JP2010530218A5 - - Google Patents

Download PDF

Info

Publication number
JP2010530218A5
JP2010530218A5 JP2010510480A JP2010510480A JP2010530218A5 JP 2010530218 A5 JP2010530218 A5 JP 2010530218A5 JP 2010510480 A JP2010510480 A JP 2010510480A JP 2010510480 A JP2010510480 A JP 2010510480A JP 2010530218 A5 JP2010530218 A5 JP 2010530218A5
Authority
JP
Japan
Prior art keywords
group
antibody
amino acid
acid sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010510480A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010530218A (ja
JP5989299B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/065045 external-priority patent/WO2008150841A1/en
Publication of JP2010530218A publication Critical patent/JP2010530218A/ja
Publication of JP2010530218A5 publication Critical patent/JP2010530218A5/ja
Application granted granted Critical
Publication of JP5989299B2 publication Critical patent/JP5989299B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010510480A 2007-05-30 2008-05-29 リゾホスファチジン酸結合のための組成物と方法 Expired - Fee Related JP5989299B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94096407P 2007-05-30 2007-05-30
US60/940,964 2007-05-30
PCT/US2008/065045 WO2008150841A1 (en) 2007-05-30 2008-05-29 Compositions and methods for binding lysophosphatidic acid

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014232393A Division JP2015096507A (ja) 2007-05-30 2014-11-17 リゾホスファチジン酸結合のための組成物と方法

Publications (3)

Publication Number Publication Date
JP2010530218A JP2010530218A (ja) 2010-09-09
JP2010530218A5 true JP2010530218A5 (enExample) 2011-08-04
JP5989299B2 JP5989299B2 (ja) 2016-09-07

Family

ID=40094082

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010510480A Expired - Fee Related JP5989299B2 (ja) 2007-05-30 2008-05-29 リゾホスファチジン酸結合のための組成物と方法
JP2014232393A Pending JP2015096507A (ja) 2007-05-30 2014-11-17 リゾホスファチジン酸結合のための組成物と方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014232393A Pending JP2015096507A (ja) 2007-05-30 2014-11-17 リゾホスファチジン酸結合のための組成物と方法

Country Status (9)

Country Link
US (3) US8158124B2 (enExample)
EP (1) EP2164992B1 (enExample)
JP (2) JP5989299B2 (enExample)
AU (1) AU2008260135A1 (enExample)
CA (1) CA2724432A1 (enExample)
DK (1) DK2164992T3 (enExample)
ES (1) ES2585702T3 (enExample)
LT (1) LT2164992T (enExample)
WO (1) WO2008150841A1 (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9274130B2 (en) * 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
US8796429B2 (en) 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US20110064744A1 (en) * 2007-05-30 2011-03-17 Sabbadini Roger A Prevention and treatment of pain using antibodies to lysophosphatidic acid
DK2164992T3 (en) * 2007-05-30 2016-08-15 Lpath Inc COMPOSITIONS AND METHODS FOR BONDING OF LYTHOPHOSPHATIC ACID
US8372888B2 (en) * 2008-04-29 2013-02-12 Enzo Therapeutics, Inc. Sphingosine kinase type 1 inhibitors, compositions and processes for using same
EP2282769A4 (en) 2008-04-29 2012-04-25 Abbott Lab DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES
EP2297209A4 (en) 2008-06-03 2012-08-01 Abbott Lab IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF
KR20110016959A (ko) 2008-06-03 2011-02-18 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
US8822645B2 (en) 2008-07-08 2014-09-02 Abbvie Inc. Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
US8629247B2 (en) 2009-04-14 2014-01-14 Proscan Rx Pharma Inc. Antibodies against prostate specific membrane antigen
EP2419446A4 (en) 2009-04-17 2013-01-23 Lpath Inc HUMANIZED ANTIBODY COMPOSITIONS AND METHOD FOR BINDING LYSOPHOSPHACIDIC ACID
US20110076269A1 (en) * 2009-06-24 2011-03-31 Pebay Alice Marie Methods of increasing neuronal differentiation using antibodies to lysophosphatidic acid
WO2011081214A1 (ja) * 2009-12-28 2011-07-07 国立大学法人東京大学 オートタキシン測定による肝線維化の検査方法および検査薬
US20110212088A1 (en) * 2010-02-26 2011-09-01 Sabbadini Roger A Anti-paf antibodies
WO2011156242A2 (en) * 2010-06-11 2011-12-15 Lpath, Inc. Improved anti-lysophospholipid antibody design using antibody structures
WO2012009576A2 (en) * 2010-07-14 2012-01-19 Lpath, Inc. Prevention and treatment of pain using monoclonal antibodies and antibody fragments to lysophosphatidic acid
KR20130100118A (ko) 2010-08-03 2013-09-09 아비에 인코포레이티드 이원 가변 도메인 면역글로불린 및 이의 용도
US9046513B2 (en) 2010-08-26 2015-06-02 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
WO2013023040A2 (en) * 2011-08-09 2013-02-14 Lpath, Inc. Stem cell therapy using inhibitors of lysophosphatidic acid
AR089529A1 (es) 2011-12-30 2014-08-27 Abbvie Inc Proteinas de union especificas duales dirigidas contra il-13 y/o il-17
HK1204061A1 (en) * 2012-02-29 2015-11-06 Lpath, Inc. Methods and kits for detecting and diagnosing neurotrauma
DE102012021222B4 (de) * 2012-10-27 2015-02-05 Forschungszentrum Jülich GmbH Verfahren zur Herstellung einer nanoporösen Schicht auf einem Substrat
PE20151179A1 (es) 2012-11-01 2015-09-12 Abbvie Inc Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas
AU2014227732A1 (en) 2013-03-15 2015-09-17 Abbvie Inc. Dual specific binding proteins directed against IL-1 beta and IL-17
WO2016025879A1 (en) * 2014-08-15 2016-02-18 Indiana University Research And Technology Corporation Treatment of cystic diseases
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗vegf、pdgf及/或其受體之結合蛋白
US9724057B2 (en) * 2015-06-30 2017-08-08 Toshiba Medical Systems Corporation Magnetic field actuation of detectors in a computed tomography scanner
JP6889432B2 (ja) * 2016-04-28 2021-06-18 学校法人甲南学園 樹脂固定ペプチド
US12054558B2 (en) 2018-05-23 2024-08-06 The Jackson Laboratory Anti-NGly-1 antibodies and methods of use
ES2736045A1 (es) * 2018-06-21 2019-12-23 Univ Cadiz Metodos para el diagnostico y/o tratamiento de enfermedades neurodegenerativas
CN113827605B (zh) * 2021-08-27 2023-06-09 上海市肺科医院 甘油磷酸胆碱在制备预防和治疗结核病药物中的应用
CN118541392A (zh) * 2021-09-28 2024-08-23 准星生物医药有限公司 多种形式的分子复合物

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
WO1990003430A1 (en) 1988-09-23 1990-04-05 Cetus Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US20040049014A1 (en) 1988-12-28 2004-03-11 Protein Design Labs, Inc. Humanized immunoglobulins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
EP0626012B1 (en) 1992-02-11 2003-07-09 Cell Genesys, Inc. Homogenotization of gene-targeting events
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US6129914A (en) 1992-03-27 2000-10-10 Protein Design Labs, Inc. Bispecific antibody effective to treat B-cell lymphoma and cell line
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
GB9223377D0 (en) 1992-11-04 1992-12-23 Medarex Inc Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
US6210671B1 (en) 1992-12-01 2001-04-03 Protein Design Labs, Inc. Humanized antibodies reactive with L-selectin
GB9325182D0 (en) 1993-12-08 1994-02-09 T Cell Sciences Inc Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
US5882644A (en) 1996-03-22 1999-03-16 Protein Design Labs, Inc. Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US6013256A (en) 1996-09-24 2000-01-11 Protein Design Labs, Inc. Method of preventing acute rejection following solid organ transplantation
WO1999029888A1 (en) 1997-12-05 1999-06-17 The Scripps Research Institute Humanization of murine antibody
WO1999045959A1 (en) 1998-03-13 1999-09-16 Dana-Farber Cancer Institute, Inc. Humanized antibody and uses thereof
AU6078399A (en) * 1998-09-29 2000-04-17 Arne Holm Ligand presenting assembly (lpa), method of preparation and uses thereof
US6248553B1 (en) 1998-10-22 2001-06-19 Atairgin Technologies, Inc. Enzyme method for detecting lysophospholipids and phospholipids and for detecting and correlating conditions associated with altered levels of lysophospholipids
WO2000032634A1 (en) 1998-12-01 2000-06-08 Protein Design Labs, Inc. Humanized antibodies to gamma-interferon
CA2389832A1 (en) * 1999-11-04 2001-05-10 Abbott Laboratories Improved automated lpa assay and methods of detecting cancer
US20030003479A1 (en) * 2001-04-19 2003-01-02 Millennium Pharmaceutical, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer
MY147019A (en) * 2002-03-13 2012-10-15 Biogen Idec Inc Anti-alpha v beta 6 antibodies
CN1678634A (zh) * 2002-06-28 2005-10-05 多曼蒂斯有限公司 免疫球蛋白单个变体抗原结合区及其特异性构建体
US7459285B2 (en) 2002-12-10 2008-12-02 Echelon Biosciences Incorporated Compounds and methods of use thereof for assaying lysophospholipase D activity
WO2005064332A1 (ja) 2003-12-26 2005-07-14 Ono Pharmaceutical Co., Ltd. 高活性型リゾホスファチジン酸およびそれを用いたスクリーニング方法
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
CA2591914C (en) 2005-01-24 2017-04-25 Board Of Regents, The University Of Texas System Fc-fusion constructs binding to phosphatidylserine and their therapeutic use
US20110123440A1 (en) 2005-03-29 2011-05-26 Genevieve Hansen Altered Antibody FC Regions and Uses Thereof
US8796429B2 (en) * 2006-05-31 2014-08-05 Lpath, Inc. Bioactive lipid derivatives, and methods of making and using same
US9274129B2 (en) * 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9217749B2 (en) * 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
DK2164992T3 (en) * 2007-05-30 2016-08-15 Lpath Inc COMPOSITIONS AND METHODS FOR BONDING OF LYTHOPHOSPHATIC ACID
US9163091B2 (en) * 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
EP2419446A4 (en) * 2009-04-17 2013-01-23 Lpath Inc HUMANIZED ANTIBODY COMPOSITIONS AND METHOD FOR BINDING LYSOPHOSPHACIDIC ACID

Similar Documents

Publication Publication Date Title
JP7815199B2 (ja) 腎疾患及び歯周疾患を検出及び診断するための方法及び組成物
CN104903350B (zh) 特异于clec14a的新抗体及其用途
US11376333B2 (en) mTG substrates for covalent conjugation of compounds
US20110262444A1 (en) Form-specific antibodies for nag-1 (mic-1, gdf-15), h6d and other tgf-beta subfamily and heart disease and cancer diagnoses
JP2013518055A5 (enExample)
UA120027C2 (uk) Ізольоване антитіло проти собачого тимусного стромального лімфопоетину (tslp)
TW202212360A (zh) 抗cldn18.2抗體及其診斷用途
JP2009544284A5 (enExample)
EP2219668A1 (en) Binding epitopes for g250 antibody
CN121219584A (zh) 针对nr1的自身抗体的检测
EP2621948A1 (en) Antibody specifically binding synovial microvasculature of arthritis patients
CA3058117C (en) Antibody binding specifically to n-terminal region of lysyl-trna synthetase exposed on cell membrane
JPWO2019202767A1 (ja) 抗線維化剤及び線維症のバイオマーカー
US20240124564A1 (en) Anti-cleaved histone h3 monoclonal antibody that specifically recognizes neutrophil extracellular traps
JP5956424B2 (ja) 抗体、乳がんの治療に用いられる医薬組成物、腫瘍検査方法、及び、腫瘍検査用試薬
WO2018182284A1 (ko) 세포 외막에 노출되는 라이실-tRNA 합성효소 N-말단 영역에 특이적으로 결합하는 항체
CN114761803B (zh) 使用抗bag2抗体诊断癌症的方法
JP2008509659A5 (enExample)
US20180201660A1 (en) Anti-angiogenic vegf-ax isoform
JP6797107B2 (ja) 膵臓機能異常の検出方法及び検出用キット
ES2339125T3 (es) Sp1 fosforilado como marcador en el diagnostico de esteatohepatitis no alcoholica (ehna) y diana en el cribado de farmacos para ehna.
WO2024084807A1 (ja) 線維芽細胞増殖因子18の測定方法及び測定用試薬
RU2562880C2 (ru) Синтетический пептид для получения моноспецифичных антител против изоформы 2 эукариотического фактора элонгации трансляции 1а
CN109152833B (zh) 针对肌腱蛋白的人类抗体和其结合片段
JP5626681B2 (ja) 癌の検出方法