JP2013519699A5 - - Google Patents
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- JP2013519699A5 JP2013519699A5 JP2012553267A JP2012553267A JP2013519699A5 JP 2013519699 A5 JP2013519699 A5 JP 2013519699A5 JP 2012553267 A JP2012553267 A JP 2012553267A JP 2012553267 A JP2012553267 A JP 2012553267A JP 2013519699 A5 JP2013519699 A5 JP 2013519699A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule
- domain
- fviii
- another embodiment
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 102100026735 Coagulation factor VIII Human genes 0.000 claims description 38
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 38
- 108010054218 Factor VIII Proteins 0.000 claims description 18
- 102000001690 Factor VIII Human genes 0.000 claims description 18
- 229960000301 factor viii Drugs 0.000 claims description 18
- 230000004927 fusion Effects 0.000 claims description 17
- 108020001507 fusion proteins Proteins 0.000 claims description 13
- 102000037865 fusion proteins Human genes 0.000 claims description 13
- 108010087819 Fc receptors Proteins 0.000 claims description 11
- 102000009109 Fc receptors Human genes 0.000 claims description 11
- 108010047303 von Willebrand Factor Proteins 0.000 claims description 10
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 230000035772 mutation Effects 0.000 claims description 5
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- 102000002110 C2 domains Human genes 0.000 claims description 3
- 108050009459 C2 domains Proteins 0.000 claims description 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 208000031220 Hemophilia Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 description 31
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 7
- 230000004989 O-glycosylation Effects 0.000 description 7
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 102000009027 Albumins Human genes 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 238000012217 deletion Methods 0.000 description 4
- 239000002243 precursor Substances 0.000 description 4
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 3
- 239000012636 effector Substances 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 230000013595 glycosylation Effects 0.000 description 3
- 238000006206 glycosylation reaction Methods 0.000 description 3
- 108010068617 neonatal Fc receptor Proteins 0.000 description 3
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 3
- 108090001126 Furin Proteins 0.000 description 2
- 102000004961 Furin Human genes 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- -1 for example Chemical class 0.000 description 1
- 238000012405 in silico analysis Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10153715.7 | 2010-02-16 | ||
| EP10153715 | 2010-02-16 | ||
| US30617710P | 2010-02-19 | 2010-02-19 | |
| US61/306,177 | 2010-02-19 | ||
| PCT/EP2011/051959 WO2011101284A1 (en) | 2010-02-16 | 2011-02-10 | Factor viii fusion protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016021624A Division JP6185097B2 (ja) | 2010-02-16 | 2016-02-08 | 因子ｖｉｉｉ融合タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013519699A JP2013519699A (ja) | 2013-05-30 |
| JP2013519699A5 true JP2013519699A5 (enExample) | 2015-07-02 |
Family
ID=42244627
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553267A Withdrawn JP2013519699A (ja) | 2010-02-16 | 2011-02-10 | 因子ｖｉｉｉ融合タンパク質 |
| JP2016021624A Expired - Fee Related JP6185097B2 (ja) | 2010-02-16 | 2016-02-08 | 因子ｖｉｉｉ融合タンパク質 |
| JP2017144266A Withdrawn JP2017190342A (ja) | 2010-02-16 | 2017-07-26 | 因子ｖｉｉｉ融合タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016021624A Expired - Fee Related JP6185097B2 (ja) | 2010-02-16 | 2016-02-08 | 因子ｖｉｉｉ融合タンパク質 |
| JP2017144266A Withdrawn JP2017190342A (ja) | 2010-02-16 | 2017-07-26 | 因子ｖｉｉｉ融合タンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9493543B2 (enExample) |
| EP (2) | EP2536754A1 (enExample) |
| JP (3) | JP2013519699A (enExample) |
| CN (2) | CN102770450B (enExample) |
| WO (1) | WO2011101284A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2771999A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor vii compositions and methods of making and using same |
| WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
| EP2536753B1 (en) * | 2010-02-16 | 2017-12-20 | Novo Nordisk A/S | Factor viii molecules with reduced vwf binding |
| CN104271150A (zh) * | 2012-01-12 | 2015-01-07 | 比奥根艾迪克Ma公司 | 嵌合因子viii多肽及其用途 |
| JP6256882B2 (ja) | 2012-02-15 | 2018-01-10 | アムニクス オペレーティング インコーポレイテッド | 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途 |
| EP2822577B1 (en) * | 2012-02-15 | 2019-02-06 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
| JP2015515482A (ja) * | 2012-04-24 | 2015-05-28 | ノヴォ ノルディスク アー／エス | 血友病の治療に適する化合物 |
| WO2013160005A1 (en) | 2012-04-24 | 2013-10-31 | Novo Nordisk A/S | Pharmaceutical composition suitable for treatment of haemophilia |
| CN104661674A (zh) | 2012-07-11 | 2015-05-27 | 阿穆尼克斯运营公司 | 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途 |
| JP6618892B2 (ja) | 2013-04-23 | 2019-12-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 細菌バイオフィルムの遺伝的リプログラミング |
| TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途 |
| WO2015035342A2 (en) | 2013-09-08 | 2015-03-12 | Oligasis Llc | Factor viii zwitterionic polymer conjugates |
| AU2015204646B2 (en) | 2014-01-10 | 2020-08-27 | Bioverativ Therapeutics Inc. | Factor VIII chimeric proteins and uses thereof |
| WO2015132724A1 (en) * | 2014-03-05 | 2015-09-11 | Pfizer Inc. | Improved muteins of clotting factor viii |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| CN106687126B (zh) | 2014-08-04 | 2020-07-28 | 杰特有限公司 | 因子viii制剂 |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| ES2772933T3 (es) | 2015-03-06 | 2020-07-08 | CSL Behring Lengnau AG | Factor de von Willebrand modificado que tiene una semivida mejorada |
| EP3280397A4 (en) * | 2015-04-06 | 2018-08-22 | President and Fellows of Harvard College | Biosynthetic amyloid-based materials displaying functional protein sequences |
| WO2016198521A1 (en) * | 2015-06-10 | 2016-12-15 | Novo Nordisk A/S | Fviii fusion proteins |
| CN104926946B (zh) * | 2015-07-13 | 2021-09-17 | 中国科学院广州生物医药与健康研究院 | 具有延长体内半衰期的adamts13-mdtcs融合蛋白及其应用 |
| EA201890423A1 (ru) | 2015-08-03 | 2018-07-31 | Биовератив Терапьютикс Инк. | Слитые белки фактора ix, способы их получения и применения |
| KR20180031775A (ko) | 2015-08-12 | 2018-03-28 | 셀 머신스, 인크. | 긴 반감기 응집 복합체와 관련된 방법 및 조성물 |
| GB201520021D0 (en) * | 2015-11-13 | 2015-12-30 | Asterion Ltd | Fusion polypeptide |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| WO2017201428A1 (en) | 2016-05-19 | 2017-11-23 | President And Fellows Of Harvard College | Methods of making gels and film using curli nanofibers |
| US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
| CN106317226B (zh) | 2016-08-19 | 2017-09-05 | 安源医药科技（上海）有限公司 | 用于构建融合蛋白的连接肽 |
| CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技（上海）有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
| MX2019006444A (es) | 2016-12-02 | 2019-10-30 | Bioverativ Therapeutics Inc | Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos. |
| CN108623695B (zh) * | 2017-03-24 | 2022-03-15 | 中国科学院过程工程研究所 | 一种白蛋白结合肽-人睫状神经营养因子融合蛋白及其制备方法和应用 |
| CA3059938A1 (en) | 2017-04-14 | 2018-10-18 | Kodiak Sciences Inc. | Complement factor d antagonist antibodies and conjugates thereof |
| GB201706781D0 (en) | 2017-04-28 | 2017-06-14 | Univ Sheffield | Parathyroid hormone fusion polypeptide |
| EP3758737A4 (en) | 2018-03-02 | 2022-10-12 | Kodiak Sciences Inc. | IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF |
| WO2019219048A1 (zh) * | 2018-05-18 | 2019-11-21 | 北京辅仁瑞辉生物医药研究院有限公司 | 具有延长半衰期的融合多肽缀合物 |
| MX2020012103A (es) * | 2018-05-18 | 2021-01-29 | Zhengzhou Gensciences Inc | Proteina de fusion fviii mejorada y uso de la misma. |
| PL3793588T3 (pl) | 2018-05-18 | 2025-09-01 | Bioverativ Therapeutics Inc. | Sposoby leczenia hemofilii a |
| CN110950964B (zh) * | 2018-09-26 | 2021-06-18 | 安源医药科技（上海）有限公司 | 突变型单链人凝血因子viii融合蛋白及其制备方法与用途 |
| WO2021001522A1 (en) | 2019-07-04 | 2021-01-07 | CSL Behring Lengnau AG | A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii |
| EP4017521A1 (en) | 2019-09-02 | 2022-06-29 | Biotest AG | Factor viii protein with increased half-life |
| EP3785726A1 (en) | 2019-09-02 | 2021-03-03 | Biotest AG | Factor viii protein with increased half-life |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| US20220348637A1 (en) | 2019-11-11 | 2022-11-03 | CSL Behring Lengnau AG | Polypeptides for inducing tolerance to factor viii |
| EP4093745A4 (en) * | 2020-01-20 | 2024-03-06 | Wuxi Biologics Ireland Limited | NEW WASH BUFFER SOLUTION FOR AFFINITY CHROMATOGRAPHY |
| US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
| EP4217402A1 (en) * | 2020-09-23 | 2023-08-02 | Ablevia biotech GmbH | Compound for the prevention or treatment of autoantibody-mediated conditions |
| CN117337307A (zh) * | 2022-05-25 | 2024-01-02 | 江苏晟斯生物制药有限公司 | 具有延长的半衰期的fviii融合蛋白缀合物及其应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE87007T1 (de) | 1987-05-29 | 1993-04-15 | Sagami Chem Res | Fusionsprotein, enthaltend lymphotoxin. |
| AU2645588A (en) | 1987-12-04 | 1989-06-15 | Scripps Clinic And Research Foundation | The von willebrand factor binding domain of factor viii |
| US5843440A (en) | 1990-10-03 | 1998-12-01 | Redcell Canada, Inc. | Cellular and serum protein anchors for modulating pharmacokinetics |
| US6939677B1 (en) | 1990-11-01 | 2005-09-06 | Cancer Research Fund Of Contra Costa | Antibody with 46 kdalton HMFG antigen binding specificity, immunoassay kit and diagnostic method |
| US5859204A (en) * | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
| US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US6172213B1 (en) | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6524572B1 (en) | 2000-06-26 | 2003-02-25 | Rainbow Therapeutic Company | Targeting recombinant virus with a bispecific fusion protein ligand in coupling with an antibody to cells for gene therapy |
| ES2411007T3 (es) | 2001-10-10 | 2013-07-04 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
| CA2512974A1 (en) | 2003-01-13 | 2004-07-29 | Macrogenics, Inc. | Soluble fc.gamma.r fusion proteins and methods of use thereof |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| US20070106066A1 (en) | 2003-10-28 | 2007-05-10 | Alexander Cherkasky | Cherkasky fusion proteins containing antibody-, antigen- and microtubule-binding regions and immune response-triggering regions |
| WO2005113584A1 (en) | 2004-04-29 | 2005-12-01 | Board Of Regents, University Of Texas System | Methods and compositions comprising protein l immunoglobulin binding domains for cell-specific targeting |
| US20100143969A1 (en) | 2005-03-24 | 2010-06-10 | Neose Technologies, Inc. | Expression of soluble, active eukaryotic glycosyltransferases in prokaryotic organisms |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| US20090215025A1 (en) * | 2005-12-07 | 2009-08-27 | Technische Universitat Munchen | Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins |
| JP5102635B2 (ja) | 2006-01-31 | 2012-12-19 | 石原産業株式会社 | エンベロープウイルスの構成成分に親和性を有するポリペプチドと細胞内物質導入への使用 |
| WO2008025856A2 (en) * | 2006-09-01 | 2008-03-06 | Novo Nordisk Health Care Ag | Modified glycoproteins |
| US20080267949A1 (en) | 2006-12-05 | 2008-10-30 | Ablynx N.V. | Peptides capable of binding to serum proteins |
| CA2673459C (en) * | 2006-12-22 | 2016-09-13 | Stefan Schulte | Modified coagulation factors with prolonged in vivo half-life |
| AU2008209436A1 (en) * | 2007-01-23 | 2008-07-31 | Zymogenetics, Inc. | Soluble Fc gamma R1a for reducing inflammation |
| US8043621B2 (en) | 2007-05-10 | 2011-10-25 | Ramot At Tel Aviv University Ltd. | Recombinant fusion protein and polynucleotide construct for immunotoxin production |
| EP2203180B1 (en) | 2007-10-22 | 2012-11-21 | Merck Serono S.A. | Single ifn-beta fused to a mutated igg fc fragment |
| PL2257311T3 (pl) * | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Koniugaty cząsteczek czynnika VIII |
| PL2291523T3 (pl) * | 2008-06-24 | 2015-05-29 | Csl Behring Gmbh | Czynnik VIII, czynnik von Willebranda lub ich kompleksy o wydłużonym okresie półtrwania in vivo |
-
2011
- 2011-02-10 JP JP2012553267A patent/JP2013519699A/ja not_active Withdrawn
- 2011-02-10 EP EP11703448A patent/EP2536754A1/en not_active Withdrawn
- 2011-02-10 WO PCT/EP2011/051959 patent/WO2011101284A1/en not_active Ceased
- 2011-02-10 CN CN201180009864.4A patent/CN102770450B/zh not_active Expired - Fee Related
- 2011-02-10 US US13/574,686 patent/US9493543B2/en not_active Expired - Fee Related
- 2011-02-10 CN CN201510524808.4A patent/CN105153313A/zh not_active Withdrawn
- 2011-02-10 EP EP15159991.7A patent/EP2977055A1/en not_active Withdrawn
-
2016
- 2016-02-08 JP JP2016021624A patent/JP6185097B2/ja not_active Expired - Fee Related
- 2016-10-04 US US15/285,138 patent/US20170015729A1/en not_active Abandoned
-
2017
- 2017-07-26 JP JP2017144266A patent/JP2017190342A/ja not_active Withdrawn
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