JP2014055127A - フィラグリン遺伝子発現促進剤 - Google Patents
フィラグリン遺伝子発現促進剤 Download PDFInfo
- Publication number
- JP2014055127A JP2014055127A JP2013072814A JP2013072814A JP2014055127A JP 2014055127 A JP2014055127 A JP 2014055127A JP 2013072814 A JP2013072814 A JP 2013072814A JP 2013072814 A JP2013072814 A JP 2013072814A JP 2014055127 A JP2014055127 A JP 2014055127A
- Authority
- JP
- Japan
- Prior art keywords
- gene expression
- filaggrin gene
- filaggrin
- oil
- expression promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/411—Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/445—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
【解決手段】フィラグリン遺伝子が約24時間周期のリズム性を持って発現が増減していることを見出し、候補物質を添加後、発現が最大となる時間において候補物質をスクリーニングし、サンショウエキス、3-(1'-ピペリジン)-プロピオン酸、ゼラニウムオイル、サイプレスオイル、ローズオイル、ガルバナムオイル、ペッパーオイル、バジルオイル、o-トルイル酸メチル、メチルアンスラニレート、ジメチルアンスラニレートをフィラグリン遺伝子発現促進剤として同定した。
【選択図】図1
Description
フィラグリン遺伝子の発現促進;
皮膚バリア機能の亢進;及び
保湿
のうち少なくとも1以上の効果を有する。
市販の正常成人皮膚由来角化細胞(Cellntec社)を3×103個/cm2となるように培養プレートに播種し、上皮細胞用培地(CnT-BM.1、Cellntec社)中で37℃、5%CO2雰囲気下で培養した。3日後、コルチゾール50ng/mLを含む培地に交換し、37℃、5%CO2で同調培養を行なった。2時間後、通常培地に交換して培養を続け、経時的に細胞を採取した。採取した細胞から、市販のRNA抽出−cDNA合成キット(FastLane Cell cDNA Kit, Qiagen社)を用いてRNAを抽出し、cDNAを調製した。このcDNAを用いて定量PCR(QPCR)法によりフィラグリン遺伝子の発現量を測定した。同時に時計遺伝子PER3とBMAL1の発現量を測定し、フィラグリン遺伝子の発現リズムと比較した。QPCR法には市販のQPCR試薬キット(Brilliant III Ultra-Fast SYBR Green QPCR Kit、Agilent社)とQPCR測定装置(MX-3000P Real-time Quantitative PCR System、Agilent社)を用いた。内部標準としてハウスキーピング遺伝子であるRPLP0遺伝子の発現量を定量し、RPLP0に対する相対発現量を算出してフィラグリン遺伝子発現量とした。PCR用プライマーには市販のフィラグリン、PER3、BMAL1、RPLP0用プライマー(Perfect Real Time Primer、タカラバイオ社)を用いた。表1に使用したプライマー配列を示す。
市販の正常成人皮膚由来角化細胞(Cellntec社)を3x103個/cm2となるように培養プレートに播種し、上皮細胞用培地(CnT-BM.1、Cellntec社)中で37℃、5%CO2で培養した。3日後、各種候補薬剤を1%濃度となるように添加した培地に交換して、37℃、5%CO2で培養を続け、2時間後と18時間後に細胞を採取した。候補薬剤として、サンショウエキス(丸善製薬社)、ゼラニウムオイル(香栄興業社)、サイプレスオイル(ビオランド社)、ローズオイル(ビオランド社)、ガルバナムオイル(ビオランド社)、ペッパーオイル(ビオランド社)、バジルオイル(ビオランド社)、o-トルイル酸メチル(アルドリッチ社)、メチルアンスラニレート(東京化成工業社)、ジメチルアンスラニレート(東京化成工業社)、クローブ・バッドカリオフィラータオイル(ビオランド社)、アルニカ(香栄興業社)を添加した。薬剤未添加を対照に、コルチゾール(培地中濃度50ng/mL)を陽性対照とした。
市販の正常成人皮膚由来角化細胞(Cellntec社)を3x103個/cm2となるように培養プレートに播種し、上皮細胞用培地(CnT-BM.1、Cellntec社)中で37℃、5%CO2で培養した。3日後、3-(1'-ピペリジン)-プロピオン酸(1PP:有機合成工業社)を0.1%、サンショウエキスを0.1%、並びに1PPを0.1%及びサンショウエキスを0.1%の濃度となるように添加した培地に交換して、37℃、5%CO2で培養を続け、18時間後に細胞を採取した。薬剤未添加を対照として用いた。
以下、本発明のフィラグリン遺伝子発現促進剤の配合例を示すが、本発明の実施は以下に限定されるものではない。
(1)アルコール 75.0
(2)精製水 残余
(3)ジプロピレングリコール 5.0
(4)本発明のフィラグリン遺伝子発現促進剤:ローズオイル 10.0
(5)酸化防止剤 8.0
(6)色素 適量
(7)紫外線吸収剤 適量
(1)アルコール 80.0
(2)精製水 残余
(3)酸化防止剤 5.0
(4)本発明のフィラグリン遺伝子発現促進剤:サイプレスオイル 3.0
(5)3−メチルー3メトキシブタノール 5.0
(6)ジベンジリデンソルビトール 5.0
(1)タブ粉 75.5
(2)安息香酸ナトリウム 15.5
(3)本発明のフィラグリン遺伝子発現促進剤:ガルバナムオイル 5.0
(4)ユーカリオイル 1.0
(5)精製水 残余
(1)硫酸ナトリウム 45.0
(2)炭酸水素ナトリウム 45.0
(3)ラベンダーオイル 9.0
(4)本発明のフィラグリン遺伝子発現促進剤:メチルアンスラニレート 1.0
(1)エリスリトール 2.0
(2)カフェイン 5.0
(3)オウバク抽出物 3.0
(4)グリセリン 50.0
(5)カルボキシビニルポリマー 0.4
(6)ポリエチレングリコール400 30.0
(7)エデト3ナトリウム 0.1
(8)ポリオキシレン(10)メチルポリシロキサン共重合体 2.0
(9)スクワラン 1.0
(10)水酸化カリウム 0.15
(11)本発明のフィラグリン遺伝子発現促進剤:ゼラニウムオイル 1.0
(1)固形パラフィン 5.0
(2)ミツロウ 10.0
(3)ワセリン 15.0
(4)流動パラフィン 41.0
(5)1.3−ブチレングリコール 4.0
(6)モノステアリン酸グリセリン 2.0
(7)POE(20)ソルビタンモノラウリン酸エステル 2.0
(8)ホウ砂 0.2
(9)カフェイン 2.0
(10)防腐剤 適量
(11)酸化防止剤 適量
(12)本発明のフィラグリン遺伝子発現促進剤:サンショウエキス 1.0
(13)精製水 残余
キュプロアンモニウムセルロース溶液(セルロース濃度10重量%、アンモニウム濃度7重量%、銅濃度3.6重量%)に、本発明のフィラグリン遺伝子発現促進剤を内包したマイクロカプセル(粒子径50μm以下、マイクロカプセルに占める剤の割合は50重量%)をセルロース重量に対して0.1〜20重量%の範囲内で添加、混和した後、通常の湿式紡糸方法に従って紡糸し、精錬工程、乾燥工程を経て、芳香性繊維を得た。
(1)スクラロース 0.1
(2)本発明のフィラグリン遺伝子発現促進剤:サンショウエキス 0.1
(3)香味料 5.0
(4)賦形剤(セオラス) 10.0
(5)マルチトール 残余
(1)イノシトール 11.0
(2)マルチトール 21.0
(3)スクロース 0.5
(4)鮭白子抽出物(DNA Na) 0.1
(5)酵母抽出物 0.1
(6)本発明のフィラグリン遺伝子発現促進剤:バジルオイル 0.1
(7)香味料 5.0
(8)賦形剤 残余
(1)潤沢剤(ショ糖脂肪酸エステル等) 1.0
(2)アラビアガム水溶液(5%) 2.0
(3)酸味料 1.0
(4)着色料 適量
(5)本発明のフィラグリン遺伝子発現促進剤:ペッパーオイル 0.1
(6)糖質(粉糖またはソルビトール等) 残余
(1)砂糖 50.0
(2)水飴 47.95
(3)有機酸 2.0
(4)本発明のフィラグリン遺伝子発現促進剤:ローズオイル 0.05
(1)砂糖 43.0
(2)ガムベース 30.95
(3)グルコース 10.0
(4)水飴 16.0
(5)本発明のフィラグリン遺伝子発現促進剤:バジルオイル 0.05
(1)1,3−ブチレングリコール 6.0
(2)グリセリン 4.0
(3)オレイルアルコール 0.1
(4)POE(20)ソルビタンモノラウリン酸エステル 0.5
(5)POE(15)ラウリルアルコールエステル 0.5
(6)エタノール 10.0
(7)本発明のフィラグリン遺伝子発現促進剤:3-(1'-ピペリジン)-プロピオン酸
1.0
(8)精製水 残余
(1)マイクロクリスタリンワックス 1.0
(2)ミツロウ 2.0
(3)ラノリン 20.0
(4)流動パラフィン 10.0
(5)スクワラン 5.0
(6)POE(20)ソルビタンモノオレイン酸エステル 1.0
(7)プロピレングリコール 7.0
(8)本発明のフィラグリン遺伝子発現促進剤:3-(1'-ピペリジン)-プロピオン酸
0.5
(9)本発明のフィラグリン遺伝子発現促進剤:サンショウエキス 0.1
(10)亜硫酸水素ナトリウム 0.01
(11)エチルパラベン 0.3
(12)香料 適量
(13)精製水 残余
Claims (8)
- サンショウエキス、3-(1'-ピペリジン)-プロピオン酸、ゼラニウムオイル、サイプレスオイル、ローズオイル、ガルバナムオイル、ペッパーオイル、バジルオイル、o-トルイル酸メチル、メチルアンスラニレート、ジメチルアンスラニレートからなる群から選択される1以上を含む、フィラグリン遺伝子発現促進剤。
- フィラグリン遺伝子発現量の生体リズムと、フィラグリン遺伝子発現促進剤の投与により生じるフィラグリン遺伝子発現量のリズムとが同期するタイミングで、当該フィラグリン遺伝子発現促進剤を投与されるように用いられることを特徴とする、フィラグリン遺伝子発現促進剤。
- フィラグリン遺伝子発現量の生体リズムが乱れている対象において、フィラグリン遺伝子発現促進剤の投与により、フィラグリン遺伝子発現量のリズムを回復させるタイミングで、当該フィラグリン遺伝子発現促進剤を投与されるように用いられることを特徴とする、フィラグリン遺伝子発現促進剤。
- 前記フィラグリン遺伝子発現促進剤が、サンショウエキスを含む、請求項1に記載のフィラグリン遺伝子発現促進剤。
- 前記フィラグリン遺伝子発現促進剤が、サンショウエキス及び3-(1'-ピペリジン)-プロピオン酸を含む、請求項4に記載のフィラグリン遺伝子発現促進剤。
- フィラグリン遺伝子発現量の生体リズムと、請求項1に記載のフィラグリン遺伝子発現促進剤の投与により生じるフィラグリン遺伝子発現量のリズムとが同期するタイミングで、当該フィラグリン遺伝子発現促進剤を投与する、美容方法。
- 前記フィラグリン遺伝子発現促進剤が、サンショウエキスを含む、請求項6に記載の美容方法。
- 前記フィラグリン遺伝子発現促進剤が、サンショウエキス及び3-(1'-ピペリジン)-プロピオン酸を含む、請求項7に記載の美容方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013072814A JP6347916B2 (ja) | 2012-08-10 | 2013-03-29 | フィラグリン遺伝子発現促進剤 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012178486 | 2012-08-10 | ||
JP2012178486 | 2012-08-10 | ||
JP2013072814A JP6347916B2 (ja) | 2012-08-10 | 2013-03-29 | フィラグリン遺伝子発現促進剤 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018039001A Division JP2018090627A (ja) | 2012-08-10 | 2018-03-05 | フィラグリン遺伝子発現促進剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014055127A true JP2014055127A (ja) | 2014-03-27 |
JP6347916B2 JP6347916B2 (ja) | 2018-06-27 |
Family
ID=50067765
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013072814A Active JP6347916B2 (ja) | 2012-08-10 | 2013-03-29 | フィラグリン遺伝子発現促進剤 |
JP2018039001A Withdrawn JP2018090627A (ja) | 2012-08-10 | 2018-03-05 | フィラグリン遺伝子発現促進剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018039001A Withdrawn JP2018090627A (ja) | 2012-08-10 | 2018-03-05 | フィラグリン遺伝子発現促進剤 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9827187B2 (ja) |
EP (1) | EP2883548B1 (ja) |
JP (2) | JP6347916B2 (ja) |
KR (1) | KR102122619B1 (ja) |
CN (1) | CN104519894B (ja) |
ES (1) | ES2717652T3 (ja) |
HK (1) | HK1209048A1 (ja) |
TW (1) | TWI616209B (ja) |
WO (1) | WO2014024518A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016108261A (ja) * | 2014-12-04 | 2016-06-20 | 共栄化学工業株式会社 | 皮膚ターンオーバー改善剤 |
WO2019193717A1 (ja) * | 2018-04-05 | 2019-10-10 | 株式会社資生堂 | Asmt発現促進剤 |
JP2021059516A (ja) * | 2019-10-09 | 2021-04-15 | 三井製糖株式会社 | 皮膚のバリア機能改善剤 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9789070B2 (en) * | 2015-07-28 | 2017-10-17 | Elc Management Llc | Sheet packs for treating facial or body surfaces |
CN107828860A (zh) * | 2017-12-12 | 2018-03-23 | 杜立波 | 一种基于基因检测的护肤品定制方法 |
CN112584820A (zh) * | 2018-11-28 | 2021-03-30 | 株式会社Sd生命工学 | 含有百里香复合提取物作为有效成分的皮肤保湿用化妆品组合物 |
JP2022543068A (ja) * | 2019-08-01 | 2022-10-07 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 角質化障害の予防および低減、ならびに関連する化粧品剤 |
JP6805385B1 (ja) * | 2020-08-31 | 2020-12-23 | ジェイ−ネットワーク,インコーポレイテッド | 表皮内の保湿関連物質の発現増強剤 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001288045A (ja) * | 2000-03-31 | 2001-10-16 | Shiseido Co Ltd | 頭皮頭髪用組成物 |
WO2002053127A1 (fr) * | 2000-12-28 | 2002-07-11 | Shiseido Company, Ltd. | Agents d'inhibition ou de reparation d'affections cutanees causees par la secheresse, et procede d'evaluation de celles-ci |
JP2002265327A (ja) * | 2001-03-13 | 2002-09-18 | Chifure Keshohin:Kk | 化粧料 |
JP2002363054A (ja) * | 2001-06-05 | 2002-12-18 | Maruzen Pharmaceut Co Ltd | フィラグリン合成促進剤、角質層保湿機能改善・増強剤および角質層遊離アミノ酸量増加剤 |
JP2003306438A (ja) * | 2002-02-18 | 2003-10-28 | Shiseido Co Ltd | ケモカイン発現阻害剤 |
JP2006016337A (ja) * | 2004-07-01 | 2006-01-19 | Maruzen Pharmaceut Co Ltd | フィラグリン産生促進剤及び皮膚化粧料 |
JP2010090113A (ja) * | 2008-09-11 | 2010-04-22 | Shiseido Co Ltd | 皮膚化粧料 |
JP2011168555A (ja) * | 2010-02-22 | 2011-09-01 | Pola Chemical Industries Inc | 鑑別方法 |
WO2011122041A1 (ja) * | 2010-03-31 | 2011-10-06 | 株式会社 資生堂 | 時計遺伝子Periodの発現調節剤 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2170185A (en) * | 1936-04-01 | 1939-08-22 | Givaudan Delawanna Inc | Menthyl anthranilate and process of preparing same |
CA2344396A1 (en) * | 1998-09-18 | 2000-03-30 | Lavipharm Laboratories, Inc. | Transdermal devices comprising essential oils for aromatherapy |
JP4215906B2 (ja) * | 1999-02-16 | 2009-01-28 | 株式会社カネボウ化粧品 | 化粧料 |
JP4540872B2 (ja) | 2001-04-02 | 2010-09-08 | 株式会社資生堂 | 乾燥による皮膚傷害の抑制剤もしくは修復剤 |
JP2007217325A (ja) * | 2006-02-16 | 2007-08-30 | Kose Corp | プロフィラグリン及び/又はフィラグリン産生促進剤 |
JP2008255020A (ja) * | 2007-04-02 | 2008-10-23 | Fujifilm Corp | 抗老化皮膚外用剤 |
KR20090119340A (ko) * | 2008-05-16 | 2009-11-19 | 주식회사 코리아나화장품 | 천초 추출물을 유효성분으로 함유하는 피부미백용 화장료조성물 |
FR2945943B1 (fr) | 2009-06-01 | 2015-04-03 | Lvmh Rech | Utilisation d'un extrait vegetal riche en polyphenols comme agent antioxydant en association avec un agent hydratant ou humectant |
JP5868312B2 (ja) * | 2010-03-31 | 2016-02-24 | 株式会社 資生堂 | 時計遺伝子Bmalの発現調節剤 |
-
2013
- 2013-03-29 JP JP2013072814A patent/JP6347916B2/ja active Active
- 2013-03-29 EP EP13828308.0A patent/EP2883548B1/en active Active
- 2013-03-29 CN CN201380041595.9A patent/CN104519894B/zh active Active
- 2013-03-29 TW TW102111591A patent/TWI616209B/zh not_active IP Right Cessation
- 2013-03-29 WO PCT/JP2013/059674 patent/WO2014024518A1/ja active Application Filing
- 2013-03-29 US US14/419,715 patent/US9827187B2/en active Active
- 2013-03-29 ES ES13828308T patent/ES2717652T3/es active Active
- 2013-03-29 KR KR1020147035656A patent/KR102122619B1/ko active IP Right Grant
-
2015
- 2015-10-07 HK HK15109783.5A patent/HK1209048A1/xx not_active IP Right Cessation
-
2018
- 2018-03-05 JP JP2018039001A patent/JP2018090627A/ja not_active Withdrawn
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001288045A (ja) * | 2000-03-31 | 2001-10-16 | Shiseido Co Ltd | 頭皮頭髪用組成物 |
WO2002053127A1 (fr) * | 2000-12-28 | 2002-07-11 | Shiseido Company, Ltd. | Agents d'inhibition ou de reparation d'affections cutanees causees par la secheresse, et procede d'evaluation de celles-ci |
JP2002265327A (ja) * | 2001-03-13 | 2002-09-18 | Chifure Keshohin:Kk | 化粧料 |
JP2002363054A (ja) * | 2001-06-05 | 2002-12-18 | Maruzen Pharmaceut Co Ltd | フィラグリン合成促進剤、角質層保湿機能改善・増強剤および角質層遊離アミノ酸量増加剤 |
JP2003306438A (ja) * | 2002-02-18 | 2003-10-28 | Shiseido Co Ltd | ケモカイン発現阻害剤 |
JP2006016337A (ja) * | 2004-07-01 | 2006-01-19 | Maruzen Pharmaceut Co Ltd | フィラグリン産生促進剤及び皮膚化粧料 |
JP2010090113A (ja) * | 2008-09-11 | 2010-04-22 | Shiseido Co Ltd | 皮膚化粧料 |
JP2011168555A (ja) * | 2010-02-22 | 2011-09-01 | Pola Chemical Industries Inc | 鑑別方法 |
WO2011122041A1 (ja) * | 2010-03-31 | 2011-10-06 | 株式会社 資生堂 | 時計遺伝子Periodの発現調節剤 |
Non-Patent Citations (2)
Title |
---|
SHISEIDO'S NEW INGREDIENT TO PROTECT SKIN FROM EXTERNAL STRESSES, 2009, [RETRIEVED ON 2017.06.20], R, JPN6017023637, ISSN: 0003640637 * |
生化学, 学会抄録CD, 2008, P.1P-1019, JPN6016045504, ISSN: 0003640636 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016108261A (ja) * | 2014-12-04 | 2016-06-20 | 共栄化学工業株式会社 | 皮膚ターンオーバー改善剤 |
WO2019193717A1 (ja) * | 2018-04-05 | 2019-10-10 | 株式会社資生堂 | Asmt発現促進剤 |
JPWO2019193717A1 (ja) * | 2018-04-05 | 2021-04-08 | 株式会社 資生堂 | Asmt発現促進剤 |
JP7142085B2 (ja) | 2018-04-05 | 2022-09-26 | 株式会社 資生堂 | Asmt発現促進剤 |
JP2021059516A (ja) * | 2019-10-09 | 2021-04-15 | 三井製糖株式会社 | 皮膚のバリア機能改善剤 |
JP7492324B2 (ja) | 2019-10-09 | 2024-05-29 | Dm三井製糖株式会社 | 皮膚のバリア機能改善剤 |
Also Published As
Publication number | Publication date |
---|---|
CN104519894A (zh) | 2015-04-15 |
TWI616209B (zh) | 2018-03-01 |
TW201406397A (zh) | 2014-02-16 |
JP2018090627A (ja) | 2018-06-14 |
US9827187B2 (en) | 2017-11-28 |
US20150190336A1 (en) | 2015-07-09 |
HK1209048A1 (en) | 2016-03-24 |
CN104519894B (zh) | 2018-11-09 |
JP6347916B2 (ja) | 2018-06-27 |
KR20150042156A (ko) | 2015-04-20 |
ES2717652T3 (es) | 2019-06-24 |
EP2883548A4 (en) | 2016-05-11 |
WO2014024518A1 (ja) | 2014-02-13 |
EP2883548A1 (en) | 2015-06-17 |
EP2883548B1 (en) | 2019-01-02 |
KR102122619B1 (ko) | 2020-06-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6347916B2 (ja) | フィラグリン遺伝子発現促進剤 | |
JP4549625B2 (ja) | 人参サポニン代謝産物を有効成分とする微細乳化粒子及びその製造方法、並びにこれを含有する皮膚老化防止用の化粧料組成物 | |
EP2554177B1 (en) | Cosmetic use of Elemi oil for improving rough skin resulting from the malfunction of the circadian rhythm | |
TW201206494A (en) | Use of Tiliacora triandra in cosmetics and compositions thereof | |
JP2016147873A (ja) | コウゾ抽出物 | |
JP5761888B2 (ja) | 抗老化剤及び皮膚化粧料 | |
JP6032734B2 (ja) | しわ改善剤 | |
JP2020502172A (ja) | 漢方薬抽出物を有効成分として含む化粧料組成物 | |
JP2008088075A (ja) | プロフィラグリン/フィラグリン産生促進剤、表皮角化細胞増殖促進剤、表皮/角層正常化用皮膚外用剤、プロフィラグリン及び/又はフィラグリン産生促進方法、及び表皮角化細胞増殖促進方法 | |
JP2012219031A (ja) | ラミニン5産生促進剤、インテグリンα6β4産生促進剤、皮膚基底膜正常化剤、皮膚損傷回復促進剤及びアクアポリン3mRNA発現促進剤 | |
JP6076832B2 (ja) | メントール誘導体、並びにこれを用いた冷感剤、trpm8活性化剤、冷感付与方法及びtrpm8活性化方法 | |
JP6125864B2 (ja) | 樹状突起負制御剤 | |
JP2010150237A (ja) | セラミド産生促進剤、並びに該セラミド産生促進剤を用いた医薬品組成物、皮膚外用剤、化粧料組成物、及び化粧料 | |
JP2016210703A (ja) | 時計遺伝子発現促進用組成物 | |
JP5155543B2 (ja) | エンドセリン−1産生抑制剤、ヘキソサミニダーゼ遊離抑制剤、抗炎症用/美白用皮膚外用剤、エンドセリン−1の産生抑制方法及びヘキソサミニダーゼの遊離抑制方法 | |
JP2006160629A (ja) | コラーゲン産生促進剤、及びそれを含有する皮膚外用剤 | |
JP5405782B2 (ja) | セラミド産生促進剤及び保湿剤 | |
JP2000143527A (ja) | ヒアルロン酸産生促進剤、及びこれを含有して成る皮膚外用剤 | |
JP6272012B2 (ja) | 樹状突起負制御剤 | |
JP2018070524A (ja) | 表皮細胞賦活剤 | |
JP5167042B2 (ja) | セラミド産生促進剤、保湿剤及び皮膚外用剤 | |
JP2006273756A (ja) | セラミド合成促進剤、コラゲナーゼ阻害剤及びコラーゲン合成促進剤 | |
JP6291466B2 (ja) | 皮膚バリア機能改善剤、細胞間接着構造の形成促進剤、タイトジャンクション形成促進剤、TRPV4活性化剤、細胞内Ca濃度上昇亢進剤及び皮脂産生促進剤 | |
JP2023072963A (ja) | 肌の質改善剤、むくみの予防及び/又は改善剤、表皮機能向上剤、毛髪のハリコシ向上剤、及び外用組成物 | |
BE1027772A1 (fr) | Composition de ginseng pour ameliorer l'etat de la peau et son utilisation pour le traitement d'une maladie dermatologique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160309 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20161129 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170127 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170627 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170825 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170912 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20171205 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180530 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6347916 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |