JP2014077003A5 - - Google Patents

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Publication number
JP2014077003A5
JP2014077003A5 JP2013257143A JP2013257143A JP2014077003A5 JP 2014077003 A5 JP2014077003 A5 JP 2014077003A5 JP 2013257143 A JP2013257143 A JP 2013257143A JP 2013257143 A JP2013257143 A JP 2013257143A JP 2014077003 A5 JP2014077003 A5 JP 2014077003A5
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JP
Japan
Prior art keywords
ischemia
pharmaceutical composition
final dose
reperfusion injury
subject
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JP2013257143A
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English (en)
Japanese (ja)
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JP5767307B2 (ja
JP2014077003A (ja
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Priority claimed from US12/466,170 external-priority patent/US7928067B2/en
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Publication of JP2014077003A publication Critical patent/JP2014077003A/ja
Publication of JP2014077003A5 publication Critical patent/JP2014077003A5/ja
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JP2013257143A 2009-05-14 2013-12-12 虚血および虚血・再灌流障害を治療するための組成物および方法 Active JP5767307B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/466,170 US7928067B2 (en) 2009-05-14 2009-05-14 Compositions and methods for treating ischemia and ischemia-reperfusion injury
US12/466,170 2009-05-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2012511009A Division JP5570590B2 (ja) 2009-05-14 2010-05-13 虚血および虚血・再灌流障害を治療するための組成物および方法

Publications (3)

Publication Number Publication Date
JP2014077003A JP2014077003A (ja) 2014-05-01
JP2014077003A5 true JP2014077003A5 (enExample) 2014-07-10
JP5767307B2 JP5767307B2 (ja) 2015-08-19

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012511009A Active JP5570590B2 (ja) 2009-05-14 2010-05-13 虚血および虚血・再灌流障害を治療するための組成物および方法
JP2013257143A Active JP5767307B2 (ja) 2009-05-14 2013-12-12 虚血および虚血・再灌流障害を治療するための組成物および方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2012511009A Active JP5570590B2 (ja) 2009-05-14 2010-05-13 虚血および虚血・再灌流障害を治療するための組成物および方法

Country Status (16)

Country Link
US (5) US7928067B2 (enExample)
EP (1) EP2429519B1 (enExample)
JP (2) JP5570590B2 (enExample)
KR (1) KR101636395B1 (enExample)
CN (1) CN102802622B (enExample)
AU (1) AU2010249001B2 (enExample)
BR (1) BRPI1012182A2 (enExample)
CA (1) CA2761798C (enExample)
DK (1) DK2429519T3 (enExample)
ES (1) ES2470673T3 (enExample)
IL (2) IL216349A (enExample)
MX (2) MX347460B (enExample)
NZ (1) NZ596364A (enExample)
PL (1) PL2429519T3 (enExample)
SG (1) SG176062A1 (enExample)
WO (1) WO2010132657A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8541396B2 (en) 2009-04-24 2013-09-24 National University Of Singapore Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent
US7928067B2 (en) 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
CA2817362C (en) 2010-11-18 2018-10-23 Ischemix Llc Lipoyl compounds and their use for treating ischemic injury
EP2540292A1 (en) * 2011-06-28 2013-01-02 Nestec S.A. DHA and EPA in the reduction of oxidative stress
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
CN108949717B (zh) 2012-05-11 2023-06-20 珍白斯凯尔有限公司 抗炎性肽及包含其的组合物
JP6267190B2 (ja) 2012-05-11 2018-01-24 ジェムバックス アンド カエル カンパニー，リミティド 悪液質の予防用または治療用組成物
US10967000B2 (en) 2012-07-11 2021-04-06 Gemvax & Kael Co., Ltd. Cell-penetrating peptide, conjugate comprising same and composition comprising same
WO2014171792A1 (ko) * 2013-04-19 2014-10-23 주식회사 카엘젬백스 허혈성 손상 치료 및 예방용 조성물
EP4063863A1 (en) 2013-06-07 2022-09-28 Gemvax & Kael Co., Ltd. Gv1001, gemcitabine and capecitabine for use in the treatment of pancreatic cancer in high eotaxin baseline level patients
ES2808076T3 (es) 2013-06-21 2021-02-25 Gemvax & Kael Co Ltd Regulador de la secreción hormonal, composición que lo contiene y procedimiento para controlar la secreción hormonal mediante su uso
CN105899224B (zh) 2013-10-23 2019-12-13 珍白斯凯尔有限公司 用于治疗和预防良性前列腺增生的组合物
CN105848667B (zh) 2013-11-22 2020-05-19 珍白斯凯尔有限公司 具有血管生成抑制活性的肽和包含所述肽的组合物
CN105939723B (zh) 2013-12-17 2020-02-28 珍白斯凯尔有限公司 前列腺癌治疗用组合物
US9937240B2 (en) 2014-04-11 2018-04-10 Gemvax & Kael Co., Ltd. Peptide having fibrosis inhibitory activity and composition containing same
ES2962532T3 (es) 2014-04-30 2024-03-19 Gemvax & Kael Co Ltd Composición para el trasplante de órganos, tejidos o células, kit y procedimiento de trasplante
WO2015174948A1 (en) 2014-05-14 2015-11-19 Ischemix, LLC Formulations comprising lipoyl compounds
CN104095835A (zh) * 2014-06-20 2014-10-15 广州军区广州总医院 对羟基苄叉丙酮在制备预防和/或治疗肝缺血/再灌注损伤药物中的应用
KR102413243B1 (ko) 2014-12-23 2022-06-27 주식회사 젬백스앤카엘 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물
US10835582B2 (en) 2015-02-27 2020-11-17 Gemvax & Kael Co. Ltd. Peptide for preventing hearing loss, and composition comprising same
ES2886946T3 (es) 2015-07-02 2021-12-21 Gemvax & Kael Co Ltd Péptido con efecto antiviral y composición que lo contiene
US10898540B2 (en) 2016-04-07 2021-01-26 Gem Vax & KAEL Co., Ltd. Peptide having effects of increasing telomerase activity and extending telomere, and composition containing same
CN106083800A (zh) * 2016-06-13 2016-11-09 崔坤峰 氯普噻吨的药物组合物及对脑缺血再灌注损伤的保护作用
MD3522880T2 (ro) * 2016-10-05 2021-03-31 Mitobridge Inc Metode de tratare a leziunilor renale acute
WO2018200680A1 (en) * 2017-04-25 2018-11-01 Ischemix Llc Compositions and methods for treating traumatic brain injury
KR102139678B1 (ko) 2017-11-24 2020-07-31 전북대학교 산학협력단 N-아세틸 또는 n-아실 아미노산을 포함하는 아토피 또는 가려움증 치료용 조성물
KR102112949B1 (ko) 2019-02-12 2020-05-19 남현규 복합 효모 발효로 불용 단백질을 가용화하여 화장품원료를 추출하는 화장품원료 제조방법

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1047991B (de) 1957-11-20 1958-12-31 Nordmark Werke Gmbh Verfahren zur Herstellung chemisch stabiler, untoxischer, steriler Injektionsloesungen von Thioctsaeure
US3875207A (en) * 1967-01-25 1975-04-01 Ciba Geigy Corp Process for the temporary protection of amino groups in peptide syntheses
CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US5288706A (en) * 1987-12-25 1994-02-22 Mitsui Toatsu Chemicals, Incorporated Medicament for prevention and remedy of diseases of the pancreas and others
FR2653334B1 (fr) 1989-10-19 1991-12-20 Erphar Ste Civile Preparation cosmetique de bronzage.
EP0812590A3 (de) 1989-11-09 1999-06-09 ASTA Medica Aktiengesellschaft Verwendung von R-Alpha-Liponsäure zur Zytoprotektion
DE4000397A1 (de) 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
WO1993021970A1 (en) 1992-04-24 1993-11-11 Biocompatibles Limited Method of reducing microorganism adhesion
DE4235912C2 (de) 1992-10-23 2002-12-05 Viatris Gmbh Verfahren zur Herstellung kristalliner Thioctsäure und deren Verwendung
DE4433764A1 (de) 1994-09-22 1996-03-28 Asta Medica Ag Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit
US6127339A (en) * 1995-06-21 2000-10-03 Asahi Kasei Kogyo Kabushiki Kaisha Peptide for binding thereto a low density lipoprotein
JPH0990542A (ja) 1995-09-28 1997-04-04 Konica Corp ハロゲン化銀写真感光材料
FR2741075B1 (fr) 1995-11-15 1998-01-30 Rech De Pathologie Appliquee S Conjugues peptidiques, leur utilisation a titre de medicament et compositions les contenant
IL123887A0 (en) 1997-04-02 1998-10-30 Sankyo Co Dithiolan derivatives their use and pharmaceutical compositions containing the same
JPH117099A (ja) 1997-06-13 1999-01-12 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US6090842A (en) 1998-03-10 2000-07-18 The Regents Of The University Of California Lipoic acid analogs
DE19834608A1 (de) 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure
JP2000169371A (ja) 1998-10-02 2000-06-20 Sankyo Co Ltd ジチオラン誘導体を含有する医薬
AU758903B2 (en) 1998-11-26 2003-04-03 Pentapharm Ag Transport system conjugate
AU6462500A (en) 1999-07-29 2001-02-19 Patrick T. Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement
US6890896B1 (en) 1999-11-18 2005-05-10 Ceremedix, Inc. Compositions and methods for counteracting effects of reactive oxygen species and free radicals
CA2389429C (en) * 1999-11-18 2012-05-29 Victor E. Shashoua Compositions and methods for counteracting effects of reactive oxygen species and free radicals
US6664287B2 (en) 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
JP2002189271A (ja) 2000-12-21 2002-07-05 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料およびその処理方法
JP4072062B2 (ja) 2001-03-19 2008-04-02 千寿製薬株式会社 新規α−リポ酸誘導体およびその用途
JP2005515156A (ja) 2001-05-25 2005-05-26 セレメディックス，インク． 反応性酸素種およびフリーラジカルの効力を中和するための単一アミノ酸に基づく化合物
JP4259813B2 (ja) 2001-05-29 2009-04-30 千寿製薬株式会社 α−リポイルアミノ酸の安定化法および安定化されたα−リポイルアミノ酸を含有する水性液剤
DE10163836A1 (de) 2001-12-22 2003-07-10 Friz Biochem Gmbh Multifunktionales Reagenz zur Synthese von thiolmodifizierten Oligomeren
JP4272068B2 (ja) 2001-12-26 2009-06-03 日本曹達株式会社 自己組織化単分子膜を形成する電子受容性化合物
AUPS065102A0 (en) 2002-02-20 2002-03-14 Unisearch Limited Fluorous acetalation
US20030187059A1 (en) 2002-02-22 2003-10-02 Levin Robert M. Methods and compounds useful in inhibiting oxidative and/or free radical damage and in the treatment and prevention of disease
JP2003286168A (ja) 2002-03-28 2003-10-07 Senju Pharmaceut Co Ltd α−リポイルアミノ酸を含有する皮膚外用剤
JP4376540B2 (ja) 2002-05-31 2009-12-02 アイバイツ株式会社 金属表面修飾剤および新規含硫黄化合物
US7030154B2 (en) 2002-06-07 2006-04-18 Juvenon, Inc. Stability of lipoic acid
TWI331034B (en) 2002-07-08 2010-10-01 Piramal Life Sciences Ltd Inhibitors of cyclin-dependent kinases and their use
EP1454627A1 (en) 2003-03-06 2004-09-08 MyoContract Ltd. Alpha-Keto carbonyl calpain inhibitors
US20040204340A1 (en) * 2003-04-11 2004-10-14 Guilford Pharmaceuticals, Inc. Polyprolyl inhibitors of cyclophilin
US7202270B2 (en) 2003-06-20 2007-04-10 Sami Labs Limited Convenient stable non-hygroscopic crystalline solid forms of racemic and chiral LA-plus salts: process for their manufacture and uses
US8088935B2 (en) 2003-12-23 2012-01-03 Ironwood Pharmaceuticals, Inc. Compounds and methods for the treatment of asthma
CN1930179B (zh) 2004-02-18 2010-06-09 独立行政法人科学技术振兴机构 糖链配体络合物和利用该配体络合物的蛋白质的分析方法
JP2006022066A (ja) 2004-07-09 2006-01-26 Shiseido Co Ltd 重合抑制剤および即時型黒化防止用皮膚外用剤
WO2006101910A2 (en) 2005-03-16 2006-09-28 Ischemix, Inc. Peptide compounds and methods of using peptide compounds to treat conditions affecting the cardiac, pulmonary, and nervous systems
WO2006101909A2 (en) 2005-03-16 2006-09-28 Ischemix, Inc. Combination therapy for treating or preventing diseases
JP2008174453A (ja) 2005-04-28 2008-07-31 Iwaki Kk 頭皮脱毛治療剤
US8507439B2 (en) * 2005-08-29 2013-08-13 Angela Shashoua Neuroprotective and neurorestorative method and compositions
JP4951226B2 (ja) 2005-09-08 2012-06-13 立山化成株式会社 α−リポ酸アルカリ塩の製法
WO2007030581A2 (en) * 2005-09-09 2007-03-15 Oregon Health & Science University Neuroprotectants
EP1844784B1 (en) 2006-03-28 2010-04-21 Epitech Group S.r.l. A pharmaceutical composition for the treatment of pathologies caused by the general response of the immune system
US20110212954A1 (en) 2008-11-07 2011-09-01 Mario Brufani Alpha-lipoic acid derivatives and their use in drug preparation
US7928067B2 (en) * 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
US8080674B2 (en) 2009-06-12 2011-12-20 Ampac Fine Chemicals Llc. Preparation of polymer-free R-(+)-α-lipoic acid magnesium salt
PL2821405T3 (pl) 2009-06-15 2017-08-31 Encore Health, Llc Estry cholinowe do leczenia prezbiopii i zaćmy
EP2442647B1 (en) 2009-06-15 2016-03-16 Encore Health LLC Dithiol compounds, derivatives, and uses therefor
IT1397154B1 (it) 2010-01-04 2013-01-04 Ghelardini Composti ad efficacia sia analgesica che antiperalgesica.
CA2817362C (en) 2010-11-18 2018-10-23 Ischemix Llc Lipoyl compounds and their use for treating ischemic injury
WO2015174948A1 (en) 2014-05-14 2015-11-19 Ischemix, LLC Formulations comprising lipoyl compounds
US20150329519A1 (en) 2014-05-14 2015-11-19 Ischemix, LLC Formulations Comprising Lipoyl Compounds

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