JP2013517487A5 - - Google Patents
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- JP2013517487A5 JP2013517487A5 JP2012549291A JP2012549291A JP2013517487A5 JP 2013517487 A5 JP2013517487 A5 JP 2013517487A5 JP 2012549291 A JP2012549291 A JP 2012549291A JP 2012549291 A JP2012549291 A JP 2012549291A JP 2013517487 A5 JP2013517487 A5 JP 2013517487A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- cancer
- antigen
- cells
- associated carbohydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010028980 Neoplasm Diseases 0.000 claims description 166
- 201000011510 cancer Diseases 0.000 claims description 93
- 239000000427 antigen Substances 0.000 claims description 83
- 108091007433 antigens Proteins 0.000 claims description 83
- 102000036639 antigens Human genes 0.000 claims description 83
- 210000000130 stem cell Anatomy 0.000 claims description 60
- 150000001720 carbohydrates Chemical class 0.000 claims description 58
- 239000011230 binding agent Substances 0.000 claims description 46
- 210000004027 cell Anatomy 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 27
- 239000012634 fragment Substances 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 108090000288 Glycoproteins Proteins 0.000 claims description 6
- 102000003886 Glycoproteins Human genes 0.000 claims description 6
- 239000002771 cell marker Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 102100032912 CD44 antigen Human genes 0.000 claims description 5
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 5
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims description 5
- 108010058905 CD44v6 antigen Proteins 0.000 claims description 4
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 4
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 4
- 101001133085 Homo sapiens Sialomucin core protein 24 Proteins 0.000 claims description 4
- 229940127089 cytotoxic agent Drugs 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 239000002246 antineoplastic agent Substances 0.000 claims description 3
- 230000014509 gene expression Effects 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 206010027476 Metastases Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
- 206010057249 Phagocytosis Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000003837 Second Primary Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 2
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 230000005907 cancer growth Effects 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 239000002254 cytotoxic agent Substances 0.000 claims description 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 201000010536 head and neck cancer Diseases 0.000 claims description 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 230000003211 malignant effect Effects 0.000 claims description 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
- 230000009401 metastasis Effects 0.000 claims description 2
- -1 multibody Proteins 0.000 claims description 2
- 210000004882 non-tumor cell Anatomy 0.000 claims description 2
- 210000004798 organs belonging to the digestive system Anatomy 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 2
- 230000008782 phagocytosis Effects 0.000 claims description 2
- 238000010186 staining Methods 0.000 claims description 2
- 230000004083 survival effect Effects 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims 1
- 230000004186 co-expression Effects 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000012217 radiopharmaceutical Substances 0.000 claims 1
- 229940121896 radiopharmaceutical Drugs 0.000 claims 1
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29673810P | 2010-01-20 | 2010-01-20 | |
| US61/296,738 | 2010-01-20 | ||
| EP10000527.1 | 2010-01-20 | ||
| EP10000527A EP2347769A1 (en) | 2010-01-20 | 2010-01-20 | Cancer stem cell markers and uses thereof |
| PCT/EP2011/000217 WO2011089004A1 (en) | 2010-01-20 | 2011-01-20 | Cancer stem cell markers and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253064A Division JP2016047848A (ja) | 2010-01-20 | 2015-12-25 | がん幹細胞マーカーおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013517487A JP2013517487A (ja) | 2013-05-16 |
| JP2013517487A5 true JP2013517487A5 (OSRAM) | 2014-02-06 |
Family
ID=42173400
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549291A Ceased JP2013517487A (ja) | 2010-01-20 | 2011-01-20 | がん幹細胞マーカーおよびその使用 |
| JP2015253064A Withdrawn JP2016047848A (ja) | 2010-01-20 | 2015-12-25 | がん幹細胞マーカーおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253064A Withdrawn JP2016047848A (ja) | 2010-01-20 | 2015-12-25 | がん幹細胞マーカーおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120294859A1 (OSRAM) |
| EP (2) | EP2347769A1 (OSRAM) |
| JP (2) | JP2013517487A (OSRAM) |
| CN (1) | CN102753199A (OSRAM) |
| AU (1) | AU2011208874B2 (OSRAM) |
| BR (1) | BR112012018132A2 (OSRAM) |
| CA (1) | CA2786212A1 (OSRAM) |
| WO (1) | WO2011089004A1 (OSRAM) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| DK2318832T3 (da) | 2008-07-15 | 2014-01-20 | Academia Sinica | Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| WO2012031280A2 (en) | 2010-09-03 | 2012-03-08 | Stem Centrx, Inc. | Identification and enrichment of cell subpopulations |
| US9778264B2 (en) | 2010-09-03 | 2017-10-03 | Abbvie Stemcentrx Llc | Identification and enrichment of cell subpopulations |
| WO2012039430A1 (ja) * | 2010-09-21 | 2012-03-29 | 株式会社Ｇｐバイオサイエンス | がん幹細胞の単離方法 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| US9914956B2 (en) | 2012-08-18 | 2018-03-13 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| US20160025717A1 (en) | 2013-03-14 | 2016-01-28 | Emory University | Hyposialylation disorders |
| EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| KR102298172B1 (ko) | 2013-09-06 | 2021-09-06 | 아카데미아 시니카 | 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화 |
| NZ714555A (en) | 2013-09-17 | 2020-03-27 | Obi Pharma Inc | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| KR20160104727A (ko) | 2014-01-16 | 2016-09-05 | 아카데미아 시니카 | 암의 치료 및 검출을 위한 조성물 및 방법 |
| JP6562942B2 (ja) | 2014-03-27 | 2019-08-28 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 反応性標識化合物およびその使用 |
| US10023651B2 (en) | 2014-04-18 | 2018-07-17 | The Research Foundation For The State University Of New York | Humanized anti-TF-antigen antibodies |
| RU2699717C2 (ru) * | 2014-04-18 | 2019-09-09 | Дзе Ресёч Фаундэйшен Фор Дзе Штат Юниверсити Ов Нью-Йорк | Гуманизированные антитела к антигену Томсена-Фриденрайха |
| CN103969437B (zh) * | 2014-04-22 | 2017-03-22 | 广州恒泰生物科技有限公司 | 用于卵巢癌早中期快速诊断试剂盒的制备方法 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CA2950440A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| CN107074945B (zh) | 2014-05-27 | 2021-08-24 | 中央研究院 | 增进抗体功效的通用糖型的组合物及方法 |
| CA2950415A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| KR102494193B1 (ko) | 2014-05-28 | 2023-01-31 | 아카데미아 시니카 | 항-ｔｎｆ-알파 글리코항체 및 이의 용도 |
| KR102422375B1 (ko) | 2014-09-08 | 2022-07-18 | 아카데미아 시니카 | 당지질을 사용한 인간 iNKT 세포 활성화 |
| MX2017006167A (es) | 2014-11-12 | 2018-03-23 | Siamab Therapeutics Inc | Compuestos que interactúan con glicanos y métodos de uso. |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| JP2018510844A (ja) * | 2015-01-24 | 2018-04-19 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | がんマーカーおよびその使用方法 |
| EP3248005B1 (en) | 2015-01-24 | 2020-12-09 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| EP3261675A1 (en) | 2015-02-25 | 2018-01-03 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Sialylation-increasing therapies for diseases associated with oxidative stress |
| AR105910A1 (es) | 2015-09-04 | 2017-11-22 | Obi Pharma Inc | Matrices de glicano y método de uso |
| CN116217729A (zh) | 2015-11-12 | 2023-06-06 | 思进公司 | 聚糖相互作用化合物及使用方法 |
| WO2017100796A1 (en) * | 2015-12-11 | 2017-06-15 | SINACA, Academia | Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers |
| WO2017156192A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| EP3436482A4 (en) | 2016-03-29 | 2020-03-11 | OBI Pharma, Inc. | ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| CA3021548A1 (en) | 2016-04-22 | 2017-10-26 | Obi Pharma, Inc. | Cancer immunotherapy by immune activation or immune modulation via globo series antigens |
| WO2018022933A1 (en) | 2016-07-27 | 2018-02-01 | Obi Pharma, Inc. | Immunogenic/therapeutic glycan compositions and uses thereof |
| KR102528998B1 (ko) | 2016-07-29 | 2023-05-03 | 오비아이 파머 인코퍼레이티드 | 인간 항체, 제약 조성물 및 방법 |
| AU2017316663B2 (en) | 2016-08-22 | 2024-02-22 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| US11401330B2 (en) | 2016-11-17 | 2022-08-02 | Seagen Inc. | Glycan-interacting compounds and methods of use |
| EP3543337B1 (en) * | 2016-11-18 | 2022-04-20 | Astellas Pharma Inc. | Novel anti-human muc1 antibody fab fragment |
| CN110290800A (zh) | 2016-11-21 | 2019-09-27 | 台湾浩鼎生技股份有限公司 | 缀合生物分子、医药组合物及方法 |
| WO2018160909A1 (en) | 2017-03-03 | 2018-09-07 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| CA3055438A1 (en) * | 2017-03-29 | 2018-10-04 | Glycotope Gmbh | Multispecific antibody constructs binding to muc1 and cd3 |
| TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段 |
| AU2019227607C1 (en) | 2018-02-27 | 2023-07-20 | Incyte Corporation | Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors |
| PT110722B (pt) * | 2018-05-03 | 2021-08-17 | Instituto De Patologia E Imunologia Molecular Da Univ Do Porto Ipatimup | Uso de anticorpos para o antigénio thomsen-friedenreich num método e estojo para avaliação de instabilidade de microsatelites |
| WO2019221269A1 (ja) | 2018-05-17 | 2019-11-21 | アステラス製薬株式会社 | 抗ヒトＭＵＣ１抗体Ｆａｂフラグメント、ペプチドリンカー及び／又は配位子を含む複合体 |
| MA52940A (fr) | 2018-05-18 | 2021-04-28 | Incyte Corp | Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b |
| SG11202010496WA (en) | 2018-05-18 | 2020-12-30 | Daiichi Sankyo Co Ltd | Anti-muc1 antibody-drug conjugate |
| WO2020006176A1 (en) | 2018-06-27 | 2020-01-02 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| CA3105721A1 (en) | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
| CN112839683B (zh) | 2018-10-10 | 2023-11-14 | 安斯泰来制药株式会社 | 含有标记部-抗人抗体Fab片段复合物的药物组合物 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| CN110161241A (zh) * | 2019-04-30 | 2019-08-23 | 丁晓昆 | 一种快速检测生物组织切片cosmc基因突变试剂盒 |
| CN115135341A (zh) | 2020-01-03 | 2022-09-30 | 因赛特公司 | 抗cd73抗体及其用途 |
| KR20220137013A (ko) | 2020-01-03 | 2022-10-11 | 인사이트 코포레이션 | Cd73 억제제 및 a2a/a2b 아데노신 수용체 억제제 병용 요법 |
| CN113461798A (zh) * | 2020-03-18 | 2021-10-01 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原、输卵管癌靶标抗原刺激培养的ctl细胞及其应用 |
| EP4171749A1 (en) | 2020-06-30 | 2023-05-03 | Glycotope GmbH | Humanized antibodies against lewis y |
| WO2022147092A1 (en) | 2020-12-29 | 2022-07-07 | Incyte Corporation | Combination therapy comprising a2a/a2b inhibitors, pd-1/pd-l1 inhibitors, and anti-cd73 antibodies |
| WO2023023840A1 (en) * | 2021-07-16 | 2023-03-02 | Université de Montréal | Novel tumor-specific antigens for cancer stem cells and uses thereof |
| CN113804531B (zh) * | 2021-09-10 | 2024-02-06 | 北京大学 | 一种细胞高活性染色方法 |
| CN119955728A (zh) * | 2022-08-01 | 2025-05-09 | 首都医科大学附属北京胸科医院 | 恶性表型大细胞肺癌细胞株及其应用 |
| CN116718774A (zh) * | 2023-07-07 | 2023-09-08 | 杭州准星医学科技有限公司 | 一种用于肿瘤体外诊断的试剂盒及其使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020145A (en) * | 1989-06-30 | 2000-02-01 | Bristol-Myers Squibb Company | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 |
| DE10256900A1 (de) * | 2002-11-29 | 2004-06-24 | Nemod Immuntherapie Ag | Tumorspezifische Erkennungsmoleküle |
| PT1654353E (pt) | 2003-08-18 | 2013-08-23 | Glycotope Gmbh | Linhas de células tumorais nm f9 (dsm acc2606) e nm d4 (dsm acc2605), suas utilizações |
| WO2006012616A2 (en) * | 2004-07-26 | 2006-02-02 | The Research Foundation Of State University Of New York At Buffalo Stor Intellectual Property Division | Therapeutic use of anti-tf-antigen antibody |
| WO2007079448A2 (en) * | 2006-01-03 | 2007-07-12 | University Of Georgia Research Foundation, Inc. | Three component carbohydrate vaccine |
| WO2007140011A2 (en) * | 2006-05-26 | 2007-12-06 | The Government Of The United States Of America | Erythroid progenitor cells and methods for producing parvovirus b19 therein |
-
2010
- 2010-01-20 EP EP10000527A patent/EP2347769A1/en not_active Withdrawn
-
2011
- 2011-01-20 US US13/574,260 patent/US20120294859A1/en not_active Abandoned
- 2011-01-20 BR BR112012018132A patent/BR112012018132A2/pt active Search and Examination
- 2011-01-20 JP JP2012549291A patent/JP2013517487A/ja not_active Ceased
- 2011-01-20 WO PCT/EP2011/000217 patent/WO2011089004A1/en not_active Ceased
- 2011-01-20 EP EP11703580A patent/EP2525832A1/en not_active Withdrawn
- 2011-01-20 CN CN2011800065922A patent/CN102753199A/zh active Pending
- 2011-01-20 AU AU2011208874A patent/AU2011208874B2/en not_active Ceased
- 2011-01-20 CA CA2786212A patent/CA2786212A1/en not_active Abandoned
-
2015
- 2015-12-25 JP JP2015253064A patent/JP2016047848A/ja not_active Withdrawn
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