AR034550A1 - Un polinucleotido, un vector, una celula hospedadora, un polipeptido, ml-236b, un metodo para su produccion, un metodo para fabricar pravastatina, un anticuerpo reactivo. - Google Patents

Un polinucleotido, un vector, una celula hospedadora, un polipeptido, ml-236b, un metodo para su produccion, un metodo para fabricar pravastatina, un anticuerpo reactivo.

Info

Publication number
AR034550A1
AR034550A1 ARP010101821A ARP010101821A AR034550A1 AR 034550 A1 AR034550 A1 AR 034550A1 AR P010101821 A ARP010101821 A AR P010101821A AR P010101821 A ARP010101821 A AR P010101821A AR 034550 A1 AR034550 A1 AR 034550A1
Authority
AR
Argentina
Prior art keywords
polynucleotide
polypeptide
amino acid
acid sequence
vector
Prior art date
Application number
ARP010101821A
Other languages
English (en)
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of AR034550A1 publication Critical patent/AR034550A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/385—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Penicillium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un polinucleótido que es seleccionado del grupo que consiste de: (a) un polinucleótido que codifica una proteína que tiene la secuencia de aminoácidos de SEQ ID NO. 38, o una variante polipeptídica del mismo que codifica una secuencia de aminoácidos modificada que tiene al menos una deleción, adición, sustitución o alteración, siendo dicha variante polinucleotídica adecuada para usarla en acelerar la biosíntesis de ML-236B; y (b) polinucleótido que codifica una proteína que tiene la secuencia de aminoácidos de SEQ ID NO 42, o a una variante polinucleotídica del mismo que codifica a una secuencia de aminoácidos modificada que tiene al menos una deleción, adición, sustitución o alteración, siendo dicha variante polinucleotídica adecuada para usarla en acelerar la biosíntesis de ML-236B; un vector, una célula hospedadora, un polipéptido, ML-236B compactina, un método para su producción, un método para fabricar pravastatina, un anticuerpo reactivo. El ML-236B es un inhibidor de la HMG-CoA reductasa y es útil para preparar otro inhibidor de este tipo tal como pravastatina; la preparación de ML-236B usando un microorganismo productor de ML-236B se mejora al usar un polinucleótido que codifica un gen relacionado con el agrupamiento de la policétido sintetasa que ocurre en dicho microorganismo.
ARP010101821A 2000-04-18 2001-04-18 Un polinucleotido, un vector, una celula hospedadora, un polipeptido, ml-236b, un metodo para su produccion, un metodo para fabricar pravastatina, un anticuerpo reactivo. AR034550A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000116591 2000-04-18
JP2000117458 2000-04-19

Publications (1)

Publication Number Publication Date
AR034550A1 true AR034550A1 (es) 2004-03-03

Family

ID=26590305

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010101821A AR034550A1 (es) 2000-04-18 2001-04-18 Un polinucleotido, un vector, una celula hospedadora, un polipeptido, ml-236b, un metodo para su produccion, un metodo para fabricar pravastatina, un anticuerpo reactivo.

Country Status (24)

Country Link
US (3) US7056710B2 (es)
EP (1) EP1149919B1 (es)
KR (1) KR100632174B1 (es)
CN (1) CN1325959B (es)
AR (1) AR034550A1 (es)
AT (1) ATE373101T1 (es)
AU (1) AU783319B2 (es)
BR (1) BR0101518A (es)
CA (1) CA2342397C (es)
CY (1) CY1106985T1 (es)
CZ (1) CZ20011367A3 (es)
DE (1) DE60130394T2 (es)
DK (1) DK1149919T3 (es)
ES (1) ES2293966T3 (es)
HK (1) HK1037683A1 (es)
HU (1) HUP0101569A3 (es)
IL (1) IL142619A (es)
MX (1) MXPA01003913A (es)
NO (1) NO328653B1 (es)
NZ (1) NZ511166A (es)
PL (1) PL202457B1 (es)
PT (1) PT1149919E (es)
RU (1) RU2236463C2 (es)
TW (1) TWI312807B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2029750T1 (sl) * 2006-06-22 2011-11-30 Dsm Ip Assets Bv Proizvajanje pravastatina
EP2334781A1 (en) * 2008-09-24 2011-06-22 DSM IP Assets B.V. Improved statin production
WO2010069914A1 (en) * 2008-12-19 2010-06-24 Dsm Ip Assets B.V. Statin transcription regulators
EP3134098A1 (en) * 2014-04-23 2017-03-01 Danmarks Tekniske Universitet Statin resistance and export

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS572240A (en) 1980-06-06 1982-01-07 Sankyo Co Ltd Ml-236b derivative
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
CA2175461A1 (en) 1993-11-02 1995-05-11 Victor A. Vinci Dna encoding triol polyketide synthase
KR100186758B1 (ko) * 1996-08-09 1999-04-01 영진약품공업 주식회사 프라바스타틴(pravastatin)전구체의제조방법
US6391583B1 (en) 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
AU6475800A (en) 1999-08-11 2001-03-13 Sankyo Company Limited Ml-236b biosynthesis-associated dna
FR2801648B1 (fr) * 1999-11-30 2002-06-21 Commissariat Energie Atomique Injecteur a vapeur haute pression comportant un drain axial

Also Published As

Publication number Publication date
US20050214909A1 (en) 2005-09-29
HK1037683A1 (en) 2002-02-15
US20070111293A1 (en) 2007-05-17
MXPA01003913A (es) 2003-08-20
NO20011890D0 (no) 2001-04-17
PL347118A1 (en) 2001-10-22
NO20011890L (no) 2001-10-19
CA2342397A1 (en) 2001-10-18
NZ511166A (en) 2002-11-26
TWI312807B (en) 2009-08-01
DE60130394T2 (de) 2008-06-19
EP1149919A3 (en) 2002-02-06
HU0101569D0 (en) 2001-06-28
ATE373101T1 (de) 2007-09-15
CY1106985T1 (el) 2012-09-26
DK1149919T3 (da) 2007-12-03
EP1149919A2 (en) 2001-10-31
US20030078395A1 (en) 2003-04-24
CA2342397C (en) 2011-08-23
CZ20011367A3 (cs) 2001-12-12
BR0101518A (pt) 2001-11-13
EP1149919B1 (en) 2007-09-12
PT1149919E (pt) 2007-12-17
KR100632174B1 (ko) 2006-10-11
RU2236463C2 (ru) 2004-09-20
HUP0101569A3 (en) 2005-01-28
CN1325959A (zh) 2001-12-12
AU3709201A (en) 2001-10-25
PL202457B1 (pl) 2009-06-30
HUP0101569A2 (hu) 2002-05-29
IL142619A (en) 2008-03-20
NO328653B1 (no) 2010-04-19
AU783319B2 (en) 2005-10-13
CN1325959B (zh) 2010-05-05
US7056710B2 (en) 2006-06-06
KR20010098713A (ko) 2001-11-08
DE60130394D1 (de) 2007-10-25
ES2293966T3 (es) 2008-04-01

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