ATE472597T2 - Kontrollierte glukosezufuhr für tierzellkultur - Google Patents

Kontrollierte glukosezufuhr für tierzellkultur Download PDF

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Publication number
ATE472597T2
ATE472597T2 AT04752591T AT04752591T ATE472597T2 AT E472597 T2 ATE472597 T2 AT E472597T2 AT 04752591 T AT04752591 T AT 04752591T AT 04752591 T AT04752591 T AT 04752591T AT E472597 T2 ATE472597 T2 AT E472597T2
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AT
Austria
Prior art keywords
glucose
cell culture
feeding
restricted
rate
Prior art date
Application number
AT04752591T
Other languages
English (en)
Inventor
Denis Drapeau
Terry Stanek
Yen-Tung Luan
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33476770&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE472597(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Application granted granted Critical
Publication of ATE472597T2 publication Critical patent/ATE472597T2/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04752591T 2003-05-15 2004-05-17 Kontrollierte glukosezufuhr für tierzellkultur ATE472597T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47093703P 2003-05-15 2003-05-15
PCT/US2004/015597 WO2004104186A1 (en) 2003-05-15 2004-05-17 Restricted glucose feed for animal cell culture

Publications (1)

Publication Number Publication Date
ATE472597T2 true ATE472597T2 (de) 2010-07-15

Family

ID=33476770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04752591T ATE472597T2 (de) 2003-05-15 2004-05-17 Kontrollierte glukosezufuhr für tierzellkultur

Country Status (10)

Country Link
US (1) US7429491B2 (de)
EP (1) EP1623019B2 (de)
AT (1) ATE472597T2 (de)
DE (1) DE602004027905D1 (de)
DK (1) DK1623019T4 (de)
ES (1) ES2344789T5 (de)
PL (1) PL1623019T5 (de)
PT (1) PT1623019E (de)
SI (1) SI1623019T1 (de)
WO (1) WO2004104186A1 (de)

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US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
EP2890782A1 (de) 2012-09-02 2015-07-08 AbbVie Inc. Verfahren zur steuerung einer proteinheterogenität
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US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US11249026B2 (en) 2013-03-15 2022-02-15 Biogen Ma Inc. Use of raman spectroscopy to monitor culture medium
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
WO2015000865A1 (en) 2013-07-04 2015-01-08 F. Hoffmann-La Roche Ag Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
MX376623B (es) 2013-10-11 2025-03-07 Regeneron Pharma Cultivo celular metabolicamente optimizado.
US11390663B2 (en) 2013-10-11 2022-07-19 Regeneron Pharmaceuticals, Inc. Metabolically optimized cell culture
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EP4512889A3 (de) * 2014-03-19 2025-05-07 Pfizer Inc. Zellkultur-verfahren
EP3164481A4 (de) 2014-07-02 2018-03-21 Biogen MA Inc. Skalenübergreifende modellierung von bioreaktorkulturen mittels raman-spektroskopie
WO2016196261A1 (en) 2015-05-29 2016-12-08 Boehringer Ingelheim International Gmbh Cell-controlled perfusion in continuous culture
EP3303561A2 (de) * 2015-05-29 2018-04-11 Biogen MA Inc. Zellkulturverfahren und systeme
TW202440903A (zh) 2015-08-04 2024-10-16 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法（一）
EP3353313B1 (de) 2015-09-23 2024-08-07 Pfizer Inc. Zellen und verfahren zur zellkultur
JP7672196B2 (ja) 2017-03-14 2025-05-07 アムジエン・インコーポレーテツド 細胞培養において産生される抗体の総非フコシル化グリコフォームの調節
GB201708655D0 (en) 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
EP3775251A1 (de) 2018-03-26 2021-02-17 Amgen Inc. Gesamte afucosylierte glycoformen von in einer zellkultur produzierten antikörpern
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JP2022513702A (ja) 2018-12-06 2022-02-09 ファイザー・インク 阻害剤産生が低下した細胞およびその使用方法
KR20220100881A (ko) * 2019-10-18 2022-07-18 얀센 바이오테크 인코포레이티드 동적 단당류 제어 방법
US12297451B1 (en) 2019-10-25 2025-05-13 Regeneron Pharmaceuticals, Inc. Cell culture medium
CA3192999A1 (en) 2020-08-31 2022-03-03 Regeneron Pharmaceuticals, Inc. Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants
JP2022060169A (ja) 2020-10-02 2022-04-14 ファイザー・インク Ｒｓｖ ｆタンパク質生産のための細胞培養工程
US12031151B2 (en) 2021-01-20 2024-07-09 Regeneron Pharmaceuticals, Inc. Methods of improving protein titer in cell culture
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TW202323817A (zh) 2021-10-07 2023-06-16 美商再生元醫藥公司 Ｐｈ建模及控制之系統及方法
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Also Published As

Publication number Publication date
EP1623019B2 (de) 2017-01-25
US20050070013A1 (en) 2005-03-31
EP1623019A1 (de) 2006-02-08
EP1623019B1 (de) 2010-06-30
PT1623019E (pt) 2010-07-20
US7429491B2 (en) 2008-09-30
SI1623019T1 (sl) 2010-10-29
PL1623019T5 (pl) 2018-02-28
WO2004104186A1 (en) 2004-12-02
ES2344789T3 (es) 2010-09-07
ES2344789T5 (es) 2017-06-14
PL1623019T3 (pl) 2010-10-29
DE602004027905D1 (de) 2010-08-12
DK1623019T4 (en) 2017-03-27
DK1623019T3 (da) 2010-09-27

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