WO2013172741A3 - Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси) циклогексен-1-карбоновые кислоты, их эфиры и способ применения - Google Patents
Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси) циклогексен-1-карбоновые кислоты, их эфиры и способ применения Download PDFInfo
- Publication number
- WO2013172741A3 WO2013172741A3 PCT/RU2013/000384 RU2013000384W WO2013172741A3 WO 2013172741 A3 WO2013172741 A3 WO 2013172741A3 RU 2013000384 W RU2013000384 W RU 2013000384W WO 2013172741 A3 WO2013172741 A3 WO 2013172741A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substituted
- pentan
- guanidino
- yloxy
- acylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112014028362-1A BR112014028362B1 (pt) | 2012-05-12 | 2013-05-07 | Ácidos (3r, 4r, 5s)-5-guanidino-4-acetamido-3-(pentan-3-iloxi)cicloexeno-1-carboxílicos flúor substituídos, os seus ésteres, composição farmacêutica e uso da mesma |
DK13791641.7T DK2848606T3 (en) | 2012-05-12 | 2013-05-07 | FLUORO-SUBSTITUTED (3R, 4R, 5S) -5-GUANIDINO-4-ACYLAMINO-3- (PENTAN-3-YLOXY) CYCLOHEXEN-1-CARBOXYLIC ACIDS, ESTERS THEREOF AND A PROCEDURE FOR USE THEREOF |
CN201380024800.0A CN104284884B (zh) | 2012-05-12 | 2013-05-07 | 氟取代的(3r,4r,5s)-5-胍基-4-乙酰氨基-3-(戊烷-3-基氧基)环己烯-1-甲酸、它们的酯及它们的应用 |
EP13791641.7A EP2848606B1 (en) | 2012-05-12 | 2013-05-07 | Fluoro-substituted (3r, 4r, 5s)-5-guanidino-4-acylamino-3-(pentan-3-yloxy) cyclohexene-1-carboxylic acids, esters thereof and a method for the use thereof |
PL13791641T PL2848606T3 (pl) | 2012-05-12 | 2013-05-07 | Fluoropodstawione kwasy (3R, 4R, 5S)-5-guanidyno-4-acyloamino-3-(pentan-3- yloksy)cyklohekseno-1-karboksylowe, ich estry i sposób ich stosowania |
AU2013263513A AU2013263513B2 (en) | 2012-05-12 | 2013-05-07 | Fluoro-substituted (3R, 4R, 5S)-5-guanidino-4-acylamino-3-(pentan-3-yloxy) cyclohexene-1-carboxylic acids, esters thereof and a method for the use thereof |
JP2015512601A JP6034960B2 (ja) | 2012-05-12 | 2013-05-07 | フッ素置換(3r、4r、5s)−5−グアニジノ−4−アセトアミド−3−(ペンタン−3−イルオキシ)シクロヘキセン−1−カルボン酸、そのエステル及びその使用 |
MX2014013761A MX360369B (es) | 2012-05-12 | 2013-05-07 | Acidos (3r,4r,5s)-5-guanidino-4-acetamido-3-(pentan-3-iloxi)cicloh exen-1-carboxilicos fluorosustituidos, sus esteres y uso de los mismos. |
KR1020147034876A KR101902567B1 (ko) | 2012-05-12 | 2013-05-07 | 플루오로치환된 (3r,4r,5s)-5-구아니디노-4-아세트아미도-3-(펜탄-3-일옥시)사이클로헥센-1-카복실릭 엑시드, 이의 에스테르 및 이의 용도 |
EA201401238A EA024765B1 (ru) | 2012-05-12 | 2013-05-07 | Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси)циклогексен-1-карбоновые кислоты, их эфиры и способ применения |
CA2872733A CA2872733C (en) | 2012-05-12 | 2013-05-07 | Fluorosubstituted (3r,4r,5s)-5-guanidino-4-acetamido-3-(pentan-3-yloxy)cyclohexene-1-carboxylic acids, their esters and use thereof |
UAA201410979A UA113201C2 (xx) | 2012-05-12 | 2013-07-05 | Фторзамісні (3r,4r,5s)-5-гуанідино-4-фторациламіно-3-(пентан-3-ілокси)циклогексен-1-карбонові кислоти, їх ефіри і спосіб застосування |
ZA2014/08026A ZA201408026B (en) | 2012-05-12 | 2014-11-03 | Flouro-substituted (3r,2r,5s)-5-guanidino-4-acylamino-3-(pentan-3-yloxy)cyclohexene-1-carbixylic acids, esters thereof and method for the use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2012119272 | 2012-05-12 | ||
RU2012119272/04A RU2489422C1 (ru) | 2012-05-12 | 2012-05-12 | Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси)циклогексен-1-карбоновые кислоты, их эфиры и способ применения |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013172741A2 WO2013172741A2 (ru) | 2013-11-21 |
WO2013172741A3 true WO2013172741A3 (ru) | 2014-01-09 |
Family
ID=49159508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/RU2013/000384 WO2013172741A2 (ru) | 2012-05-12 | 2013-05-07 | Фторзамещенные (3r,4r,5s)-5-гуанидино-4-ациламино-3-(пентан-3-илокси) циклогексен-1-карбоновые кислоты, их эфиры и способ применения |
Country Status (17)
Country | Link |
---|---|
US (1) | US8895613B2 (ru) |
EP (1) | EP2848606B1 (ru) |
JP (1) | JP6034960B2 (ru) |
KR (1) | KR101902567B1 (ru) |
CN (1) | CN104284884B (ru) |
AU (1) | AU2013263513B2 (ru) |
BR (1) | BR112014028362B1 (ru) |
CA (1) | CA2872733C (ru) |
DK (1) | DK2848606T3 (ru) |
EA (1) | EA024765B1 (ru) |
HU (1) | HUE035856T2 (ru) |
MX (1) | MX360369B (ru) |
PL (1) | PL2848606T3 (ru) |
RU (1) | RU2489422C1 (ru) |
UA (1) | UA113201C2 (ru) |
WO (1) | WO2013172741A2 (ru) |
ZA (1) | ZA201408026B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103923060B (zh) * | 2014-03-27 | 2016-05-25 | 山东大学 | 奥司他韦衍生物及其制备方法和应用 |
CN106905193B (zh) * | 2017-02-15 | 2018-11-27 | 中国药科大学 | 芳酰基胍基奥司他韦羧酸衍生物及其制备方法和应用 |
US20190081317A1 (en) * | 2017-09-11 | 2019-03-14 | Andreas Keil | Web coating and calendering system and method |
CN110272381A (zh) * | 2019-06-19 | 2019-09-24 | 五邑大学 | 含吡啶片段的奥司他韦类似物及其应用 |
WO2022022448A1 (zh) * | 2020-07-29 | 2022-02-03 | 广州市恒诺康医药科技有限公司 | 神经氨酸酶抑制剂类化合物、其药物组合物及其用途 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5952375A (en) * | 1995-02-27 | 1999-09-14 | Gilead Sciences, Inc. | Compounds and methods for synthesis and therapy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPM354694A0 (en) * | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
JP3233392B2 (ja) * | 1998-01-22 | 2001-11-26 | 三共株式会社 | ノイラミン酸誘導体を含有する抗インフルエンザ薬 |
US6518048B2 (en) * | 2000-04-10 | 2003-02-11 | Hoffmann-La Roche Inc. | Stereo-specific synthesis of shimikic acid derivatives with improved efficiency |
WO2009129305A2 (en) * | 2008-04-15 | 2009-10-22 | Tsrl, Inc. | Prodrugs of neuraminidase inhibitors |
RU2469020C1 (ru) * | 2011-11-08 | 2012-12-10 | Александр Васильевич Иващенко | (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения |
-
2012
- 2012-05-12 RU RU2012119272/04A patent/RU2489422C1/ru active
-
2013
- 2013-04-29 US US13/872,174 patent/US8895613B2/en active Active
- 2013-05-07 WO PCT/RU2013/000384 patent/WO2013172741A2/ru active Application Filing
- 2013-05-07 PL PL13791641T patent/PL2848606T3/pl unknown
- 2013-05-07 MX MX2014013761A patent/MX360369B/es active IP Right Grant
- 2013-05-07 HU HUE13791641A patent/HUE035856T2/hu unknown
- 2013-05-07 DK DK13791641.7T patent/DK2848606T3/en active
- 2013-05-07 CA CA2872733A patent/CA2872733C/en not_active Expired - Fee Related
- 2013-05-07 AU AU2013263513A patent/AU2013263513B2/en not_active Ceased
- 2013-05-07 JP JP2015512601A patent/JP6034960B2/ja active Active
- 2013-05-07 KR KR1020147034876A patent/KR101902567B1/ko active IP Right Grant
- 2013-05-07 EA EA201401238A patent/EA024765B1/ru not_active IP Right Cessation
- 2013-05-07 CN CN201380024800.0A patent/CN104284884B/zh active Active
- 2013-05-07 EP EP13791641.7A patent/EP2848606B1/en not_active Not-in-force
- 2013-05-07 BR BR112014028362-1A patent/BR112014028362B1/pt active IP Right Grant
- 2013-07-05 UA UAA201410979A patent/UA113201C2/uk unknown
-
2014
- 2014-11-03 ZA ZA2014/08026A patent/ZA201408026B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5952375A (en) * | 1995-02-27 | 1999-09-14 | Gilead Sciences, Inc. | Compounds and methods for synthesis and therapy |
Non-Patent Citations (3)
Title |
---|
DATABASE CA accession no. 45757-32-4 * |
DU OI-SHI ET AL.: "Fragment-based quantitative structure-activity relationship (FB-QSAR) for fragment-based drug design.", JOURNAL OF COMPUTATIONAL CHEMISTRY, vol. 30, no. 2, 2009, pages 295 - 304, XP055165717 * |
ZHENG MINGYUE ET AL.: "QSAR analyses on avian influenza virus neuraminidase inhibitors using CoMFA, CoMSIA, and HQSAR.", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 20, no. 9, 2006, pages 549 - 566, XP019450536 * |
Also Published As
Publication number | Publication date |
---|---|
CN104284884B (zh) | 2016-07-13 |
EA024765B1 (ru) | 2016-10-31 |
CA2872733A1 (en) | 2013-11-21 |
ZA201408026B (en) | 2015-11-25 |
JP6034960B2 (ja) | 2016-11-30 |
WO2013172741A2 (ru) | 2013-11-21 |
EP2848606A2 (en) | 2015-03-18 |
EP2848606A4 (en) | 2015-12-23 |
MX2014013761A (es) | 2015-02-04 |
UA113201C2 (xx) | 2016-12-26 |
PL2848606T3 (pl) | 2018-01-31 |
MX360369B (es) | 2018-10-29 |
EA201401238A1 (ru) | 2015-02-27 |
AU2013263513A1 (en) | 2014-11-06 |
BR112014028362B1 (pt) | 2022-02-01 |
JP2015521186A (ja) | 2015-07-27 |
CA2872733C (en) | 2017-03-21 |
HUE035856T2 (hu) | 2018-05-28 |
US8895613B2 (en) | 2014-11-25 |
AU2013263513B2 (en) | 2016-10-06 |
DK2848606T3 (en) | 2017-10-02 |
CN104284884A (zh) | 2015-01-14 |
BR112014028362A2 (pt) | 2018-04-17 |
KR101902567B1 (ko) | 2018-09-28 |
KR20150017734A (ko) | 2015-02-17 |
RU2489422C1 (ru) | 2013-08-10 |
US20130303609A1 (en) | 2013-11-14 |
EP2848606B1 (en) | 2017-08-30 |
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