JP5868312B2 - 時計遺伝子Bmalの発現調節剤 - Google Patents
時計遺伝子Bmalの発現調節剤 Download PDFInfo
- Publication number
- JP5868312B2 JP5868312B2 JP2012508100A JP2012508100A JP5868312B2 JP 5868312 B2 JP5868312 B2 JP 5868312B2 JP 2012508100 A JP2012508100 A JP 2012508100A JP 2012508100 A JP2012508100 A JP 2012508100A JP 5868312 B2 JP5868312 B2 JP 5868312B2
- Authority
- JP
- Japan
- Prior art keywords
- oil
- expression
- bmal
- gene
- clock
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Description
培養ヒト皮膚線維芽細胞を用いた系で時計遺伝子発現の概日リズムを評価できることを確認した。
上記の結果から、培養ヒト皮膚線維芽細胞評価系において、Bmal1は薬剤による刺激の約16時間後に発現量がピークとなる概日リズムを刻むことが認められ、刺激の16時間後の遺伝子発現量を指標として、試験物質のBmal遺伝子発現調節効果について評価した。尚、Bmal遺伝子発現リズムの誘導を確認するため、刺激の2時間後のBmal1遺伝子発現量もあわせて測定した。
以下、本発明のBmal発現調整剤の配合例を示すが、本発明の実施は以下に限定されるものではない。尚、下記の配合例では本発明のBmal 発現調整剤としてイランイランオイルを用いているが、それに限定されるものではなく、上記のBmal遺伝子発現を調節し得る生薬および/または香料の1種または2種以上の混合物を同様に配合することができる。配合量は全て製品全量に対する質量%で表す。
(1)アルコール 75.0
(2)精製水 残余
(3)ジプロピレングリコール 5.0
(4)本発明のBmal発現調整剤:イランイランオイル 10.0
(5)酸化防止剤 8.0
(6)色素 適量
(7)紫外線吸収剤 適量
(1)アルコール 80.0
(2)精製水 残余
(3)酸化防止剤 5.0
(4)本発明のBmal発現調整剤:イランイランオイル 3.0
(5)3−メチルー3メトキシブタノール 5.0
(6)ジベンジリデンソルビトール 5.0
(1)タブ粉 75.5
(2)安息香酸ナトリウム 15.5
(3)本発明のBmal発現調整剤:イランイランオイル 5.0
(4)ユーカリオイル 1.0
(5)精製水 残余
(1)硫酸ナトリウム 45.0
(2)炭酸水素ナトリウム 45.0
(3)ラベンダーオイル 9.0
(4)本発明のBmal発現調整剤:イランイランオイル 1.0
(1)エリスリトール 2.0
(2)カフェイン 5.0
(3)オウバク抽出物 3.0
(4)グリセリン 50.0
(5)カルボキシビニルポリマー 0.4
(6)ポリエチレングリコール400 30.0
(7)エデト3ナトリウム 0.1
(8)ポリオキシレン(10)メチルポリシロキサン共重合体 2.0
(9)スクワラン 1.0
(10)水酸化カリウム 0.15
(11)本発明のBmal発現調整剤:イランイランオイル 1.0
(1)固形パラフィン 5.0
(2)ミツロウ 10.0
(3)ワセリン 15.0
(4)流動パラフィン 41.0
(5)1.3−ブチレングリコール 4.0
(6)モノステアリン酸グリセリン 2.0
(7)POE(20)ソルビタンモノラウリン酸エステル 2.0
(8)ホウ砂 0.2
(9)カフェイン 2.0
(10)防腐剤 適量
(11)酸化防止剤 適量
(12)本発明のBmal発現調整剤:イランイランオイル 1.0
(13)精製水 残余
キュプロアンモニウムセルロース溶液(セルロース濃度10重量%、アンモニウム濃度7重量%、銅濃度3.6重量%)に、本発明のBmal発現調整剤を内包したマイクロカプセル(粒子径50μm以下、マイクロカプセルに占める精油の割合は50重量%)をセルロース重量に対して0.1〜20重量%の範囲内で添加、混和した後、通常の湿式紡糸方法に従って紡糸し、精錬工程、乾燥工程を経て、芳香性繊維を得た。
(1)スクラロース 0.1
(2)本発明のBmal発現調整剤:イランイランオイル 0.1
(3)香味料 5.0
(4)賦形剤(セオラス) 10.0
(5)マルチトール 残余
(1)イノシトール 11.0
(2)マルチトール 21.0
(3)スクロース 0.5
(4)鮭白子抽出物(DNA Na) 0.1
(5)酵母抽出物 0.1
(6)本発明のBmal発現調整剤:イランイランオイル 0.1
(7)香味料 5.0
(8)賦形剤 残余
(1)潤沢剤(ショ糖脂肪酸エステル等) 1.0
(2)アラビアガム水溶液(5%) 2.0
(3)酸味料 1.0
(4)着色料 適量
(5)本発明のBmal発現調整剤:イランイランオイル 0.1
(6)糖質(粉糖またはソルビトール等) 残余
(1)砂糖 50.0
(2)水飴 47.95
(3)有機酸 2.0
(4)本発明のBmal発現調整剤:イランイランオイル 0.05
(1)砂糖 43.0
(2)ガムベース 30.95
(3)グルコース 10.0
(4)水飴 16.0
(5)本発明のBmal発現調整剤:イランイランオイル 0.05
Claims (2)
- エレミオイルを有効成分として含む、時計遺伝子Bmalの発現リズムを誘導することにより概日リズムを調整する概日リズム調整剤。
- エレミオイルを有効成分として含む、時計遺伝子Bmalの発現リズムを誘導するBmal遺伝子発現調節剤であって、概日リズムを調整するために使用されるBmal遺伝子発現調節剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012508100A JP5868312B2 (ja) | 2010-03-31 | 2011-03-30 | 時計遺伝子Bmalの発現調節剤 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010083016 | 2010-03-31 | ||
JP2010083016 | 2010-03-31 | ||
PCT/JP2011/001940 WO2011122040A1 (ja) | 2010-03-31 | 2011-03-30 | 時計遺伝子Bmalの発現調節剤 |
JP2012508100A JP5868312B2 (ja) | 2010-03-31 | 2011-03-30 | 時計遺伝子Bmalの発現調節剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2011122040A1 JPWO2011122040A1 (ja) | 2013-07-04 |
JP5868312B2 true JP5868312B2 (ja) | 2016-02-24 |
Family
ID=44711795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012508100A Active JP5868312B2 (ja) | 2010-03-31 | 2011-03-30 | 時計遺伝子Bmalの発現調節剤 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20130022635A1 (ja) |
EP (1) | EP2554177B1 (ja) |
JP (1) | JP5868312B2 (ja) |
KR (1) | KR101822874B1 (ja) |
CN (1) | CN102858355B (ja) |
ES (1) | ES2584329T3 (ja) |
HK (1) | HK1179897A1 (ja) |
TW (2) | TWI523656B (ja) |
WO (1) | WO2011122040A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9795811B2 (en) | 2011-09-29 | 2017-10-24 | Shiseido Company, Ltd. | Expression promoting agent for clock gene and hyaluronic acid synthase gene |
JPWO2013046272A1 (ja) * | 2011-09-29 | 2015-03-26 | 株式会社 資生堂 | 時計遺伝子およびヒアルロン酸合成酵素遺伝子発現促進剤 |
JP2013184921A (ja) * | 2012-03-07 | 2013-09-19 | Shiseido Co Ltd | 時計遺伝子の発現調節剤 |
ES2717652T3 (es) * | 2012-08-10 | 2019-06-24 | Shiseido Co Ltd | Potenciador de expresión del gen de la filagrina |
CN103417638A (zh) * | 2013-08-26 | 2013-12-04 | 容景禧 | 一种调节睡眠外用复合液及其制备方法 |
CN105491896A (zh) * | 2013-08-27 | 2016-04-13 | 三得利控股株式会社 | 时钟基因的表达量调整剂 |
EP3068415A4 (en) * | 2013-11-13 | 2017-09-13 | In Ingredients Inc. | Treatment or prophylaxis of circadian protein related conditions |
JP2014074063A (ja) * | 2013-12-27 | 2014-04-24 | Shiseido Co Ltd | ヒアルロン酸合成酵素遺伝子の発現促進剤 |
US9833393B2 (en) * | 2015-09-24 | 2017-12-05 | Elc Management Llc | Method and compositions for treating skin |
JP6188881B2 (ja) * | 2016-07-12 | 2017-08-30 | 株式会社 資生堂 | ヒアルロン酸合成酵素遺伝子発現促進剤 |
JP6188986B1 (ja) * | 2017-03-23 | 2017-08-30 | 株式会社ノエビア | 時計遺伝子発現量調整剤及びエラスチン産生促進剤 |
US10167691B2 (en) * | 2017-03-29 | 2019-01-01 | Baker Hughes, A Ge Company, Llc | Downhole tools having controlled disintegration |
JP7432999B2 (ja) * | 2019-07-11 | 2024-02-19 | ヱスビー食品株式会社 | 概日周期短周期化剤、概日リズム調整剤、時計遺伝子発現周期短縮剤、概日周期短周期化用飲食物 |
JP2022030442A (ja) * | 2020-08-07 | 2022-02-18 | エステー株式会社 | 睡眠の質改善剤 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003192567A (ja) * | 2001-12-27 | 2003-07-09 | Nonogawa Shoji Kk | 化粧料 |
JP2006232740A (ja) * | 2005-02-25 | 2006-09-07 | Shiseido Co Ltd | コラーゲン産生促進剤、コラーゲン産生促進方法および抗老化剤 |
JP2008266319A (ja) * | 2007-03-29 | 2008-11-06 | Ezaki Glico Co Ltd | 概日リズム調整組成物 |
WO2008145692A2 (en) * | 2007-05-29 | 2008-12-04 | Chanel Parfums Beaute | Cosmetic composition comprising an active agent capable of stimulating tensin 1 expression |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR920005729B1 (ko) * | 1984-09-06 | 1992-07-16 | 미쓰비시 레이온 캄파니 리미티드 | 방향성 섬유 |
JPS62161311A (ja) * | 1985-12-14 | 1987-07-17 | 株式会社ニチボ | 枕材 |
US6537308B2 (en) * | 2000-04-14 | 2003-03-25 | Alma D. Burkhart | Cosmetic and therapeutic face mask |
JP2004204421A (ja) * | 2002-12-13 | 2004-07-22 | Nisshinbo Ind Inc | 睡眠改善効果を有する繊維構造物及びその製法 |
-
2011
- 2011-03-30 US US13/638,620 patent/US20130022635A1/en not_active Abandoned
- 2011-03-30 EP EP11762282.9A patent/EP2554177B1/en active Active
- 2011-03-30 CN CN201180017285.4A patent/CN102858355B/zh active Active
- 2011-03-30 ES ES11762282.9T patent/ES2584329T3/es active Active
- 2011-03-30 WO PCT/JP2011/001940 patent/WO2011122040A1/ja active Application Filing
- 2011-03-30 KR KR1020127028528A patent/KR101822874B1/ko active IP Right Grant
- 2011-03-30 JP JP2012508100A patent/JP5868312B2/ja active Active
- 2011-03-31 TW TW104100435A patent/TWI523656B/zh not_active IP Right Cessation
- 2011-03-31 TW TW100111420A patent/TWI542356B/zh not_active IP Right Cessation
-
2013
- 2013-06-25 HK HK13107393.3A patent/HK1179897A1/xx not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003192567A (ja) * | 2001-12-27 | 2003-07-09 | Nonogawa Shoji Kk | 化粧料 |
JP2006232740A (ja) * | 2005-02-25 | 2006-09-07 | Shiseido Co Ltd | コラーゲン産生促進剤、コラーゲン産生促進方法および抗老化剤 |
JP2008266319A (ja) * | 2007-03-29 | 2008-11-06 | Ezaki Glico Co Ltd | 概日リズム調整組成物 |
WO2008145692A2 (en) * | 2007-05-29 | 2008-12-04 | Chanel Parfums Beaute | Cosmetic composition comprising an active agent capable of stimulating tensin 1 expression |
Non-Patent Citations (2)
Title |
---|
JPN6014049875; International Journal of Aromatherapy Vol.13,No.2-3, 2003, pp.108-113 * |
JPN6014049876; アンチ・エイジング医学 Vol.5,No.3, 2009, page.375-379 * |
Also Published As
Publication number | Publication date |
---|---|
EP2554177A4 (en) | 2013-11-06 |
KR20130023233A (ko) | 2013-03-07 |
ES2584329T3 (es) | 2016-09-27 |
CN102858355A (zh) | 2013-01-02 |
TWI542356B (zh) | 2016-07-21 |
WO2011122040A1 (ja) | 2011-10-06 |
EP2554177B1 (en) | 2016-04-27 |
EP2554177A1 (en) | 2013-02-06 |
KR101822874B1 (ko) | 2018-01-29 |
TWI523656B (zh) | 2016-03-01 |
HK1179897A1 (en) | 2013-10-11 |
JPWO2011122040A1 (ja) | 2013-07-04 |
CN102858355B (zh) | 2014-10-15 |
TW201201822A (en) | 2012-01-16 |
US20130022635A1 (en) | 2013-01-24 |
TW201513876A (zh) | 2015-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5868312B2 (ja) | 時計遺伝子Bmalの発現調節剤 | |
JP5868313B2 (ja) | 時計遺伝子Periodの発現調節剤 | |
TW201116286A (en) | Ceramide production enhancer and moisturizing agent | |
CN110072516A (zh) | 包含作为有效成分的中药材提取物的化妆料组合物 | |
JP2014221739A (ja) | Vii型コラーゲン発現促進剤 | |
US20140057979A1 (en) | Expression Modulator For Clock Gene | |
JP5487227B2 (ja) | ヒアルロン酸合成酵素遺伝子の発現促進剤 | |
JP7436975B2 (ja) | 精油組成物 | |
JP6017259B2 (ja) | エンドセリン作用抑制剤 | |
JP2012116764A (ja) | Cgrp応答性促進剤 | |
JP6629271B2 (ja) | Endo180産生促進剤 | |
WO2014050003A1 (ja) | 時計遺伝子Periodの発現調節剤 | |
JP2014074063A (ja) | ヒアルロン酸合成酵素遺伝子の発現促進剤 | |
KR20220114210A (ko) | 백수오 추출물을 유효성분으로 포함하는 피부 재생 또는 상처 치료용 조성물 | |
KR101500044B1 (ko) | 증법 포제 처리된 서목태 추출물을 함유하는 피부 주름 개선용 화장료 조성물 | |
JP2014133711A (ja) | Cgi−58発現促進剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20131128 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20141125 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150126 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20150623 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150902 |
|
A911 | Transfer of reconsideration by examiner before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20150910 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20151110 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151112 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20151208 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160105 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5868312 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |