JP2010110331A5 - - Google Patents
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- Publication number
- JP2010110331A5 JP2010110331A5 JP2010009094A JP2010009094A JP2010110331A5 JP 2010110331 A5 JP2010110331 A5 JP 2010110331A5 JP 2010009094 A JP2010009094 A JP 2010009094A JP 2010009094 A JP2010009094 A JP 2010009094A JP 2010110331 A5 JP2010110331 A5 JP 2010110331A5
- Authority
- JP
- Japan
- Prior art keywords
- glucose
- cell line
- cell
- cells
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- 239000002609 medium Substances 0.000 claims 5
- 230000007967 glucose restriction Effects 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 238000010924 continuous production Methods 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 238000004886 process control Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10255508A DE10255508A1 (de) | 2002-11-27 | 2002-11-27 | Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen |
| DE10255508.7 | 2002-11-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004554195A Division JP4469283B2 (ja) | 2002-11-27 | 2003-11-07 | 物質を生産するために細胞を培養する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010110331A JP2010110331A (ja) | 2010-05-20 |
| JP2010110331A5 true JP2010110331A5 (enExample) | 2011-03-10 |
| JP5221573B2 JP5221573B2 (ja) | 2013-06-26 |
Family
ID=32318751
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004554195A Expired - Lifetime JP4469283B2 (ja) | 2002-11-27 | 2003-11-07 | 物質を生産するために細胞を培養する方法 |
| JP2010009094A Expired - Lifetime JP5221573B2 (ja) | 2002-11-27 | 2010-01-19 | 物質を生産するために細胞を培養する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004554195A Expired - Lifetime JP4469283B2 (ja) | 2002-11-27 | 2003-11-07 | 物質を生産するために細胞を培養する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20060127975A1 (enExample) |
| EP (3) | EP1585810B1 (enExample) |
| JP (2) | JP4469283B2 (enExample) |
| AT (1) | ATE462013T1 (enExample) |
| CY (2) | CY1110267T1 (enExample) |
| DE (2) | DE10255508A1 (enExample) |
| DK (2) | DK1585810T3 (enExample) |
| ES (3) | ES2749217T3 (enExample) |
| HU (1) | HUE028862T2 (enExample) |
| PT (1) | PT1585810E (enExample) |
| SI (3) | SI2226381T1 (enExample) |
| WO (1) | WO2004048556A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2284271C (en) | 1997-03-21 | 2012-05-08 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized t cell-mediated diseases comprising il-6 antagonist as an active ingredient |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| SI1623019T1 (sl) * | 2003-05-15 | 2010-10-29 | Wyeth Llc | Omejeno glukozno dovajanje za živalsko celično kulturo |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| DE102008002210A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von Erythropoietin |
| AU2016210748B2 (en) * | 2009-10-26 | 2018-03-01 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| ES2981683T3 (es) * | 2009-10-26 | 2024-10-10 | Hoffmann La Roche | Procedimiento para la producción de una inmunoglobulina glucosilada |
| AU2015203309B2 (en) * | 2009-10-26 | 2016-05-05 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| TWI563090B (en) * | 2009-12-22 | 2016-12-21 | Dsm Ip Assets Bv | The preparation of caprolactam from 6-amino caproic acid obtained in a fermentation process |
| KR20130086628A (ko) | 2010-11-08 | 2013-08-02 | 제넨테크, 인크. | 피하 투여용 항―ｉｌ―6 수용체 항체 |
| JP6563910B2 (ja) | 2013-07-04 | 2019-08-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ |
| EP3119876B1 (en) | 2014-03-19 | 2024-12-18 | Pfizer Inc. | Method of cell culture |
| ES2989780T3 (es) | 2015-09-23 | 2024-11-27 | Pfizer | Células y procedimiento de cultivo celular |
| US20220073942A1 (en) | 2018-12-06 | 2022-03-10 | Pfizer Inc. | Cells with reduced inhibitor production and methods of use thereof |
| WO2025088516A1 (en) | 2023-10-26 | 2025-05-01 | Pfizer Inc. | Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657863A (en) * | 1982-07-02 | 1987-04-14 | Celanese Corporation | Stabilization of a mutant microorganism population |
| JPH066054B2 (ja) * | 1987-10-15 | 1994-01-26 | 帝人株式会社 | 動物細胞の培養方法 |
| ATE125157T1 (de) * | 1990-04-03 | 1995-08-15 | Genentech Inc | Methoden und zusammensetzungen zur impfung gegen hiv. |
| GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
| CA2111561A1 (en) | 1992-05-01 | 1993-11-11 | Yoshiharu Takazawa | Fed batch culture method for protein secreting cells |
| GB9506249D0 (en) * | 1995-03-27 | 1995-05-17 | Karobio Ab | Media for insect cell cultures |
| US6156570A (en) * | 1997-03-20 | 2000-12-05 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
| US6338964B1 (en) * | 1999-05-07 | 2002-01-15 | Bayer Corporation | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration |
-
2002
- 2002-11-27 DE DE10255508A patent/DE10255508A1/de not_active Withdrawn
-
2003
- 2003-11-07 WO PCT/DE2003/003693 patent/WO2004048556A1/de not_active Ceased
- 2003-11-07 JP JP2004554195A patent/JP4469283B2/ja not_active Expired - Lifetime
- 2003-11-07 HU HUE10152393A patent/HUE028862T2/en unknown
- 2003-11-07 SI SI200332473A patent/SI2226381T1/sl unknown
- 2003-11-07 SI SI200331791T patent/SI1585810T1/sl unknown
- 2003-11-07 DE DE50312554T patent/DE50312554D1/de not_active Expired - Lifetime
- 2003-11-07 AT AT03767406T patent/ATE462013T1/de active
- 2003-11-07 ES ES10176622T patent/ES2749217T3/es not_active Expired - Lifetime
- 2003-11-07 SI SI200332602T patent/SI2275530T1/sl unknown
- 2003-11-07 US US10/535,581 patent/US20060127975A1/en not_active Abandoned
- 2003-11-07 DK DK03767406.6T patent/DK1585810T3/da active
- 2003-11-07 EP EP03767406A patent/EP1585810B1/de not_active Expired - Lifetime
- 2003-11-07 ES ES10152393.4T patent/ES2567161T3/es not_active Expired - Lifetime
- 2003-11-07 PT PT03767406T patent/PT1585810E/pt unknown
- 2003-11-07 DK DK10152393.4T patent/DK2226381T3/en active
- 2003-11-07 EP EP10152393.4A patent/EP2226381B1/de not_active Expired - Lifetime
- 2003-11-07 ES ES03767406T patent/ES2340377T3/es not_active Expired - Lifetime
- 2003-11-07 EP EP10176622.8A patent/EP2275530B1/de not_active Expired - Lifetime
-
2010
- 2010-01-19 JP JP2010009094A patent/JP5221573B2/ja not_active Expired - Lifetime
- 2010-06-11 CY CY20101100518T patent/CY1110267T1/el unknown
-
2014
- 2014-01-21 US US14/160,336 patent/US20140329277A1/en not_active Abandoned
-
2016
- 2016-05-13 CY CY20161100413T patent/CY1117558T1/el unknown
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