EA201892285A1 - Нуклеотиды, модифицированные циклофосфонатом по положению 5' - Google Patents

Нуклеотиды, модифицированные циклофосфонатом по положению 5'

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Publication number
EA201892285A1
EA201892285A1 EA201892285A EA201892285A EA201892285A1 EA 201892285 A1 EA201892285 A1 EA 201892285A1 EA 201892285 A EA201892285 A EA 201892285A EA 201892285 A EA201892285 A EA 201892285A EA 201892285 A1 EA201892285 A1 EA 201892285A1
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Eurasian Patent Office
Prior art keywords
cyclophosphonate
nucleotides modified
stranded
regulation
oligonucleotides
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EA201892285A
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English (en)
Inventor
Чжэнь Ли
Тао Пэй
Майкл Лоулер
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Эрроухэд Фармасьютикалз, Инк.
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Publication of EA201892285A1 publication Critical patent/EA201892285A1/ru

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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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Abstract

Описаны нуклеотиды, модифицированные циклофосфонатом по положению 5', и олигонуклеотиды, такие как агенты РНК-интерференции (РНКи), содержащие нуклеотиды, модифицированные циклофосфонатом по положению 5'. Агенты РНКи, содержащие двухцепочечные или одноцепочечные олигонуклеотиды, описанные в настоящем документе, содержащие нуклеотиды, модифицированные циклофосфонатом по положению 5', подходят для модуляции экспрессии гена, а также применения в терапии, диагностике, подтверждении мишени и изучении генома. Агенты РНКи и одноцепочечные антисмысловые олигонуклеотиды, содержащие нуклеотиды, модифицированные циклофосфонатом по положению 5', подходят для лечения заболеваний или состояний, при которых имеется ответ на подавление экспрессии или активности гена в клетке, ткани или организме.
EA201892285A 2016-06-06 2017-06-06 Нуклеотиды, модифицированные циклофосфонатом по положению 5' EA201892285A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662346304P 2016-06-06 2016-06-06
PCT/US2017/036108 WO2017214112A1 (en) 2016-06-06 2017-06-06 5'-cyclo-phosphonate modified nucleotides

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EA201892285A1 true EA201892285A1 (ru) 2019-07-31

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US (2) US11078227B2 (ru)
EP (1) EP3464313A4 (ru)
JP (2) JP7028865B2 (ru)
KR (2) KR102639586B1 (ru)
CN (2) CN114736256A (ru)
AU (3) AU2017279512B2 (ru)
CA (1) CA3023764A1 (ru)
EA (1) EA201892285A1 (ru)
IL (2) IL263437B (ru)
MX (2) MX2018015109A (ru)
TW (1) TWI815794B (ru)
WO (1) WO2017214112A1 (ru)

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MX2023008478A (es) 2023-07-27
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IL290633A (en) 2022-04-01
MX2018015109A (es) 2019-04-22
CA3023764A1 (en) 2017-12-14
TW201801748A (zh) 2018-01-16
JP7028865B2 (ja) 2022-03-02
KR102639586B1 (ko) 2024-02-23
JP2019517588A (ja) 2019-06-24
CN114736256A (zh) 2022-07-12
WO2017214112A1 (en) 2017-12-14
KR102426487B1 (ko) 2022-07-27
AU2021266265A1 (en) 2021-12-09
EP3464313A4 (en) 2020-02-26
IL263437B (en) 2022-03-01
AU2023275805A1 (en) 2024-02-22
AU2017279512B2 (en) 2021-08-19
AU2017279512A1 (en) 2018-12-06
IL290633B1 (en) 2024-07-01
KR20190015277A (ko) 2019-02-13
KR20220108204A (ko) 2022-08-02
US11078227B2 (en) 2021-08-03
US20220119439A1 (en) 2022-04-21
CN109526222A (zh) 2019-03-26
CN109526222B (zh) 2022-04-29
IL263437A (en) 2019-01-31
JP2022059052A (ja) 2022-04-12
EP3464313A1 (en) 2019-04-10
US20190085012A1 (en) 2019-03-21

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