JP2013512694A - 養子細胞療法のための細胞を培養する方法 - Google Patents
養子細胞療法のための細胞を培養する方法 Download PDFInfo
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- JP2013512694A JP2013512694A JP2012543271A JP2012543271A JP2013512694A JP 2013512694 A JP2013512694 A JP 2013512694A JP 2012543271 A JP2012543271 A JP 2012543271A JP 2012543271 A JP2012543271 A JP 2012543271A JP 2013512694 A JP2013512694 A JP 2013512694A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26776109P | 2009-12-08 | 2009-12-08 | |
| US61/267,761 | 2009-12-08 | ||
| PCT/US2010/059591 WO2011072088A2 (en) | 2009-12-08 | 2010-12-08 | Improved methods of cell culture for adoptive cell therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015095864A Division JP2015133997A (ja) | 2009-12-08 | 2015-05-08 | 養子細胞療法のための細胞を培養する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013512694A true JP2013512694A (ja) | 2013-04-18 |
| JP2013512694A5 JP2013512694A5 (https=) | 2014-01-30 |
Family
ID=44082417
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543271A Pending JP2013512694A (ja) | 2009-12-08 | 2010-12-08 | 養子細胞療法のための細胞を培養する方法 |
| JP2015095864A Pending JP2015133997A (ja) | 2009-12-08 | 2015-05-08 | 養子細胞療法のための細胞を培養する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015095864A Pending JP2015133997A (ja) | 2009-12-08 | 2015-05-08 | 養子細胞療法のための細胞を培養する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8809050B2 (https=) |
| EP (2) | EP2510086A4 (https=) |
| JP (2) | JP2013512694A (https=) |
| CN (1) | CN102762719A (https=) |
| CA (1) | CA2783550A1 (https=) |
| IL (1) | IL220232A0 (https=) |
| SG (1) | SG181559A1 (https=) |
| WO (1) | WO2011072088A2 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015133997A (ja) * | 2009-12-08 | 2015-07-27 | ウィルソン ウォルフ マニュファクチャリング コーポレイションWilson Wolf Manufacturing Corporation | 養子細胞療法のための細胞を培養する方法 |
| JP2016530895A (ja) * | 2013-09-23 | 2016-10-06 | ウィルソン ウォルフ マニュファクチャリング コーポレイションWilson Wolf Manufacturing Corporation | 動物細胞を遺伝子改変する改良された方法 |
| US9567565B2 (en) | 2009-12-08 | 2017-02-14 | Juan F. Vera | Methods of cell culture for adoptive cell therapy |
| CN110199016A (zh) * | 2016-11-17 | 2019-09-03 | 艾欧凡斯生物治疗公司 | 残余肿瘤浸润淋巴细胞及其制备和使用方法 |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3101122B1 (en) | 2009-08-24 | 2023-06-14 | Baylor College of Medicine | Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses |
| WO2012129201A1 (en) * | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| CN104769104A (zh) | 2011-12-12 | 2015-07-08 | 细胞药物有限公司 | 扩大t细胞的方法 |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| PT2812431T (pt) | 2012-02-09 | 2019-10-18 | Baylor College Medicine | Pepmixes para gerar ctls multivirais com larga especifidade |
| SG11201407226WA (en) * | 2012-05-18 | 2014-12-30 | Wolf Wilson Mfg Corp | Improved methods of cell culture for adoptive cell therapy |
| CN104411819B (zh) * | 2012-06-11 | 2019-05-10 | 威尔逊沃夫制造公司 | 用于过继细胞疗法的改进的细胞培养方法 |
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| CN118562610A (zh) * | 2013-06-24 | 2024-08-30 | 威尔逊沃夫制造公司 | 用于透气性细胞培养过程的封闭系统装置和方法 |
| WO2015157636A1 (en) | 2014-04-10 | 2015-10-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
| JP6999941B2 (ja) | 2015-09-18 | 2022-02-10 | ベイラー カレッジ オブ メディスン | 病原体からの免疫原性抗原同定および臨床的有効性との相関 |
| GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
| CN105418766A (zh) * | 2015-12-22 | 2016-03-23 | 深圳市北科生物科技有限公司 | 一种用于免疫治疗的eb病毒lmp2a串联表位肽及其应用 |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| US10052372B2 (en) * | 2016-05-24 | 2018-08-21 | Tessa Therapeutics Pte Ltd | T cell expansion |
| CN109843921B (zh) | 2016-07-07 | 2023-05-26 | 艾欧凡斯生物治疗公司 | 程序性死亡1配体1(pd-l1)结合蛋白及其应用方法 |
| MX2019004707A (es) | 2016-10-26 | 2019-08-12 | Iovance Biotherapeutics Inc | Reestimulacion de linfocitos infiltrantes de tumor crioconservados. |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| BR112019013940A2 (pt) | 2017-01-06 | 2020-02-11 | Iovance Biotherapeutics, Inc. | Método de tratar um câncer com uma população de linfócitos infiltrantes de tumor, processo para preparação de uma população de linfócitos infiltrantes de tumor, população de linfócitos infiltrantes de tumor, e, composição farmacêutica. |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| CN110612119B (zh) | 2017-02-07 | 2024-10-29 | 西雅图儿童医院(Dba西雅图儿童研究所) | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Car t細胞療法のための組成物および方法 |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| WO2018195014A1 (en) | 2017-04-19 | 2018-10-25 | Neubiser Richard | Bioreactor for biological material |
| US20200224161A1 (en) | 2017-05-10 | 2020-07-16 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| BR112019024556A2 (pt) | 2017-05-24 | 2020-06-23 | Novartis Ag | Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer |
| EP3635097A1 (en) | 2017-06-05 | 2020-04-15 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
| EP4501408A3 (en) | 2017-11-17 | 2025-04-09 | Iovance Biotherapeutics, Inc. | Til expansion from fine needle aspirates and small biopsies |
| EP3714041A1 (en) | 2017-11-22 | 2020-09-30 | Iovance Biotherapeutics, Inc. | Expansion of peripheral blood lymphocytes (pbls) from peripheral blood |
| EP3724885A2 (en) | 2017-12-15 | 2020-10-21 | Iovance Biotherapeutics, Inc. | Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| SG11202006541UA (en) | 2018-01-08 | 2020-08-28 | Iovance Biotherapeutics Inc | Processes for generating til products enriched for tumor antigen-specific t-cells |
| JP7549303B2 (ja) | 2018-01-22 | 2024-09-11 | エンドサイト・インコーポレイテッド | Car t細胞の使用方法 |
| SG11202007426XA (en) | 2018-02-06 | 2020-09-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors |
| CN112105382A (zh) | 2018-02-23 | 2020-12-18 | 恩多塞特公司 | 用于car t细胞疗法的顺序方法 |
| MA52667B1 (fr) | 2018-03-29 | 2024-07-31 | Iovance Biotherapeutics, Inc. | Procédés de production de lymphocytes infiltrant les tumeurs et leurs utilisations en immunothérapie |
| US20210130779A1 (en) | 2018-04-27 | 2021-05-06 | Iovance Biotherapeutics, Inc. | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
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- 2010-12-08 EP EP10836660.0A patent/EP2510086A4/en not_active Withdrawn
- 2010-12-08 JP JP2012543271A patent/JP2013512694A/ja active Pending
- 2010-12-08 EP EP13192463.1A patent/EP2698430A3/en not_active Withdrawn
- 2010-12-08 CN CN2010800637927A patent/CN102762719A/zh active Pending
- 2010-12-08 SG SG2012041893A patent/SG181559A1/en unknown
- 2010-12-08 CA CA2783550A patent/CA2783550A1/en not_active Abandoned
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2012
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| US11268066B2 (en) | 2009-12-08 | 2022-03-08 | Wilson Wolf Manufacturing | Methods of cell culture for adoptive cell therapy |
| US9567565B2 (en) | 2009-12-08 | 2017-02-14 | Juan F. Vera | Methods of cell culture for adoptive cell therapy |
| US12454667B2 (en) | 2009-12-08 | 2025-10-28 | Wilson Wolf Manufacturing, LLC | Methods of cell culture for adoptive cell therapy |
| JP2015133997A (ja) * | 2009-12-08 | 2015-07-27 | ウィルソン ウォルフ マニュファクチャリング コーポレイションWilson Wolf Manufacturing Corporation | 養子細胞療法のための細胞を培養する方法 |
| US10533156B2 (en) | 2009-12-08 | 2020-01-14 | Baylor College Of Medicine | Methods of cell culture for adoptive cell therapy |
| US11999969B2 (en) | 2009-12-08 | 2024-06-04 | Wilson Wolf Manufacturing | Methods of cell culture for adoptive cell therapy |
| JP2016530895A (ja) * | 2013-09-23 | 2016-10-06 | ウィルソン ウォルフ マニュファクチャリング コーポレイションWilson Wolf Manufacturing Corporation | 動物細胞を遺伝子改変する改良された方法 |
| JP2019534030A (ja) * | 2016-11-17 | 2019-11-28 | アイオバンス バイオセラピューティクス,インコーポレイテッド | レムナント腫瘍浸潤リンパ球並びにそれを調製及び使用する方法 |
| US11293009B2 (en) | 2016-11-17 | 2022-04-05 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| US11401507B2 (en) | 2016-11-17 | 2022-08-02 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| JP7125392B2 (ja) | 2016-11-17 | 2022-08-24 | アイオバンス バイオセラピューティクス,インコーポレイテッド | レムナント腫瘍浸潤リンパ球並びにそれを調製及び使用する方法 |
| JP2022167931A (ja) * | 2016-11-17 | 2022-11-04 | アイオバンス バイオセラピューティクス,インコーポレイテッド | レムナント腫瘍浸潤リンパ球並びにそれを調製及び使用する方法 |
| US11220670B2 (en) | 2016-11-17 | 2022-01-11 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| US12233075B2 (en) | 2016-11-17 | 2025-02-25 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| JP7675688B2 (ja) | 2016-11-17 | 2025-05-13 | アイオバンス バイオセラピューティクス,インコーポレイテッド | レムナント腫瘍浸潤リンパ球並びにそれを調製及び使用する方法 |
| CN110199016A (zh) * | 2016-11-17 | 2019-09-03 | 艾欧凡斯生物治疗公司 | 残余肿瘤浸润淋巴细胞及其制备和使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| SG181559A1 (en) | 2012-07-30 |
| EP2698430A3 (en) | 2014-03-05 |
| JP2015133997A (ja) | 2015-07-27 |
| EP2698430A2 (en) | 2014-02-19 |
| CA2783550A1 (en) | 2011-06-16 |
| US8809050B2 (en) | 2014-08-19 |
| WO2011072088A2 (en) | 2011-06-16 |
| IL220232A0 (en) | 2012-07-31 |
| WO2011072088A3 (en) | 2011-10-13 |
| EP2510086A2 (en) | 2012-10-17 |
| US20110136228A1 (en) | 2011-06-09 |
| CN102762719A (zh) | 2012-10-31 |
| EP2510086A4 (en) | 2013-05-22 |
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