|
US2773702A
(en)
|
1955-05-16 |
1956-12-11 |
William T Safko |
Jack-knifing preventing device for tractor-trailers
|
|
FR2413974A1
(fr)
|
1978-01-06 |
1979-08-03 |
David Bernard |
Sechoir pour feuilles imprimees par serigraphie
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4703004A
(en)
|
1984-01-24 |
1987-10-27 |
Immunex Corporation |
Synthesis of protein with an identification peptide
|
|
DE3668186D1
(de)
|
1985-04-01 |
1990-02-15 |
Celltech Ltd |
Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert.
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
|
DE69029036T2
(de)
|
1989-06-29 |
1997-05-22 |
Medarex Inc |
Bispezifische reagenzien für die aids-therapie
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
AU651068B2
(en)
|
1989-07-21 |
1994-07-14 |
Washington University |
Recombinantly produced human membrane cofactor protein (MCP)
|
|
US5514787A
(en)
|
1989-07-21 |
1996-05-07 |
Washington University |
DNA sequences encoding human membrane cofactor protein (MCP)
|
|
FR2650598B1
(fr)
|
1989-08-03 |
1994-06-03 |
Rhone Poulenc Sante |
Derives de l'albumine a fonction therapeutique
|
|
WO1991005855A1
(en)
|
1989-10-12 |
1991-05-02 |
Imutran Limited |
Modified biological material
|
|
US6482404B1
(en)
|
1989-10-12 |
2002-11-19 |
David James White |
Transplantation of tissue comprising a DNA sequence encoding a homologous complement restriction factor
|
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5846715A
(en)
|
1990-05-11 |
1998-12-08 |
The Austin Research Institute |
CD46 variants
|
|
EP0537171B1
(en)
|
1990-05-11 |
2002-09-18 |
The Austin Research Institute |
CD46 isoforms
|
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
|
JPH0445796A
(ja)
*
|
1990-06-08 |
1992-02-14 |
Kyowa Hakko Kogyo Co Ltd |
抗ｍｃｐモノクローナル抗体
|
|
ES2139598T3
(es)
|
1990-07-10 |
2000-02-16 |
Medical Res Council |
Procedimientos para la produccion de miembros de parejas de union especifica.
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
JP2938569B2
(ja)
|
1990-08-29 |
1999-08-23 |
ジェンファーム インターナショナル，インコーポレイティド |
異種免疫グロブリンを作る方法及びトランスジェニックマウス
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
WO1992010591A1
(en)
|
1990-12-14 |
1992-06-25 |
Cell Genesys, Inc. |
Chimeric chains for receptor-associated signal transduction pathways
|
|
ATE439435T1
(de)
|
1991-03-01 |
2009-08-15 |
Dyax Corp |
Chimäres protein mit mikroprotein mit zwei oder mehr disulfidbindungen und ausgestaltungen davon
|
|
EP1471142B1
(en)
|
1991-04-10 |
2008-11-19 |
The Scripps Research Institute |
Heterodimeric receptor libraries using phagemids
|
|
EP1413587A2
(en)
|
1991-05-03 |
2004-04-28 |
Washington University |
Modified complement system regulator
|
|
JPH06507398A
(ja)
|
1991-05-14 |
1994-08-25 |
リプリジェン コーポレーション |
Ｈｉｖ感染治療のための異種複合抗体
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
FR2686901A1
(fr)
|
1992-01-31 |
1993-08-06 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
CA2140280A1
(en)
|
1992-08-17 |
1994-03-03 |
Avi J. Ashkenazi |
Bispecific immunoadhesins
|
|
CA2141602A1
(en)
|
1992-08-26 |
1994-03-03 |
Philip Leder |
Use of the cytokine ip-10 as an anti-tumor agent
|
|
US7744877B2
(en)
|
1992-11-13 |
2010-06-29 |
Biogen Idec Inc. |
Expression and use of anti-CD20 Antibodies
|
|
PT752248E
(pt)
|
1992-11-13 |
2001-01-31 |
Idec Pharma Corp |
Aplicacao terapeutica de anticorpos quimericos e marcados radioactivamente contra antigenios de diferenciacao restrita de linfocitos b humanos para o tratamento do linfoma de celulas b
|
|
US5679546A
(en)
|
1993-09-24 |
1997-10-21 |
Cytomed, Inc. |
Chimeric proteins which block complement activation
|
|
NZ292124A
(en)
|
1994-07-29 |
1998-10-28 |
Smithkline Beecham Plc |
Il-4 antagonist comprising a fusion of a mutant il-4-antibody fragment
|
|
AUPM772494A0
(en)
|
1994-08-30 |
1994-09-22 |
Austin Research Institute, The |
Improvements in production of proteins in host cells
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
ES2176484T3
(es)
|
1995-08-18 |
2002-12-01 |
Morphosys Ag |
Bancos de proteinas/(poli)peptidos.
|
|
AU5711196A
(en)
|
1996-03-14 |
1997-10-01 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule i
|
|
AU728657B2
(en)
|
1996-03-18 |
2001-01-18 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
KR100497017B1
(ko)
|
1996-03-22 |
2005-11-29 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
고사유도분자ii
|
|
AUPN912396A0
(en)
|
1996-04-03 |
1996-05-02 |
St. Vincent's Hospital (Melbourne) Limited |
Complement mediated rejection of transfected tumour cells
|
|
US6086876A
(en)
|
1997-02-07 |
2000-07-11 |
The Wistar Insitute |
Methods and compositions for the inhibition of interleukin-12 production
|
|
GB2339430A
(en)
|
1997-05-21 |
2000-01-26 |
Biovation Ltd |
Method for the production of non-immunogenic proteins
|
|
CA2309541C
(en)
|
1997-11-03 |
2011-01-11 |
Human Genome Sciences, Inc. |
Vegi, an inhibitor of angiogenesis and tumor growth
|
|
ATE531812T1
(de)
|
1997-12-05 |
2011-11-15 |
Scripps Research Inst |
Humanisierung von nager-antikörpern
|
|
PT1071700E
(pt)
|
1998-04-20 |
2010-04-23 |
Glycart Biotechnology Ag |
Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
|
|
DE69934967T2
(de)
|
1998-12-08 |
2007-12-06 |
Biovation Ltd. |
Verfahren zur verminderung der immunogenität von proteinen
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
ES2694002T3
(es)
|
1999-01-15 |
2018-12-17 |
Genentech, Inc. |
Polipéptido que comprende una región Fc de IgG1 humana variante
|
|
WO2000061739A1
(fr)
|
1999-04-09 |
2000-10-19 |
Kyowa Hakko Kogyo Co., Ltd. |
Methode de regulation de l'activite d'une molecule immunologiquement fonctionnelle
|
|
US6642009B2
(en)
|
1999-05-17 |
2003-11-04 |
Cytyc Health Corporation |
Isolated ductal fluid sample
|
|
EP1094110A1
(en)
|
1999-10-21 |
2001-04-25 |
Leadd B.V. |
Apoptosis inducing proteinaceous substance
|
|
AU2001261024A1
(en)
|
2000-04-12 |
2001-10-30 |
Delta Biotechnology Limited |
Albumin fusion proteins
|
|
US20030129677A1
(en)
|
2000-05-12 |
2003-07-10 |
Martens Mark G. |
Diagnostic method for screening complement regulatory protein levels
|
|
AU2001261259A1
(en)
|
2000-05-12 |
2001-11-26 |
Anil K. Kaul |
Diagnostic method for screening complement regulatory protein levels
|
|
EP1184458A1
(en)
*
|
2000-08-28 |
2002-03-06 |
U-BISys B.V. |
Differentially expressed CD46 epitopes, proteinaceous molecules capable of binding thereto, and uses thereof
|
|
US20020115065A1
(en)
|
2000-08-28 |
2002-08-22 |
Ton Logtenberg |
Differentially expressed epitopes and uses thereof
|
|
MXPA03002974A
(es)
|
2000-10-06 |
2004-05-05 |
Kyowa Hakko Kogyo Kk |
Celulas que producen composiciones de anticuerpo.
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
EP1333032A4
(en)
|
2000-10-06 |
2005-03-16 |
Kyowa Hakko Kogyo Kk |
PROCESS FOR PURIFYING ANTIBODY
|
|
US7138496B2
(en)
|
2002-02-08 |
2006-11-21 |
Genetastix Corporation |
Human monoclonal antibodies against human CXCR4
|
|
ES2649037T3
(es)
|
2000-12-12 |
2018-01-09 |
Medimmune, Llc |
Moléculas con semividas prolongadas, composiciones y usos de las mismas
|
|
CA2463927A1
(en)
|
2001-10-16 |
2003-04-24 |
Raven Biotechnologies, Inc. |
Antibodies that bind to cancer-associated antigen cd46 and methods of use thereof
|
|
US20040126762A1
(en)
|
2002-12-17 |
2004-07-01 |
Morris David W. |
Novel compositions and methods in cancer
|
|
NZ532526A
(en)
|
2001-10-25 |
2007-01-26 |
Genentech Inc |
Compositions comprising a glycoprotein having a Fc region
|
|
JP2005512044A
(ja)
|
2001-12-03 |
2005-04-28 |
アブジェニックス・インコーポレーテッド |
結合特性に基づく抗体分類
|
|
ATE477276T1
(de)
|
2002-03-01 |
2010-08-15 |
Immunomedics Inc |
Internalisierung von anti cd74 monoklonalen antikörpern und deren verwendungen
|
|
EP1487492A4
(en)
|
2002-03-04 |
2008-10-01 |
Medimmune Inc |
PREVENTION OR TREATMENT OF CANCER USING INTEGRIN ALPHAVBETA3 ANTAGONISTS COMBINED WITH OTHER AGENTS
|
|
ES2627445T3
(es)
|
2002-05-01 |
2017-07-28 |
Miltenyi Biotec Technology, Inc. |
Partículas de vector de lentivirus resistentes a la inactivación por el complemento
|
|
US7906118B2
(en)
|
2005-04-06 |
2011-03-15 |
Ibc Pharmaceuticals, Inc. |
Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology
|
|
CN105884893A
(zh)
|
2002-07-18 |
2016-08-24 |
莫鲁斯有限公司 |
抗体混合物的重组生产
|
|
EP3321282A1
(en)
|
2002-09-27 |
2018-05-16 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US7534427B2
(en)
|
2002-12-31 |
2009-05-19 |
Immunomedics, Inc. |
Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
|
|
US7575893B2
(en)
|
2003-01-23 |
2009-08-18 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
|
CN1767860A
(zh)
|
2003-01-31 |
2006-05-03 |
免疫医疗公司 |
施用治疗和诊断剂的方法和组合物
|
|
US20050008625A1
(en)
|
2003-02-13 |
2005-01-13 |
Kalobios, Inc. |
Antibody affinity engineering by serial epitope-guided complementarity replacement
|
|
DK1633784T3
(da)
|
2003-05-09 |
2011-10-24 |
Diadexus Inc |
OVR110 antistofsammensætninger og -anvendelsesfremgangsmåder
|
|
EP1482052A1
(en)
*
|
2003-05-27 |
2004-12-01 |
Cytos Biotechnology AG |
Modified polypeptides for targeting cell-entry of the adenoviruses of subtype B
|
|
US7425421B2
(en)
|
2003-06-26 |
2008-09-16 |
Litron Laboratories, Ltd. |
Method for the enumeration of micronucleated erythrocyte populations while distinguishing platelets and/or platelet-associated aggregates
|
|
EP2216342B1
(en)
|
2003-07-31 |
2015-04-22 |
Immunomedics, Inc. |
Anti-CD19 antibodies
|
|
WO2005019258A2
(en)
|
2003-08-11 |
2005-03-03 |
Genentech, Inc. |
Compositions and methods for the treatment of immune related diseases
|
|
DE60300339T2
(de)
|
2003-08-25 |
2006-04-13 |
Mtm Laboratories Ag |
Verfahren zum Nachweis von Karzinomen in solubilisierten zervikalen Körperproben
|
|
MX2007001221A
(es)
|
2004-08-04 |
2007-03-23 |
Amgen Inc |
Anticuerpos para proteina dickkopf-1 (dkk-1).
|
|
US20070123448A1
(en)
|
2005-11-23 |
2007-05-31 |
The Hospital For Sick Children |
Novel chemical entities affecting neuroblastoma tumor-initiating cells
|
|
SG170750A1
(en)
|
2006-03-17 |
2011-05-30 |
Biogen Idec Inc |
Stabilized polypeptide compositions
|
|
WO2007145901A1
(en)
|
2006-06-06 |
2007-12-21 |
University Of Tennessee Research Foundation |
Compositions enriched in neoplastic stem cells and methods comprising same
|
|
WO2008007648A1
(fr)
*
|
2006-07-10 |
2008-01-17 |
Institute For Antibodies Co., Ltd. |
Procédé de classification d'antigène, procédé d'identification d'antigène, procédé d'obtention d' un ensemble d'antigènes ou d'anticorps, procédés de construction d'un panel d'anticorps, anticorps et ens
|
|
WO2008008917A2
(en)
|
2006-07-12 |
2008-01-17 |
Mayo Foundation For Medical Education And Research |
Hydroxyapatite particles
|
|
DK3207941T6
(da)
|
2006-09-07 |
2020-11-09 |
Scott & White Memorial Hospital |
Fremgangsmåder og sammensætninger baseret på diphtheritoksin-interleukin-3-konjugater
|
|
WO2008034076A2
(en)
|
2006-09-15 |
2008-03-20 |
The Johns Hopkins University |
Cyclophosphamide in combination with immune therapeutics
|
|
EP1975239A1
(en)
*
|
2006-09-27 |
2008-10-01 |
Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer |
Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening
|
|
KR101523698B1
(ko)
|
2007-01-22 |
2015-05-29 |
마크로제닉스 웨스트 인코퍼레이티드 |
사람 암 줄기세포
|
|
EP2022848A1
(en)
|
2007-08-10 |
2009-02-11 |
Hubrecht Institut |
A method for identifying, expanding, and removing adult stem cells and cancer stem cells
|
|
CA2697922A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Compositions that bind multiple epitopes of igf-1r
|
|
WO2009043051A2
(en)
|
2007-09-27 |
2009-04-02 |
Biogen Idec Ma Inc. |
Cd23 binding molecules and methods of use thereof
|
|
CA2712404A1
(en)
|
2008-01-18 |
2009-07-23 |
Hadasit Medical Research Services & Development Ltd. |
Combination therapy of beta-glycolipids and antibodies for the treatment of immune-related disorders
|
|
JP5699362B2
(ja)
*
|
2008-04-10 |
2015-04-08 |
アイビーシー ファーマスーティカルズ，インコーポレイテッド |
薬物動態が改善された四量体サイトカインをドック・アンド・ロック（ｄｎｌ）技術により調製するためのモジュール法
|
|
WO2009129538A2
(en)
*
|
2008-04-18 |
2009-10-22 |
Xencor, Inc. |
Human equivalent monoclonal antibodies engineered from nonhuman variable regions
|
|
WO2010037134A2
(en)
|
2008-09-29 |
2010-04-01 |
Stemlifeline, Inc. |
Multi-stage stem cell carcinogenesis
|
|
EP2414385B1
(en)
|
2009-03-31 |
2015-04-22 |
University of Washington |
Compositions and methods for modulating the activity of complement regulatory proteins on target cells
|
|
US20110020221A1
(en)
|
2009-04-09 |
2011-01-27 |
The Johns Hopkins University |
Cancer stem cell expression patterns and compounds to target cancer stem cells
|
|
SG185483A1
(en)
|
2010-05-14 |
2012-12-28 |
Univ Colorado Regents |
Improved complement receptor 2 (cr2) targeting groups
|
|
WO2013119964A2
(en)
|
2012-02-08 |
2013-08-15 |
Stem Centrx, Inc. |
Identification and enrichment of cell subpopulations
|
|
SG10201506767QA
(en)
|
2010-09-03 |
2015-10-29 |
Stemcentrx Inc |
Identification and enrichment of cell subpopulations
|
|
US9778264B2
(en)
|
2010-09-03 |
2017-10-03 |
Abbvie Stemcentrx Llc |
Identification and enrichment of cell subpopulations
|
|
SG10201506959SA
(en)
*
|
2010-09-03 |
2015-10-29 |
Stemcentrx Inc |
Novel modulators and methods of use
|
|
US20130061340A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
US20130061342A1
(en)
|
2011-09-02 |
2013-03-07 |
Stem Centrx, Inc. |
Identification and Enrichment of Cell Subpopulations
|
|
MX377339B
(es)
|
2013-08-28 |
2025-03-06 |
Abbvie Stemcentrx Llc |
Metodos de conjugacion de anticuerpos especificos de sitio y composiciones.
|
|
US20190209704A1
(en)
|
2014-10-20 |
2019-07-11 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions and methods of use
|
|
US11392902B2
(en)
|
2017-06-06 |
2022-07-19 |
United Parcel Service Of America, Inc. |
Systems, methods, apparatuses and computer program products for providing notification of items for pickup and delivery
|