ATE462013T1 - Verfahren zur kultivierung von zellen zur produktion von substanzen - Google Patents
Verfahren zur kultivierung von zellen zur produktion von substanzenInfo
- Publication number
- ATE462013T1 ATE462013T1 AT03767406T AT03767406T ATE462013T1 AT E462013 T1 ATE462013 T1 AT E462013T1 AT 03767406 T AT03767406 T AT 03767406T AT 03767406 T AT03767406 T AT 03767406T AT E462013 T1 ATE462013 T1 AT E462013T1
- Authority
- AT
- Austria
- Prior art keywords
- glucose
- limitation
- dgl
- cells
- qglc
- Prior art date
Links
- 239000000126 substance Substances 0.000 title abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 7
- 239000008103 glucose Substances 0.000 abstract 6
- 238000012258 culturing Methods 0.000 abstract 2
- 238000004321 preservation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10255508A DE10255508A1 (de) | 2002-11-27 | 2002-11-27 | Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen |
| PCT/DE2003/003693 WO2004048556A1 (de) | 2002-11-27 | 2003-11-07 | Verfahren zur kultivierung von zellen zur produktion von substanzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE462013T1 true ATE462013T1 (de) | 2010-04-15 |
Family
ID=32318751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03767406T ATE462013T1 (de) | 2002-11-27 | 2003-11-07 | Verfahren zur kultivierung von zellen zur produktion von substanzen |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20060127975A1 (enExample) |
| EP (3) | EP1585810B1 (enExample) |
| JP (2) | JP4469283B2 (enExample) |
| AT (1) | ATE462013T1 (enExample) |
| CY (2) | CY1110267T1 (enExample) |
| DE (2) | DE10255508A1 (enExample) |
| DK (2) | DK1585810T3 (enExample) |
| ES (3) | ES2749217T3 (enExample) |
| HU (1) | HUE028862T2 (enExample) |
| PT (1) | PT1585810E (enExample) |
| SI (3) | SI2226381T1 (enExample) |
| WO (1) | WO2004048556A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2284271C (en) | 1997-03-21 | 2012-05-08 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized t cell-mediated diseases comprising il-6 antagonist as an active ingredient |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| SI1623019T1 (sl) * | 2003-05-15 | 2010-10-29 | Wyeth Llc | Omejeno glukozno dovajanje za živalsko celično kulturo |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| DE102008002210A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von Erythropoietin |
| AU2016210748B2 (en) * | 2009-10-26 | 2018-03-01 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| ES2981683T3 (es) * | 2009-10-26 | 2024-10-10 | Hoffmann La Roche | Procedimiento para la producción de una inmunoglobulina glucosilada |
| AU2015203309B2 (en) * | 2009-10-26 | 2016-05-05 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| TWI563090B (en) * | 2009-12-22 | 2016-12-21 | Dsm Ip Assets Bv | The preparation of caprolactam from 6-amino caproic acid obtained in a fermentation process |
| KR20130086628A (ko) | 2010-11-08 | 2013-08-02 | 제넨테크, 인크. | 피하 투여용 항―ｉｌ―6 수용체 항체 |
| JP6563910B2 (ja) | 2013-07-04 | 2019-08-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ |
| EP3119876B1 (en) | 2014-03-19 | 2024-12-18 | Pfizer Inc. | Method of cell culture |
| ES2989780T3 (es) | 2015-09-23 | 2024-11-27 | Pfizer | Células y procedimiento de cultivo celular |
| US20220073942A1 (en) | 2018-12-06 | 2022-03-10 | Pfizer Inc. | Cells with reduced inhibitor production and methods of use thereof |
| WO2025088516A1 (en) | 2023-10-26 | 2025-05-01 | Pfizer Inc. | Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657863A (en) * | 1982-07-02 | 1987-04-14 | Celanese Corporation | Stabilization of a mutant microorganism population |
| JPH066054B2 (ja) * | 1987-10-15 | 1994-01-26 | 帝人株式会社 | 動物細胞の培養方法 |
| ATE125157T1 (de) * | 1990-04-03 | 1995-08-15 | Genentech Inc | Methoden und zusammensetzungen zur impfung gegen hiv. |
| GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
| CA2111561A1 (en) | 1992-05-01 | 1993-11-11 | Yoshiharu Takazawa | Fed batch culture method for protein secreting cells |
| GB9506249D0 (en) * | 1995-03-27 | 1995-05-17 | Karobio Ab | Media for insect cell cultures |
| US6156570A (en) * | 1997-03-20 | 2000-12-05 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
| US6338964B1 (en) * | 1999-05-07 | 2002-01-15 | Bayer Corporation | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration |
-
2002
- 2002-11-27 DE DE10255508A patent/DE10255508A1/de not_active Withdrawn
-
2003
- 2003-11-07 WO PCT/DE2003/003693 patent/WO2004048556A1/de not_active Ceased
- 2003-11-07 JP JP2004554195A patent/JP4469283B2/ja not_active Expired - Lifetime
- 2003-11-07 HU HUE10152393A patent/HUE028862T2/en unknown
- 2003-11-07 SI SI200332473A patent/SI2226381T1/sl unknown
- 2003-11-07 SI SI200331791T patent/SI1585810T1/sl unknown
- 2003-11-07 DE DE50312554T patent/DE50312554D1/de not_active Expired - Lifetime
- 2003-11-07 AT AT03767406T patent/ATE462013T1/de active
- 2003-11-07 ES ES10176622T patent/ES2749217T3/es not_active Expired - Lifetime
- 2003-11-07 SI SI200332602T patent/SI2275530T1/sl unknown
- 2003-11-07 US US10/535,581 patent/US20060127975A1/en not_active Abandoned
- 2003-11-07 DK DK03767406.6T patent/DK1585810T3/da active
- 2003-11-07 EP EP03767406A patent/EP1585810B1/de not_active Expired - Lifetime
- 2003-11-07 ES ES10152393.4T patent/ES2567161T3/es not_active Expired - Lifetime
- 2003-11-07 PT PT03767406T patent/PT1585810E/pt unknown
- 2003-11-07 DK DK10152393.4T patent/DK2226381T3/en active
- 2003-11-07 EP EP10152393.4A patent/EP2226381B1/de not_active Expired - Lifetime
- 2003-11-07 ES ES03767406T patent/ES2340377T3/es not_active Expired - Lifetime
- 2003-11-07 EP EP10176622.8A patent/EP2275530B1/de not_active Expired - Lifetime
-
2010
- 2010-01-19 JP JP2010009094A patent/JP5221573B2/ja not_active Expired - Lifetime
- 2010-06-11 CY CY20101100518T patent/CY1110267T1/el unknown
-
2014
- 2014-01-21 US US14/160,336 patent/US20140329277A1/en not_active Abandoned
-
2016
- 2016-05-13 CY CY20161100413T patent/CY1117558T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20140329277A1 (en) | 2014-11-06 |
| SI2226381T1 (sl) | 2016-05-31 |
| SI2275530T1 (sl) | 2019-11-29 |
| ES2340377T3 (es) | 2010-06-02 |
| ES2567161T3 (es) | 2016-04-20 |
| EP2275530A2 (de) | 2011-01-19 |
| CY1117558T1 (el) | 2017-04-26 |
| DE10255508A1 (de) | 2004-06-17 |
| EP2226381B1 (de) | 2016-03-09 |
| WO2004048556A1 (de) | 2004-06-10 |
| EP1585810B1 (de) | 2010-03-24 |
| EP2275530A3 (de) | 2012-05-23 |
| JP2010110331A (ja) | 2010-05-20 |
| CY1110267T1 (el) | 2015-01-14 |
| SI1585810T1 (sl) | 2010-06-30 |
| PT1585810E (pt) | 2010-05-05 |
| EP2275530B1 (de) | 2019-08-07 |
| EP1585810A1 (de) | 2005-10-19 |
| DK2226381T3 (en) | 2016-04-11 |
| JP2006507821A (ja) | 2006-03-09 |
| ES2749217T3 (es) | 2020-03-19 |
| HUE028862T2 (en) | 2017-01-30 |
| DK1585810T3 (da) | 2010-06-07 |
| JP5221573B2 (ja) | 2013-06-26 |
| DE50312554D1 (de) | 2010-05-06 |
| US20060127975A1 (en) | 2006-06-15 |
| EP2226381A1 (de) | 2010-09-08 |
| JP4469283B2 (ja) | 2010-05-26 |
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