ES2340377T3 - Procedimiento para el cultivo de celulas para la produccion de substancias. - Google Patents

Procedimiento para el cultivo de celulas para la produccion de substancias. Download PDF

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Publication number
ES2340377T3
ES2340377T3 ES03767406T ES03767406T ES2340377T3 ES 2340377 T3 ES2340377 T3 ES 2340377T3 ES 03767406 T ES03767406 T ES 03767406T ES 03767406 T ES03767406 T ES 03767406T ES 2340377 T3 ES2340377 T3 ES 2340377T3
Authority
ES
Spain
Prior art keywords
glucose
cells
limitation
qglc
dgl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03767406T
Other languages
English (en)
Spanish (es)
Inventor
Thomas Link
Ruth Essers
Kerstin SKOPNIK
Jochen Gatgens
Thomas Noll
Christian Wandrey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2340377T3 publication Critical patent/ES2340377T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES03767406T 2002-11-27 2003-11-07 Procedimiento para el cultivo de celulas para la produccion de substancias. Expired - Lifetime ES2340377T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10255508 2002-11-27
DE10255508A DE10255508A1 (de) 2002-11-27 2002-11-27 Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen

Publications (1)

Publication Number Publication Date
ES2340377T3 true ES2340377T3 (es) 2010-06-02

Family

ID=32318751

Family Applications (3)

Application Number Title Priority Date Filing Date
ES03767406T Expired - Lifetime ES2340377T3 (es) 2002-11-27 2003-11-07 Procedimiento para el cultivo de celulas para la produccion de substancias.
ES10152393.4T Expired - Lifetime ES2567161T3 (es) 2002-11-27 2003-11-07 Procedimiento para el cultivo de células para la producción de sustancias
ES10176622T Expired - Lifetime ES2749217T3 (es) 2002-11-27 2003-11-07 Procedimiento para cultivar células para la producción de sustancias

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES10152393.4T Expired - Lifetime ES2567161T3 (es) 2002-11-27 2003-11-07 Procedimiento para el cultivo de células para la producción de sustancias
ES10176622T Expired - Lifetime ES2749217T3 (es) 2002-11-27 2003-11-07 Procedimiento para cultivar células para la producción de sustancias

Country Status (12)

Country Link
US (2) US20060127975A1 (enExample)
EP (3) EP2275530B1 (enExample)
JP (2) JP4469283B2 (enExample)
AT (1) ATE462013T1 (enExample)
CY (2) CY1110267T1 (enExample)
DE (2) DE10255508A1 (enExample)
DK (2) DK2226381T3 (enExample)
ES (3) ES2340377T3 (enExample)
HU (1) HUE028862T2 (enExample)
PT (1) PT1585810E (enExample)
SI (3) SI1585810T1 (enExample)
WO (1) WO2004048556A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2312184T3 (es) 1997-03-21 2009-02-16 Chugai Seiyaku Kabushiki Kaisha Agentes preventivos terapeuticos para el tratamiento de esclerosis multiple, que contienen anticuerpos anti-receptores de il-6 antagonistas.
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
GB2401040A (en) * 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
US7429491B2 (en) * 2003-05-15 2008-09-30 Wyeth Restricted glucose feed for animal cell culture
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
DE102008002210A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
CN104928336B (zh) * 2009-10-26 2020-05-08 弗·哈夫曼-拉罗切有限公司 用于生产糖基化免疫球蛋白的方法
AU2016210748B2 (en) * 2009-10-26 2018-03-01 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
AU2015203309B2 (en) * 2009-10-26 2016-05-05 Chugai Seiyaku Kabushiki Kaisha Method for the production of a glycosylated immunoglobulin
TWI537386B (zh) * 2009-12-22 2016-06-11 Ｄｓｍ智慧財產有限公司 由發酵法獲得的６－胺己酸製備己內醯胺
EP2787007A3 (en) 2010-11-08 2015-03-11 F. Hoffmann-La Roche AG Subcutaneously administered ANTI-IL-6 receptor antibody
BR112015032960B1 (pt) 2013-07-04 2021-01-05 F. Hoffmann-La Roche Ag imunoensaio suprimido por interferência para detectar anticorpos anti-fármaco em amostras de soro
EP4512889A3 (en) 2014-03-19 2025-05-07 Pfizer Inc. Method of cell culture
CA3214798A1 (en) 2015-09-23 2017-03-30 Pfizer Inc. Cells and method of cell culture
JP2022513702A (ja) 2018-12-06 2022-02-09 ファイザー・インク 阻害剤産生が低下した細胞およびその使用方法
WO2025088516A1 (en) 2023-10-26 2025-05-01 Pfizer Inc. Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657863A (en) * 1982-07-02 1987-04-14 Celanese Corporation Stabilization of a mutant microorganism population
JPH066054B2 (ja) * 1987-10-15 1994-01-26 帝人株式会社 動物細胞の培養方法
CA2078546A1 (en) * 1990-04-03 1991-10-04 Phillip W. Berman Methods and compositions for vaccination against hiv
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
WO1993022448A1 (en) * 1992-05-01 1993-11-11 Teijin Limited Fed batch culture method for protein secreting cells
GB9506249D0 (en) * 1995-03-27 1995-05-17 Karobio Ab Media for insect cell cultures
WO1998041611A1 (en) * 1997-03-20 1998-09-24 Regents Of The University Of Minnesota Process for the continuous culture of cells
US6338964B1 (en) * 1999-05-07 2002-01-15 Bayer Corporation Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration

Also Published As

Publication number Publication date
JP4469283B2 (ja) 2010-05-26
EP1585810A1 (de) 2005-10-19
EP2275530A2 (de) 2011-01-19
SI1585810T1 (sl) 2010-06-30
HUE028862T2 (en) 2017-01-30
EP1585810B1 (de) 2010-03-24
US20060127975A1 (en) 2006-06-15
EP2226381B1 (de) 2016-03-09
JP5221573B2 (ja) 2013-06-26
JP2010110331A (ja) 2010-05-20
WO2004048556A1 (de) 2004-06-10
CY1117558T1 (el) 2017-04-26
ATE462013T1 (de) 2010-04-15
EP2275530B1 (de) 2019-08-07
DK1585810T3 (da) 2010-06-07
SI2275530T1 (sl) 2019-11-29
EP2275530A3 (de) 2012-05-23
JP2006507821A (ja) 2006-03-09
DK2226381T3 (en) 2016-04-11
DE10255508A1 (de) 2004-06-17
ES2749217T3 (es) 2020-03-19
ES2567161T3 (es) 2016-04-20
SI2226381T1 (sl) 2016-05-31
CY1110267T1 (el) 2015-01-14
US20140329277A1 (en) 2014-11-06
DE50312554D1 (de) 2010-05-06
EP2226381A1 (de) 2010-09-08
PT1585810E (pt) 2010-05-05

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