JP2013527158A5 - - Google Patents

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Publication number
JP2013527158A5
JP2013527158A5 JP2013505200A JP2013505200A JP2013527158A5 JP 2013527158 A5 JP2013527158 A5 JP 2013527158A5 JP 2013505200 A JP2013505200 A JP 2013505200A JP 2013505200 A JP2013505200 A JP 2013505200A JP 2013527158 A5 JP2013527158 A5 JP 2013527158A5
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Japan
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composition
agent
inhibitor
polysaccharide
tumor
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JP2013505200A
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English (en)
Japanese (ja)
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JP5982361B2 (ja
JP2013527158A (ja
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Priority claimed from PCT/US2011/032771 external-priority patent/WO2011130697A2/en
Publication of JP2013527158A publication Critical patent/JP2013527158A/ja
Publication of JP2013527158A5 publication Critical patent/JP2013527158A5/ja
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JP2013505200A 2010-04-16 2011-04-15 組織標的化方法 Active JP5982361B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32514610P 2010-04-16 2010-04-16
US61/325,146 2010-04-16
PCT/US2011/032771 WO2011130697A2 (en) 2010-04-16 2011-04-15 Tissue targeting

Publications (3)

Publication Number Publication Date
JP2013527158A JP2013527158A (ja) 2013-06-27
JP2013527158A5 true JP2013527158A5 (https=) 2014-05-29
JP5982361B2 JP5982361B2 (ja) 2016-08-31

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ID=44799366

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JP2013505200A Active JP5982361B2 (ja) 2010-04-16 2011-04-15 組織標的化方法

Country Status (7)

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US (1) US9387256B2 (https=)
EP (1) EP2558506B1 (https=)
JP (1) JP5982361B2 (https=)
CN (1) CN102985443B (https=)
BR (1) BR112012026542A2 (https=)
CA (1) CA2795360A1 (https=)
WO (1) WO2011130697A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104142405A (zh) * 2014-07-31 2014-11-12 温州市中心医院 硼替佐米对k562细胞株中dna甲基转移酶表达的检测方法
CN107802833A (zh) * 2016-09-09 2018-03-16 埃提斯生物技术(上海)有限公司 赫赛汀、依维莫司和长春瑞滨的药物组合
WO2019222272A1 (en) 2018-05-14 2019-11-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CN113811333B (zh) 2019-05-14 2024-03-12 诺维逊生物股份有限公司 靶向抗癌核激素受体的化合物
WO2021097046A1 (en) 2019-11-13 2021-05-20 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
KR20230160299A (ko) 2021-03-23 2023-11-23 누베이션 바이오 인크. 항암 핵 호르몬 수용체 표적화 화합물
US12006314B2 (en) 2021-05-03 2024-06-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE620906A (https=)
US3118816A (en) 1962-04-03 1964-01-21 Abbott Lab N-succinyl heparin and process
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
CA1136620A (en) 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
FR2538404B1 (https=) 1982-12-28 1985-08-23 Anic Spa
IT1195497B (it) 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
FR2553287B1 (fr) 1983-10-18 1986-09-12 Choay Sa Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire
IT1169888B (it) 1983-10-25 1987-06-03 Italfarmaco Spa Glicosaminoglicani modificati dotati di attivita' antitrombotica
US4916219A (en) 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
US4847338A (en) 1985-03-28 1989-07-11 University Of Iowa Research Foundation Low molecular weight heparin fragments as inhibitors of complement activation
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5262403A (en) 1986-03-10 1993-11-16 Board Of Regents, The University Of Texas System Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
US5541166A (en) 1987-01-23 1996-07-30 The Australian National University Sulphated polysaccharides having anti-metastatic and/or anti-inflammatory activity
US5668116A (en) 1987-03-19 1997-09-16 Anthropharm Pty. Limited Anti-inflammatory compounds and compositions
FR2614026B1 (fr) 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
US5264425A (en) 1988-06-03 1993-11-23 Italfarmaco S.P.A. Glycosaminoglycan salts and pharmaceutical compositions containing them
IL86753A0 (en) 1988-06-15 1988-11-30 Hadassah Med Org Pharmaceutical compositions for treatment of lupus
US5308617A (en) 1988-08-10 1994-05-03 Halzyme Ltd. Protein heparin conjugates
DK191889D0 (da) 1989-04-20 1989-04-20 Bukh Meditec Kosmetisk middel
SE9002550D0 (sv) 1990-08-01 1990-08-01 Kabivitrum Ab Heparinfragment
IT1243987B (it) 1990-10-29 1994-06-28 Derivati Organici Lab Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
US5250519A (en) 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
US5280016A (en) 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
SE9101155D0 (sv) 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
IT1254216B (it) 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
US5668118A (en) 1992-07-24 1997-09-16 Cavalier Pharmaceuticals Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
US5696100A (en) 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en) 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
EP0690720B1 (en) 1993-03-12 2001-06-27 XOMA Technology Ltd. Therapeutic uses of bactericidal/permeability increasing protein products
IT1264709B1 (it) 1993-07-12 1996-10-04 Italfarmaco Spa Derivati eparinici ad attivita' antimetastatica
US5583121A (en) 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US6127347A (en) 1994-01-12 2000-10-03 Univ Michigan Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
AU2435795A (en) 1994-05-06 1995-11-29 Glycomed Incorporated O-desulfated heparin derivatives, methods of making and uses thereof
US6140481A (en) 1994-07-01 2000-10-31 Seikagaku Corporation Process for producing desulfated polysaccharide, and desulfated heparin
US5733893A (en) 1995-03-15 1998-03-31 Washington University Method of identifying molecules that regulate FGF activity
US6001820A (en) 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
EP0735050B1 (en) 1995-03-31 2002-09-25 Hamilton Civic Hospitals Research Development, Inc. Compositions for inhibiting thrombogenesis
US5744457A (en) 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5690910A (en) 1995-08-18 1997-11-25 Baker Norton Pharmaceuticals, Inc. Method for treating asthma
ES2231880T3 (es) 1996-07-29 2005-05-16 Paringenix, Inc. Procedimiento para tratar el asma con heparina o-desulfatada.
US5767269A (en) 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US6248334B1 (en) 1997-01-08 2001-06-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
AUPO573697A0 (en) 1997-03-20 1997-04-10 Prince Henry's Institute Of Medical Research Diagnosis of endometrial cancer
US6596705B1 (en) 1998-02-09 2003-07-22 The Regents Of The University Of California Inhibition of L-selectin and P-selection mediated binding using heparin
US6656922B2 (en) 1998-05-28 2003-12-02 Mediplex Corporation, Korea Oral delivery of macromolecules
KR100314496B1 (ko) 1998-05-28 2001-11-22 윤동진 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도
US7781416B2 (en) 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
US6749865B2 (en) 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
CN1197587C (zh) 2000-06-09 2005-04-20 中国科学院上海细胞生物学研究所 N-位脱硫酸肝素在预防和治疗炎症中的应用
US6514866B2 (en) 2001-01-12 2003-02-04 North Carolina State University Chemically enhanced focused ion beam micro-machining of copper
BRPI0101486B1 (pt) 2001-04-17 2017-09-19 Cristália Produtos Químicos Farmacêuticos Ltda. Pharmaceutical composition for topic use containing heparin for the treatment of skin or mucosal injuries caused by burns
SK288335B6 (sk) 2001-09-12 2016-02-02 Sigma-Tau Research Switzerland S.A. Čiastočne alebo úplne N-desulfatovaný, N-reacetylovaný heparín, spôsob jeho prípravy, jeho použitie na prípravu liečiva s inhibičným účinkom na heparanázu, s antiangiogénnym a protizápalovým účinkom a farmaceutický prostriedok s jeho obsahom
US7575886B2 (en) 2002-03-11 2009-08-18 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
EP1551852A4 (en) * 2002-04-25 2007-03-21 Momenta Pharmaceuticals Inc METHOD AND PRODUCTS FOR MUCOSAL DELIVERY
US8071569B2 (en) 2002-09-20 2011-12-06 Mousa Shaker A Oxidized heparin fractions and their use in inhibiting angiogenesis
US7964439B2 (en) 2002-12-20 2011-06-21 The Trustees Of Princeton University Methods of fabricating devices by transfer of organic material
WO2004113278A2 (en) 2003-05-20 2004-12-29 Genentech, Inc. Acylsulfamide inhibitors of factor viia
US7560444B2 (en) * 2003-10-01 2009-07-14 Momenta Pharmaceuticals, Inc. Polysaccharides for pulmonary delivery of active agents
FR2866650B1 (fr) 2004-02-24 2006-04-28 Aventis Pharma Sa Oligosaccharides, procede de preparation, utilisation et compositions pharmaceutiques les renfermant
US20050282775A1 (en) 2004-06-16 2005-12-22 Paringenix, Inc. Method and medicament for sulfated polysaccharide treatment of inflammation without inducing platelet activation and heparin-induced thrombocytopenia syndrome
US20060040896A1 (en) 2004-08-18 2006-02-23 Paringenix, Inc. Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity
ZA200801696B (en) 2005-07-22 2009-08-26 Univ California Heparin compositions and selection inhibition
US7517856B2 (en) 2005-10-11 2009-04-14 Ben-Gurion University Of The Negev Research And Development Authority Bioconjugates comprising sulfated polysaccharides and their uses
US7767420B2 (en) 2005-11-03 2010-08-03 Momenta Pharmaceuticals, Inc. Heparan sulfate glycosaminoglycan lyase and uses thereof
AU2006315348A1 (en) 2005-11-16 2007-05-24 Beth Israel Deaconess Medical Center Method to assess breast cancer risk
CN101495517B (zh) * 2006-05-25 2012-10-10 莫曼塔医药品有限公司 低分子量肝素及其用途
EP1867995A1 (en) 2006-06-15 2007-12-19 Cézanne S.A.S. In vitro method for diagnosing and monitoring metastasized bladder cancer using the determination of MMP-7 in the circulation of patients
US10166271B2 (en) 2006-06-21 2019-01-01 The Regents Of The University Of California Methods for promoting hair growth
JP4964577B2 (ja) 2006-12-15 2012-07-04 有限会社応用糖質化学研究所 親脂質性ヘパリン修飾体、その製造方法及び毛髪成長促進剤
FR2912409B1 (fr) 2007-02-14 2012-08-24 Sanofi Aventis Heparines de bas poids moleculaire comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine leur procede de preparation,leur utilisation
US8088753B2 (en) 2007-06-29 2012-01-03 Mediplex Corporation, Korea Heparin conjugates and methods
US20090012165A1 (en) 2007-07-03 2009-01-08 Sucampo Ag Pharmaceutical combination of nsaid and prostaglandin compound
WO2009007224A1 (en) 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2207811B1 (en) * 2007-11-02 2017-01-04 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
WO2009105522A1 (en) 2008-02-20 2009-08-27 Momenta Pharmaceuticals, Inc. Methods of making low molecular weight heparin compositions
JP5421366B2 (ja) 2008-07-21 2014-02-19 オトノミ―,インク. 制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法
US20100331746A1 (en) 2009-02-20 2010-12-30 Aventis Pharma S.A. Method of using enoxaparin for reducing the risk of death in acutely ill medical patients
US8435795B2 (en) 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

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