JP2013534810A5 - - Google Patents

Download PDF

Info

Publication number
JP2013534810A5
JP2013534810A5 JP2013512140A JP2013512140A JP2013534810A5 JP 2013534810 A5 JP2013534810 A5 JP 2013534810A5 JP 2013512140 A JP2013512140 A JP 2013512140A JP 2013512140 A JP2013512140 A JP 2013512140A JP 2013534810 A5 JP2013534810 A5 JP 2013534810A5
Authority
JP
Japan
Prior art keywords
nucleic acid
seq
polynucleotide probe
sequence
risk hpv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013512140A
Other languages
English (en)
Japanese (ja)
Other versions
JP6153866B2 (ja
JP2013534810A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/037684 external-priority patent/WO2011149897A1/en
Publication of JP2013534810A publication Critical patent/JP2013534810A/ja
Publication of JP2013534810A5 publication Critical patent/JP2013534810A5/ja
Application granted granted Critical
Publication of JP6153866B2 publication Critical patent/JP6153866B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013512140A 2010-05-25 2011-05-24 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ Expired - Fee Related JP6153866B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34794110P 2010-05-25 2010-05-25
US61/347,941 2010-05-25
PCT/US2011/037684 WO2011149897A1 (en) 2010-05-25 2011-05-24 Fast results hybrid capture assay and associated strategically-truncated probes

Publications (3)

Publication Number Publication Date
JP2013534810A JP2013534810A (ja) 2013-09-09
JP2013534810A5 true JP2013534810A5 (https=) 2014-05-29
JP6153866B2 JP6153866B2 (ja) 2017-06-28

Family

ID=44275651

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013512140A Expired - Fee Related JP6153866B2 (ja) 2010-05-25 2011-05-24 迅速なハイブリッド捕捉アッセイ、及び関連する戦略的に切断されたプローブ

Country Status (6)

Country Link
US (1) US9376727B2 (https=)
EP (1) EP2576840B1 (https=)
JP (1) JP6153866B2 (https=)
AU (1) AU2011258501B2 (https=)
CA (1) CA2799205A1 (https=)
WO (1) WO2011149897A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062546A1 (en) 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay on an automated platform
CA2787924A1 (en) * 2010-01-29 2011-08-04 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CN105368982B (zh) * 2014-08-28 2019-01-29 杭州德同生物技术有限公司 一种高危型人乳头瘤病毒检测及分型方法
JP7646548B2 (ja) * 2019-01-03 2025-03-17 杭州諾輝健康科技有限公司 ヒトパピローマウイルスを検出するための組成物及び方法

Family Cites Families (223)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732847A (en) 1981-06-09 1988-03-22 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4486536A (en) 1982-05-28 1984-12-04 Smithkline Diagnostics, Inc. Specimen slide for occult blood testing
US4865980A (en) 1982-12-29 1989-09-12 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
EP0131052B1 (en) 1983-01-10 1993-12-08 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5288611A (en) 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5200313A (en) 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
EP0144914A3 (en) 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
US4743535A (en) 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
FI71768C (fi) 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
CA1260372A (en) 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
CA1253777A (en) 1984-06-01 1989-05-09 Robert J. Carrico Nucleic acid hybridization assay employing immobilized rna probes
US4563417A (en) 1984-08-31 1986-01-07 Miles Laboratories, Inc. Nucleic acid hybridization assay employing antibodies to intercalation complexes
US4689294A (en) 1984-11-19 1987-08-25 Miles Laboratories, Inc. Enhancement of hybridization of nucleic acids by anionic polymers
US5876922A (en) 1985-07-31 1999-03-02 Institute Pasteur Papillomavirus probe and a process for in vitro diagnosis of papillomavirus infections
CA1276575C (fr) 1984-11-30 1990-11-20 Sylvie Beaudenon Sondes a papillomavirus et procede de diagnostic in vitro d'infections a papillomavirus
US5411857A (en) 1985-07-31 1995-05-02 Institut Nationale De La Sante Probes for papillomaviruses and an in vitro diagnostic procedure for papilloma infections
IL79112A (en) 1985-06-13 1992-01-15 Abbott Lab Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
US4751177A (en) 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
AU615159B2 (en) 1986-03-21 1991-09-26 F. Hoffmann-La Roche Ltd Determined dna sequences derived from a papillomavirus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions
US5750338A (en) 1986-10-23 1998-05-12 Amoco Corporation Target and background capture methods with amplification for affinity assays
JP3116353B2 (ja) 1986-11-24 2000-12-11 ジエン‐プローブ・インコーポレイテツド 非ウイルス微生物の検出及び/又は定量用核酸プローブ
AU619170B2 (en) 1987-01-09 1992-01-23 Abbott Laboratories Diagnostic assays using nucleic acid probes
JP3096704B2 (ja) 1987-02-26 2000-10-10 バイオサーチ インターナショナル ピティ リミテッド ヒトの発癌性乳頭腫ウイルスの検出方法
AU601021B2 (en) 1987-03-11 1990-08-30 Molecular Diagnostics, Inc. Assay for necleic acid sequences in a sample
IL85551A0 (en) 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
DE3722968A1 (de) 1987-07-11 1989-01-19 Behringwerke Ag Humaner papillomvirus typ 41, seine dna und die dafuer kodierenden proteine
US5656731A (en) 1987-10-15 1997-08-12 Chiron Corporation Nucleic acid-amplified immunoassay probes
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
EP0333465B1 (en) 1988-03-18 1994-07-13 Baylor College Of Medicine Mutation detection by competitive oligonucleotide priming
US5374524A (en) 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
FR2632956B2 (fr) 1988-05-13 1991-07-12 Pasteur Institut Sondes a papillomavirus hpv49, hpv50, hpv54, hpv55; produits genetiquement et immunologiquement lies a ce papillomavirus hpv49, hpv50, hpv54, hpv55; procede de diagnostic in vitro d'infections a papillomavirus et d'immunisation in vivo contre ces papillomavirus
NO165894C (no) 1988-05-24 1991-04-24 Gunnar Paulsen Analysemetode for gener.
DE3826793A1 (de) 1988-08-06 1990-03-08 Behringwerke Ag Humaner papillomvirus typ 57, seine dna und die davon kodierten proteine
US5447839A (en) 1988-09-09 1995-09-05 Hoffmann-La Roche Inc. Detection of human papillomavirus by the polymerase chain reaction
US5639871A (en) 1988-09-09 1997-06-17 Roche Molecular Systems, Inc. Detection of human papillomavirus by the polymerase chain reaction
US5182377A (en) 1988-09-09 1993-01-26 Hoffmann-La Roche Inc. Probes for detection of human papillomavirus
EP0703296B1 (en) 1988-09-29 1998-07-22 Chiron Corporation Polynucleotide determination by displacement of a strand on a capture probe
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5077192A (en) 1988-10-25 1991-12-31 The General Hospital Corporation Method of detecting antigenic, nucleic acid-containing macromolecular entities
CA1339729C (en) 1988-10-26 1998-03-17 Wayne D. Lancaster Human papillomavirus type 52 dna sequences and methods for employing thesame
DE3838269A1 (de) 1988-11-11 1990-05-17 Behringwerke Ag Nachweis humaner papillomavirus dna und ihrer expression in zervix-abstrichen
JP3046837B2 (ja) 1989-03-10 2000-05-29 バイシス・インコーポレーテツド 固定化されたオリゴヌクレオチドのプローブおよびそれらの使用
US5106727A (en) 1989-04-27 1992-04-21 Life Technologies, Inc. Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
US5863717A (en) 1989-11-03 1999-01-26 Abbott Laboratories Use of conserved oligonucleotide primers to amplify human papillomavirus DNA sequences
US5580970A (en) 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
JPH05501650A (ja) 1989-12-01 1993-04-02 バイシス・インコーポレーテツド Hpv転写物の検出
US6174870B1 (en) 1989-12-04 2001-01-16 Isis Pharmaceuticals, Inc. Antisense oligonucleotide inhibition of papillomavirus
US5811232A (en) 1989-12-04 1998-09-22 Isis Pharmaceuticals, Inc. Oligonucleotides for Papillomavirus
US5756282A (en) 1989-12-04 1998-05-26 Isis Pharmaceuticals, Inc. Oligonucleotides for the diagnosis of papillomavirus
NL9000134A (nl) 1990-01-19 1991-08-16 Stichting Res Fonds Pathologie Primers en werkwijze voor het detecteren van humaan papilloma virus genotypen m.b.v. pcr.
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
CA2039517C (en) 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5695926A (en) 1990-06-11 1997-12-09 Bio Merieux Sandwich hybridization assays using very short capture probes noncovalently bound to a hydrophobic support
GB9015845D0 (en) 1990-07-19 1990-09-05 Emery Vincent C Diagnostic method
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5484699A (en) 1990-09-28 1996-01-16 Abbott Laboratories Nucleotide sequences useful as type specific probes, PCR primers and LCR probes for the amplification and detection of human papilloma virus, and related kits and methods
US5474895A (en) 1990-11-14 1995-12-12 Siska Diagnostics Inc. Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
EP0566670A4 (en) 1990-12-17 1993-12-08 Idexx Laboratories, Inc. Nucleic acid sequence detection by triple helix formation
FR2670797A1 (fr) * 1990-12-20 1992-06-26 Pasteur Institut Sequences d'adn determinees derivees du genome du papillomavirus hpv39, application de ces sequences au diagnostic in vitro d'infection par ce papillomavirus, et a la production de composition immunogene.
US5219990A (en) 1991-01-28 1993-06-15 Biogen, Inc. Papillomavirus e2 trans-activation repressors
GB9105383D0 (en) 1991-03-14 1991-05-01 Immunology Ltd An immunotherapeutic for cervical cancer
FR2678284B1 (fr) 1991-06-28 1993-10-08 Pasteur Institut Sequences d'adn derivees du genome du papillomavirus hpv42, application de ces sequences au diagnostic in vitro d'infection par ce papillomavirus et a la production de compositions immunogenes.
US5543294A (en) 1991-07-19 1996-08-06 The Trustees Of Columbia University In The City Of New York Polymerase chain reaction/restriction fragment length polymorphism method for the detection and typing of myobacteria
DE122007000016I1 (de) 1991-07-19 2007-05-24 Univ Queensland Impfstoffe gegen Papillomavirus
US5346811A (en) 1991-07-22 1994-09-13 Cerveceria Polar Method and products for human papillomavirus detection
US5556748A (en) 1991-07-30 1996-09-17 Xenopore Corporation Methods of sandwich hybridization for the quantitative analysis of oligonucleotides
ES2145750T3 (es) 1991-11-14 2000-07-16 Dgi Inc Kit y dosificado que utiliza la hibridacion no radioactiva.
US5981179A (en) 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
US5506105A (en) 1991-12-10 1996-04-09 Dade International Inc. In situ assay of amplified intracellular mRNA targets
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5437951A (en) 1992-09-03 1995-08-01 The United States Of America As Represented By The Department Of Health And Human Services Self-assembling recombinant papillomavirus capsid proteins
WO1994006859A1 (en) 1992-09-15 1994-03-31 The Dow Chemical Company Impact modification of thermoplastics
DE69327454T2 (de) 1992-10-09 2000-05-11 Vysis, Inc. Analytisches verfahren
EP0688366B1 (en) 1993-01-15 2002-05-22 The Public Health Research Institute Of The City Of New York, Inc. Sensitive nucleic acid sandwich hybridization assays and kits
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
WO1995003430A1 (en) 1993-07-23 1995-02-02 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
DE4331012A1 (de) 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US5679509A (en) 1993-09-28 1997-10-21 University Of New Mexico Methods and a diagnostic aid for distinguishing a subset of HPV that is associated with an increased risk of developing cervical dysplasia and cervical cancer
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
DK145493D0 (da) 1993-12-23 1993-12-23 Dako As Antistof
AUPM358894A0 (en) 1994-01-31 1994-02-24 Csl Limited Modified papilloma virus l2 protein and vlps formed therefrom
DE69535500D1 (de) 1994-02-14 2007-07-05 Macfarlane Burnet Ct For Medic Nicht pathogene stämme des hiv-1
JP3659646B2 (ja) 1994-02-21 2005-06-15 スティヒティング リサーチフォンズ パトロジー 普遍プライマーを用いる核酸増幅方法によるヒト乳頭腫ウィルス検出
DE4415743C2 (de) 1994-05-04 1996-10-10 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
AUPM566794A0 (en) 1994-05-17 1994-06-09 University Of Queensland, The Process and product
US6045995A (en) 1994-08-24 2000-04-04 Isis Pharmaceuticals, Inc. Capillary electrophoretic detection of nucleic acids
US5622822A (en) 1994-09-13 1997-04-22 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using polyethyleneimine and an anionic phosphate ester surfactant and amplification of same
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
NZ293461A (en) 1994-09-22 1998-04-27 Merck & Co Inc Dna encoding human papillomavirus type 6a, compounds derived therefrom
JP3093116B2 (ja) 1994-09-30 2000-10-03 株式会社豊田中央研究所 核酸検出方法
GB9420146D0 (en) 1994-10-06 1994-11-23 Cancer Res Campaign Tech Papillomavirus vaccine
US6057099A (en) 1994-12-02 2000-05-02 Intelligene Ltd. Detection of nucleic acid sequences
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US5731153A (en) 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5888724A (en) 1995-02-17 1999-03-30 The Trustees Of Columbia University In The City Of New York Detection of high oncogenic-risk papilloma virus in high grade cervical lesions and cancers by a PCR/ELISA assay
DE19506561C1 (de) 1995-02-24 1996-10-10 Deutsches Krebsforsch Verfahren zur Früherkennung von HPV-assoziierten Karzinomen bzw. von hochgradigen, durch HPV-verursachten Dysplasien
US5820870A (en) 1995-03-22 1998-10-13 Merck & Co., Inc. Recombinant human papillomavirus type 18 vaccine
US5840306A (en) 1995-03-22 1998-11-24 Merck & Co., Inc. DNA encoding human papillomavirus type 18
IL117591A0 (en) 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
US6458940B2 (en) 1995-06-06 2002-10-01 Hybridon, Inc. HPV-specific oligonucleotides
US6509149B2 (en) 1995-06-06 2003-01-21 Hybridon, Inc. HPV-specific oligonucleotides
EP0832280A2 (en) 1995-06-07 1998-04-01 Abbott Laboratories Probe masking method of reducing background in an amplification reaction
DE19526386C1 (de) 1995-07-19 1997-01-02 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
FR2737502B1 (fr) 1995-07-31 1997-10-24 Genset Sa Procede de detection d'acides nucleiques utilisant des sondes nucleotidiques permettant a la fois une capture specifique et une detection
CA2237891C (en) 1995-11-15 2013-07-30 Gen-Probe Incorporated Nucleic acid probes complementary to human papillomavirus nucleic acid and related methods and kits
US5888736A (en) 1995-12-22 1999-03-30 Visible Genetics, Inc. Method, compositions and kit for detection and identification of microorganisms
EP2332958B1 (en) 1996-02-09 2016-04-20 Cornell Research Foundation, Inc. Detection of nucleic and sequence differences using the ligase detection reaction with addressable arrays
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US5981173A (en) 1996-02-14 1999-11-09 Institut Pasteur Genital human papillomavirus type 68a (HPV-68a), related to the potentially oncogenic HPV-39
US6511805B1 (en) 1996-03-15 2003-01-28 The Penn State Research Foundation Methods for detecting papillomavirus DNA in blood plasma and serum
US6214555B1 (en) 1996-05-01 2001-04-10 Visible Genetics Inc. Method compositions and kit for detection
WO1998001148A1 (en) 1996-07-09 1998-01-15 President And Fellows Of Harvard College Use of papillomavirus e2 protein in treating papillomavirus-infected cells and compositions containing the protein
US6218105B1 (en) 1996-07-19 2001-04-17 Kathleen S. Hall High throughput papilloma virus in vitro infectivity assay
US5853993A (en) 1996-10-21 1998-12-29 Hewlett-Packard Company Signal enhancement method and kit
US6265154B1 (en) 1996-10-25 2001-07-24 Abbott Laboratories Nucleic acid primers and probes for detecting oncogenic human papillomaviruses
US6117631A (en) 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
GB9624165D0 (en) 1996-11-19 1997-01-08 Amdex A S Use of nucleic acids bound to carrier macromolecules
DE19648962C1 (de) 1996-11-26 1998-02-26 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
US6388065B1 (en) 1996-11-27 2002-05-14 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts DNA for evaluating the progression potential of cervical lesions
US6110676A (en) 1996-12-04 2000-08-29 Boston Probes, Inc. Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays
US20020034737A1 (en) 1997-03-04 2002-03-21 Hyseq, Inc. Methods and compositions for detection or quantification of nucleic acid species
DE19712541C1 (de) 1997-03-25 1998-11-05 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
US5843995A (en) 1997-07-07 1998-12-01 University Of Medicine And Dentistry Of New Jersey Inhibition of HIV-1 replication using oligocarbamate derivatives
DE19735118C1 (de) 1997-08-13 1998-08-13 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
DE69806024T2 (de) 1997-09-16 2003-02-13 Delft Diagnostic Laboratory B.V., Delft Erkennung und identifizierung von menschlichem papillomavirus durch pcr und typ-spezifischer reverser hybridisierung
US6013258A (en) 1997-10-09 2000-01-11 Zycos Inc. Immunogenic peptides from the HPV E7 protein
AU741141B2 (en) 1997-11-04 2001-11-22 Roche Diagnostics Gmbh Specific and sensitive method for detecting nucleic acids
WO1999031273A2 (en) 1997-12-12 1999-06-24 Digene Corporation Universal collection medium
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
ATE506449T1 (de) 1997-12-22 2011-05-15 Hitachi Chemical Co Ltd Direkte rt-pcr auf oligonukleotid-immobilisierten pcr-mikroplatten
EP1047794A2 (en) 1998-01-13 2000-11-02 BioChip Technologies GmbH Method for the detection or nucleic acid of nucleic acid sequences
US6686151B1 (en) 1998-02-06 2004-02-03 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US5994079A (en) 1998-02-06 1999-11-30 Digene Corporation Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function
US7399589B2 (en) 1998-02-06 2008-07-15 Digene Corporation Immunological detection of RNA:DNA hybrids on microarrays
US20020039584A1 (en) 1998-02-20 2002-04-04 Medigene Ag Papilloma virus capsomere vaccine formulations and methods of use
CA2229955C (en) 1998-02-20 2003-12-09 Medigene Gmbh Papilloma virus capsomere vaccine formulations and methods of use
ES2212251T3 (es) 1998-03-23 2004-07-16 Spal S.R.L. Ventilador de flujo axial.
US6183956B1 (en) 1998-03-31 2001-02-06 Tularik, Incorporated High throughput in vitro screening assays for transcription modulators
US6045993A (en) 1998-05-30 2000-04-04 Visible Genetics Inc. Method, reagent and kit for genotyping of human papillomavirus
US6284532B1 (en) 1998-08-17 2001-09-04 Indiana University Purified human papillomavirus
DE19840263C1 (de) 1998-09-03 2000-05-25 Deutsches Krebsforsch Papillomviren, Mittel zu deren Nachweis sowie zur Therapie von durch sie verursachten Erkrankungen
EP1728865A1 (en) 1998-09-04 2006-12-06 Aventis Pasteur Limited Treatment of cervical cancer
US7569344B2 (en) 1998-10-26 2009-08-04 Ventana Medical Systems, Inc. Detection of human papilloma virus in papanicolaou (Pap) smears
US6951722B2 (en) 1999-03-19 2005-10-04 Takara Bio Inc. Method for amplifying nucleic acid sequence
US20010055766A1 (en) 1999-04-02 2001-12-27 Alexander Aristarkhov Immunosorbant assay using branched bis-biotin/avidin/multiple label complex as a detection reagent
AU4051300A (en) 1999-04-02 2000-10-23 Tropix, Inc. High throughput and high sensitivity detection assays
ES2343104T3 (es) 1999-04-07 2010-07-23 Daiichi Sankyo Company, Limited Derivados de amina.
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
US6420106B1 (en) 1999-06-09 2002-07-16 Quantovir Ab Method and kit for early cancer prediction
US6200746B1 (en) 1999-08-25 2001-03-13 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
US7001995B1 (en) 1999-08-25 2006-02-21 Merck & Co., Inc. Synthetic human papillomavirus genes
US20060275784A1 (en) * 1999-10-26 2006-12-07 Ventana Medical Systems, Inc. Detection of Human Papilloma Virus in Papanicolaou (Pap) Smears
US6893819B1 (en) 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
DE10009143B4 (de) 2000-02-26 2012-04-26 Eberhard-Karls-Universität Tübingen Universitätsklinikum Nachweis von Humanen Papillomviren
KR100382703B1 (ko) 2000-03-15 2003-05-09 주식회사 바이오메드랩 인유두종바이러스의 유전형 진단키트 및 상기 진단키트의제조방법
US6936443B2 (en) 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
US7510834B2 (en) 2000-04-13 2009-03-31 Hidetoshi Inoko Gene mapping method using microsatellite genetic polymorphism markers
US6828098B2 (en) 2000-05-20 2004-12-07 The Regents Of The University Of Michigan Method of producing a DNA library using positional amplification based on the use of adaptors and nick translation
US6331423B1 (en) 2000-06-01 2001-12-18 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US7033758B2 (en) 2000-06-02 2006-04-25 Bayer Corporation Highly sensitive gene detection and localization using in situ branched-DNA hybridization
US7439016B1 (en) 2000-06-15 2008-10-21 Digene Corporation Detection of nucleic acids by type-specific hybrid capture method
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
AU2002210791A1 (en) 2000-07-28 2002-02-13 Compugen Inc. Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome
US6329152B1 (en) 2000-11-30 2001-12-11 Bruce K. Patterson Process for detecting low abundance RNA in intact cells
US6803200B2 (en) 2000-12-12 2004-10-12 Invitrogen Corporation Compositions and methods for the release of nucleic acid molecules from solid matrices
ES2322841T3 (es) 2001-02-16 2009-06-30 Promega Corporation Aislamiento y purificacion magnetica de acidos nucleicos.
US6670150B1 (en) 2001-05-10 2003-12-30 Applera Corporation Isolated human receptor proteins, nucleic acid molecules encoding human receptor proteins, and uses thereof
US6884605B2 (en) 2001-08-09 2005-04-26 Board Of Trustees Of The University Of Arkansas Compositions, methods and products comprising human papillomavirus for detecting and treating a cancer
EP1806410A3 (en) 2001-08-23 2007-10-24 Merck & Co., Inc. Fluorescent multiplex HPV PCR assays using multiple fluorophores
KR100452163B1 (ko) 2001-09-14 2004-10-12 주식회사 바이오메드랩 인유두종 바이러스의 감염을 진단하기 위한 유전형 분석키트
US20050032105A1 (en) 2001-10-12 2005-02-10 Bair Robert Jackson Compositions and methods for using a solid support to purify DNA
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
ES2654909T3 (es) 2002-01-07 2018-02-15 Pretect As Método para detectar ARNm del virus del papiloma humano
WO2003068163A2 (en) 2002-02-14 2003-08-21 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
HUP0200981A3 (en) 2002-03-14 2004-06-28 Genoid Kft Pcr reactions with hybridizing probes using primers with broad genotype-specificity for detection of human papilloma-viruses and typing amplificates by using specifically hybridizing oligonucleotides
CA2484681A1 (en) 2002-04-16 2003-10-23 Dot Diagnostics B.V. Human papilloma virus detection with dna microarray
DK1506222T3 (da) 2002-05-17 2009-07-06 Univ Cape Town Kimæriske, humane papillomavirus16 L1-proteiner omfattende et L2-peptid, viruslignende partikler fremstillet deraf samt en fremgangsmåde til at fremstille partiklerne
US7704965B2 (en) 2002-06-26 2010-04-27 The Penn State Research Foundation Methods and materials for treating human papillomavirus infections
SE0202896D0 (sv) 2002-10-01 2002-10-01 Quantovir Ab Method for estimating the risk of carcinoma development
MXPA05003395A (es) 2002-10-03 2005-06-22 Wyeth Corp Polipeptidos de virus de papiloma humano y composiciones inmunogenas.
WO2004061124A2 (en) 2002-12-31 2004-07-22 Mmi Genomics, Inc. Compositions, methods, and systems for inferring bovine breed
US7276243B2 (en) 2003-03-24 2007-10-02 Merck & Co., Inc. Optimized expression of HPV31 L1 in yeast
ATE550099T1 (de) 2003-04-04 2012-04-15 Hoffmann La Roche Verbessertes system für mehrfarbige echtzeit-pcr
US7129260B2 (en) 2003-06-02 2006-10-31 Abbott Laboratories Isoindolinone kinase inhibitors
US20040248107A1 (en) 2003-06-09 2004-12-09 Sokolova Irina A. Detection of high grade dysplasia in cervical cells
EP1641809B2 (en) 2003-07-05 2018-10-03 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
DE60300339T2 (de) 2003-08-25 2006-04-13 Mtm Laboratories Ag Verfahren zum Nachweis von Karzinomen in solubilisierten zervikalen Körperproben
WO2005030041A2 (en) 2003-09-25 2005-04-07 Third Wave Technologies, Inc. Detection of hpv
MY140664A (en) 2003-09-29 2010-01-15 Merck Sharp & Dohme Optimized expression of hpv 45 l1 in yeast
WO2005033333A2 (en) * 2003-10-07 2005-04-14 Dako Denmark A/S Methods and compositions for the diagnosis of cancer
US8012944B2 (en) 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
JP2005243132A (ja) 2004-02-26 2005-09-08 Renesas Technology Corp 半導体装置
EP1730175B1 (en) 2004-03-24 2010-04-28 Merck Sharp & Dohme Corp. Optimized expression of hpv 52 l1 in yeast
CN1690223B (zh) 2004-04-27 2010-05-05 亚能生物技术(深圳)有限公司 人乳头瘤病毒分型基因芯片检测系统
US7482142B1 (en) 2004-05-07 2009-01-27 Roche Molecular Systems, Inc. High-risk human papillomavirus detection
EP2458015B1 (en) 2004-09-30 2015-12-23 Epigenomics AG Method for providing DNA fragments derived from an archived sample
US7670774B2 (en) 2004-10-04 2010-03-02 Goodgene Inc. Probe of human papillomavirus and DNA chip comprising the same
DE602005022759D1 (de) 2004-12-08 2010-09-16 Gen Probe Inc Nukleinsäuredetektion aus verschiedenen typen des humanen papillomavirus
CN101151379A (zh) 2005-01-14 2008-03-26 密执安州立大学董事会 检测生物样品中的人乳头瘤病毒的系统、方法和组合物
US20060240449A1 (en) 2005-01-19 2006-10-26 Mcglennen Ronald C Methods and compositions for preparation of biological samples
US7524631B2 (en) 2005-02-02 2009-04-28 Patterson Bruce K HPV E6, E7 mRNA assay and methods of use thereof
CA2602185A1 (en) 2005-04-06 2006-10-06 Verenium Corporation Enzymes and formulations for broad-specificity decontamination of chemical and biological warfare agents
WO2006124771A2 (en) 2005-05-12 2006-11-23 Panomics, Inc. Multiplex branched-chain dna assays
US20080003565A1 (en) 2006-05-02 2008-01-03 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services Viral nucleic acid microarray and method of use
US8962262B2 (en) 2006-05-11 2015-02-24 Arbor Vita Corporation Method of protein extraction from cells
WO2008139938A1 (ja) 2007-05-02 2008-11-20 National University Corporation Tokyo Medical And Dental University ヒトパピローマウイルス16型遺伝子を標的とする二本鎖核酸分子及びそれを含む医薬
US8623599B2 (en) 2007-06-08 2014-01-07 Epigenomics Ag Method for methylation analysis
CN101177701B (zh) 2007-09-29 2010-08-18 潮州凯普生物化学有限公司 人乳头状瘤病毒基因分型检测试剂盒及其基因芯片制备方法
JP2009106220A (ja) 2007-10-31 2009-05-21 Genodive Pharma Kk 基板上での等温増幅反応による標的塩基配列の捕捉及び検出方法
WO2009057993A1 (en) 2007-11-01 2009-05-07 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg NEW DETECTION METHOD FOR CERVICAL HPVs
US20110027798A1 (en) 2008-03-31 2011-02-03 The Ohio State University Research Foundation Hybridization Quantitation Method for Modified Micro-RNA and -DNA Based Oligonucleotides
WO2010004251A1 (en) 2008-06-16 2010-01-14 Oncomethylome Sciences Sa Dna methylomes
WO2010028382A2 (en) 2008-09-05 2010-03-11 Mayo Foundation For Medical Education And Research Collecting and processing complex macromolecular mixtures
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
WO2010062546A1 (en) * 2008-10-27 2010-06-03 Qiagen Gaithersburg Inc. Fast results hybrid capture assay on an automated platform
EP2184368A1 (en) 2008-11-07 2010-05-12 DKFZ Deutsches Krebsforschungszentrum Diagnostic transcript and splice patterns of HPV16 in different cervical lesions
EP2425019B1 (en) 2009-05-01 2014-03-19 QIAGEN Gaithersburg, Inc. A non-target amplification method for detection of rna splice-forms in a sample

Similar Documents

Publication Publication Date Title
US20210292824A1 (en) Crispr effector system based coronavirus diagnostics
US20230127948A1 (en) Field deployable crispr-cas diagnostics and methods of use thereof
US20180340215A1 (en) Sample analysis, presence determination of a target sequence
Andersson et al. Properties of targeted preamplification in DNA and cDNA quantification
JP2015156872A5 (https=)
RU2018105835A (ru) Способы амплификации последовательностей нуклеиновых кислот
WO2015095226A3 (en) Preserving genomic connectivity information in fragmented genomic dna samples
JP2016518843A5 (https=)
JP2012518421A5 (https=)
JP2016195614A5 (https=)
JP6596442B2 (ja) Dna増幅を増強および/または予測するための組成物および方法
JP2017519774A5 (https=)
JP2016531569A5 (https=)
JP2012245004A5 (https=)
JP2014520525A5 (https=)
HRP20200264T1 (hr) Nukleinskokiselinska sonda s jednim fluorofornim biljegom vezanim na unutarnji citozin, namijenjena upotrebi kod izotermalne amplifikacije posredovane petljom
JP2016512437A5 (https=)
JP2017522015A5 (https=)
JP2012513191A5 (https=)
JP2015091235A5 (https=)
JP2017537658A5 (https=)
JP2016537005A5 (https=)
ATE505562T1 (de) Doppel-oligonukleotid- nukleinsäurenachweisverfahren
KR20190063512A (ko) 리얼타임 pcr을 이용한 코로나바이러스 검사 키트 및 방법
Lee et al. Poly-adenine-coupled LAMP barcoding to detect apple scar skin viroid