JP2013537966A5 - - Google Patents
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- JP2013537966A5 JP2013537966A5 JP2013526209A JP2013526209A JP2013537966A5 JP 2013537966 A5 JP2013537966 A5 JP 2013537966A5 JP 2013526209 A JP2013526209 A JP 2013526209A JP 2013526209 A JP2013526209 A JP 2013526209A JP 2013537966 A5 JP2013537966 A5 JP 2013537966A5
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- JP
- Japan
- Prior art keywords
- met
- staining intensity
- cancer
- moderate
- tumor cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 8
- 229960001433 erlotinib Drugs 0.000 claims description 8
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 8
- 230000002411 adverse Effects 0.000 claims description 3
- 206010030113 Oedema Diseases 0.000 claims description 2
- 238000010186 staining Methods 0.000 claims 83
- 239000000090 biomarker Substances 0.000 claims 44
- 210000004881 tumor cell Anatomy 0.000 claims 42
- 238000003364 immunohistochemistry Methods 0.000 claims 40
- 238000000034 method Methods 0.000 claims 39
- 206010028980 Neoplasm Diseases 0.000 claims 28
- 201000011510 cancer Diseases 0.000 claims 24
- 239000005557 antagonist Substances 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 20
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 14
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 14
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
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- 229940122558 EGFR antagonist Drugs 0.000 claims 4
- 239000003560 cancer drug Substances 0.000 claims 4
- 230000004083 survival effect Effects 0.000 claims 4
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 2
- 239000002146 L01XE16 - Crizotinib Substances 0.000 claims 2
- 239000002176 L01XE26 - Cabozantinib Substances 0.000 claims 2
- UCEQXRCJXIVODC-PMACEKPBSA-N LSM-1131 Chemical compound C1CCC2=CC=CC3=C2N1C=C3[C@@H]1C(=O)NC(=O)[C@H]1C1=CNC2=CC=CC=C12 UCEQXRCJXIVODC-PMACEKPBSA-N 0.000 claims 2
- UFICVEHDQUKCEA-UHFFFAOYSA-N N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamide Chemical compound CN1C=NC(C=2SC3=C(OC=4C(=CC(NC(=S)NC(=O)CC=5C=CC=CC=5)=CC=4)F)C=CN=C3C=2)=C1 UFICVEHDQUKCEA-UHFFFAOYSA-N 0.000 claims 2
- CXQHYVUVSFXTMY-UHFFFAOYSA-N N1'-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CN=C2C=C(OCCCN3CCOCC3)C(OC)=CC2=C1OC(C(=C1)F)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 CXQHYVUVSFXTMY-UHFFFAOYSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- ONIQOQHATWINJY-UHFFFAOYSA-N cabozantinib Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 ONIQOQHATWINJY-UHFFFAOYSA-N 0.000 claims 2
- 229960001292 cabozantinib Drugs 0.000 claims 2
- KTEIFNKAUNYNJU-GFCCVEGCSA-N crizotinib Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NC=1)N)=CC=1C(=C1)C=NN1C1CCNCC1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 0.000 claims 2
- 229960005061 crizotinib Drugs 0.000 claims 2
- 206010016256 fatigue Diseases 0.000 claims 2
- 229950002846 ficlatuzumab Drugs 0.000 claims 2
- 229950008692 foretinib Drugs 0.000 claims 2
- 229950007540 glesatinib Drugs 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 229950000846 onartuzumab Drugs 0.000 claims 2
- 239000008188 pellet Substances 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 229950005976 tivantinib Drugs 0.000 claims 2
- GMDWHBVEZCVCHU-UHFFFAOYSA-N 2-(2-methoxyethoxy)quinazolin-4-amine Chemical compound C1=CC=CC2=NC(OCCOC)=NC(N)=C21 GMDWHBVEZCVCHU-UHFFFAOYSA-N 0.000 claims 1
- LIOLIMKSCNQPLV-UHFFFAOYSA-N 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1C1=NN2C(CC=3C=C4C=CC=NC4=CC=3)=CN=C2N=C1 LIOLIMKSCNQPLV-UHFFFAOYSA-N 0.000 claims 1
- -1 3-ethynylphenyl Chemical group 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 101000666856 Homo sapiens Vasoactive intestinal polypeptide receptor 1 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 102100038388 Vasoactive intestinal polypeptide receptor 1 Human genes 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 description 2
- 241000282320 Panthera leo Species 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37891110P | 2010-08-31 | 2010-08-31 | |
| US61/378,911 | 2010-08-31 | ||
| US38992210P | 2010-10-05 | 2010-10-05 | |
| US61/389,922 | 2010-10-05 | ||
| US39099510P | 2010-10-07 | 2010-10-07 | |
| US61/390,995 | 2010-10-07 | ||
| US42070310P | 2010-12-07 | 2010-12-07 | |
| US61/420,703 | 2010-12-07 | ||
| US201161487527P | 2011-05-18 | 2011-05-18 | |
| US61/487,527 | 2011-05-18 | ||
| US201161492338P | 2011-06-01 | 2011-06-01 | |
| US61/492,338 | 2011-06-01 | ||
| US201161503489P | 2011-06-30 | 2011-06-30 | |
| US61/503,489 | 2011-06-30 | ||
| PCT/US2011/050069 WO2012031027A1 (en) | 2010-08-31 | 2011-08-31 | Biomarkers and methods of treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253669A Division JP2016105096A (ja) | 2010-08-31 | 2015-12-25 | バイオマーカー及び治療の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013537966A JP2013537966A (ja) | 2013-10-07 |
| JP2013537966A5 true JP2013537966A5 (enExample) | 2014-10-16 |
Family
ID=44583514
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526209A Pending JP2013537966A (ja) | 2010-08-31 | 2011-08-31 | バイオマーカー及び治療の方法 |
| JP2015253669A Pending JP2016105096A (ja) | 2010-08-31 | 2015-12-25 | バイオマーカー及び治療の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253669A Pending JP2016105096A (ja) | 2010-08-31 | 2015-12-25 | バイオマーカー及び治療の方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20120089541A1 (enExample) |
| EP (2) | EP3264089A1 (enExample) |
| JP (2) | JP2013537966A (enExample) |
| KR (1) | KR20130103734A (enExample) |
| CN (1) | CN103221825A (enExample) |
| AU (1) | AU2011295919A1 (enExample) |
| BR (1) | BR112013004673A8 (enExample) |
| CA (1) | CA2808236A1 (enExample) |
| DK (1) | DK2612151T3 (enExample) |
| ES (1) | ES2641916T3 (enExample) |
| IL (1) | IL248530A0 (enExample) |
| MX (1) | MX2013002084A (enExample) |
| RU (1) | RU2013114360A (enExample) |
| SG (2) | SG10201408229WA (enExample) |
| WO (1) | WO2012031027A1 (enExample) |
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| JP2011513427A (ja) * | 2008-03-06 | 2011-04-28 | ジェネンテック， インコーポレイテッド | ｃ−ｍｅｔ及びＥＧＦＲアンタゴニストの併用療法 |
| TWI600760B (zh) | 2009-11-05 | 2017-10-01 | 建南德克公司 | 分泌異源多肽之方法及組合物 |
| AU2012275233A1 (en) | 2011-06-30 | 2013-11-28 | Genentech, Inc. | Anti-c-met antibody formulations |
| KR20140064971A (ko) | 2011-09-19 | 2014-05-28 | 제넨테크, 인크. | c-met 길항제 및 B-raf 길항제를 포함하는 조합 치료 |
| CA2848512A1 (en) * | 2011-09-22 | 2013-03-28 | Exelixis, Inc. | Method for treating osteoporosis |
| US9861624B2 (en) | 2012-05-02 | 2018-01-09 | Exelixis, Inc. | Method of treating cancer |
| KR101938698B1 (ko) | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Ｃｂｌ의 항 ｃ－ｍｅｔ 항체 적용 대상 환자 선별을 위한 바이오마커로서의 용도 |
| KR101938699B1 (ko) | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Ｌｒｉｇ１의 항 ｃ―ｍｅｔ 항체 적용 대상 환자 선별을 위한 용도 |
| KR20150037876A (ko) * | 2012-07-27 | 2015-04-08 | 제넨테크, 인크. | Fgfr3 관련 상태의 치료 방법 |
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-
2011
- 2011-08-31 EP EP17183227.2A patent/EP3264089A1/en not_active Withdrawn
- 2011-08-31 AU AU2011295919A patent/AU2011295919A1/en not_active Abandoned
- 2011-08-31 MX MX2013002084A patent/MX2013002084A/es not_active Application Discontinuation
- 2011-08-31 ES ES11754597.0T patent/ES2641916T3/es active Active
- 2011-08-31 RU RU2013114360/15A patent/RU2013114360A/ru not_active Application Discontinuation
- 2011-08-31 WO PCT/US2011/050069 patent/WO2012031027A1/en not_active Ceased
- 2011-08-31 SG SG10201408229WA patent/SG10201408229WA/en unknown
- 2011-08-31 US US13/223,173 patent/US20120089541A1/en not_active Abandoned
- 2011-08-31 CA CA2808236A patent/CA2808236A1/en not_active Abandoned
- 2011-08-31 BR BR112013004673A patent/BR112013004673A8/pt not_active IP Right Cessation
- 2011-08-31 EP EP11754597.0A patent/EP2612151B1/en active Active
- 2011-08-31 SG SG2013011911A patent/SG187886A1/en unknown
- 2011-08-31 KR KR1020137008025A patent/KR20130103734A/ko not_active Ceased
- 2011-08-31 DK DK11754597.0T patent/DK2612151T3/en active
- 2011-08-31 CN CN2011800517811A patent/CN103221825A/zh active Pending
- 2011-08-31 JP JP2013526209A patent/JP2013537966A/ja active Pending
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2013
- 2013-10-04 US US14/046,867 patent/US20140037625A1/en not_active Abandoned
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2015
- 2015-12-25 JP JP2015253669A patent/JP2016105096A/ja active Pending
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2016
- 2016-10-26 IL IL248530A patent/IL248530A0/en unknown
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