WO2008139938A1 - ヒトパピローマウイルス１６型遺伝子を標的とする二本鎖核酸分子及びそれを含む医薬 - Google Patents

ヒトパピローマウイルス１６型遺伝子を標的とする二本鎖核酸分子及びそれを含む医薬 Download PDF

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WO2008139938A1
WO2008139938A1 PCT/JP2008/058289 JP2008058289W WO2008139938A1 WO 2008139938 A1 WO2008139938 A1 WO 2008139938A1 JP 2008058289 W JP2008058289 W JP 2008058289W WO 2008139938 A1 WO2008139938 A1 WO 2008139938A1
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double
nucleic acid
stranded nucleic
acid molecule
pharmaceutical agent
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PCT/JP2008/058289
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English (en)
French (fr)
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Kenji Yamato
Yukikazu Natori
Masato Fujino
Taketo Yamada
Mitsuo Yoshinouchi
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National University Corporation Tokyo Medical And Dental University
Rnai Co., Ltd.
National University Corporation Okayama University
Keio University
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Priority to JP2009514103A priority Critical patent/JPWO2008139938A1/ja
Publication of WO2008139938A1 publication Critical patent/WO2008139938A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
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  • Organic Chemistry (AREA)
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  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

　本発明の目的は、ヒトパピローマウイルス（ＨＰＶ）１６型癌遺伝子の発現に対して高い抑制活性と高い特異性を有するｓｉＲＮＡ等の二本鎖核酸分子、及び、ＨＰＶ１６型感染に起因する疾患（例えば、子宮頸癌）の治療又は予防に好適な医薬等を提供することにある。即ち本発明は、ＨＰＶ１６型のＥ６及びＥ７癌遺伝子における特定の配列を標的とした、該遺伝子の発現に対して高い抑制活性と高い特異性を有する二本鎖核酸分子；並びに、前記二本鎖核酸分子を含む、ＤＮＡ、ベクター、及び医薬に関する。
PCT/JP2008/058289 2007-05-02 2008-04-30 ヒトパピローマウイルス１６型遺伝子を標的とする二本鎖核酸分子及びそれを含む医薬 WO2008139938A1 (ja)

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JP2009514103A JPWO2008139938A1 (ja) 2007-05-02 2008-04-30 ヒトパピローマウイルス１６型遺伝子を標的とする二本鎖核酸分子及びそれを含む医薬

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JP2007121498 2007-05-02
JP2007-121498 2007-05-02

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WO2008139938A1 true WO2008139938A1 (ja) 2008-11-20

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012094682A3 (en) * 2011-01-07 2012-12-06 Qiagen Gaithersburg, Inc. Materials and method for genotyping and quantifying a high-risk human papillomavirus
US8389219B2 (en) 2000-06-15 2013-03-05 Qiagen Gaithersburg, Inc. Detection of nucleic acids by type-specific hybrid capture method
JP2013118839A (ja) * 2011-12-07 2013-06-17 Bio Think Tank Co Ltd 遺伝子発現阻害剤及び阻害方法
US8722328B2 (en) 2010-01-04 2014-05-13 Qiagen Gaithersburg, Inc. Methods, compositions, and kits for recovery of nucleic acids or proteins from fixed tissue samples
US8735564B2 (en) 2008-10-27 2014-05-27 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and system
US8901287B2 (en) 2004-10-20 2014-12-02 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
JP2015529654A (ja) * 2012-08-02 2015-10-08 アビオン インコーポレーテッド Ｈｐｖ感染に係わる癌の治療用組成物
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
US9410146B2 (en) 2009-09-14 2016-08-09 Qiagen Gaithersburg Inc. Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
US9422593B2 (en) 2010-05-19 2016-08-23 Qiagen Gaithresburg, Inc Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9605303B2 (en) 2010-01-29 2017-03-28 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an HPV in a sample
US9689047B2 (en) 2010-01-29 2017-06-27 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9777264B2 (en) 2011-11-03 2017-10-03 Qiagen Gaithersburg, Inc. Materials and method for immobilizing, isolating, and concentrating cells using carboxylated surfaces
US9797000B2 (en) 2009-05-01 2017-10-24 Qiagen Gaithersburg Inc. Non-target amplification method for detection of RNA splice-forms in a sample
US9885092B2 (en) 2011-02-24 2018-02-06 Qiagen Gaithersburg Inc. Materials and methods for detection of HPV nucleic acids

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3803318B2 (ja) * 2001-11-21 2006-08-02 株式会社ＲＮＡｉ 遺伝子発現阻害方法

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
JP3803318B2 (ja) * 2001-11-21 2006-08-02 株式会社ＲＮＡｉ 遺伝子発現阻害方法

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Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8389219B2 (en) 2000-06-15 2013-03-05 Qiagen Gaithersburg, Inc. Detection of nucleic acids by type-specific hybrid capture method
US8557973B2 (en) 2000-06-15 2013-10-15 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US8901287B2 (en) 2004-10-20 2014-12-02 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US9115410B2 (en) 2004-10-20 2015-08-25 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US8735564B2 (en) 2008-10-27 2014-05-27 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and system
US8877436B2 (en) 2008-10-27 2014-11-04 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay on an automated platform
US9797000B2 (en) 2009-05-01 2017-10-24 Qiagen Gaithersburg Inc. Non-target amplification method for detection of RNA splice-forms in a sample
US9410146B2 (en) 2009-09-14 2016-08-09 Qiagen Gaithersburg Inc. Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media
US8722328B2 (en) 2010-01-04 2014-05-13 Qiagen Gaithersburg, Inc. Methods, compositions, and kits for recovery of nucleic acids or proteins from fixed tissue samples
US9689047B2 (en) 2010-01-29 2017-06-27 Qiagen Gaithersburg Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9605303B2 (en) 2010-01-29 2017-03-28 Qiagen Gaithersburg, Inc. Method of determining and confirming the presence of an HPV in a sample
US9422593B2 (en) 2010-05-19 2016-08-23 Qiagen Gaithresburg, Inc Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
US9376727B2 (en) 2010-05-25 2016-06-28 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically truncated probes
AU2012204158B2 (en) * 2011-01-07 2017-02-02 Qiagen Gaithersburg, Inc. Materials and method for genotyping and quantifying a high-risk human papillomavirus
WO2012094682A3 (en) * 2011-01-07 2012-12-06 Qiagen Gaithersburg, Inc. Materials and method for genotyping and quantifying a high-risk human papillomavirus
US9885092B2 (en) 2011-02-24 2018-02-06 Qiagen Gaithersburg Inc. Materials and methods for detection of HPV nucleic acids
US9777264B2 (en) 2011-11-03 2017-10-03 Qiagen Gaithersburg, Inc. Materials and method for immobilizing, isolating, and concentrating cells using carboxylated surfaces
JP2013118839A (ja) * 2011-12-07 2013-06-17 Bio Think Tank Co Ltd 遺伝子発現阻害剤及び阻害方法
JP2016190845A (ja) * 2012-08-02 2016-11-10 アビオン インコーポレーテッド Ｈｐｖ感染に係わる癌の治療用組成物
AU2013297196B2 (en) * 2012-08-02 2017-01-05 EnhancedBio Inc. Composition for treating cancer associated with HPV infection
EP2881123A4 (en) * 2012-08-02 2016-07-06 Abion Inc COMPOSITION FOR THE TREATMENT OF CANCER ASSOCIATED WITH HPV INFECTION
JP2015529654A (ja) * 2012-08-02 2015-10-08 アビオン インコーポレーテッド Ｈｐｖ感染に係わる癌の治療用組成物
US9719093B2 (en) 2012-08-02 2017-08-01 Abion Inc. Composition for treating cancer associated with HPV infection
EP3178498A3 (en) * 2012-08-02 2017-09-27 Abion Inc. Composition for treating cancer associated with hpv infection
US10221418B2 (en) 2012-08-02 2019-03-05 EnhancedBio Inc. Composition for treating cancer associated with HPV infection

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