HUE028862T2 - A method for culturing cells for the preparation of compounds - Google Patents
A method for culturing cells for the preparation of compounds Download PDFInfo
- Publication number
- HUE028862T2 HUE028862T2 HUE10152393A HUE10152393A HUE028862T2 HU E028862 T2 HUE028862 T2 HU E028862T2 HU E10152393 A HUE10152393 A HU E10152393A HU E10152393 A HUE10152393 A HU E10152393A HU E028862 T2 HUE028862 T2 HU E028862T2
- Authority
- HU
- Hungary
- Prior art keywords
- glucose
- dgl
- cells
- cell
- specific
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 59
- 238000004519 manufacturing process Methods 0.000 title claims description 19
- 150000001875 compounds Chemical class 0.000 title description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 83
- 239000008103 glucose Substances 0.000 claims abstract description 82
- 239000000126 substance Substances 0.000 claims abstract description 8
- 210000004027 cell Anatomy 0.000 claims description 63
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 229940072221 immunoglobulins Drugs 0.000 claims description 6
- 238000012423 maintenance Methods 0.000 claims description 4
- 230000004060 metabolic process Effects 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 claims description 4
- 230000007967 glucose restriction Effects 0.000 claims 4
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 229920001817 Agar Polymers 0.000 claims 1
- 235000016623 Fragaria vesca Nutrition 0.000 claims 1
- 240000009088 Fragaria x ananassa Species 0.000 claims 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims 1
- 240000002129 Malva sylvestris Species 0.000 claims 1
- 235000006770 Malva sylvestris Nutrition 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 238000010923 batch production Methods 0.000 claims 1
- 235000013351 cheese Nutrition 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000002431 foraging effect Effects 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 239000002893 slag Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 abstract description 3
- 238000004321 preservation Methods 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 description 12
- 230000007423 decrease Effects 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 9
- 239000002609 medium Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 101001133081 Homo sapiens Mucin-2 Proteins 0.000 description 2
- 102100034263 Mucin-2 Human genes 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 230000004190 glucose uptake Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 101100290380 Caenorhabditis elegans cel-1 gene Proteins 0.000 description 1
- 241000288673 Chiroptera Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 101100452750 Ipomoea batatas IPO gene Proteins 0.000 description 1
- 101100502819 Mus musculus Fimp gene Proteins 0.000 description 1
- 206010034016 Paronychia Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 241000985694 Polypodiopsida Species 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 101150001671 Tfec gene Proteins 0.000 description 1
- SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 description 1
- 235000003560 Valerianella locusta Nutrition 0.000 description 1
- 240000004668 Valerianella locusta Species 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10255508A DE10255508A1 (de) | 2002-11-27 | 2002-11-27 | Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE028862T2 true HUE028862T2 (en) | 2017-01-30 |
Family
ID=32318751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE10152393A HUE028862T2 (en) | 2002-11-27 | 2003-11-07 | A method for culturing cells for the preparation of compounds |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20060127975A1 (enExample) |
| EP (3) | EP1585810B1 (enExample) |
| JP (2) | JP4469283B2 (enExample) |
| AT (1) | ATE462013T1 (enExample) |
| CY (2) | CY1110267T1 (enExample) |
| DE (2) | DE10255508A1 (enExample) |
| DK (2) | DK1585810T3 (enExample) |
| ES (3) | ES2749217T3 (enExample) |
| HU (1) | HUE028862T2 (enExample) |
| PT (1) | PT1585810E (enExample) |
| SI (3) | SI2226381T1 (enExample) |
| WO (1) | WO2004048556A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2284271C (en) | 1997-03-21 | 2012-05-08 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized t cell-mediated diseases comprising il-6 antagonist as an active ingredient |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| SI1623019T1 (sl) * | 2003-05-15 | 2010-10-29 | Wyeth Llc | Omejeno glukozno dovajanje za živalsko celično kulturo |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| DE102008002210A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von Erythropoietin |
| AU2016210748B2 (en) * | 2009-10-26 | 2018-03-01 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| ES2981683T3 (es) * | 2009-10-26 | 2024-10-10 | Hoffmann La Roche | Procedimiento para la producción de una inmunoglobulina glucosilada |
| AU2015203309B2 (en) * | 2009-10-26 | 2016-05-05 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
| TWI563090B (en) * | 2009-12-22 | 2016-12-21 | Dsm Ip Assets Bv | The preparation of caprolactam from 6-amino caproic acid obtained in a fermentation process |
| KR20130086628A (ko) | 2010-11-08 | 2013-08-02 | 제넨테크, 인크. | 피하 투여용 항―ｉｌ―6 수용체 항체 |
| JP6563910B2 (ja) | 2013-07-04 | 2019-08-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ |
| EP3119876B1 (en) | 2014-03-19 | 2024-12-18 | Pfizer Inc. | Method of cell culture |
| ES2989780T3 (es) | 2015-09-23 | 2024-11-27 | Pfizer | Células y procedimiento de cultivo celular |
| US20220073942A1 (en) | 2018-12-06 | 2022-03-10 | Pfizer Inc. | Cells with reduced inhibitor production and methods of use thereof |
| WO2025088516A1 (en) | 2023-10-26 | 2025-05-01 | Pfizer Inc. | Method of forming multi-specific antibodies from homodimer antibodies and pharmaceutical product including multi-specific antibodies thus obtained |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657863A (en) * | 1982-07-02 | 1987-04-14 | Celanese Corporation | Stabilization of a mutant microorganism population |
| JPH066054B2 (ja) * | 1987-10-15 | 1994-01-26 | 帝人株式会社 | 動物細胞の培養方法 |
| ATE125157T1 (de) * | 1990-04-03 | 1995-08-15 | Genentech Inc | Methoden und zusammensetzungen zur impfung gegen hiv. |
| GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
| US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
| CA2111561A1 (en) | 1992-05-01 | 1993-11-11 | Yoshiharu Takazawa | Fed batch culture method for protein secreting cells |
| GB9506249D0 (en) * | 1995-03-27 | 1995-05-17 | Karobio Ab | Media for insect cell cultures |
| US6156570A (en) * | 1997-03-20 | 2000-12-05 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
| US6338964B1 (en) * | 1999-05-07 | 2002-01-15 | Bayer Corporation | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration |
-
2002
- 2002-11-27 DE DE10255508A patent/DE10255508A1/de not_active Withdrawn
-
2003
- 2003-11-07 WO PCT/DE2003/003693 patent/WO2004048556A1/de not_active Ceased
- 2003-11-07 JP JP2004554195A patent/JP4469283B2/ja not_active Expired - Lifetime
- 2003-11-07 HU HUE10152393A patent/HUE028862T2/en unknown
- 2003-11-07 SI SI200332473A patent/SI2226381T1/sl unknown
- 2003-11-07 SI SI200331791T patent/SI1585810T1/sl unknown
- 2003-11-07 DE DE50312554T patent/DE50312554D1/de not_active Expired - Lifetime
- 2003-11-07 AT AT03767406T patent/ATE462013T1/de active
- 2003-11-07 ES ES10176622T patent/ES2749217T3/es not_active Expired - Lifetime
- 2003-11-07 SI SI200332602T patent/SI2275530T1/sl unknown
- 2003-11-07 US US10/535,581 patent/US20060127975A1/en not_active Abandoned
- 2003-11-07 DK DK03767406.6T patent/DK1585810T3/da active
- 2003-11-07 EP EP03767406A patent/EP1585810B1/de not_active Expired - Lifetime
- 2003-11-07 ES ES10152393.4T patent/ES2567161T3/es not_active Expired - Lifetime
- 2003-11-07 PT PT03767406T patent/PT1585810E/pt unknown
- 2003-11-07 DK DK10152393.4T patent/DK2226381T3/en active
- 2003-11-07 EP EP10152393.4A patent/EP2226381B1/de not_active Expired - Lifetime
- 2003-11-07 ES ES03767406T patent/ES2340377T3/es not_active Expired - Lifetime
- 2003-11-07 EP EP10176622.8A patent/EP2275530B1/de not_active Expired - Lifetime
-
2010
- 2010-01-19 JP JP2010009094A patent/JP5221573B2/ja not_active Expired - Lifetime
- 2010-06-11 CY CY20101100518T patent/CY1110267T1/el unknown
-
2014
- 2014-01-21 US US14/160,336 patent/US20140329277A1/en not_active Abandoned
-
2016
- 2016-05-13 CY CY20161100413T patent/CY1117558T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20140329277A1 (en) | 2014-11-06 |
| SI2226381T1 (sl) | 2016-05-31 |
| SI2275530T1 (sl) | 2019-11-29 |
| ES2340377T3 (es) | 2010-06-02 |
| ES2567161T3 (es) | 2016-04-20 |
| EP2275530A2 (de) | 2011-01-19 |
| CY1117558T1 (el) | 2017-04-26 |
| DE10255508A1 (de) | 2004-06-17 |
| EP2226381B1 (de) | 2016-03-09 |
| WO2004048556A1 (de) | 2004-06-10 |
| EP1585810B1 (de) | 2010-03-24 |
| EP2275530A3 (de) | 2012-05-23 |
| JP2010110331A (ja) | 2010-05-20 |
| CY1110267T1 (el) | 2015-01-14 |
| SI1585810T1 (sl) | 2010-06-30 |
| PT1585810E (pt) | 2010-05-05 |
| EP2275530B1 (de) | 2019-08-07 |
| EP1585810A1 (de) | 2005-10-19 |
| DK2226381T3 (en) | 2016-04-11 |
| JP2006507821A (ja) | 2006-03-09 |
| ES2749217T3 (es) | 2020-03-19 |
| DK1585810T3 (da) | 2010-06-07 |
| JP5221573B2 (ja) | 2013-06-26 |
| DE50312554D1 (de) | 2010-05-06 |
| US20060127975A1 (en) | 2006-06-15 |
| ATE462013T1 (de) | 2010-04-15 |
| EP2226381A1 (de) | 2010-09-08 |
| JP4469283B2 (ja) | 2010-05-26 |
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