008-12-02 | Echelon Biosciences Incorporated | Compounds and methods of use thereof for assaying lysophospholipase D activity |
| US7700792B2 (en) * | 2003-12-26 | 2010-04-20 | Ono Pharmaceutical Co., Ltd. | Highly active lysophosphatidic acid and method of screening therewith |
| US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
| NZ556065A (en) * | 2005-01-24 | 2009-04-30 | Univ Texas | FC-fusion constructs binding to phosphatidylserine and their therapeutic use |
| US20110123440A1 (en) | 2005-03-29 | 2011-05-26 | Genevieve Hansen | Altered Antibody FC Regions and Uses Thereof |
| US9274129B2 (en) * | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Methods and reagents for detecting bioactive lipids |
| US20080138334A1 (en) * | 2006-05-31 | 2008-06-12 | Sabbadini Roger A | Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same |
| US8796429B2 (en) * | 2006-05-31 | 2014-08-05 | Lpath, Inc. | Bioactive lipid derivatives, and methods of making and using same |
| US9163091B2 (en) * | 2007-05-30 | 2015-10-20 | Lpath, Inc. | Compositions and methods for binding lysophosphatidic acid |
| AU2008260135A1 (en) * | 2007-05-30 | 2008-12-11 | Lpath, Inc. | Compositions and methods for binding lysophosphatidic acid |
| EP2419446A4 (en) * | 2009-04-17 | 2013-01-23 | Lpath Inc | HUMANIZED ANTIBODY COMPOSITIONS AND METHOD FOR BINDING LYSOPHOSPHACIDIC ACID |
-
2008
- 2008-05-29 AU AU2008260135A patent/AU2008260135A1/en not_active Abandoned
- 2008-05-29 ES ES08756421.7T patent/ES2585702T3/es active Active
- 2008-05-29 DK DK08756421.7T patent/DK2164992T3/en active
- 2008-05-29 LT LTEP08756421.7T patent/LT2164992T/lt unknown
- 2008-05-29 JP JP2010510480A patent/JP5989299B2/ja active Active
- 2008-05-29 CA CA2724432A patent/CA2724432A1/en not_active Abandoned
- 2008-05-29 WO PCT/US2008/065045 patent/WO2008150841A1/en not_active Ceased
- 2008-05-29 US US12/129,109 patent/US8158124B2/en not_active Expired - Fee Related
- 2008-05-29 EP EP08756421.7A patent/EP2164992B1/en active Active
-
2012
- 2012-04-16 US US13/448,269 patent/US20120195901A1/en not_active Abandoned
-
2014
- 2014-11-17 JP JP2014232393A patent/JP2015096507A/ja active Pending
-
2015
- 2015-07-29 US US14/812,325 patent/US20160146844A1/en not_active Abandoned
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