DE60322921D1 - Aldehyddehyrdrogenase-gen - Google Patents

Aldehyddehyrdrogenase-gen

Info

Publication number
DE60322921D1
DE60322921D1 DE60322921T DE60322921T DE60322921D1 DE 60322921 D1 DE60322921 D1 DE 60322921D1 DE 60322921 T DE60322921 T DE 60322921T DE 60322921 T DE60322921 T DE 60322921T DE 60322921 D1 DE60322921 D1 DE 60322921D1
Authority
DE
Germany
Prior art keywords
aldehyde dehydrogenase
recombinant
dna
expression vector
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60322921T
Other languages
German (de)
English (en)
Inventor
Tatsuo Hoshino
Taro Miyazaki
Teruhide Sugisawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of DE60322921D1 publication Critical patent/DE60322921D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60322921T 2002-09-27 2003-09-22 Aldehyddehyrdrogenase-gen Expired - Lifetime DE60322921D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02021650 2002-09-27
PCT/EP2003/010498 WO2004029235A2 (en) 2002-09-27 2003-09-22 Aldehyde dehydrogenase gene

Publications (1)

Publication Number Publication Date
DE60322921D1 true DE60322921D1 (de) 2008-09-25

Family

ID=32039112

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60322921T Expired - Lifetime DE60322921D1 (de) 2002-09-27 2003-09-22 Aldehyddehyrdrogenase-gen

Country Status (9)

Country Link
US (1) US7135315B2 (enExample)
EP (1) EP1543114B1 (enExample)
JP (1) JP4528624B2 (enExample)
KR (1) KR101070110B1 (enExample)
CN (2) CN100558886C (enExample)
AT (1) ATE404664T1 (enExample)
AU (1) AU2003299104A1 (enExample)
DE (1) DE60322921D1 (enExample)
WO (1) WO2004029235A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA009287B1 (ru) * 2003-08-14 2007-12-28 ДСМ Ай Пи ЭССЕТС Б.В. Получение l-аскорбиновой кислоты в результате микробиологического процесса
WO2006084647A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Gene vcs 01
WO2006084720A2 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Hpr kinase from gluconobacter oxydan
US9279138B2 (en) * 2005-02-11 2016-03-08 Dsm Assets B.V. Vitamin C production in a microorganism, gluconobacter
WO2006084725A1 (en) * 2005-02-11 2006-08-17 Dsm Ip Assets B.V. Novel gene sts 16
WO2007028602A1 (en) * 2005-09-08 2007-03-15 Dsm Ip Assets B.V. Novel gene sms 37
EP1931785A2 (en) * 2005-09-09 2008-06-18 DSMIP Assets B.V. Novel gene gms 01
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
EP3514242A3 (en) 2008-09-10 2019-08-28 Genomatica, Inc. Microrganisms for the production of 1,4-butanediol
EP3696158A1 (en) 2009-06-04 2020-08-19 Genomatica, Inc. Process of separating components of a fermentation broth
CN107384846B (zh) 2009-06-04 2021-08-10 基因组股份公司 生产1,4-丁二醇的微生物和相关方法
CN101649323B (zh) * 2009-06-16 2011-06-22 武汉工程大学 按毕赤酵母偏爱密码子设计人乙醛脱氢酶2序列的方法
PH12012500729A1 (en) 2009-10-13 2012-10-29 Genomatica Inc Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds and methods related thereto
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
CN102492762A (zh) * 2011-12-09 2012-06-13 天津大学 含有编码山梨酮脱氢酶基因载体的氧化葡糖杆菌的用途
US9677045B2 (en) 2012-06-04 2017-06-13 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
CN113179645A (zh) * 2018-09-26 2021-07-27 基因组股份公司 醛脱氢酶变体及其使用方法
CN111321153B (zh) * 2020-04-26 2021-08-17 广西大学 一种来源于玉米的黑暗响应gd2基因及其应用
KR102460589B1 (ko) 2021-02-17 2022-10-28 주식회사 피코엔텍 글루타치온과 알데히드탈수소효소를 함유하는 숙취해소제
CN115948430B (zh) * 2022-05-26 2024-06-14 南京农业大学 梨醛脱氢酶PusALDH1及其编码基因和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006688A2 (en) 1988-01-14 1989-07-27 F. Hoffmann-La Roche & Co. Aktiengesellschaft Novel enzyme
US5437989A (en) * 1992-12-30 1995-08-01 Hoffmann-La Roche Inc. Alcohol/aldehyde dehydrogenase from Gluconobacter oxydans DSM 4025 FERM BP-3812
US5776742A (en) * 1996-02-19 1998-07-07 Roche Vitamins Inc. Aldehyde dehydrogenase enzyme
EP0922759B1 (en) * 1997-12-01 2004-01-28 F. Hoffmann-La Roche Ag Aldehyde dehydrogenase
US6825018B1 (en) * 1999-03-17 2004-11-30 Fujisawa Pharmaceutical Co. Ltd. Sorbitol dehydrogenase, gene encoding the same and use thereof
JP2002125689A (ja) 2000-10-25 2002-05-08 Koji Hayade 融合蛋白質
KR100519902B1 (ko) * 2000-10-27 2005-10-10 에프. 호프만-라 로슈 아게 가용성 피롤로퀴놀린 퀴논 의존성 글루코오스 디히드로게나아제의 변이체

Also Published As

Publication number Publication date
ATE404664T1 (de) 2008-08-15
CN101693896A (zh) 2010-04-14
CN100558886C (zh) 2009-11-11
KR20050052664A (ko) 2005-06-03
CN101693896B (zh) 2012-07-11
AU2003299104A1 (en) 2004-04-19
EP1543114A2 (en) 2005-06-22
US7135315B2 (en) 2006-11-14
WO2004029235A2 (en) 2004-04-08
AU2003299104A8 (en) 2004-04-19
KR101070110B1 (ko) 2011-10-05
US20060127994A1 (en) 2006-06-15
WO2004029235A3 (en) 2004-07-08
JP2006500052A (ja) 2006-01-05
CN1688689A (zh) 2005-10-26
EP1543114B1 (en) 2008-08-13
JP4528624B2 (ja) 2010-08-18

Similar Documents

Publication Publication Date Title
DE60322921D1 (de) Aldehyddehyrdrogenase-gen
Bremus et al. The use of microorganisms in L-ascorbic acid production
Leonard et al. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli
Yang et al. Industrial fermentation of vitamin C
DK1647594T3 (da) Koryneform bakteriel transformant og fremgangsmåde til fremstilling af dicarboxylsyre under anvendelse af denne
BRPI0401812A (pt) Métodos para produzir um dicarboxilato de cadaverina, e, náilon
BR0012712B1 (pt) métodos de produção de l-aminoácidos aumentando-se o nadph celular.
HUP0400261A2 (hu) Szubsztituált acetofenon sztereoszelektív redukciója
ATE360075T1 (de) Ein mit der synthese von delta-12 epoxy-gruppen in fettsäuren von pflanzen assoziiertes cytochrom p450 enzym
ATE326523T1 (de) Verfahren zur fermentativen herstellung von l- methionin
BRPI0413542A (pt) molécula isolada de polinucleotìdeo, polipeptìdeo, molécula de dna recombinante, vetor de expressão, organismo recombinante, bem como processos para produção de ácido l-ascórbico, de l-sorbosona desidrogenase e de vitamina c
Shi et al. Identification of a novel promoter gHp0169 for gene expression in Gluconobacter oxydans
ATE248916T1 (de) Gene, die verzweigte-alpha-ketosäure- dehydrogenasekomplexe von streptomyces avermitius kodieren
DE60043509D1 (de) Biosynthese von Polyketidsynthase-Substrate
DK1305421T3 (da) Foröget 2-keto-L-gulonsyre-produktion
Leichnitz et al. Total synthesis and functional analysis of microbial signalling molecules
WO2001072974A3 (en) L-galactose dehydrogenase from arabidopsis thaliana, and uses thereof
Ben Azoun et al. Investigating the effect of carbon source on rabies virus glycoprotein production in Pichia pastoris by a transcriptomic approach
EA200701694A1 (ru) Ферментативное получение витамина с
AR034550A1 (es) Un polinucleotido, un vector, una celula hospedadora, un polipeptido, ml-236b, un metodo para su produccion, un metodo para fabricar pravastatina, un anticuerpo reactivo.
ATE220104T1 (de) Expressionssystem zur produktion von proteinen
ATE323172T1 (de) Herstellung von l-ascorbinsäure und d- erythorbinsäure
WO2002061106A3 (de) Verfahren zur fermentativen herstellung von cystein, cystin und glutathion
Kudo et al. Rapid Identification of γ-Butyrolactone Signalling Molecules in Diverse Actinomycetes Using Resin-Assisted Isolation and Chemoenzymatic Synthesis
Liu et al. Coding Synthetic Chemistry Strategies into Bacterial Designer Cells

Legal Events

Date Code Title Description
8364 No opposition during term of opposition