JP2023182587A5 - - Google Patents
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- JP2023182587A5 JP2023182587A5 JP2023144942A JP2023144942A JP2023182587A5 JP 2023182587 A5 JP2023182587 A5 JP 2023182587A5 JP 2023144942 A JP2023144942 A JP 2023144942A JP 2023144942 A JP2023144942 A JP 2023144942A JP 2023182587 A5 JP2023182587 A5 JP 2023182587A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- human
- microglia
- population
- hematopoietic progenitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 40
- 238000000034 method Methods 0.000 claims 38
- 210000004027 cell Anatomy 0.000 claims 24
- 101000980898 Homo sapiens Cell division cycle-associated protein 4 Proteins 0.000 claims 18
- 102000044493 human CDCA4 Human genes 0.000 claims 18
- 230000004069 differentiation Effects 0.000 claims 15
- 239000001963 growth medium Substances 0.000 claims 15
- 210000000274 microglia Anatomy 0.000 claims 13
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 9
- 102100039564 Leukosialin Human genes 0.000 claims 9
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 7
- 239000002609 medium Substances 0.000 claims 7
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 6
- 101001120086 Homo sapiens P2Y purinoceptor 12 Proteins 0.000 claims 5
- 102100026171 P2Y purinoceptor 12 Human genes 0.000 claims 5
- 230000024245 cell differentiation Effects 0.000 claims 5
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 4
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims 4
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 4
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 4
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 4
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 claims 4
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 102100024119 CDK5 and ABL1 enzyme substrate 1 Human genes 0.000 claims 3
- 108090000835 CX3C Chemokine Receptor 1 Proteins 0.000 claims 3
- 102100039196 CX3C chemokine receptor 1 Human genes 0.000 claims 3
- 102100020997 Fractalkine Human genes 0.000 claims 3
- 102100033864 G-protein coupled receptor 84 Human genes 0.000 claims 3
- 101000910461 Homo sapiens CDK5 and ABL1 enzyme substrate 1 Proteins 0.000 claims 3
- 101000854520 Homo sapiens Fractalkine Proteins 0.000 claims 3
- 101001069589 Homo sapiens G-protein coupled receptor 84 Proteins 0.000 claims 3
- 101001086535 Homo sapiens Olfactomedin-like protein 3 Proteins 0.000 claims 3
- 101000598051 Homo sapiens Transmembrane protein 119 Proteins 0.000 claims 3
- 101000795117 Homo sapiens Triggering receptor expressed on myeloid cells 2 Proteins 0.000 claims 3
- 101000807561 Homo sapiens Tyrosine-protein kinase receptor UFO Proteins 0.000 claims 3
- -1 IBA-1 Proteins 0.000 claims 3
- 102100032750 Olfactomedin-like protein 3 Human genes 0.000 claims 3
- 101150094159 PU1 gene Proteins 0.000 claims 3
- 102100037029 Transmembrane protein 119 Human genes 0.000 claims 3
- 102100029678 Triggering receptor expressed on myeloid cells 2 Human genes 0.000 claims 3
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 claims 3
- 101000995200 Homo sapiens Neurabin-2 Proteins 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000003394 haemopoietic effect Effects 0.000 claims 2
- 102000050471 human SPN Human genes 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 230000002025 microglial effect Effects 0.000 claims 2
- 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 claims 1
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762464925P | 2017-02-28 | 2017-02-28 | |
| US62/464,925 | 2017-02-28 | ||
| PCT/US2018/019763 WO2018160496A1 (en) | 2017-02-28 | 2018-02-26 | Differentiation and use of human microglia-like cells from pluripotent stem cells and hematopoietic progenitors |
| JP2019546831A JP2020513794A (ja) | 2017-02-28 | 2018-02-26 | 多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用 |
| JP2023020284A JP7668551B2 (ja) | 2017-02-28 | 2023-02-13 | 多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023020284A Division JP7668551B2 (ja) | 2017-02-28 | 2023-02-13 | 多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023182587A JP2023182587A (ja) | 2023-12-26 |
| JP2023182587A5 true JP2023182587A5 (enExample) | 2024-07-01 |
Family
ID=63370557
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546831A Withdrawn JP2020513794A (ja) | 2017-02-28 | 2018-02-26 | 多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用 |
| JP2023020284A Active JP7668551B2 (ja) | 2017-02-28 | 2023-02-13 | 多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用 |
| JP2023144942A Pending JP2023182587A (ja) | 2017-02-28 | 2023-09-07 | 多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546831A Withdrawn JP2020513794A (ja) | 2017-02-28 | 2018-02-26 | 多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用 |
| JP2023020284A Active JP7668551B2 (ja) | 2017-02-28 | 2023-02-13 | 多能性幹細胞および造血始原細胞からのヒトミクログリア様細胞の分化と使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20200239844A1 (enExample) |
| EP (2) | EP3589293A4 (enExample) |
| JP (3) | JP2020513794A (enExample) |
| CA (1) | CA3054730A1 (enExample) |
| WO (1) | WO2018160496A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201619876D0 (en) | 2016-11-24 | 2017-01-11 | Cambridge Entpr Ltd | Controllable transcription |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| EP3856765A4 (en) * | 2018-09-28 | 2022-10-05 | Memorial Sloan Kettering Cancer Center | STEM CELL-DERIVED HUMAN MICROGLIACELLS, PROCESS FOR THEIR PRODUCTION AND THEIR USE |
| CN113924362B (zh) * | 2019-03-29 | 2025-03-07 | 新加坡科技研究局 | 小胶质细胞充足的脑类器官 |
| US20220235322A1 (en) * | 2019-05-30 | 2022-07-28 | President And Fellows Of Harvard College | Reproducible brain organoids and methods of making |
| GB2584664B (en) * | 2019-06-10 | 2023-05-24 | Newcells Biotech Ltd | Improved retinal organoids and methods of making the same |
| CN110205295B (zh) * | 2019-06-25 | 2021-10-29 | 中国科学院动物研究所 | 一种多能干细胞诱导产生小胶质细胞的方法及试剂盒 |
| KR20210077634A (ko) * | 2019-12-17 | 2021-06-25 | 코아스템(주) | 인간 만능 줄기세포로부터 3d 오가노이드를 이용하여 미세교세포를 다량 확보하는 미세교세포의 분화방법 |
| CN112011509A (zh) * | 2020-09-25 | 2020-12-01 | 南京中医药大学 | 脊髓损伤大鼠原代小胶质细胞分离方法及应用 |
| CN114426951B (zh) * | 2020-10-29 | 2024-05-14 | 北京赛尔湃腾科技咨询合伙企业(有限合伙) | 利用多能干细胞制备小胶质细胞样细胞的方法 |
| DE202022003132U1 (de) | 2021-04-01 | 2025-02-17 | The Regents Of The University Of California | Genetische Modifikation von Säugerzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten |
| WO2024015933A2 (en) * | 2022-07-13 | 2024-01-18 | The Regents Of The University Of California | Transplanting stem cell-derived microglia to treat leukodystrophies |
| US20240269189A1 (en) | 2022-12-19 | 2024-08-15 | FUJIFILM Holdings America Corporation | Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2424976B1 (en) * | 2009-04-28 | 2013-07-31 | Life & Brain GmbH | Method for obtaining human microglial precursor cells from pluripotent stem cells |
| US10081792B2 (en) * | 2014-12-31 | 2018-09-25 | Wisconsin Alumni Research Foundation | Derivation of human microglia from pluripotent stem cells |
| CA2972598C (en) * | 2014-12-31 | 2024-03-12 | Wisconsin Alumni Research Foundation | Human pluripotent stem cell-based models for predictive developmental neural toxicity |
| CN114058582A (zh) | 2015-01-26 | 2022-02-18 | 菲特治疗公司 | 用于诱导造血细胞分化的方法和组合物 |
| WO2016210313A1 (en) * | 2015-06-24 | 2016-12-29 | Whitehead Institute For Biomedical Research | Culture medium for generating microglia from pluripotent stem cells and related methods |
| WO2017152081A1 (en) * | 2016-03-03 | 2017-09-08 | New York Stem Cell Foundation, Inc. | Microglia derived from pluripotent stem cells and methods of making and using the same |
-
2018
- 2018-02-26 EP EP18760945.8A patent/EP3589293A4/en active Pending
- 2018-02-26 US US16/489,338 patent/US20200239844A1/en active Pending
- 2018-02-26 WO PCT/US2018/019763 patent/WO2018160496A1/en not_active Ceased
- 2018-02-26 CA CA3054730A patent/CA3054730A1/en active Pending
- 2018-02-26 JP JP2019546831A patent/JP2020513794A/ja not_active Withdrawn
- 2018-02-26 EP EP23178750.8A patent/EP4272551A3/en active Pending
-
2023
- 2023-02-13 JP JP2023020284A patent/JP7668551B2/ja active Active
- 2023-09-07 JP JP2023144942A patent/JP2023182587A/ja active Pending
-
2024
- 2024-06-20 US US18/749,358 patent/US20240417684A1/en active Pending
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