JP2024511354A5 - - Google Patents

Info

Publication number
JP2024511354A5
JP2024511354A5 JP2023556938A JP2023556938A JP2024511354A5 JP 2024511354 A5 JP2024511354 A5 JP 2024511354A5 JP 2023556938 A JP2023556938 A JP 2023556938A JP 2023556938 A JP2023556938 A JP 2023556938A JP 2024511354 A5 JP2024511354 A5 JP 2024511354A5
Authority
JP
Japan
Prior art keywords
inhibitor
cell death
inducing
receptor
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023556938A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024511354A (ja
Filing date
Publication date
Priority claimed from EP21163448.0A external-priority patent/EP4059495A1/en
Application filed filed Critical
Publication of JP2024511354A publication Critical patent/JP2024511354A/ja
Publication of JP2024511354A5 publication Critical patent/JP2024511354A5/ja
Pending legal-status Critical Current

Links

JP2023556938A 2021-03-18 2022-03-18 増殖性疾患の治療および予防のためのp2x4受容体の阻害剤を含む併用療法 Pending JP2024511354A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21163448.0A EP4059495A1 (en) 2021-03-18 2021-03-18 Therapeutic combinations including inhibitors of the p2x4 receptor for treating and preventing proliferative disorders
EP21163448.0 2021-03-18
PCT/EP2022/057133 WO2022195066A1 (en) 2021-03-18 2022-03-18 Therapeutic combinations including inhibitors of the p2x4 receptor for treating and preventing proliferative disorders

Publications (2)

Publication Number Publication Date
JP2024511354A JP2024511354A (ja) 2024-03-13
JP2024511354A5 true JP2024511354A5 (https=) 2025-03-03

Family

ID=75108224

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023556938A Pending JP2024511354A (ja) 2021-03-18 2022-03-18 増殖性疾患の治療および予防のためのp2x4受容体の阻害剤を含む併用療法

Country Status (6)

Country Link
US (1) US20240075036A1 (https=)
EP (2) EP4059495A1 (https=)
JP (1) JP2024511354A (https=)
CN (1) CN117062600A (https=)
CA (1) CA3212209A1 (https=)
WO (1) WO2022195066A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4542231A1 (en) * 2023-10-16 2025-04-23 Johann-Wolfgang-Goethe-Universität Frankfurt am Main Methods for identifying and stratifying cancers and cancer patients based on p2x4 receptor expression
CN120661500A (zh) * 2025-08-25 2025-09-19 华中科技大学同济医学院附属协和医院 具有双靶点调控功能的gsk9027在治疗结直肠癌中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040002152A1 (en) * 2002-07-01 2004-01-01 Isis Pharmaceuticals Inc. Antisense modulation of P2X4 expression
CN100453118C (zh) * 2005-04-06 2009-01-21 山东蓝金生物工程有限公司 一种含拓扑酶抑制剂的抗实体肿瘤药物组合物
EP2641969A1 (en) 2012-03-21 2013-09-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel therapeutic target for the prevention of tumour metastasis
WO2017070660A1 (en) 2015-10-23 2017-04-27 Baylor College Of Medicine Targeting p2 purinergic receptors to treat hepatocellular carcinoma (hcc)

Similar Documents

Publication Publication Date Title
Litmanovich et al. The role of interleukin-1 in the pathogenesis of cancer and its potential as a therapeutic target in clinical practice
Li et al. Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing DNA damage-dependent cell cycle arrest
Kutluk Cenik et al. BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer
Chai et al. The effective combination therapies with irinotecan for colorectal cancer
CN110478487B (zh) 一种大环内酯化合物在逆转肿瘤多药耐药增强抗肿瘤疗效方面的应用
CN101743005B (zh) 用7-(2,5-二氢-4-咪唑并[1,2-a]吡啶-3-基-2,5-二氧代-1H-吡咯-3-基)-9-氟-1,2,3,4-四氢-2-(1-哌啶基羰基)-吡咯并[3,2,1-jk][1,4]苯并二氮*增强癌症的化学疗法
KR20120004523A (ko) Dna 손상제를 강화시키기 위한 체크포인트 키나제 1 억제제
Ozawa‐Umeta et al. Curcumin β‐D‐glucuronide exhibits anti–tumor effects on oxaliplatin‐resistant colon cancer with less toxicity in vivo
CN110573166B (zh) 用于癌症治疗的吉西他滨衍生物
CA3116234A1 (en) Combination therapy utilizing dna alkylating agents and atr inhibitors
JP2024511354A5 (https=)
TW202214243A (zh) 西奧羅尼聯合免疫檢查點抑製劑在抗腫瘤治療中的應用
US11248016B2 (en) Glycolipids and pharmaceutical compositions thereof for use in therapy
UA124748C2 (uk) N-заміщені індольні похідні
Liu et al. Bevacizumab‐enhanced antitumor effect of 5‐fluorouracil via upregulation of thymidine phosphorylase through vascular endothelial growth factor A/vascular endothelial growth factor receptor 2‐specificity protein 1 pathway
WO2013170637A1 (zh) 芍药苷类化合物在制备抗肿瘤药物中的用途
JP2023024618A (ja) がんの処置のためのトランス-[テトラクロロビス(1h-インダゾール)ルテネート(iii)]の使用
Fukushima et al. Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo
Razi et al. Antitumor activity of paclitaxel is significantly enhanced by a novel proapoptotic agent in non–small cell lung cancer
Wang et al. Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents
Xia et al. Synergistic Antitumor Effects of Anlotinib Combined with Oral 5‐Fluorouracil/S‐1 via Inhibiting Src/AKT Signaling Pathway in Small‐Cell Lung Cancer
Li et al. A multi-targeted tyrosine kinase inhibitor lenvatinib for the treatment of mice with advanced glioblastoma
GB2580963A (en) Cancer therapies
JP2007531728A5 (https=)
TW201929883A (zh) Parp抑制劑和溶瘤病毒用於製備抗腫瘤藥物之用途