JP2013531978A5 - - Google Patents
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- JP2013531978A5 JP2013531978A5 JP2013512251A JP2013512251A JP2013531978A5 JP 2013531978 A5 JP2013531978 A5 JP 2013531978A5 JP 2013512251 A JP2013512251 A JP 2013512251A JP 2013512251 A JP2013512251 A JP 2013512251A JP 2013531978 A5 JP2013531978 A5 JP 2013531978A5
- Authority
- JP
- Japan
- Prior art keywords
- pdhk
- nucleic acid
- acid sequence
- cell
- heterologous nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34972710P | 2010-05-28 | 2010-05-28 | |
| US61/349,727 | 2010-05-28 | ||
| PCT/US2011/038191 WO2011150241A2 (en) | 2010-05-28 | 2011-05-26 | Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016227876A Division JP6325060B2 (ja) | 2010-05-28 | 2016-11-24 | Ｌｄｈ及びｐｄｈｋ発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531978A JP2013531978A (ja) | 2013-08-15 |
| JP2013531978A5 true JP2013531978A5 (enExample) | 2014-07-10 |
| JP6050226B2 JP6050226B2 (ja) | 2016-12-21 |
Family
ID=45004831
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512251A Active JP6050226B2 (ja) | 2010-05-28 | 2011-05-26 | Ｌｄｈ及びｐｄｈｋ発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 |
| JP2016227876A Active JP6325060B2 (ja) | 2010-05-28 | 2016-11-24 | Ｌｄｈ及びｐｄｈｋ発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 |
| JP2018076234A Active JP6706642B2 (ja) | 2010-05-28 | 2018-04-11 | Ｌｄｈ及びｐｄｈｋ発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016227876A Active JP6325060B2 (ja) | 2010-05-28 | 2016-11-24 | Ｌｄｈ及びｐｄｈｋ発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 |
| JP2018076234A Active JP6706642B2 (ja) | 2010-05-28 | 2018-04-11 | Ｌｄｈ及びｐｄｈｋ発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US9487809B2 (enExample) |
| EP (1) | EP2576580B1 (enExample) |
| JP (3) | JP6050226B2 (enExample) |
| KR (3) | KR101989762B1 (enExample) |
| CN (1) | CN102985437B (enExample) |
| BR (1) | BR112012030197A2 (enExample) |
| CA (1) | CA2800728C (enExample) |
| DK (1) | DK2576580T3 (enExample) |
| ES (1) | ES2599412T3 (enExample) |
| HU (1) | HUE030820T2 (enExample) |
| MX (3) | MX374851B (enExample) |
| PL (1) | PL2576580T3 (enExample) |
| RU (1) | RU2614125C2 (enExample) |
| SI (1) | SI2576580T1 (enExample) |
| WO (1) | WO2011150241A2 (enExample) |
Families Citing this family (42)
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| BRPI0920572A8 (pt) | 2008-10-20 | 2015-10-27 | Abbott Lab | Inativação viral durante a purificação dos anticorpos |
| CA2800728C (en) | 2010-05-28 | 2020-10-27 | Genentech, Inc. | Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
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| HK1207960A1 (en) | 2013-03-12 | 2016-02-19 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
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| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
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| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| KR102243980B1 (ko) * | 2013-10-11 | 2021-04-26 | 리제너론 파마슈티칼스 인코포레이티드 | 대사적으로 최적화된 세포 배양 |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| WO2015142903A2 (en) * | 2014-03-17 | 2015-09-24 | Genentech, Inc. | Method of controlling lactate production with piperdine-dione derivatives |
| AU2015330670B2 (en) | 2014-10-10 | 2022-01-06 | Novo Nordisk Health Care Ag | Therapeutic inhibition of lactate dehydrogenase and agents therefor |
| KR102265924B1 (ko) | 2014-10-31 | 2021-06-15 | 삼성바이오에피스 주식회사 | Pdk 불활성화에 의한 폴리펩타이드의 생산 |
| KR101978277B1 (ko) * | 2015-02-06 | 2019-05-14 | 경북대학교 산학협력단 | Pdk2를 이용한 여성 갱년기 질환 예방 또는 치료제의 스크리닝 방법 및 상기 방법으로 스크리닝 된 치료제를 유효성분으로 포함하는 여성 갱년기 질환의 예방 또는 치료용 약학적 조성물 |
| CN105368839A (zh) * | 2015-12-22 | 2016-03-02 | 中国人民解放军第三军医大学 | 一种有效抑制小鼠pdk2表达的rna干扰序列及其应用 |
| EP3452080A4 (en) * | 2016-05-02 | 2019-10-09 | The Regents of the University of California | MAMMALIAN CELLS WITHOUT LACTATE DEHYDROGENASE ACTIVITY |
| WO2019075419A1 (en) | 2017-10-13 | 2019-04-18 | Dicerna Pharmaceuticals, Inc. | METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION |
| CN107904257B (zh) * | 2017-11-22 | 2021-05-04 | 上海药明生物技术有限公司 | 一种增加cho细胞群蛋白表达量的方法 |
| JP2021505662A (ja) * | 2017-12-04 | 2021-02-18 | ザ ジェネラル ホスピタル コーポレイション | 疾患を軽減するための細胞外酸化還元酵素系 |
| JP2021519073A (ja) * | 2018-03-29 | 2021-08-10 | ジェネンテック， インコーポレイテッド | 哺乳動物細胞におけるラクトジェニック活性の制御 |
| WO2020260327A1 (en) * | 2019-06-26 | 2020-12-30 | F. Hoffmann-La Roche Ag | Mammalian cell lines with sirt-1 gene knockout |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| US12188060B2 (en) | 2020-05-15 | 2025-01-07 | Crispr Therapeutics Ag | Messenger RNA encoding Cas9 for use in genome-editing systems |
| CN119534671A (zh) * | 2021-03-08 | 2025-02-28 | 江成鸿 | 组合物在制备诊断婴幼儿血管瘤和/或监测其进展及预后的药物中的应用 |
| CN115948404B (zh) * | 2023-02-01 | 2024-06-04 | 重庆医科大学 | 一种抑制环状RNA circPDHK1的siRNA及其用途 |
| EP4574966A1 (en) * | 2023-12-18 | 2025-06-25 | Good Meat, Inc. | Engineered cell lines for the production of cultivated meat |
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-
2011
- 2011-05-26 CA CA2800728A patent/CA2800728C/en active Active
- 2011-05-26 EP EP11787435.4A patent/EP2576580B1/en active Active
- 2011-05-26 MX MX2016014767A patent/MX374851B/es unknown
- 2011-05-26 KR KR1020187016873A patent/KR101989762B1/ko not_active Expired - Fee Related
- 2011-05-26 ES ES11787435.4T patent/ES2599412T3/es active Active
- 2011-05-26 MX MX2012013579A patent/MX343604B/es active IP Right Grant
- 2011-05-26 CN CN201180026517.2A patent/CN102985437B/zh active Active
- 2011-05-26 JP JP2013512251A patent/JP6050226B2/ja active Active
- 2011-05-26 SI SI201131017A patent/SI2576580T1/sl unknown
- 2011-05-26 KR KR1020127033948A patent/KR101869987B1/ko not_active Expired - Fee Related
- 2011-05-26 KR KR1020197016381A patent/KR20190067277A/ko not_active Withdrawn
- 2011-05-26 RU RU2012157307A patent/RU2614125C2/ru active
- 2011-05-26 PL PL11787435T patent/PL2576580T3/pl unknown
- 2011-05-26 HU HUE11787435A patent/HUE030820T2/en unknown
- 2011-05-26 BR BR112012030197A patent/BR112012030197A2/pt not_active Application Discontinuation
- 2011-05-26 DK DK11787435.4T patent/DK2576580T3/en active
- 2011-05-26 WO PCT/US2011/038191 patent/WO2011150241A2/en not_active Ceased
-
2012
- 2012-11-22 MX MX2020009460A patent/MX2020009460A/es unknown
- 2012-11-28 US US13/688,075 patent/US9487809B2/en active Active
-
2016
- 2016-09-16 US US15/268,424 patent/US10011856B2/en active Active
- 2016-11-24 JP JP2016227876A patent/JP6325060B2/ja active Active
-
2018
- 2018-04-11 JP JP2018076234A patent/JP6706642B2/ja active Active
- 2018-05-31 US US15/994,950 patent/US10704071B2/en active Active
-
2020
- 2020-05-29 US US16/888,344 patent/US11046987B2/en active Active
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