JP2013508456A5 - - Google Patents
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- Publication number
- JP2013508456A5 JP2013508456A5 JP2012536897A JP2012536897A JP2013508456A5 JP 2013508456 A5 JP2013508456 A5 JP 2013508456A5 JP 2012536897 A JP2012536897 A JP 2012536897A JP 2012536897 A JP2012536897 A JP 2012536897A JP 2013508456 A5 JP2013508456 A5 JP 2013508456A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydropyrazino
- pyrazin
- methyl
- triazol
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25491709P | 2009-10-26 | 2009-10-26 | |
| US61/254,917 | 2009-10-26 | ||
| US32848010P | 2010-04-27 | 2010-04-27 | |
| US61/328,480 | 2010-04-27 | ||
| PCT/US2010/053678 WO2011053518A1 (en) | 2009-10-26 | 2010-10-22 | Methods of synthesis and purification of heteroaryl compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148782A Division JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013508456A JP2013508456A (ja) | 2013-03-07 |
| JP2013508456A5 true JP2013508456A5 (OSRAM) | 2013-11-07 |
Family
ID=43922466
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012536897A Pending JP2013508456A (ja) | 2009-10-26 | 2010-10-22 | ヘテロアリール化合物の合成方法および精製方法 |
| JP2016148782A Active JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148782A Active JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8569494B2 (OSRAM) |
| EP (2) | EP3091021B1 (OSRAM) |
| JP (2) | JP2013508456A (OSRAM) |
| KR (2) | KR20120091240A (OSRAM) |
| CN (2) | CN106117213B (OSRAM) |
| AR (1) | AR078788A1 (OSRAM) |
| AU (1) | AU2010313585B2 (OSRAM) |
| BR (1) | BR112012009751A2 (OSRAM) |
| CA (1) | CA2778615C (OSRAM) |
| CO (1) | CO6541598A2 (OSRAM) |
| CR (1) | CR20120211A (OSRAM) |
| EC (1) | ECSP12011831A (OSRAM) |
| ES (2) | ES2613664T3 (OSRAM) |
| IL (1) | IL219368A (OSRAM) |
| MX (1) | MX341704B (OSRAM) |
| MY (1) | MY177695A (OSRAM) |
| NI (1) | NI201200066A (OSRAM) |
| NZ (2) | NZ618135A (OSRAM) |
| PH (2) | PH12012500825A1 (OSRAM) |
| RU (1) | RU2557242C2 (OSRAM) |
| SG (1) | SG10201500511TA (OSRAM) |
| WO (1) | WO2011053518A1 (OSRAM) |
| ZA (1) | ZA201202959B (OSRAM) |
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| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| KR101978537B1 (ko) * | 2011-10-19 | 2019-05-14 | 시그날 파마소티칼 엘엘씨 | Tor 키나제 억제제를 사용한 암의 치료 |
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| JP6114317B2 (ja) | 2012-02-24 | 2017-04-12 | シグナル ファーマシューティカルズ,エルエルシー | Torキナーゼ阻害剤の組合せ療法を用いて、非小細胞肺がんを処置する方法 |
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| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
| LT3495367T (lt) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai |
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| HK1221168A1 (zh) | 2013-04-17 | 2017-05-26 | 西格诺药品有限公司 | 用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法 |
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| US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
| EP3131552B1 (en) | 2014-04-16 | 2020-07-15 | Signal Pharmaceuticals, LLC | Methods for treating cancer using tor kinase inhibitor combination therapy |
| JP2017511367A (ja) * | 2014-04-16 | 2017-04-20 | シグナル ファーマシューティカルズ,エルエルシー | 1−エチル−7−(2−メチル−6−(1H−1,2,4−トリアゾール−3−イル)ピリジン−3−イル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン及び共形成物を含む固体形態、その組成物及び使用方法 |
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| TWI891666B (zh) | 2019-10-14 | 2025-08-01 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
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