ES2340377T3 - Procedimiento para el cultivo de celulas para la produccion de substancias. - Google Patents

Procedimiento para el cultivo de celulas para la produccion de substancias. Download PDF

Info

Publication number
ES2340377T3
ES2340377T3 ES03767406T ES03767406T ES2340377T3 ES 2340377 T3 ES2340377 T3 ES 2340377T3 ES 03767406 T ES03767406 T ES 03767406T ES 03767406 T ES03767406 T ES 03767406T ES 2340377 T3 ES2340377 T3 ES 2340377T3
Authority
ES
Spain
Prior art keywords
glucose
cells
limitation
qglc
dgl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03767406T
Other languages
English (en)
Spanish (es)
Inventor
Thomas Link
Ruth Essers
Kerstin SKOPNIK
Jochen Gatgens
Thomas Noll
Christian Wandrey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2340377T3 publication Critical patent/ES2340377T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES03767406T 2002-11-27 2003-11-07 Procedimiento para el cultivo de celulas para la produccion de substancias. Expired - Lifetime ES2340377T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10255508 2002-11-27
DE10255508A DE10255508A1 (de) 2002-11-27 2002-11-27 Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen

Publications (1)

Publication Number Publication Date
ES2340377T3 true ES2340377T3 (es) 2010-06-02

Family

ID=32318751

Family Applications (3)

Application Number Title Priority Date Filing Date
ES03767406T Expired - Lifetime ES2340377T3 (es) 2002-11-27 2003-11-07 Procedimiento para el cultivo de celulas para la produccion de substancias.
ES10152393.4T Expired - Lifetime ES2567161T3 (es) 2002-11-27 2003-11-07 Procedimiento para el cultivo de células para la producción de sustancias
ES10176622T Expired - Lifetime ES2749217T3 (es) 2002-11-27 2003-11-07 Procedimiento para cultivar células para la producción de sustancias

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES10152393.4T Expired - Lifetime ES2567161T3 (es) 2002-11-27 2003-11-07 Procedimiento para el cultivo de células para la producción de sustancias
ES10176622T Expired - Lifetime ES2749217T3 (es) 2002-11-27 2003-11-07 Procedimiento para cultivar células para la producción de sustancias

Country Status (12)

Country Link
US (2) US20060127975A1 (enExample)
EP (3) EP2275530B1 (enExample)
JP (2) JP4469283B2 (enExample)
AT (1) ATE462013T1 (enExample)
CY (2) CY1110267T1 (enExample)
DE (2) DE10255508A1 (enExample)
DK (2) DK1585810T3 (enExample)
ES (3) ES2340377T3 (enExample)
HU (1) HUE028862T2 (enExample)
PT (1) PT1585810E (enExample)
SI (3) SI2275530T1 (enExample)
WO (1) WO2004048556A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU736282B2 (en) 1997-03-21 2001-07-26 Chugai Seiyaku Kabushiki Kaisha A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
PT1623019E (pt) 2003-05-15 2010-07-20 Wyeth Llc ALIMENTAÆO COM GLUCOSE DE MODO LIMITADO PARA CULTURA DE CéLULAS ANIMAIS
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
DE102008002210A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
AU2015203309B2 (en) * 2009-10-26 2016-05-05 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
EP4406615A3 (en) * 2009-10-26 2024-12-11 F. Hoffmann-La Roche AG Method for the production of a glycosylated immunoglobulin
AU2016210748B2 (en) * 2009-10-26 2018-03-01 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
TWI537386B (zh) * 2009-12-22 2016-06-11 Ｄｓｍ智慧財產有限公司 由發酵法獲得的６－胺己酸製備己內醯胺
EP2638067A2 (en) 2010-11-08 2013-09-18 Genentech, Inc. Subcutaneously administered anti-il-6 receptor antibody
KR102248581B1 (ko) 2013-07-04 2021-05-06 에프. 호프만-라 로슈 아게 혈청 샘플 중 항-약물 항체를 검출하기 위한 간섭-억제된 면역분석
ES3005909T3 (en) 2014-03-19 2025-03-17 Pfizer Method of cell culture
EP4446338A3 (en) 2015-09-23 2025-05-07 Pfizer Inc. Cells and method of cell culture
CA3121884A1 (en) 2018-12-06 2020-06-11 Pfizer Inc. Cells with reduced inhibitor production and methods of use thereof
WO2025088516A1 (en) 2023-10-26 2025-05-01 Pfizer Inc. Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657863A (en) * 1982-07-02 1987-04-14 Celanese Corporation Stabilization of a mutant microorganism population
JPH066054B2 (ja) * 1987-10-15 1994-01-26 帝人株式会社 動物細胞の培養方法
EP0527760B1 (en) * 1990-04-03 1995-07-19 Genentech, Inc. Methods and compositions for vaccination against hiv
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
EP0592692B1 (en) * 1992-05-01 1997-07-02 Teijin Limited Fed batch process for protein secreting cells
GB9506249D0 (en) * 1995-03-27 1995-05-17 Karobio Ab Media for insect cell cultures
WO1998041611A1 (en) * 1997-03-20 1998-09-24 Regents Of The University Of Minnesota Process for the continuous culture of cells
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration

Also Published As

Publication number Publication date
EP2226381A1 (de) 2010-09-08
ES2567161T3 (es) 2016-04-20
EP2275530B1 (de) 2019-08-07
EP1585810A1 (de) 2005-10-19
DK2226381T3 (en) 2016-04-11
DE50312554D1 (de) 2010-05-06
CY1117558T1 (el) 2017-04-26
DE10255508A1 (de) 2004-06-17
EP1585810B1 (de) 2010-03-24
JP2006507821A (ja) 2006-03-09
US20060127975A1 (en) 2006-06-15
SI1585810T1 (sl) 2010-06-30
EP2275530A2 (de) 2011-01-19
JP5221573B2 (ja) 2013-06-26
ATE462013T1 (de) 2010-04-15
ES2749217T3 (es) 2020-03-19
JP2010110331A (ja) 2010-05-20
CY1110267T1 (el) 2015-01-14
JP4469283B2 (ja) 2010-05-26
US20140329277A1 (en) 2014-11-06
PT1585810E (pt) 2010-05-05
HUE028862T2 (en) 2017-01-30
SI2275530T1 (sl) 2019-11-29
WO2004048556A1 (de) 2004-06-10
EP2226381B1 (de) 2016-03-09
SI2226381T1 (sl) 2016-05-31
DK1585810T3 (da) 2010-06-07
EP2275530A3 (de) 2012-05-23

Similar Documents

Publication Publication Date Title
ES2340377T3 (es) Procedimiento para el cultivo de celulas para la produccion de substancias.
ES2248657T3 (es) Metodos mejorados para el cultivo de celulas de mamiferos "in vitro".
CA2795461C (en) Improved cell cultivation process
ES2485374T3 (es) Procedimientos de producción de proteínas usando compuestos anti senescencia
Chuppa et al. Fermentor temperature as a tool for control of high‐density perfusion cultures of mammalian cells
ES2642629T3 (es) Métodos para la producción mejorada de proteínas
TWI734775B (zh) 細胞培養基
AU2011246502A1 (en) Improved cell cultivation process
CN106520658A (zh) 包含小肽的细胞培养基
TW200831669A (en) Cell culture improvements
CN106029871A (zh) 通过优化培养基调节重组蛋白的半乳糖基化的方法
ES2191064T5 (es) Procedimiento para producir proteinas.
CN109576212B (zh) 高密度接种培养中种子细胞的培养方法及其应用
AU780122B2 (en) Production of peptides by fedbatch cultivation of a microorganism
KR101318498B1 (ko) 재조합 단백질의 생산성 향상을 위한 배양용 배지 첨가용 조성물
JPH01101882A (ja) 動物細胞の培養方法
US20250034521A1 (en) Mammalian cell culture process for recombinant protein production
Sheu et al. The biological effects of dissolved oxygen tension on a hybridoma cell line and its control as a means of improving MAb production in a protein‐free medium
KR20240172522A (ko) 지속형 호르몬 수용체 길항제의 생산 방법
HEINE et al. Ultrasonic Cell Separation–Production of Monoclonal
Ofiţeru et al. Two level control of the sequence fed batch–continuous hybridoma bioreactor