JP2013526837A5 - - Google Patents
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- Publication number
- JP2013526837A5 JP2013526837A5 JP2012539021A JP2012539021A JP2013526837A5 JP 2013526837 A5 JP2013526837 A5 JP 2013526837A5 JP 2012539021 A JP2012539021 A JP 2012539021A JP 2012539021 A JP2012539021 A JP 2012539021A JP 2013526837 A5 JP2013526837 A5 JP 2013526837A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant listeria
- listeria strain
- her2
- pharmaceutical composition
- neu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26027709P | 2009-11-11 | 2009-11-11 | |
| PCT/US2010/056534 WO2011060260A2 (en) | 2009-11-11 | 2010-11-12 | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016152578A Division JP6329211B2 (ja) | 2016-08-03 | 2016-08-03 | 脳腫瘍または乳腺腫瘍の発症を遅延させるための医薬の製造における組換えリステリア株の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013526837A JP2013526837A (ja) | 2013-06-27 |
| JP2013526837A5 true JP2013526837A5 (enExample) | 2013-12-26 |
| JP5985397B2 JP5985397B2 (ja) | 2016-09-06 |
Family
ID=43992418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012539021A Expired - Fee Related JP5985397B2 (ja) | 2009-11-11 | 2010-11-12 | 組換えリステリア株およびそれを含む免疫原性組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9084747B2 (enExample) |
| EP (1) | EP2498808A4 (enExample) |
| JP (1) | JP5985397B2 (enExample) |
| WO (1) | WO2011060260A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| US9017660B2 (en) * | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| ES2741730T3 (es) | 2008-05-19 | 2020-02-12 | Advaxis Inc | Sistema de administración doble para antígenos heterólogos que comprende una cepa de Listeria recombinante atenuada por la mutación de dal/dat y la deleción de ActA que comprende una molécula de ácido nucleico que codifica una proteína de fusión de listeriolisina O - antígeno prostático específico |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| EP2498808A4 (en) | 2009-11-11 | 2014-01-08 | Advaxis | COMPOSITIONS AND METHOD FOR PREVENTING FLUID MUTATIONS IN THE TREATMENT OF TUMORS WITH HER2 / NEW OVEREXPRESSION |
| WO2012138377A2 (en) | 2010-10-01 | 2012-10-11 | Trustees Of The University Of Pennsylvania | The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
| LT2629791T (lt) * | 2010-10-19 | 2017-02-27 | Merial, Inc. | Her2 dnr vakcina, kaip naminių gyvūnų vėžio papildomas gydymas |
| WO2012125551A1 (en) | 2011-03-11 | 2012-09-20 | Advaxis | Listeria-based adjuvants |
| US9956276B2 (en) | 2012-01-19 | 2018-05-01 | Duke University | Vaccines against antigens involved in therapy resistance and methods of using same |
| EP2825195A4 (en) * | 2012-03-12 | 2015-10-07 | Advaxis Inc | INHIBITION OF SUPPRESSOR CELL FUNCTION AFTER TREATMENT WITH A LISTERIAL VACCINE |
| MX2016010791A (es) | 2014-02-18 | 2017-04-27 | Advaxis Inc | Inmunoterapia con multiples objetivos dirigida por biomarcadores. |
| CN103897067B (zh) * | 2014-04-16 | 2016-04-13 | 中国医学科学院基础医学研究所 | 一种治疗肿瘤的重组多肽 |
| MA39849A (fr) | 2014-04-24 | 2017-03-01 | Advaxis Inc | Souches de listeria utilisées comme vaccin recombinant et procédé de production |
| SG11201609135VA (en) * | 2014-05-02 | 2016-11-29 | Univ Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of her-2-positive cancers |
| WO2016007499A1 (en) | 2014-07-07 | 2016-01-14 | Duke University | Vaccines against an oncogenic isoform of her2 (erbb2) and methods of using the same |
| CA2954279C (en) | 2014-07-07 | 2023-11-14 | Duke University | Vaccines against an oncogenic isoform of esr1 and methods of using the same |
| WO2016011320A1 (en) * | 2014-07-18 | 2016-01-21 | Advaxis, Inc. | Bivalent listeria-based delivery system of heterologous antigens |
| US20160228530A1 (en) * | 2014-10-14 | 2016-08-11 | The Trustees Of The University Of Pennsylvania | Combination therapy for use in cancer therapy |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| CA2987239A1 (en) * | 2015-05-26 | 2016-12-01 | Advaxis, Inc. | Personalized delivery vector-based immunotherapy and uses thereof |
| CN108601731A (zh) | 2015-12-16 | 2018-09-28 | 磨石肿瘤生物技术公司 | 新抗原的鉴别、制造及使用 |
| CN108697779B (zh) | 2016-01-07 | 2023-09-19 | 杜克大学 | 癌症疫苗和递送方法 |
| US10487143B2 (en) | 2016-10-05 | 2019-11-26 | Duke University | Vaccines against HER3 antigens and methods of using the same |
| US11224665B2 (en) | 2016-10-05 | 2022-01-18 | Duke University | Mitochondrial antiviral signaling (MAVS) protein compositions and methods of using the same |
| MX2019005685A (es) | 2016-11-30 | 2019-09-04 | Advaxis Inc | Composiciones inmunogenicas contra mutaciones de cancer recurrentes y metodos de uso de las mismas. |
| KR102748132B1 (ko) | 2017-09-19 | 2025-01-02 | 어드박시스, 인크. | 박테리아 또는 리스테리아 균주의 동결건조를 위한 조성물 및 방법 |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| EP3714275A4 (en) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS |
| KR20200130399A (ko) | 2018-03-09 | 2020-11-18 | 어드박시스, 인크. | 리스테리아 균주의 약독화 및 감염성을 평가하기 위한 조성물 및 방법 |
| WO2019210034A1 (en) | 2018-04-27 | 2019-10-31 | Advaxis, Inc. | Compositions and methods for evaluating potency of listeria-based immunotherapeutics |
| BR112022026509A2 (pt) | 2020-06-23 | 2023-03-07 | Univ Colorado Regents | Métodos para diagnosticar patógenos respiratórios e prever resultados relacionados à covid-19 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US7794729B2 (en) | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US7820180B2 (en) * | 2004-09-24 | 2010-10-26 | The Trustees Of The University Of Pennsylvania | Listeria-based and LLO-based vaccines |
| US7662396B2 (en) | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| CA2223103A1 (en) | 1995-06-06 | 1996-12-12 | Isis Pharmaceuticals Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
| US5985662A (en) | 1995-07-13 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of hepatitis B virus replication |
| US5922583A (en) | 1995-10-17 | 1999-07-13 | Biostar Inc. | Methods for production of recombinant plasmids |
| US6740506B2 (en) | 1995-12-07 | 2004-05-25 | Diversa Corporation | End selection in directed evolution |
| KR20050084536A (ko) * | 1997-04-17 | 2005-08-26 | 세키스이가가쿠 고교가부시키가이샤 | 도전성 미립자의 제조장치, 그 제조장치를 이용한 도전성미립자의 제조방법, 그 제조장치를 이용하여 이루어지는전자회로부품 |
| US6099848A (en) | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US7198920B1 (en) | 1999-01-29 | 2007-04-03 | Corika Corporation | HER-2/neu fusion proteins |
| US6855320B2 (en) | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| JP2005527240A (ja) | 2002-05-29 | 2005-09-15 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 弱毒リステリア種とこれを使用する方法 |
| EP1408048A1 (en) | 2002-10-07 | 2004-04-14 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vaccines of enhanced immunogenicity, and methods for preparing such vaccines |
| CA2512812A1 (en) | 2003-01-09 | 2004-07-29 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector |
| DE10310261A1 (de) | 2003-03-05 | 2004-09-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Identifizierung von Antigen-Epitopen |
| JP2007509067A (ja) | 2003-10-15 | 2007-04-12 | メディミューン,インコーポレーテッド | リステリアに基づくEphA2ワクチン |
| US7855064B2 (en) * | 2004-08-13 | 2010-12-21 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free vaccines and methods for constructing and using same |
| ES2684749T3 (es) | 2004-08-13 | 2018-10-04 | The Trustees Of The University Of Pennsylvania | Métodos para construir vacunas sin resistencia a antibióticos |
| WO2007061848A2 (en) | 2005-11-17 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Methods for producing, growing, and preserving listeria vaccine vectors |
| US20070207171A1 (en) | 2006-03-01 | 2007-09-06 | Cerus Corporation | Engineered listeria and methods of use thereof |
| US8268326B2 (en) | 2006-08-15 | 2012-09-18 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
| WO2008130551A2 (en) | 2007-04-16 | 2008-10-30 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free listeria strains and methods for constructing and using same |
| US9017660B2 (en) * | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| ES2741730T3 (es) | 2008-05-19 | 2020-02-12 | Advaxis Inc | Sistema de administración doble para antígenos heterólogos que comprende una cepa de Listeria recombinante atenuada por la mutación de dal/dat y la deleción de ActA que comprende una molécula de ácido nucleico que codifica una proteína de fusión de listeriolisina O - antígeno prostático específico |
| EP2498808A4 (en) | 2009-11-11 | 2014-01-08 | Advaxis | COMPOSITIONS AND METHOD FOR PREVENTING FLUID MUTATIONS IN THE TREATMENT OF TUMORS WITH HER2 / NEW OVEREXPRESSION |
| US20110223187A1 (en) | 2010-02-15 | 2011-09-15 | Vafa Shahabi | Live listeria-based vaccines for central nervous system therapy |
-
2010
- 2010-11-12 EP EP10830785.1A patent/EP2498808A4/en not_active Ceased
- 2010-11-12 JP JP2012539021A patent/JP5985397B2/ja not_active Expired - Fee Related
- 2010-11-12 WO PCT/US2010/056534 patent/WO2011060260A2/en not_active Ceased
- 2010-11-12 US US12/945,386 patent/US9084747B2/en active Active
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