JP2018516079A5 - - Google Patents
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- Publication number
- JP2018516079A5 JP2018516079A5 JP2017561773A JP2017561773A JP2018516079A5 JP 2018516079 A5 JP2018516079 A5 JP 2018516079A5 JP 2017561773 A JP2017561773 A JP 2017561773A JP 2017561773 A JP2017561773 A JP 2017561773A JP 2018516079 A5 JP2018516079 A5 JP 2018516079A5
- Authority
- JP
- Japan
- Prior art keywords
- perfusion
- predetermined value
- medium
- permeate
- bioreactor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 22
- 230000010412 perfusion Effects 0.000 claims 20
- 239000002609 medium Substances 0.000 claims 10
- 239000012466 permeate Substances 0.000 claims 10
- 239000012737 fresh medium Substances 0.000 claims 9
- 238000004113 cell culture Methods 0.000 claims 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- 229940116871 l-lactate Drugs 0.000 claims 6
- 238000012544 monitoring process Methods 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000000415 inactivating effect Effects 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 238000010923 batch production Methods 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- PHZLMBHDXVLRIX-DKWTVANSSA-M potassium;(2s)-2-hydroxypropanoate Chemical compound [K+].C[C@H](O)C([O-])=O PHZLMBHDXVLRIX-DKWTVANSSA-M 0.000 claims 1
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 1
- NGSFWBMYFKHRBD-DKWTVANSSA-M sodium;(2s)-2-hydroxypropanoate Chemical group [Na+].C[C@H](O)C([O-])=O NGSFWBMYFKHRBD-DKWTVANSSA-M 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022001006A JP7579289B2 (ja) | 2015-05-29 | 2022-01-06 | 連続培養における細胞コントロール灌流 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562168297P | 2015-05-29 | 2015-05-29 | |
| US62/168,297 | 2015-05-29 | ||
| US201562199388P | 2015-07-31 | 2015-07-31 | |
| US62/199,388 | 2015-07-31 | ||
| US201562246774P | 2015-10-27 | 2015-10-27 | |
| US62/246,774 | 2015-10-27 | ||
| PCT/US2016/034570 WO2016196261A1 (en) | 2015-05-29 | 2016-05-27 | Cell-controlled perfusion in continuous culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001006A Division JP7579289B2 (ja) | 2015-05-29 | 2022-01-06 | 連続培養における細胞コントロール灌流 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516079A JP2018516079A (ja) | 2018-06-21 |
| JP2018516079A5 true JP2018516079A5 (enExample) | 2019-06-27 |
| JP7340324B2 JP7340324B2 (ja) | 2023-09-07 |
Family
ID=56133061
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017561773A Active JP7340324B2 (ja) | 2015-05-29 | 2016-05-27 | 連続培養における細胞コントロール灌流 |
| JP2022001006A Active JP7579289B2 (ja) | 2015-05-29 | 2022-01-06 | 連続培養における細胞コントロール灌流 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022001006A Active JP7579289B2 (ja) | 2015-05-29 | 2022-01-06 | 連続培養における細胞コントロール灌流 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11597903B2 (enExample) |
| EP (2) | EP4148121A3 (enExample) |
| JP (2) | JP7340324B2 (enExample) |
| KR (2) | KR20240055117A (enExample) |
| CN (1) | CN107922919A (enExample) |
| AU (2) | AU2016271607C1 (enExample) |
| CA (1) | CA2985702A1 (enExample) |
| WO (1) | WO2016196261A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| KR20240173213A (ko) | 2016-01-26 | 2024-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 연결된 관류 대 연속-유동식 교반-탱크 반응기 세포 배양 시스템 |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| CN110494543A (zh) | 2016-10-19 | 2019-11-22 | 弗洛设计声能学公司 | 通过声学的亲和细胞提取 |
| EP3692358A1 (en) | 2017-10-06 | 2020-08-12 | Lonza Ltd | Automated control of cell culture using raman spectroscopy |
| SG11202002339XA (en) * | 2017-10-16 | 2020-04-29 | Regeneron Pharma | Perfusion bioreactor and related methods of use |
| SG11202003907WA (en) | 2017-12-14 | 2020-05-28 | Flodesign Sonics Inc | Acoustic transducer drive and controller |
| IL258738B (en) * | 2018-04-16 | 2020-04-30 | Pluristem Ltd | Methods and compositions for formulating and dispensing pharmaceutical formulations |
| JP7231355B2 (ja) | 2018-08-22 | 2023-03-01 | 日機装株式会社 | 細胞培養方法および細胞培養装置 |
| WO2020086408A1 (en) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A high-yield perfusion-based transient gene expression bioprocess |
| CN110117527A (zh) * | 2019-05-15 | 2019-08-13 | 刘宝全 | 一种干细胞代谢废物的强化排出方法 |
| US11774287B2 (en) | 2019-05-28 | 2023-10-03 | WuXi Biologics Ireland Limited | Raman spectroscopy integrated perfusion cell culture system for monitoring and auto-controlling perfusion cell culture |
| AU2020290573B2 (en) * | 2019-06-13 | 2026-01-29 | Amgen Inc. | Automated biomass-based perfusion control in the manufacturing of biologics |
| CN114901794B (zh) | 2019-11-15 | 2026-05-01 | 隆萨有限公司 | 用于生产接种物的过程和系统 |
| WO2022118987A1 (ja) * | 2020-12-04 | 2022-06-09 | 国立大学法人東海国立大学機構 | 滅菌が不要な微生物の連続製造法およびそのためのシステム |
| EP4026892A1 (en) * | 2021-01-12 | 2022-07-13 | Sartorius Stedim Biotech GmbH | Device assembly and method for controlling an integrated continuous pharmaceutical or biopharmaceutical manufacturing process |
| JPWO2023190829A1 (enExample) * | 2022-03-31 | 2023-10-05 | ||
| WO2025124527A1 (zh) * | 2023-12-15 | 2025-06-19 | 南京蓬勃生物科技有限公司 | 细胞稳态灌流培养的方法和系统 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| EP0567738A3 (en) * | 1992-05-01 | 1995-09-06 | American Cyanamid Co | Controlling perfusion rates in continuous bioreactor culture of animal cells |
| US20030054544A1 (en) * | 2001-09-14 | 2003-03-20 | Medcell Biologics, Inc. | Oxygen enriched bioreactor and method of culturing cells |
| US7429491B2 (en) | 2003-05-15 | 2008-09-30 | Wyeth | Restricted glucose feed for animal cell culture |
| JP2006527642A (ja) * | 2003-06-17 | 2006-12-07 | セントカー・インコーポレーテツド | バイオリアクターの組換えタンパク質の濾過のための方法及び装置 |
| TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| CN1778903A (zh) * | 2005-09-29 | 2006-05-31 | 华东理工大学 | 一种动物细胞高密度连续灌注培养方法 |
| EP2188371B1 (en) * | 2007-08-09 | 2017-12-20 | Wyeth LLC | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| US8539209B2 (en) | 2009-08-24 | 2013-09-17 | Via Technologies, Inc. | Microprocessor that performs a two-pass breakpoint check for a cache line-crossing load/store operation |
| US8470552B2 (en) * | 2009-10-12 | 2013-06-25 | Keck Graduate Institute | Strategy to reduce lactic acid production and control PH in animal cell culture |
| CN102296029B (zh) * | 2010-06-28 | 2013-01-30 | 裴国献 | 灌注式生物反应器系统 |
| CN103881984A (zh) * | 2013-12-06 | 2014-06-25 | 深圳市赛百诺基因技术有限公司 | 无血清悬浮细胞生产重组腺病毒的方法及其药品制剂生产方法 |
-
2016
- 2016-05-27 KR KR1020247012127A patent/KR20240055117A/ko active Pending
- 2016-05-27 US US15/577,415 patent/US11597903B2/en active Active
- 2016-05-27 AU AU2016271607A patent/AU2016271607C1/en active Active
- 2016-05-27 CN CN201680040537.8A patent/CN107922919A/zh active Pending
- 2016-05-27 CA CA2985702A patent/CA2985702A1/en active Pending
- 2016-05-27 EP EP22173014.6A patent/EP4148121A3/en active Pending
- 2016-05-27 EP EP16729692.0A patent/EP3303558B1/en active Active
- 2016-05-27 JP JP2017561773A patent/JP7340324B2/ja active Active
- 2016-05-27 KR KR1020177034457A patent/KR102658955B1/ko active Active
- 2016-05-27 WO PCT/US2016/034570 patent/WO2016196261A1/en not_active Ceased
-
2022
- 2022-01-06 JP JP2022001006A patent/JP7579289B2/ja active Active
- 2022-10-27 AU AU2022259788A patent/AU2022259788A1/en not_active Abandoned
-
2023
- 2023-01-30 US US18/161,246 patent/US12173267B2/en active Active
-
2024
- 2024-11-07 US US18/940,041 patent/US20250059486A1/en active Pending
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