EA201391341A1 - Производные гетероциклических аминов - Google Patents

Производные гетероциклических аминов

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Publication number
EA201391341A1
EA201391341A1 EA201391341A EA201391341A EA201391341A1 EA 201391341 A1 EA201391341 A1 EA 201391341A1 EA 201391341 A EA201391341 A EA 201391341A EA 201391341 A EA201391341 A EA 201391341A EA 201391341 A1 EA201391341 A1 EA 201391341A1
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Eurasian Patent Office
Prior art keywords
halogen
lower alkyl
hydrogen
substituted
cycloalkyl
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EA201391341A
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English (en)
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EA023237B1 (ru
Inventor
Гуидо Галлей
Роджер Норкросс
Филипп Пфлигер
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Ф.Хоффманн-Ля Рош Аг
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Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA201391341A1 publication Critical patent/EA201391341A1/ru
Publication of EA023237B1 publication Critical patent/EA023237B1/ru

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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I)где Rпредставляет собой водород, низший алкил, галоген, низший алкил, замещенный галогеном, низший алкокси, низший алкокси, замещенный галогеном, циано, нитро, С-циклоалкил, -СН-С-циклоалкил, -О-СН-С-циклоалкил, -О-(СН)-О-низший алкил, S(O)CH, SF, -С(О)NH-низший алкил, фенил, -О-пиримидинил, возможно замещенный низшим алкокси, замещенным галогеном, или представляет собой бензил, оксетанил или фуранил; m представляет собой 1 или 2; Ar представляет собой арил или гетероарил, выбранный из группы, состоящей из фенила, нафтила, пиримидинила, пиридинила, бензотиазолила, хинолинила, хиназолинила, бензо[d][1.3]диоксолила, 5,6,7,8-тетрагидрохиназолинила, пиразолила, пиразинила, пиридазинила или 1,3,4-оксадиазолила; Y представляет собой связь, -СН-, -СНСН-, -CH(CF)- или -СН(СН)-; Rпредставляет собой водород или низший алкил; А представляет собой CR или N и R представляет собой водород, циано, галоген или низший алкил; R' представляет собой водород или галоген; при условии, что, когда R' представляет собой галоген, тогда А представляет собой СН; В представляет собой СН или N; n представляет собой 0, 1 или 2; X представляет собой связь, -СН- или -О-; или к их фармацевтическим активным кислотно-аддитивным солям. Установлено, что соединения формулы I обладают хорошим сродством к рецепторам, ассоциированным со следовыми аминами (TAARs), особенно к TAAR1. Соединения могут быть использованы для лечения депрессии, тревожных расстройств, биполярного расстройства, синдрома дефицита внимания с гиперактивностью (СДВГ), расстройств, обусловленных стрессом, психотических расстройств, таких как шизофрения, неврологических заболеваний, таких как болезнь Паркинсона, нейродегенеративных расстройств, таких
EA201391341A 2011-03-24 2012-03-21 Производные гетероциклических аминов EA023237B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11159566 2011-03-24
PCT/EP2012/054939 WO2012126922A1 (en) 2011-03-24 2012-03-21 Heterocyclic amine derivatives

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EA201391341A1 true EA201391341A1 (ru) 2014-06-30
EA023237B1 EA023237B1 (ru) 2016-05-31

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EP (1) EP2688870B1 (ru)
JP (1) JP5716128B2 (ru)
KR (1) KR101518660B1 (ru)
CN (1) CN103443074B (ru)
AR (1) AR085478A1 (ru)
AU (1) AU2012230378B2 (ru)
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ECSP13012896A (es) 2013-11-29
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JP2014508790A (ja) 2014-04-10
CL2013002664A1 (es) 2014-05-09
AU2012230378A1 (en) 2013-09-12
CN103443074B (zh) 2016-04-13
CR20130419A (es) 2013-10-09
JP5716128B2 (ja) 2015-05-13
BR112013024312A2 (pt) 2016-07-19
KR101518660B1 (ko) 2015-05-07
NZ616150A (en) 2014-09-26
SG193556A1 (en) 2013-11-29
AU2012230378B2 (en) 2016-09-15
PE20140425A1 (es) 2014-03-28
CN103443074A (zh) 2013-12-11
ZA201306757B (en) 2015-04-29
KR20130132656A (ko) 2013-12-04
MX351918B (es) 2017-11-03
CA2828283A1 (en) 2012-09-27
EP2688870A1 (en) 2014-01-29
MA35062B1 (fr) 2014-04-03
AR085478A1 (es) 2013-10-02
HK1190703A1 (zh) 2014-07-11
EA023237B1 (ru) 2016-05-31
UA113167C2 (xx) 2016-12-26
IL228246A (en) 2017-10-31
WO2012126922A1 (en) 2012-09-27
US8802673B2 (en) 2014-08-12
CO6801736A2 (es) 2013-11-29
US20120245172A1 (en) 2012-09-27

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