JP2014139255A5 - - Google Patents

Info

Publication number

JP2014139255A5

JP2014139255A5 JP2014097072A JP2014097072A JP2014139255A5 JP 2014139255 A5 JP2014139255 A5 JP 2014139255A5 JP 2014097072 A JP2014097072 A JP 2014097072A JP 2014097072 A JP2014097072 A JP 2014097072A JP 2014139255 A5 JP2014139255 A5 JP 2014139255A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

tissue

nitrite

pharmaceutically acceptable

Prior art date

2014-05-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims description 21
• 210000001519 tissue Anatomy 0.000 claims description 17
• IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims description 12
• 230000000302 ischemic effect Effects 0.000 claims description 11
• 150000003839 salts Chemical class 0.000 claims description 11
• 206010052428 Wound Diseases 0.000 claims description 8
• 208000027418 Wounds and injury Diseases 0.000 claims description 8
• 230000001684 chronic effect Effects 0.000 claims description 8
• 150000002826 nitrites Chemical class 0.000 claims description 6
• 208000023589 ischemic disease Diseases 0.000 claims description 5
• 206010022562 Intermittent claudication Diseases 0.000 claims description 4
• 210000002808 connective tissue Anatomy 0.000 claims description 4
• 206010012601 diabetes mellitus Diseases 0.000 claims description 4
• 208000021156 intermittent vascular claudication Diseases 0.000 claims description 4
• 208000033808 peripheral neuropathy Diseases 0.000 claims description 4
• 210000003491 skin Anatomy 0.000 claims description 4
• LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical group [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 4
• 230000029663 wound healing Effects 0.000 claims description 4
• 208000024891 symptom Diseases 0.000 claims description 3
• 201000001320 Atherosclerosis Diseases 0.000 claims description 2
• 208000010392 Bone Fractures Diseases 0.000 claims description 2
• 206010010356 Congenital anomaly Diseases 0.000 claims description 2
• 206010017076 Fracture Diseases 0.000 claims description 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
• 241000124008 Mammalia Species 0.000 claims description 2
• 206010031252 Osteomyelitis Diseases 0.000 claims description 2
• 208000005764 Peripheral Arterial Disease Diseases 0.000 claims description 2
• 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims description 2
• 208000006011 Stroke Diseases 0.000 claims description 2
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
• AZFNGPAYDKGCRB-XCPIVNJJSA-M [(1s,2s)-2-amino-1,2-diphenylethyl]-(4-methylphenyl)sulfonylazanide;chlororuthenium(1+);1-methyl-4-propan-2-ylbenzene Chemical compound [Ru+]Cl.CC(C)C1=CC=C(C)C=C1.C1=CC(C)=CC=C1S(=O)(=O)[N-][C@@H](C=1C=CC=CC=1)[C@@H](N)C1=CC=CC=C1 AZFNGPAYDKGCRB-XCPIVNJJSA-M 0.000 claims description 2
• 239000000730 antalgic agent Substances 0.000 claims description 2
• 239000003242 anti bacterial agent Substances 0.000 claims description 2
• 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
• 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
• 230000002253 anti-ischaemic effect Effects 0.000 claims description 2
• 239000002246 antineoplastic agent Substances 0.000 claims description 2
• 210000000988 bone and bone Anatomy 0.000 claims description 2
• 229940127089 cytotoxic agent Drugs 0.000 claims description 2
• 230000002496 gastric effect Effects 0.000 claims description 2
• 239000003102 growth factor Substances 0.000 claims description 2
• 208000014674 injury Diseases 0.000 claims description 2
• 208000030175 lameness Diseases 0.000 claims description 2
• 201000002818 limb ischemia Diseases 0.000 claims description 2
• 230000036244 malformation Effects 0.000 claims description 2
• 210000003205 muscle Anatomy 0.000 claims description 2
• 208000010125 myocardial infarction Diseases 0.000 claims description 2
• 210000004165 myocardium Anatomy 0.000 claims description 2
• 210000000944 nerve tissue Anatomy 0.000 claims description 2
• 201000001119 neuropathy Diseases 0.000 claims description 2
• 230000007823 neuropathy Effects 0.000 claims description 2
• RAFRTSDUWORDLA-UHFFFAOYSA-N phenyl 3-chloropropanoate Chemical compound ClCCC(=O)OC1=CC=CC=C1 RAFRTSDUWORDLA-UHFFFAOYSA-N 0.000 claims description 2
• 235000010289 potassium nitrite Nutrition 0.000 claims description 2
• 239000004304 potassium nitrite Substances 0.000 claims description 2
• 230000000284 resting effect Effects 0.000 claims description 2
• 210000002027 skeletal muscle Anatomy 0.000 claims description 2
• 210000002460 smooth muscle Anatomy 0.000 claims description 2
• 235000010288 sodium nitrite Nutrition 0.000 claims description 2
• 238000001356 surgical procedure Methods 0.000 claims description 2
• 230000008736 traumatic injury Effects 0.000 claims description 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims 1
• 238000007917 intracranial administration Methods 0.000 claims 1
• 238000000034 method Methods 0.000 description 32
• 208000028867 ischemia Diseases 0.000 description 4
• 239000008280 blood Substances 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 229910002651 NO3 Inorganic materials 0.000 description 2
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
• 210000004204 blood vessel Anatomy 0.000 description 2
• 229910001959 inorganic nitrate Inorganic materials 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 230000006444 vascular growth Effects 0.000 description 1