JP2006500052A5 - - Google Patents
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- Publication number
- JP2006500052A5 JP2006500052A5 JP2004538969A JP2004538969A JP2006500052A5 JP 2006500052 A5 JP2006500052 A5 JP 2006500052A5 JP 2004538969 A JP2004538969 A JP 2004538969A JP 2004538969 A JP2004538969 A JP 2004538969A JP 2006500052 A5 JP2006500052 A5 JP 2006500052A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- acid molecule
- microorganism
- aldehyde dehydrogenase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000005700 microbiome Species 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 7
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 7
- 239000001963 growth medium Substances 0.000 claims 6
- VBUYCZFBVCCYFD-NUNKFHFFSA-N 2-dehydro-L-idonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-NUNKFHFFSA-N 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- VBUYCZFBVCCYFD-UHFFFAOYSA-N D-arabino-2-Hexulosonic acid Natural products OCC(O)C(O)C(O)C(=O)C(O)=O VBUYCZFBVCCYFD-UHFFFAOYSA-N 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 2
- 241000589232 Gluconobacter oxydans Species 0.000 claims 2
- DCNMIDLYWOTSGK-KVQBGUIXSA-N L-xylo-hexos-2-ulose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C=O DCNMIDLYWOTSGK-KVQBGUIXSA-N 0.000 claims 2
- 229930003268 Vitamin C Natural products 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 235000019154 vitamin C Nutrition 0.000 claims 2
- 239000011718 vitamin C Substances 0.000 claims 2
- 241000589220 Acetobacter Species 0.000 claims 1
- 241000589291 Acinetobacter Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000589236 Gluconobacter Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000013611 chromosomal DNA Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02021650 | 2002-09-27 | ||
| PCT/EP2003/010498 WO2004029235A2 (en) | 2002-09-27 | 2003-09-22 | Aldehyde dehydrogenase gene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500052A JP2006500052A (ja) | 2006-01-05 |
| JP2006500052A5 true JP2006500052A5 (enExample) | 2006-11-16 |
| JP4528624B2 JP4528624B2 (ja) | 2010-08-18 |
Family
ID=32039112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004538969A Expired - Fee Related JP4528624B2 (ja) | 2002-09-27 | 2003-09-22 | アルデヒドデヒドロゲナーゼ遺伝子 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7135315B2 (enExample) |
| EP (1) | EP1543114B1 (enExample) |
| JP (1) | JP4528624B2 (enExample) |
| KR (1) | KR101070110B1 (enExample) |
| CN (2) | CN100558886C (enExample) |
| AT (1) | ATE404664T1 (enExample) |
| AU (1) | AU2003299104A1 (enExample) |
| DE (1) | DE60322921D1 (enExample) |
| WO (1) | WO2004029235A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA009287B1 (ru) * | 2003-08-14 | 2007-12-28 | ДСМ Ай Пи ЭССЕТС Б.В. | Получение l-аскорбиновой кислоты в результате микробиологического процесса |
| WO2006084647A1 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Gene vcs 01 |
| WO2006084720A2 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Hpr kinase from gluconobacter oxydan |
| US9279138B2 (en) * | 2005-02-11 | 2016-03-08 | Dsm Assets B.V. | Vitamin C production in a microorganism, gluconobacter |
| WO2006084725A1 (en) * | 2005-02-11 | 2006-08-17 | Dsm Ip Assets B.V. | Novel gene sts 16 |
| WO2007028602A1 (en) * | 2005-09-08 | 2007-03-15 | Dsm Ip Assets B.V. | Novel gene sms 37 |
| EP1931785A2 (en) * | 2005-09-09 | 2008-06-18 | DSMIP Assets B.V. | Novel gene gms 01 |
| TWI568847B (zh) | 2007-03-16 | 2017-02-01 | 奇諾麥提卡公司 | 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法 |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| EP3514242A3 (en) | 2008-09-10 | 2019-08-28 | Genomatica, Inc. | Microrganisms for the production of 1,4-butanediol |
| EP3696158A1 (en) | 2009-06-04 | 2020-08-19 | Genomatica, Inc. | Process of separating components of a fermentation broth |
| CN107384846B (zh) | 2009-06-04 | 2021-08-10 | 基因组股份公司 | 生产1,4-丁二醇的微生物和相关方法 |
| CN101649323B (zh) * | 2009-06-16 | 2011-06-22 | 武汉工程大学 | 按毕赤酵母偏爱密码子设计人乙醛脱氢酶2序列的方法 |
| PH12012500729A1 (en) | 2009-10-13 | 2012-10-29 | Genomatica Inc | Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds and methods related thereto |
| WO2011066076A1 (en) | 2009-11-25 | 2011-06-03 | Genomatica, Inc. | Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone |
| US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
| CN102492762A (zh) * | 2011-12-09 | 2012-06-13 | 天津大学 | 含有编码山梨酮脱氢酶基因载体的氧化葡糖杆菌的用途 |
| US9677045B2 (en) | 2012-06-04 | 2017-06-13 | Genomatica, Inc. | Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds |
| CN113179645A (zh) * | 2018-09-26 | 2021-07-27 | 基因组股份公司 | 醛脱氢酶变体及其使用方法 |
| CN111321153B (zh) * | 2020-04-26 | 2021-08-17 | 广西大学 | 一种来源于玉米的黑暗响应gd2基因及其应用 |
| KR102460589B1 (ko) | 2021-02-17 | 2022-10-28 | 주식회사 피코엔텍 | 글루타치온과 알데히드탈수소효소를 함유하는 숙취해소제 |
| CN115948430B (zh) * | 2022-05-26 | 2024-06-14 | 南京农业大学 | 梨醛脱氢酶PusALDH1及其编码基因和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989006688A2 (en) | 1988-01-14 | 1989-07-27 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Novel enzyme |
| US5437989A (en) * | 1992-12-30 | 1995-08-01 | Hoffmann-La Roche Inc. | Alcohol/aldehyde dehydrogenase from Gluconobacter oxydans DSM 4025 FERM BP-3812 |
| US5776742A (en) * | 1996-02-19 | 1998-07-07 | Roche Vitamins Inc. | Aldehyde dehydrogenase enzyme |
| EP0922759B1 (en) * | 1997-12-01 | 2004-01-28 | F. Hoffmann-La Roche Ag | Aldehyde dehydrogenase |
| US6825018B1 (en) * | 1999-03-17 | 2004-11-30 | Fujisawa Pharmaceutical Co. Ltd. | Sorbitol dehydrogenase, gene encoding the same and use thereof |
| JP2002125689A (ja) | 2000-10-25 | 2002-05-08 | Koji Hayade | 融合蛋白質 |
| KR100519902B1 (ko) * | 2000-10-27 | 2005-10-10 | 에프. 호프만-라 로슈 아게 | 가용성 피롤로퀴놀린 퀴논 의존성 글루코오스 디히드로게나아제의 변이체 |
-
2003
- 2003-09-22 DE DE60322921T patent/DE60322921D1/de not_active Expired - Lifetime
- 2003-09-22 EP EP03798171A patent/EP1543114B1/en not_active Expired - Lifetime
- 2003-09-22 US US10/528,675 patent/US7135315B2/en not_active Expired - Lifetime
- 2003-09-22 AU AU2003299104A patent/AU2003299104A1/en not_active Abandoned
- 2003-09-22 AT AT03798171T patent/ATE404664T1/de not_active IP Right Cessation
- 2003-09-22 WO PCT/EP2003/010498 patent/WO2004029235A2/en not_active Ceased
- 2003-09-22 CN CNB038231956A patent/CN100558886C/zh not_active Expired - Fee Related
- 2003-09-22 JP JP2004538969A patent/JP4528624B2/ja not_active Expired - Fee Related
- 2003-09-22 CN CN2009101755968A patent/CN101693896B/zh not_active Expired - Fee Related
- 2003-09-22 KR KR1020057005353A patent/KR101070110B1/ko not_active Expired - Fee Related
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