JP2013528577A5 - - Google Patents
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- Publication number
- JP2013528577A5 JP2013528577A5 JP2013506566A JP2013506566A JP2013528577A5 JP 2013528577 A5 JP2013528577 A5 JP 2013528577A5 JP 2013506566 A JP2013506566 A JP 2013506566A JP 2013506566 A JP2013506566 A JP 2013506566A JP 2013528577 A5 JP2013528577 A5 JP 2013528577A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- fluorobenzyloxy
- benzylamino
- crystallization
- propanamide methanesulfonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10161207 | 2010-04-27 | ||
| EP10161207.5 | 2010-04-27 | ||
| PCT/EP2011/055309 WO2011134763A1 (en) | 2010-04-27 | 2011-04-06 | Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015104930A Division JP6345154B2 (ja) | 2010-04-27 | 2015-05-22 | ラルフィナミドメタンスルホネート塩またはそのｒ−エナンチオマーの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528577A JP2013528577A (ja) | 2013-07-11 |
| JP2013528577A5 true JP2013528577A5 (cg-RX-API-DMAC7.html) | 2015-03-05 |
| JP5808392B2 JP5808392B2 (ja) | 2015-11-10 |
Family
ID=42634917
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013506566A Active JP5808392B2 (ja) | 2010-04-27 | 2011-04-06 | ラルフィナミドメタンスルホネート塩またはそのｒ−エナンチオマーの製造方法 |
| JP2015104930A Active JP6345154B2 (ja) | 2010-04-27 | 2015-05-22 | ラルフィナミドメタンスルホネート塩またはそのｒ−エナンチオマーの製造方法 |
| JP2017106571A Active JP6450420B2 (ja) | 2010-04-27 | 2017-05-30 | ラルフィナミドメタンスルホネート塩またはそのｒ−エナンチオマーの製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015104930A Active JP6345154B2 (ja) | 2010-04-27 | 2015-05-22 | ラルフィナミドメタンスルホネート塩またはそのｒ−エナンチオマーの製造方法 |
| JP2017106571A Active JP6450420B2 (ja) | 2010-04-27 | 2017-05-30 | ラルフィナミドメタンスルホネート塩またはそのｒ−エナンチオマーの製造方法 |
Country Status (27)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE030504T2 (en) * | 2010-04-27 | 2017-05-29 | Newron Pharm Spa | Process for the preparation of ralfinamide methanesulfonate salts or their R-enantiomers |
| CN103804341B (zh) * | 2012-11-13 | 2018-04-10 | 中国人民解放军军事医学科学院毒物药物研究所 | 酰胺衍生物及其医药用途 |
| CN104761531B (zh) * | 2014-01-03 | 2017-12-01 | 中国人民解放军军事医学科学院毒物药物研究所 | 镇痛活性化合物及其医药用途 |
| CN104292128A (zh) * | 2014-07-01 | 2015-01-21 | 南京正科制药有限公司 | 一种沙芬酰胺晶型a |
| CN115368310B (zh) * | 2021-05-18 | 2025-06-27 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94466A (en) | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| GB9515412D0 (en) * | 1995-07-27 | 1995-09-27 | Pharmacia Spa | 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| ATE317280T1 (de) | 2001-09-03 | 2006-02-15 | Newron Pharm Spa | Pharmazeutische zusammensetzung mit gabapentin oder deren analog und einem alpha-aminoamid und analgetische verwendung dieser zusammensetzung |
| EP1438956A1 (en) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| WO2004066987A2 (en) * | 2003-01-30 | 2004-08-12 | Dynogen Pharmaceuticals, Inc. | Use of sodium channel modulators for treating gastrointestinal tract disorders |
| AR044007A1 (es) | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
| SI1658062T1 (sl) | 2003-08-25 | 2010-05-31 | Newron Pharm Spa | Alfa aminoamidni derivati uporabni kot protivnetna sredstva |
| EP1557166A1 (en) | 2004-01-21 | 2005-07-27 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders |
| EP1588704A1 (en) | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
| DK1809271T5 (da) * | 2004-09-10 | 2010-12-06 | Newron Pharm Spa | Anvendelse af (R)-(halogenbenzyloxy)benzylaminopropanamider som natrium- og/eller calciumkanalselektive modulatorer |
| EP1870097A1 (en) | 2006-06-15 | 2007-12-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of cognitive disorders |
| AU2007263328C1 (en) | 2006-06-19 | 2012-09-06 | Newron Pharmaceuticals S.P.A. | Process for the production of 2- [4 - ( 3- and 2-fluorobenzyloxy) benzylamino] propan amides |
| JP5315674B2 (ja) * | 2007-11-19 | 2013-10-16 | セントラル硝子株式会社 | 非水電池用電解液及びこれを用いた非水電池 |
| PT2229351T (pt) | 2007-12-11 | 2018-01-19 | Newron Pharm Spa | Processo para a produção de 2-[4-(3- ou 2-fluorobenziloxi)benzilamino]propanamidas com grau de pureza alto |
| ES2878063T3 (es) | 2007-12-19 | 2021-11-18 | Newron Pharm Spa | Derivados de la alfa-aminoamida para el tratamiento de trastornos psiquiátricos |
| WO2009109334A1 (en) | 2008-03-07 | 2009-09-11 | Newron Pharmaceuticals S.P.A. | (s)-(+)-2-[4-fluorbenzyloxy)benzylamino]propanamide for use in the treatment of mixed or combined pain |
| HUE030504T2 (en) * | 2010-04-27 | 2017-05-29 | Newron Pharm Spa | Process for the preparation of ralfinamide methanesulfonate salts or their R-enantiomers |
-
2011
- 2011-04-06 HU HUE11714958A patent/HUE030504T2/en unknown
- 2011-04-06 ME MEP-2016-169A patent/ME02509B/me unknown
- 2011-04-06 BR BR112012027623-9A patent/BR112012027623B1/pt active IP Right Grant
- 2011-04-06 NZ NZ700221A patent/NZ700221A/en unknown
- 2011-04-06 EP EP11714958.3A patent/EP2563355B1/en active Active
- 2011-04-06 NZ NZ602648A patent/NZ602648A/en unknown
- 2011-04-06 KR KR1020127030931A patent/KR101851118B1/ko active Active
- 2011-04-06 DK DK11714958.3T patent/DK2563355T3/en active
- 2011-04-06 CN CN201510387405.XA patent/CN105037188B/zh active Active
- 2011-04-06 LT LTEP11714958.3T patent/LT2563355T/lt unknown
- 2011-04-06 PT PT117149583T patent/PT2563355T/pt unknown
- 2011-04-06 SI SI201130927A patent/SI2563355T1/sl unknown
- 2011-04-06 CN CN201180020748.2A patent/CN102858330B/zh active Active
- 2011-04-06 AU AU2011246707A patent/AU2011246707B2/en active Active
- 2011-04-06 HR HRP20161077TT patent/HRP20161077T1/hr unknown
- 2011-04-06 US US13/643,716 patent/US9505708B2/en active Active
- 2011-04-06 WO PCT/EP2011/055309 patent/WO2011134763A1/en not_active Ceased
- 2011-04-06 JP JP2013506566A patent/JP5808392B2/ja active Active
- 2011-04-06 MX MX2012012093A patent/MX342697B/es active IP Right Grant
- 2011-04-06 CA CA2794389A patent/CA2794389C/en active Active
- 2011-04-06 ES ES11714958.3T patent/ES2590128T3/es active Active
- 2011-04-06 PL PL11714958.3T patent/PL2563355T3/pl unknown
- 2011-04-06 EA EA201291116A patent/EA021389B1/ru unknown
- 2011-04-06 RS RS20160665A patent/RS55084B1/sr unknown
- 2011-04-18 TW TW100113339A patent/TWI492919B/zh active
- 2011-04-25 AR ARP110101401A patent/AR085171A1/es not_active Application Discontinuation
-
2012
- 2012-10-18 IL IL222532A patent/IL222532A/en active IP Right Grant
-
2015
- 2015-05-22 JP JP2015104930A patent/JP6345154B2/ja active Active
-
2016
- 2016-08-05 SM SM201600266T patent/SMT201600266B/it unknown
- 2016-08-10 CY CY20161100786T patent/CY1117879T1/el unknown
- 2016-10-12 US US15/291,202 patent/US9856207B2/en active Active
-
2017
- 2017-05-30 JP JP2017106571A patent/JP6450420B2/ja active Active
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