JP2013508456A - ヘテロアリール化合物の合成方法および精製方法 - Google Patents

Info

Publication number

JP2013508456A

JP2013508456A JP2012536897A JP2012536897A JP2013508456A JP 2013508456 A JP2013508456 A JP 2013508456A JP 2012536897 A JP2012536897 A JP 2012536897A JP 2012536897 A JP2012536897 A JP 2012536897A JP 2013508456 A JP2013508456 A JP 2013508456A

Authority

JP

Japan

Prior art keywords

dihydropyrazino

pyrazin

methyl

triazol

pyridin

Prior art date

2009-10-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 63
• 125000001072 heteroaryl group Chemical group 0.000 title abstract description 36
• 230000002194 synthesizing effect Effects 0.000 title description 3
• -1 heteroaryl compound Chemical class 0.000 claims abstract description 245
• 239000000126 substance Substances 0.000 claims abstract description 28
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 219
• 150000001875 compounds Chemical class 0.000 claims description 190
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 174
• 125000000217 alkyl group Chemical group 0.000 claims description 155
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 145
• 229910001868 water Inorganic materials 0.000 claims description 145
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 114
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 85
• KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 80
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 68
• 239000002904 solvent Substances 0.000 claims description 68
• 229910052736 halogen Inorganic materials 0.000 claims description 66
• 125000000623 heterocyclic group Chemical group 0.000 claims description 61
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 60
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethyl sulfoxide Natural products CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 58
• DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 58
• 150000002367 halogens Chemical class 0.000 claims description 53
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 48
• ZHGNHOOVYPHPNJ-UHFFFAOYSA-N Amigdalin Chemical compound FC(F)(F)C(=O)OCC1OC(OCC2OC(OC(C#N)C3=CC=CC=C3)C(OC(=O)C(F)(F)F)C(OC(=O)C(F)(F)F)C2OC(=O)C(F)(F)F)C(OC(=O)C(F)(F)F)C(OC(=O)C(F)(F)F)C1OC(=O)C(F)(F)F ZHGNHOOVYPHPNJ-UHFFFAOYSA-N 0.000 claims description 48
• HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical compound OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 claims description 45
• 238000002360 preparation method Methods 0.000 claims description 43
• 239000002585 base Substances 0.000 claims description 42
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 40
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 40
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 40
• 229910052763 palladium Inorganic materials 0.000 claims description 39
• UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 36
• 150000003839 salts Chemical class 0.000 claims description 35
• NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 claims description 32
• 125000004429 atom Chemical group 0.000 claims description 31
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 30
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 29
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 27
• 125000003118 aryl group Chemical group 0.000 claims description 27
• 239000003054 catalyst Substances 0.000 claims description 27
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 26
• 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 24
• 229910052739 hydrogen Inorganic materials 0.000 claims description 23
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 23
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 22
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 21
• 229910000029 sodium carbonate Inorganic materials 0.000 claims description 20
• 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 17
• 235000017557 sodium bicarbonate Nutrition 0.000 claims description 17
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 14
• 239000002253 acid Substances 0.000 claims description 14
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
• 229910052794 bromium Inorganic materials 0.000 claims description 13
• 239000001257 hydrogen Substances 0.000 claims description 13
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 12
• 229910052799 carbon Inorganic materials 0.000 claims description 12
• COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 claims description 12
• CXNIUSPIQKWYAI-UHFFFAOYSA-N xantphos Chemical compound C=12OC3=C(P(C=4C=CC=CC=4)C=4C=CC=CC=4)C=CC=C3C(C)(C)C2=CC=CC=1P(C=1C=CC=CC=1)C1=CC=CC=C1 CXNIUSPIQKWYAI-UHFFFAOYSA-N 0.000 claims description 12
• BSHICDXRSZQYBP-UHFFFAOYSA-N dichloromethane;palladium(2+) Chemical compound [Pd+2].ClCCl BSHICDXRSZQYBP-UHFFFAOYSA-N 0.000 claims description 11
• USVZFSNDGFNNJT-UHFFFAOYSA-N cyclopenta-1,4-dien-1-yl(diphenyl)phosphane (2,3-dichlorocyclopenta-1,4-dien-1-yl)-diphenylphosphane iron(2+) Chemical group [Fe++].c1cc[c-](c1)P(c1ccccc1)c1ccccc1.Clc1c(cc[c-]1Cl)P(c1ccccc1)c1ccccc1 USVZFSNDGFNNJT-UHFFFAOYSA-N 0.000 claims description 10
• 229910052740 iodine Inorganic materials 0.000 claims description 10
• 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 10
• ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical group [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims description 10
• ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims description 9
• 229910052796 boron Inorganic materials 0.000 claims description 9
• YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 claims description 8
• 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 7
• 230000008569 process Effects 0.000 claims description 7
• 229910052783 alkali metal Inorganic materials 0.000 claims description 6
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 6
• MUJIDPITZJWBSW-UHFFFAOYSA-N palladium(2+) Chemical compound [Pd+2] MUJIDPITZJWBSW-UHFFFAOYSA-N 0.000 claims description 6
• LXNAVEXFUKBNMK-UHFFFAOYSA-N palladium(II) acetate Substances [Pd].CC(O)=O.CC(O)=O LXNAVEXFUKBNMK-UHFFFAOYSA-N 0.000 claims description 6
• 238000007363 ring formation reaction Methods 0.000 claims description 6
• NPHVLMHNJRXDQF-UHFFFAOYSA-N 4-dibutylphosphanyl-n,n-dimethylaniline Chemical compound CCCCP(CCCC)C1=CC=C(N(C)C)C=C1 NPHVLMHNJRXDQF-UHFFFAOYSA-N 0.000 claims description 5
• FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 5
• IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 5
• IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims description 5
• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 4
• SQZFAHVRCZXZAI-UHFFFAOYSA-N 3,3-dimethyl-6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-4-[2-(oxan-4-yl)ethyl]-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)C(C)(C)N2CCC1CCOCC1 SQZFAHVRCZXZAI-UHFFFAOYSA-N 0.000 claims description 4
• MQPPZKPGGLJZKL-UHFFFAOYSA-N 3-(2-amino-7-methyl-3h-benzimidazol-5-yl)-5-(oxan-4-ylmethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C=1C=2NC(N)=NC=2C(C)=CC=1C(N=C12)=CN=C1NCC(=O)N2CC1CCOCC1 MQPPZKPGGLJZKL-UHFFFAOYSA-N 0.000 claims description 4
• PYBNTHVXUJFNOG-UHFFFAOYSA-N 3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5-propan-2-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)C(=O)CNC2=NC=C1C(C(=N1)C)=CC=C1C1=NN=CN1 PYBNTHVXUJFNOG-UHFFFAOYSA-N 0.000 claims description 4
• NVSABGFUPYOXBC-UHFFFAOYSA-N 5-(2-methoxyethyl)-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C(C(=N1)C)=CC=C1C1=NN=CN1 NVSABGFUPYOXBC-UHFFFAOYSA-N 0.000 claims description 4
• SPLZOLLOHZXLCV-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-(1h-pyrrolo[2,3-b]pyridin-4-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=4C=CNC=4N=CC=3)N=C2N1CCC1CCOCC1 SPLZOLLOHZXLCV-UHFFFAOYSA-N 0.000 claims description 4
• GMYLVKUGJMYTFB-UHFFFAOYSA-N 5-ethyl-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)C(=O)CNC2=NC=C1C(C(=N1)C)=CC=C1C1=NN=CN1 GMYLVKUGJMYTFB-UHFFFAOYSA-N 0.000 claims description 4
• LYLMERCWTSHTGW-UHFFFAOYSA-N 8-(oxan-4-yl)-2-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)CN1C1CCOCC1 LYLMERCWTSHTGW-UHFFFAOYSA-N 0.000 claims description 4
• 150000001408 amides Chemical class 0.000 claims description 4
• 125000003963 dichloro group Chemical group Cl* 0.000 claims description 4
• NJXKFIOLXCRUCQ-UHFFFAOYSA-N 2-[4-(2-hydroxypropan-2-yl)phenyl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=CC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CCC3CCOCC3)C2=N1 NJXKFIOLXCRUCQ-UHFFFAOYSA-N 0.000 claims description 3
• UWUPKVZQISLSSA-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(oxan-4-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CC3CCOCC3)C2=N1 UWUPKVZQISLSSA-UHFFFAOYSA-N 0.000 claims description 3
• XLONNVXPSUTRBD-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=C4C=CNC4=NC=3)N=C2N1CCC1CCOCC1 XLONNVXPSUTRBD-UHFFFAOYSA-N 0.000 claims description 3
• UFKLYTOEMRFKAD-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O UFKLYTOEMRFKAD-SHTZXODSSA-N 0.000 claims description 3
• 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
• 239000003446 ligand Substances 0.000 claims description 3
• ZRGPQVFLCQCXGM-CQSZACIVSA-N (2r)-6-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-2-methyl-4-[2-(oxan-4-yl)ethyl]-1,2-dihydropyrazino[2,3-b]pyrazin-3-one Chemical compound N([C@@H](C1=O)C)C2=NC=C(C=3C=NC(=CC=3)C(C)(C)O)N=C2N1CCC1CCOCC1 ZRGPQVFLCQCXGM-CQSZACIVSA-N 0.000 claims description 2
• ZRGPQVFLCQCXGM-AWEZNQCLSA-N (2s)-6-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-2-methyl-4-[2-(oxan-4-yl)ethyl]-1,2-dihydropyrazino[2,3-b]pyrazin-3-one Chemical compound N([C@H](C1=O)C)C2=NC=C(C=3C=NC(=CC=3)C(C)(C)O)N=C2N1CCC1CCOCC1 ZRGPQVFLCQCXGM-AWEZNQCLSA-N 0.000 claims description 2
• JGVQLNHQPVSEMZ-UHFFFAOYSA-N 2-(1h-imidazo[4,5-b]pyridin-6-yl)-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=C4NC=NC4=NC=3)=CN=C2NC(=O)CN1CCC1CCOCC1 JGVQLNHQPVSEMZ-UHFFFAOYSA-N 0.000 claims description 2
• ZWGFWBUSBXEMAU-UHFFFAOYSA-N 2-(1h-indazol-5-yl)-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=C4C=NNC4=CC=3)=CN=C2NC(=O)CN1CCC1CCOCC1 ZWGFWBUSBXEMAU-UHFFFAOYSA-N 0.000 claims description 2
• GPRUOGSZNIVNIG-UHFFFAOYSA-N 2-(1h-indazol-6-yl)-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=C4NN=CC4=CC=3)=CN=C2NC(=O)CN1CCC1CCOCC1 GPRUOGSZNIVNIG-UHFFFAOYSA-N 0.000 claims description 2
• FLGMERISMNGPIM-UHFFFAOYSA-N 2-(1h-indol-5-yl)-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=C4C=CNC4=CC=3)=CN=C2NC(=O)CN1CCC1CCOCC1 FLGMERISMNGPIM-UHFFFAOYSA-N 0.000 claims description 2
• UCNUXNCLAQVMMR-UHFFFAOYSA-N 2-(1h-indol-6-yl)-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=C4NC=CC4=CC=3)=CN=C2NC(=O)CN1CCC1CCOCC1 UCNUXNCLAQVMMR-UHFFFAOYSA-N 0.000 claims description 2
• OVPLJWRLASUHJY-UHFFFAOYSA-N 2-(2-amino-7-methyl-3h-benzimidazol-5-yl)-8-[[3-(trifluoromethyl)phenyl]methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C=1C=2N=C(N)NC=2C(C)=CC=1C(N=C12)=CN=C1NC(=O)CN2CC1=CC=CC(C(F)(F)F)=C1 OVPLJWRLASUHJY-UHFFFAOYSA-N 0.000 claims description 2
• IZBPPYCCPMSLQI-UHFFFAOYSA-N 2-(4-hydroxyphenyl)-8-[(3-methoxyphenyl)methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound COC1=CC=CC(CN2C3=NC(=CN=C3NC(=O)C2)C=2C=CC(O)=CC=2)=C1 IZBPPYCCPMSLQI-UHFFFAOYSA-N 0.000 claims description 2
• JWGOSMIWSZNTEA-UHFFFAOYSA-N 2-(7-methyl-3h-benzimidazol-5-yl)-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C=1C=2NC=NC=2C(C)=CC=1C(N=C12)=CN=C1NC(=O)CN2CCC1CCOCC1 JWGOSMIWSZNTEA-UHFFFAOYSA-N 0.000 claims description 2
• UZUWXKYUGWKVFP-UHFFFAOYSA-N 2-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-7,8-dihydro-5h-pyrazino[2,3-b]pyrazin-6-one Chemical compound C=1C=C(C=2N=C3NCC(=O)NC3=NC=2)C(C)=CC=1C1=NN=CN1 UZUWXKYUGWKVFP-UHFFFAOYSA-N 0.000 claims description 2
• MQKOPINQZVDCFE-UHFFFAOYSA-N 2-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)CN2CCC1CCOCC1 MQKOPINQZVDCFE-UHFFFAOYSA-N 0.000 claims description 2
• MLEUAHJZHFABNI-UHFFFAOYSA-N 2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-8-(oxan-4-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)CN2CC1CCOCC1 MLEUAHJZHFABNI-UHFFFAOYSA-N 0.000 claims description 2
• RBLRRVZXUXIHNG-UHFFFAOYSA-N 2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)CN2CCC1CCOCC1 RBLRRVZXUXIHNG-UHFFFAOYSA-N 0.000 claims description 2
• QSTJXBOEOLUXBG-UHFFFAOYSA-N 2-[3-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-(2-methoxyethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C(C(=C1F)C)=CC=C1C1=NN=CN1 QSTJXBOEOLUXBG-UHFFFAOYSA-N 0.000 claims description 2
• RPFKJQXAUBYMLL-UHFFFAOYSA-N 2-[3-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-(oxan-4-yl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=C(F)C(C2=NNC=N2)=CC=C1C(N=C12)=CN=C1NC(=O)CN2C1CCOCC1 RPFKJQXAUBYMLL-UHFFFAOYSA-N 0.000 claims description 2
• KDNANMZVIXBBHI-UHFFFAOYSA-N 2-[3-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=C(F)C(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)CN2CCC1CCOCC1 KDNANMZVIXBBHI-UHFFFAOYSA-N 0.000 claims description 2
• XCAKYWRPAFRUKL-UHFFFAOYSA-N 2-[3-fluoro-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-(2-methoxyethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C(C=C1F)=CC=C1C1=NN=CN1 XCAKYWRPAFRUKL-UHFFFAOYSA-N 0.000 claims description 2
• VQOJDNXHKRRVKG-UHFFFAOYSA-N 2-[3-fluoro-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound FC1=CC(C=2N=C3N(CCC4CCOCC4)CC(=O)NC3=NC=2)=CC=C1C1=NN=CN1 VQOJDNXHKRRVKG-UHFFFAOYSA-N 0.000 claims description 2
• OSCZBKPQIHRLCX-UHFFFAOYSA-N 2-[4-(1h-1,2,4-triazol-5-yl)phenyl]-8-[[3-(trifluoromethyl)phenyl]methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound FC(F)(F)C1=CC=CC(CN2C3=NC(=CN=C3NC(=O)C2)C=2C=CC(=CC=2)C=2NC=NN=2)=C1 OSCZBKPQIHRLCX-UHFFFAOYSA-N 0.000 claims description 2
• BPXGEUALTFPZOM-UHFFFAOYSA-N 2-[4-(2-hydroxypropan-2-yl)phenyl]-8-(oxan-4-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=CC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CC3CCOCC3)C2=N1 BPXGEUALTFPZOM-UHFFFAOYSA-N 0.000 claims description 2
• BDYYRVQPWCHOGW-UHFFFAOYSA-N 2-[4-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-8-(oxan-4-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=CC(C2=NNC=N2)=NC=C1C(N=C12)=CN=C1NC(=O)CN2CC1CCOCC1 BDYYRVQPWCHOGW-UHFFFAOYSA-N 0.000 claims description 2
• CKRKNYZYXVCPMX-UHFFFAOYSA-N 2-[5-fluoro-2-methyl-4-(1H-1,2,4-triazol-5-yl)phenyl]-4-propan-2-yl-1,2-dihydropyrazino[2,3-b]pyrazin-3-one Chemical compound FC=1C(=CC(=C(C1)C1NC=2C(=NC=CN2)N(C1=O)C(C)C)C)C1=NNC=N1 CKRKNYZYXVCPMX-UHFFFAOYSA-N 0.000 claims description 2
• QXCHUWFFMQNYIJ-UHFFFAOYSA-N 2-[5-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-(2-methoxyethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C(C(=C1)C)=CC(F)=C1C=1N=CNN=1 QXCHUWFFMQNYIJ-UHFFFAOYSA-N 0.000 claims description 2
• MGLOYVHEYOOETR-UHFFFAOYSA-N 2-[5-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-(oxan-4-yl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound FC=1C=C(C=2N=C3N(C4CCOCC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 MGLOYVHEYOOETR-UHFFFAOYSA-N 0.000 claims description 2
• HLKYWXBABQWMDJ-UHFFFAOYSA-N 2-[5-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-8-propan-2-yl-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)CC(=O)NC2=NC=C1C(C(=C1)C)=CC(F)=C1C=1N=CNN=1 HLKYWXBABQWMDJ-UHFFFAOYSA-N 0.000 claims description 2
• KQVBDNFZBDBYCA-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)-2-methylpyridin-3-yl]-8-(oxan-4-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=NC(C(C)(C)O)=CC=C1C1=CN=C(NC(=O)CN2CC3CCOCC3)C2=N1 KQVBDNFZBDBYCA-UHFFFAOYSA-N 0.000 claims description 2
• NJPJPESOUGQOMJ-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(2-methoxyethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C1=CC=C(C(C)(C)O)N=C1 NJPJPESOUGQOMJ-UHFFFAOYSA-N 0.000 claims description 2
• TYAMMNKVQSFFRX-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(2-methylpropyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC(C)C)CC(=O)NC2=NC=C1C1=CC=C(C(C)(C)O)N=C1 TYAMMNKVQSFFRX-UHFFFAOYSA-N 0.000 claims description 2
• GXKVTFYWASGFEH-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(2-morpholin-4-ylethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CCN3CCOCC3)C2=N1 GXKVTFYWASGFEH-UHFFFAOYSA-N 0.000 claims description 2
• BLYAPPOKCOQUMX-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(2-phenylethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CCC=3C=CC=CC=3)C2=N1 BLYAPPOKCOQUMX-UHFFFAOYSA-N 0.000 claims description 2
• CBIIYNCVOYUQDQ-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(3-methoxypropyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCCOC)CC(=O)NC2=NC=C1C1=CC=C(C(C)(C)O)N=C1 CBIIYNCVOYUQDQ-UHFFFAOYSA-N 0.000 claims description 2
• IBHHJGZOOHWZKC-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(oxan-4-yl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2C3CCOCC3)C2=N1 IBHHJGZOOHWZKC-UHFFFAOYSA-N 0.000 claims description 2
• RRSHKGLMZARSTK-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-(oxolan-3-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CC3COCC3)C2=N1 RRSHKGLMZARSTK-UHFFFAOYSA-N 0.000 claims description 2
• CXWODWYNTIZYON-ZIAGYGMSSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[(1r,3r)-3-methoxycyclopentyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 CXWODWYNTIZYON-ZIAGYGMSSA-N 0.000 claims description 2
• CXWODWYNTIZYON-KGLIPLIRSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[(1r,3s)-3-methoxycyclopentyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 CXWODWYNTIZYON-KGLIPLIRSA-N 0.000 claims description 2
• CXWODWYNTIZYON-UONOGXRCSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[(1s,3r)-3-methoxycyclopentyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 CXWODWYNTIZYON-UONOGXRCSA-N 0.000 claims description 2
• CXWODWYNTIZYON-KBPBESRZSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[(1s,3s)-3-methoxycyclopentyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 CXWODWYNTIZYON-KBPBESRZSA-N 0.000 claims description 2
• TUHJKXZTDPWLDV-GFCCVEGCSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[(3r)-oxolan-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2[C@H]3COCC3)C2=N1 TUHJKXZTDPWLDV-GFCCVEGCSA-N 0.000 claims description 2
• TUHJKXZTDPWLDV-LBPRGKRZSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[(3s)-oxolan-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2[C@@H]3COCC3)C2=N1 TUHJKXZTDPWLDV-LBPRGKRZSA-N 0.000 claims description 2
• LRCRCWGIMZXSLR-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[2-(oxan-3-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CCC3COCCC3)C2=N1 LRCRCWGIMZXSLR-UHFFFAOYSA-N 0.000 claims description 2
• UVDSVTKKZYTBOB-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CCC3CCOCC3)C2=N1 UVDSVTKKZYTBOB-UHFFFAOYSA-N 0.000 claims description 2
• FEXBAHRJAIMNNR-UKRRQHHQSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[[(1r,3r)-3-methoxycyclopentyl]methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 FEXBAHRJAIMNNR-UKRRQHHQSA-N 0.000 claims description 2
• FEXBAHRJAIMNNR-HIFRSBDPSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[[(1r,3s)-3-methoxycyclopentyl]methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 FEXBAHRJAIMNNR-HIFRSBDPSA-N 0.000 claims description 2
• FEXBAHRJAIMNNR-DZGCQCFKSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[[(1s,3r)-3-methoxycyclopentyl]methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 FEXBAHRJAIMNNR-DZGCQCFKSA-N 0.000 claims description 2
• VGYOLLKVSKNHQS-CYBMUJFWSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[[(2r)-oxolan-2-yl]methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2C[C@@H]3OCCC3)C2=N1 VGYOLLKVSKNHQS-CYBMUJFWSA-N 0.000 claims description 2
• VGYOLLKVSKNHQS-ZDUSSCGKSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[[(2s)-oxolan-2-yl]methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2C[C@H]3OCCC3)C2=N1 VGYOLLKVSKNHQS-ZDUSSCGKSA-N 0.000 claims description 2
• NUFDTTCJPSICSY-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[[3-(trifluoromethyl)phenyl]methyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CC=3C=C(C=CC=3)C(F)(F)F)C2=N1 NUFDTTCJPSICSY-UHFFFAOYSA-N 0.000 claims description 2
• KWZWONSVPZJSDW-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-phenyl-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2C=3C=CC=CC=3)C2=N1 KWZWONSVPZJSDW-UHFFFAOYSA-N 0.000 claims description 2
• XBTBXISVXWQPKC-UHFFFAOYSA-N 2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-piperidin-4-yl-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2C3CCNCC3)C2=N1 XBTBXISVXWQPKC-UHFFFAOYSA-N 0.000 claims description 2
• MVLKBZNTEDMOIR-CYBMUJFWSA-N 2-[6-[(1r)-1-hydroxyethyl]pyridin-3-yl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC([C@H](O)C)=CC=C1C1=CN=C(NC(=O)CN2CCC3CCOCC3)C2=N1 MVLKBZNTEDMOIR-CYBMUJFWSA-N 0.000 claims description 2
• MVLKBZNTEDMOIR-ZDUSSCGKSA-N 2-[6-[(1s)-1-hydroxyethyl]pyridin-3-yl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC([C@@H](O)C)=CC=C1C1=CN=C(NC(=O)CN2CCC3CCOCC3)C2=N1 MVLKBZNTEDMOIR-ZDUSSCGKSA-N 0.000 claims description 2
• KYDBWAOQRGEKAM-UHFFFAOYSA-N 2-[7-methyl-2-(methylamino)-3h-benzimidazol-5-yl]-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C2NC(NC)=NC2=C(C)C=C1C(N=C12)=CN=C1NC(=O)CN2CCC1CCOCC1 KYDBWAOQRGEKAM-UHFFFAOYSA-N 0.000 claims description 2
• JQDISYRIHPZMLX-UHFFFAOYSA-N 3,3-dimethyl-6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-1,4-dihydropyrazino[2,3-b]pyrazin-2-one Chemical compound C=1C=C(C=2N=C3NC(C)(C)C(=O)NC3=NC=2)C(C)=CC=1C1=NN=CN1 JQDISYRIHPZMLX-UHFFFAOYSA-N 0.000 claims description 2
• FIUYRRXZRKTKGS-UHFFFAOYSA-N 3,3-dimethyl-6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-4-(oxan-4-ylmethyl)-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)C(C)(C)N2CC1CCOCC1 FIUYRRXZRKTKGS-UHFFFAOYSA-N 0.000 claims description 2
• HPSIHXPEEQAULT-UHFFFAOYSA-N 3,3-dimethyl-6-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-4-(oxan-4-ylmethyl)-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)C(C)(C)N2CC1CCOCC1 HPSIHXPEEQAULT-UHFFFAOYSA-N 0.000 claims description 2
• KQFYZQKLUAHDHM-UHFFFAOYSA-N 3,3-dimethyl-6-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-4-[2-(oxan-4-yl)ethyl]-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)C(C)(C)N2CCC1CCOCC1 KQFYZQKLUAHDHM-UHFFFAOYSA-N 0.000 claims description 2
• SYHZXWIXJYELOD-UHFFFAOYSA-N 3,3-dimethyl-6-[4-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-4-(oxan-4-ylmethyl)-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound CC1=CC(C=2NC=NN=2)=NC=C1C(N=C12)=CN=C1NC(=O)C(C)(C)N2CC1CCOCC1 SYHZXWIXJYELOD-UHFFFAOYSA-N 0.000 claims description 2
• DZTGDFKHOGKAQD-UHFFFAOYSA-N 3-(1h-benzimidazol-4-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=4N=CNC=4C=CC=3)N=C2N1CCC1CCOCC1 DZTGDFKHOGKAQD-UHFFFAOYSA-N 0.000 claims description 2
• QGIFMOBTYJUZDF-UHFFFAOYSA-N 3-(1h-imidazo[4,5-b]pyridin-6-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=C4NC=NC4=NC=3)N=C2N1CCC1CCOCC1 QGIFMOBTYJUZDF-UHFFFAOYSA-N 0.000 claims description 2
• ZGSASUQYKCYWOH-UHFFFAOYSA-N 3-(1h-indazol-4-yl)-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C1=CC=CC2=C1C=NN2 ZGSASUQYKCYWOH-UHFFFAOYSA-N 0.000 claims description 2
• KEHLMISTGOWRBK-UHFFFAOYSA-N 3-(1h-indazol-4-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=4C=NNC=4C=CC=3)N=C2N1CCC1CCOCC1 KEHLMISTGOWRBK-UHFFFAOYSA-N 0.000 claims description 2
• GFRLZMVZCPDWRI-UHFFFAOYSA-N 3-(1h-indazol-5-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=C4C=NNC4=CC=3)N=C2N1CCC1CCOCC1 GFRLZMVZCPDWRI-UHFFFAOYSA-N 0.000 claims description 2
• SKIWQHRZDIRSSR-UHFFFAOYSA-N 3-(1h-indazol-6-yl)-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C2C=NNC2=CC(C2=CN=C3NCC(=O)N(C3=N2)CCOC)=C1 SKIWQHRZDIRSSR-UHFFFAOYSA-N 0.000 claims description 2
• JSQUAMCOBUROON-UHFFFAOYSA-N 3-(1h-indazol-6-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=C4NN=CC4=CC=3)N=C2N1CCC1CCOCC1 JSQUAMCOBUROON-UHFFFAOYSA-N 0.000 claims description 2
• LGPLNSCXMJYALD-UHFFFAOYSA-N 3-(1h-indol-4-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=4C=CNC=4C=CC=3)N=C2N1CCC1CCOCC1 LGPLNSCXMJYALD-UHFFFAOYSA-N 0.000 claims description 2
• HODBKAKOJZVOEF-UHFFFAOYSA-N 3-(1h-indol-5-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=C4C=CNC4=CC=3)N=C2N1CCC1CCOCC1 HODBKAKOJZVOEF-UHFFFAOYSA-N 0.000 claims description 2
• PLAKARKZIOKICJ-UHFFFAOYSA-N 3-(1h-indol-6-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=C4NC=CC4=CC=3)N=C2N1CCC1CCOCC1 PLAKARKZIOKICJ-UHFFFAOYSA-N 0.000 claims description 2
• DKWHGLUBDUEFJU-UHFFFAOYSA-N 3-(2-amino-7-methyl-3h-benzimidazol-5-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C=1C=2NC(N)=NC=2C(C)=CC=1C(N=C12)=CN=C1NCC(=O)N2CCC1CCOCC1 DKWHGLUBDUEFJU-UHFFFAOYSA-N 0.000 claims description 2
• UJPSHKFRYPVGNA-UHFFFAOYSA-N 3-(2-aminopyridin-4-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(N)=CC(C=2N=C3N(CCC4CCOCC4)C(=O)CNC3=NC=2)=C1 UJPSHKFRYPVGNA-UHFFFAOYSA-N 0.000 claims description 2
• MHYJMKMYZAYBRD-UHFFFAOYSA-N 3-(2-aminopyrimidin-5-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(N)=NC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 MHYJMKMYZAYBRD-UHFFFAOYSA-N 0.000 claims description 2
• WMCKBCJWRQYWFS-UHFFFAOYSA-N 3-(6-aminopyridin-3-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(N)=CC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 WMCKBCJWRQYWFS-UHFFFAOYSA-N 0.000 claims description 2
• YIBNAOSYIXQTJW-UHFFFAOYSA-N 3-(6-methoxypyridin-3-yl)-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(OC)=CC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 YIBNAOSYIXQTJW-UHFFFAOYSA-N 0.000 claims description 2
• PMDUGGRRKRONFN-UHFFFAOYSA-N 3-(7-methyl-2-oxo-1,3-dihydrobenzimidazol-5-yl)-5-(oxan-4-ylmethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C=1C=2NC(=O)NC=2C(C)=CC=1C(N=C12)=CN=C1NCC(=O)N2CC1CCOCC1 PMDUGGRRKRONFN-UHFFFAOYSA-N 0.000 claims description 2
• ZAEAHBWLSUALDG-UHFFFAOYSA-N 3-(cyclohexylmethyl)-6-[4-(1h-1,2,4-triazol-5-yl)phenyl]-3,4-dihydro-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound O=C1NC2=NC=C(C=3C=CC(=CC=3)C=3NN=CN=3)N=C2NC1CC1CCCCC1 ZAEAHBWLSUALDG-UHFFFAOYSA-N 0.000 claims description 2
• WVSLRWFLPGLENR-UHFFFAOYSA-N 3-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=CC(C2=NNC=N2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2CCC1CCOCC1 WVSLRWFLPGLENR-UHFFFAOYSA-N 0.000 claims description 2
• HYNXATWPOPIBJD-UHFFFAOYSA-N 3-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-7,8-dihydro-5h-pyrazino[2,3-b]pyrazin-6-one Chemical compound C=1C=C(C=2N=C3NC(=O)CNC3=NC=2)C(C)=CC=1C1=NN=CN1 HYNXATWPOPIBJD-UHFFFAOYSA-N 0.000 claims description 2
• SXJWIRIRCLXOIF-UHFFFAOYSA-N 3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5-(2-morpholin-4-ylethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2CCN1CCOCC1 SXJWIRIRCLXOIF-UHFFFAOYSA-N 0.000 claims description 2
• YXNXKPZWTPLWQK-UHFFFAOYSA-N 3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5-(oxan-4-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2C1CCOCC1 YXNXKPZWTPLWQK-UHFFFAOYSA-N 0.000 claims description 2
• GSZOKDIAJHWSJC-UHFFFAOYSA-N 3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5-(oxan-4-ylmethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2CC1CCOCC1 GSZOKDIAJHWSJC-UHFFFAOYSA-N 0.000 claims description 2
• VLSSMLSPCKXABU-UHFFFAOYSA-N 3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2CCC1CCOCC1 VLSSMLSPCKXABU-UHFFFAOYSA-N 0.000 claims description 2
• IEICKBNZQSCLBX-UHFFFAOYSA-N 3-[3-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C(C(=C1F)C)=CC=C1C=1N=CNN=1 IEICKBNZQSCLBX-UHFFFAOYSA-N 0.000 claims description 2
• BATASGNNQUEPGG-UHFFFAOYSA-N 3-[3-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=C(F)C(C2=NNC=N2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2CCC1CCOCC1 BATASGNNQUEPGG-UHFFFAOYSA-N 0.000 claims description 2
• IWVZQMZLHLNEHO-UHFFFAOYSA-N 3-[3-fluoro-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C(C=C1F)=CC=C1C1=NN=CN1 IWVZQMZLHLNEHO-UHFFFAOYSA-N 0.000 claims description 2
• GCVDTBDFHANTQU-UHFFFAOYSA-N 3-[3-fluoro-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound FC1=CC(C=2N=C3N(CCC4CCOCC4)C(=O)CNC3=NC=2)=CC=C1C1=NN=CN1 GCVDTBDFHANTQU-UHFFFAOYSA-N 0.000 claims description 2
• DZUZGHMCJFXRHJ-UHFFFAOYSA-N 3-[4-(2-hydroxypropan-2-yl)phenyl]-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C1=CC=C(C(C)(C)O)C=C1 DZUZGHMCJFXRHJ-UHFFFAOYSA-N 0.000 claims description 2
• DHITXWXYWZPVSM-UHFFFAOYSA-N 3-[4-(2-hydroxypropan-2-yl)phenyl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=CC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 DHITXWXYWZPVSM-UHFFFAOYSA-N 0.000 claims description 2
• ZAPSUJZEAZNSRD-UHFFFAOYSA-N 3-[4-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=CC(C2=NNC=N2)=NC=C1C(N=C12)=CN=C1NCC(=O)N2CCC1CCOCC1 ZAPSUJZEAZNSRD-UHFFFAOYSA-N 0.000 claims description 2
• UGKQZBCVFBXDFV-UHFFFAOYSA-N 3-[4-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5-propan-2-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)C(=O)CNC2=NC=C1C(C(=C1)C)=CN=C1C=1N=CNN=1 UGKQZBCVFBXDFV-UHFFFAOYSA-N 0.000 claims description 2
• WRHQICCPKGSXAD-UHFFFAOYSA-N 3-[5-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C(C(=C1)C)=CC(F)=C1C=1N=CNN=1 WRHQICCPKGSXAD-UHFFFAOYSA-N 0.000 claims description 2
• JCOCCYPZCGPHBP-UHFFFAOYSA-N 3-[5-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-(oxan-4-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound FC=1C=C(C=2N=C3N(C4CCOCC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 JCOCCYPZCGPHBP-UHFFFAOYSA-N 0.000 claims description 2
• OUEFEFGOKIPWCD-UHFFFAOYSA-N 3-[5-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound FC=1C=C(C=2N=C3N(CCC4CCOCC4)C(=O)CNC3=NC=2)C(C)=CC=1C1=NN=CN1 OUEFEFGOKIPWCD-UHFFFAOYSA-N 0.000 claims description 2
• XSQAJVDTZWOBMX-UHFFFAOYSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C1=CC=C(C(C)(C)O)N=C1 XSQAJVDTZWOBMX-UHFFFAOYSA-N 0.000 claims description 2
• TUHIMPAVUZMPBC-UHFFFAOYSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-(2-morpholin-4-ylethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2CCN3CCOCC3)C2=N1 TUHIMPAVUZMPBC-UHFFFAOYSA-N 0.000 claims description 2
• IHCVPLCAIWFKAI-UHFFFAOYSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-(oxan-4-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2C3CCOCC3)C2=N1 IHCVPLCAIWFKAI-UHFFFAOYSA-N 0.000 claims description 2
• HDJQPSZZAWLLJX-UHFFFAOYSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-(oxan-4-ylmethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2CC3CCOCC3)C2=N1 HDJQPSZZAWLLJX-UHFFFAOYSA-N 0.000 claims description 2
• IZSFXJSROVCKBE-ZIAGYGMSSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-[(1r,3r)-3-methoxycyclopentyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O IZSFXJSROVCKBE-ZIAGYGMSSA-N 0.000 claims description 2
• IZSFXJSROVCKBE-KGLIPLIRSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-[(1r,3s)-3-methoxycyclopentyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O IZSFXJSROVCKBE-KGLIPLIRSA-N 0.000 claims description 2
• IZSFXJSROVCKBE-UONOGXRCSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-[(1s,3r)-3-methoxycyclopentyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O IZSFXJSROVCKBE-UONOGXRCSA-N 0.000 claims description 2
• IZSFXJSROVCKBE-KBPBESRZSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-[(1s,3s)-3-methoxycyclopentyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O IZSFXJSROVCKBE-KBPBESRZSA-N 0.000 claims description 2
• SSVPJPIEWYQHJS-UHFFFAOYSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 SSVPJPIEWYQHJS-UHFFFAOYSA-N 0.000 claims description 2
• GGXBOWLHTYZICB-UHFFFAOYSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-[[3-(trifluoromethyl)phenyl]methyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2CC=3C=C(C=CC=3)C(F)(F)F)C2=N1 GGXBOWLHTYZICB-UHFFFAOYSA-N 0.000 claims description 2
• FTWKDRGLXUXFIA-UHFFFAOYSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-[[4-(trifluoromethyl)phenyl]methyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2CC=3C=CC(=CC=3)C(F)(F)F)C2=N1 FTWKDRGLXUXFIA-UHFFFAOYSA-N 0.000 claims description 2
• RTEGTQQTUYNWRY-UHFFFAOYSA-N 3-[6-(methylamino)pyridin-3-yl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(NC)=CC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 RTEGTQQTUYNWRY-UHFFFAOYSA-N 0.000 claims description 2
• OHBOJKQXJVEZOB-CYBMUJFWSA-N 3-[6-[(1r)-1-hydroxyethyl]pyridin-3-yl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC([C@H](O)C)=CC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 OHBOJKQXJVEZOB-CYBMUJFWSA-N 0.000 claims description 2
• OHBOJKQXJVEZOB-ZDUSSCGKSA-N 3-[6-[(1s)-1-hydroxyethyl]pyridin-3-yl]-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC([C@@H](O)C)=CC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 OHBOJKQXJVEZOB-ZDUSSCGKSA-N 0.000 claims description 2
• XRNYWLDXBHUCBM-UHFFFAOYSA-N 3-[7-methyl-2-(methylamino)-3h-benzimidazol-5-yl]-5-(oxan-4-ylmethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C2NC(NC)=NC2=C(C)C=C1C(N=C12)=CN=C1NCC(=O)N2CC1CCOCC1 XRNYWLDXBHUCBM-UHFFFAOYSA-N 0.000 claims description 2
• LKZBJBNIHVHKPM-UHFFFAOYSA-N 3-[8-[2-(oxan-4-yl)ethyl]-6-oxo-5,7-dihydropyrazino[2,3-b]pyrazin-2-yl]benzonitrile Chemical compound C12=NC(C=3C=C(C=CC=3)C#N)=CN=C2NC(=O)CN1CCC1CCOCC1 LKZBJBNIHVHKPM-UHFFFAOYSA-N 0.000 claims description 2
• AIIZSXHNWBDUIY-UHFFFAOYSA-N 3-[[3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-6-oxo-7,8-dihydropyrazino[2,3-b]pyrazin-5-yl]methyl]benzonitrile Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2CC1=CC=CC(C#N)=C1 AIIZSXHNWBDUIY-UHFFFAOYSA-N 0.000 claims description 2
• KGKGEMANEQVBIB-UHFFFAOYSA-N 3-[[3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-oxo-7,8-dihydropyrazino[2,3-b]pyrazin-5-yl]methyl]benzonitrile Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2CC=3C=C(C=CC=3)C#N)C2=N1 KGKGEMANEQVBIB-UHFFFAOYSA-N 0.000 claims description 2
• QIUBCQAHVFJLRL-UHFFFAOYSA-N 3-methyl-6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-4-[2-(oxan-4-yl)ethyl]-1,3-dihydropyrazino[2,3-b]pyrazin-2-one Chemical compound C12=NC(C=3C(=CC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C(C)N1CCC1CCOCC1 QIUBCQAHVFJLRL-UHFFFAOYSA-N 0.000 claims description 2
• UYDXGEDUFCQCKY-UHFFFAOYSA-N 4-(2-methoxyethyl)-3,3-dimethyl-6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound C=1N=C2NC(=O)C(C)(C)N(CCOC)C2=NC=1C(C(=C1)C)=CC=C1C1=NN=CN1 UYDXGEDUFCQCKY-UHFFFAOYSA-N 0.000 claims description 2
• GHGBFKSWXMVGCZ-UHFFFAOYSA-N 4-ethyl-3,3-dimethyl-6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound C=1N=C2NC(=O)C(C)(C)N(CC)C2=NC=1C(C(=C1)C)=CC=C1C1=NN=CN1 GHGBFKSWXMVGCZ-UHFFFAOYSA-N 0.000 claims description 2
• FBBNTTOMEWSAAE-UHFFFAOYSA-N 4-methyl-5-(6-oxo-5-propan-2-yl-7,8-dihydropyrazino[2,3-b]pyrazin-3-yl)pyridine-2-carboxamide Chemical compound N1=C2N(C(C)C)C(=O)CNC2=NC=C1C1=CN=C(C(N)=O)C=C1C FBBNTTOMEWSAAE-UHFFFAOYSA-N 0.000 claims description 2
• MSXKZSYIJSJAEO-UHFFFAOYSA-N 5-(1-hydroxypropan-2-yl)-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(CO)C)C(=O)CNC2=NC=C1C(C(=N1)C)=CC=C1C=1N=CNN=1 MSXKZSYIJSJAEO-UHFFFAOYSA-N 0.000 claims description 2
• ILMIPKIKBDDHMT-UHFFFAOYSA-N 5-(2-methoxyethyl)-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2NC=CC2=CC(C2=CN=C3NCC(=O)N(C3=N2)CCOC)=C1 ILMIPKIKBDDHMT-UHFFFAOYSA-N 0.000 claims description 2
• NFQHGHLEMBPSNM-UHFFFAOYSA-N 5-(2-methoxyethyl)-3-[4-(1h-pyrazol-5-yl)phenyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C(C=C1)=CC=C1C=1C=CNN=1 NFQHGHLEMBPSNM-UHFFFAOYSA-N 0.000 claims description 2
• NUJKYWRSJNHBNP-UHFFFAOYSA-N 5-(2-methoxyethyl)-3-[4-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C(C(=C1)C)=CN=C1C=1N=CNN=1 NUJKYWRSJNHBNP-UHFFFAOYSA-N 0.000 claims description 2
• ZPSNIJRHIXWNJC-UHFFFAOYSA-N 5-(2-methoxyethyl)-3-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)C(=O)CNC2=NC=C1C(C=N1)=CC=C1C=1N=CNN=1 ZPSNIJRHIXWNJC-UHFFFAOYSA-N 0.000 claims description 2
• INRMHRKIRHNHFX-UHFFFAOYSA-N 5-(2-methoxyethyl)-3-[7-methyl-2-(methylamino)-3h-benzimidazol-5-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1CC(=O)N(CCOC)C2=NC(C3=CC(C)=C4N=C(NC4=C3)NC)=CN=C21 INRMHRKIRHNHFX-UHFFFAOYSA-N 0.000 claims description 2
• RSGNOWXSFSNENG-UHFFFAOYSA-N 5-(cyclopentylmethyl)-3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2CC3CCCC3)C2=N1 RSGNOWXSFSNENG-UHFFFAOYSA-N 0.000 claims description 2
• HJFAQFKQYPQCMC-UHFFFAOYSA-N 5-(oxan-4-yl)-3-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=NC(=CC=3)C3=NNC=N3)N=C2N1C1CCOCC1 HJFAQFKQYPQCMC-UHFFFAOYSA-N 0.000 claims description 2
• JZXXYQZWXCXZJY-CHWSQXEVSA-N 5-[(1r,3r)-3-methoxycyclopentyl]-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NCC1=O JZXXYQZWXCXZJY-CHWSQXEVSA-N 0.000 claims description 2
• JZXXYQZWXCXZJY-OLZOCXBDSA-N 5-[(1r,3s)-3-methoxycyclopentyl]-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NCC1=O JZXXYQZWXCXZJY-OLZOCXBDSA-N 0.000 claims description 2
• JZXXYQZWXCXZJY-QWHCGFSZSA-N 5-[(1s,3r)-3-methoxycyclopentyl]-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NCC1=O JZXXYQZWXCXZJY-QWHCGFSZSA-N 0.000 claims description 2
• JZXXYQZWXCXZJY-STQMWFEESA-N 5-[(1s,3s)-3-methoxycyclopentyl]-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NCC1=O JZXXYQZWXCXZJY-STQMWFEESA-N 0.000 claims description 2
• RGGDWENTCRAFSY-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-(1h-pyrazol-4-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C3=CNN=C3)N=C2N1CCC1CCOCC1 RGGDWENTCRAFSY-UHFFFAOYSA-N 0.000 claims description 2
• YKVLWVMMPGATFA-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-(1h-pyrrolo[2,3-b]pyridin-3-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C4=CC=CN=C4NC=3)N=C2N1CCC1CCOCC1 YKVLWVMMPGATFA-UHFFFAOYSA-N 0.000 claims description 2
• OURMEBMAEXJYKX-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-(2-oxo-1h-pyridin-4-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(O)=CC(C=2N=C3N(CCC4CCOCC4)C(=O)CNC3=NC=2)=C1 OURMEBMAEXJYKX-UHFFFAOYSA-N 0.000 claims description 2
• FRJAQAFSPPSOKO-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-(6-oxo-1h-pyridin-3-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(O)=CC=C1C1=CN=C(NCC(=O)N2CCC3CCOCC3)C2=N1 FRJAQAFSPPSOKO-UHFFFAOYSA-N 0.000 claims description 2
• MRVNZUNWYGONNW-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-[4-(1h-1,2,4-triazol-5-yl)phenyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=CC(=CC=3)C=3NN=CN=3)N=C2N1CCC1CCOCC1 MRVNZUNWYGONNW-UHFFFAOYSA-N 0.000 claims description 2
• VRFQFZUAZKJJNU-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-pyridin-3-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=NC=CC=3)N=C2N1CCC1CCOCC1 VRFQFZUAZKJJNU-UHFFFAOYSA-N 0.000 claims description 2
• MGQSNZBPSZSJIQ-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-pyridin-4-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=CN=CC=3)N=C2N1CCC1CCOCC1 MGQSNZBPSZSJIQ-UHFFFAOYSA-N 0.000 claims description 2
• YVIZSJLCDJZZDV-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-pyrimidin-5-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound O=C1CNC2=NC=C(C=3C=NC=NC=3)N=C2N1CCC1CCOCC1 YVIZSJLCDJZZDV-UHFFFAOYSA-N 0.000 claims description 2
• HGTQAYOZNVZMGR-HOCLYGCPSA-N 5-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-8-[[(1S,3S)-3-methoxycyclopentyl]methyl]-7H-pyrazino[2,3-b]pyrazin-6-one Chemical compound OC(C)(C)C1=CC=C(C=N1)N1C(CN(C=2C1=NC=CN2)C[C@@H]2C[C@H](CC2)OC)=O HGTQAYOZNVZMGR-HOCLYGCPSA-N 0.000 claims description 2
• WYOUELOPRDHRFN-UHFFFAOYSA-N 5-[8-(2-methoxyethyl)-6-oxo-5,7-dihydropyrazino[2,3-b]pyrazin-2-yl]-4-methylpyridine-2-carboxamide Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C1=CN=C(C(N)=O)C=C1C WYOUELOPRDHRFN-UHFFFAOYSA-N 0.000 claims description 2
• VXXIEBRDQDDWJJ-UHFFFAOYSA-N 5-benzyl-3-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2CC1=CC=CC=C1 VXXIEBRDQDDWJJ-UHFFFAOYSA-N 0.000 claims description 2
• WYLXUTPYMYKVJF-UHFFFAOYSA-N 5-ethyl-3-(1h-indazol-4-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)C(=O)CNC2=NC=C1C1=CC=CC2=C1C=NN2 WYLXUTPYMYKVJF-UHFFFAOYSA-N 0.000 claims description 2
• GZPJUEHGNHAVKF-UHFFFAOYSA-N 5-ethyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2NC=CC2=CC(C2=CN=C3NCC(=O)N(C3=N2)CC)=C1 GZPJUEHGNHAVKF-UHFFFAOYSA-N 0.000 claims description 2
• UYCWOEZHBUCWAC-UHFFFAOYSA-N 5-ethyl-3-(1h-pyrrolo[3,2-b]pyridin-5-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C2NC=CC2=NC(C2=CN=C3NCC(=O)N(C3=N2)CC)=C1 UYCWOEZHBUCWAC-UHFFFAOYSA-N 0.000 claims description 2
• ZZQICLYBVODNQP-UHFFFAOYSA-N 5-ethyl-3-[5-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)C(=O)CNC2=NC=C1C(C(=C1)C)=CC(F)=C1C=1N=CNN=1 ZZQICLYBVODNQP-UHFFFAOYSA-N 0.000 claims description 2
• UAIVVAVQNKLODW-UHFFFAOYSA-N 5-ethyl-3-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)C(=O)CNC2=NC=C1C(C=N1)=CC=C1C=1N=CNN=1 UAIVVAVQNKLODW-UHFFFAOYSA-N 0.000 claims description 2
• YYVCGFXRDDLIIQ-UHFFFAOYSA-N 5-methyl-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C)C(=O)CNC2=NC=C1C(C(=N1)C)=CC=C1C1=NN=CN1 YYVCGFXRDDLIIQ-UHFFFAOYSA-N 0.000 claims description 2
• RPVUSNPGWPFBMC-UHFFFAOYSA-N 5-propan-2-yl-3-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)C(=O)CNC2=NC=C1C(C=N1)=CC=C1C=1N=CNN=1 RPVUSNPGWPFBMC-UHFFFAOYSA-N 0.000 claims description 2
• ILNOEDXAWIRCKH-UHFFFAOYSA-N 6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-4-(oxan-4-ylmethyl)spiro[1h-pyrazino[2,3-b]pyrazine-3,1'-cyclobutane]-2-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C1N2CC3CCOCC3)=CN=C1NC(=O)C12CCC1 ILNOEDXAWIRCKH-UHFFFAOYSA-N 0.000 claims description 2
• PJQVEQKFGGSAEV-UHFFFAOYSA-N 6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-4-(oxan-4-ylmethyl)spiro[1h-pyrazino[2,3-b]pyrazine-3,1'-cyclopentane]-2-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C1N2CC3CCOCC3)=CN=C1NC(=O)C12CCCC1 PJQVEQKFGGSAEV-UHFFFAOYSA-N 0.000 claims description 2
• STXPSSAFZHNAFA-UHFFFAOYSA-N 6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]spiro[1,4-dihydropyrazino[2,3-b]pyrazine-3,1'-cyclobutane]-2-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C1N2)=CN=C1NC(=O)C12CCC1 STXPSSAFZHNAFA-UHFFFAOYSA-N 0.000 claims description 2
• CSGDQYPPEGPFMJ-UHFFFAOYSA-N 6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]spiro[1,4-dihydropyrazino[2,3-b]pyrazine-3,1'-cyclopentane]-2-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C1N2)=CN=C1NC(=O)C12CCCC1 CSGDQYPPEGPFMJ-UHFFFAOYSA-N 0.000 claims description 2
• VKHASUACNKVOCT-UHFFFAOYSA-N 6-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]spiro[1,4-dihydropyrazino[2,3-b]pyrazine-3,1'-cyclopropane]-2-one Chemical compound CC1=CC(C=2NC=NN=2)=CC=C1C(N=C1N2)=CN=C1NC(=O)C12CC1 VKHASUACNKVOCT-UHFFFAOYSA-N 0.000 claims description 2
• VWKCUHUGNGSMKP-UHFFFAOYSA-N 6-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-2,2-dimethyl-4-[2-(oxan-4-yl)ethyl]-1h-pyrazino[2,3-b]pyrazin-3-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(C)(C)C(=O)N2CCC3CCOCC3)C2=N1 VWKCUHUGNGSMKP-UHFFFAOYSA-N 0.000 claims description 2
• AUOAXJCFODXAQR-UHFFFAOYSA-N 6-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-3,3-dimethyl-4-[2-(oxan-4-yl)ethyl]-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)C(C)(C)N2CCC3CCOCC3)C2=N1 AUOAXJCFODXAQR-UHFFFAOYSA-N 0.000 claims description 2
• KVDWSOSXHPMIDY-UHFFFAOYSA-N 8-(2,2-dimethylpropyl)-5-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-7H-pyrazino[2,3-b]pyrazin-6-one Chemical compound OC(C)(C)C1=CC=C(C=N1)N1C(CN(C=2C1=NC=CN2)CC(C)(C)C)=O KVDWSOSXHPMIDY-UHFFFAOYSA-N 0.000 claims description 2
• LBQBMEVXMVNFHK-UHFFFAOYSA-N 8-(2-methoxyethyl)-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C(C(=N1)C)=CC=C1C1=NN=CN1 LBQBMEVXMVNFHK-UHFFFAOYSA-N 0.000 claims description 2
• KFVVAZHOBVROKG-UHFFFAOYSA-N 8-(2-methoxyethyl)-2-[4-(1h-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C(C=C1)=CC=C1C1=NN=CN1 KFVVAZHOBVROKG-UHFFFAOYSA-N 0.000 claims description 2
• GSTUONVZFWSEFP-UHFFFAOYSA-N 8-(2-methoxyethyl)-2-[4-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C(C(=C1)C)=CN=C1C=1N=CNN=1 GSTUONVZFWSEFP-UHFFFAOYSA-N 0.000 claims description 2
• NRHQSISFDUSJJZ-UHFFFAOYSA-N 8-(2-methoxyethyl)-2-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CCOC)CC(=O)NC2=NC=C1C(C=N1)=CC=C1C=1N=CNN=1 NRHQSISFDUSJJZ-UHFFFAOYSA-N 0.000 claims description 2
• QKLRYTKMUYKEAJ-UHFFFAOYSA-N 8-(cyclohexylmethyl)-2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CC3CCCCC3)C2=N1 QKLRYTKMUYKEAJ-UHFFFAOYSA-N 0.000 claims description 2
• BXQHXEPMIVXXOS-UHFFFAOYSA-N 8-(cyclopentylmethyl)-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NC(=O)CN2CC1CCCC1 BXQHXEPMIVXXOS-UHFFFAOYSA-N 0.000 claims description 2
• WLBNKPWTZVPTCA-UHFFFAOYSA-N 8-(cyclopentylmethyl)-2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CC3CCCC3)C2=N1 WLBNKPWTZVPTCA-UHFFFAOYSA-N 0.000 claims description 2
• MLQAPXUPBCAVDD-UHFFFAOYSA-N 8-(cyclopropylmethyl)-2-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2CC3CC3)C2=N1 MLQAPXUPBCAVDD-UHFFFAOYSA-N 0.000 claims description 2
• GHZNTMVDONIJMJ-UHFFFAOYSA-N 8-(oxan-4-ylmethyl)-2-[4-(1h-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=CC(=CC=3)C=3NC=NN=3)=CN=C2NC(=O)CN1CC1CCOCC1 GHZNTMVDONIJMJ-UHFFFAOYSA-N 0.000 claims description 2
• PRRWMVAYVIIEBP-CHWSQXEVSA-N 8-[(1r,3r)-3-methoxycyclopentyl]-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 PRRWMVAYVIIEBP-CHWSQXEVSA-N 0.000 claims description 2
• PRRWMVAYVIIEBP-OLZOCXBDSA-N 8-[(1r,3s)-3-methoxycyclopentyl]-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 PRRWMVAYVIIEBP-OLZOCXBDSA-N 0.000 claims description 2
• PRRWMVAYVIIEBP-QWHCGFSZSA-N 8-[(1s,3r)-3-methoxycyclopentyl]-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 PRRWMVAYVIIEBP-QWHCGFSZSA-N 0.000 claims description 2
• PRRWMVAYVIIEBP-STQMWFEESA-N 8-[(1s,3s)-3-methoxycyclopentyl]-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 PRRWMVAYVIIEBP-STQMWFEESA-N 0.000 claims description 2
• SWRPWGNFTYMVQO-UHFFFAOYSA-N 8-[2-(oxan-4-yl)ethyl]-2-(1h-pyrrolo[2,3-b]pyridin-5-yl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=C4C=CNC4=NC=3)=CN=C2NC(=O)CN1CCC1CCOCC1 SWRPWGNFTYMVQO-UHFFFAOYSA-N 0.000 claims description 2
• WGVBIPHUSCOSGR-UHFFFAOYSA-N 8-[2-(oxan-4-yl)ethyl]-2-[3-(1h-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=C(C=CC=3)C=3NN=CN=3)=CN=C2NC(=O)CN1CCC1CCOCC1 WGVBIPHUSCOSGR-UHFFFAOYSA-N 0.000 claims description 2
• RBCVZOQQBMCWAL-UHFFFAOYSA-N 8-[2-(oxan-4-yl)ethyl]-2-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=NC(=CC=3)C=3NC=NN=3)=CN=C2NC(=O)CN1CCC1CCOCC1 RBCVZOQQBMCWAL-UHFFFAOYSA-N 0.000 claims description 2
• IKJNTZVWDMXCEA-KGLIPLIRSA-N 8-[[(1r,3s)-3-methoxycyclopentyl]methyl]-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@@H](OC)CC[C@H]1CN1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 IKJNTZVWDMXCEA-KGLIPLIRSA-N 0.000 claims description 2
• IKJNTZVWDMXCEA-UONOGXRCSA-N 8-[[(1s,3r)-3-methoxycyclopentyl]methyl]-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 IKJNTZVWDMXCEA-UONOGXRCSA-N 0.000 claims description 2
• XQHYPZYISNXXOH-CQSZACIVSA-N 8-[[(2r)-oxolan-2-yl]methyl]-2-[4-(1h-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=CC(=CC=3)C=3NC=NN=3)=CN=C2NC(=O)CN1C[C@H]1CCCO1 XQHYPZYISNXXOH-CQSZACIVSA-N 0.000 claims description 2
• XQHYPZYISNXXOH-AWEZNQCLSA-N 8-[[(2s)-oxolan-2-yl]methyl]-2-[4-(1h-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=CC(=CC=3)C=3NC=NN=3)=CN=C2NC(=O)CN1C[C@@H]1CCCO1 XQHYPZYISNXXOH-AWEZNQCLSA-N 0.000 claims description 2
• RGGGKLOHVQCLKI-UHFFFAOYSA-N 8-ethyl-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)CC(=O)NC2=NC=C1C(C(=N1)C)=CC=C1C1=NN=CN1 RGGGKLOHVQCLKI-UHFFFAOYSA-N 0.000 claims description 2
• ZSMPGGSXRQZDSI-UHFFFAOYSA-N 8-ethyl-2-[4-(1h-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)CC(=O)NC2=NC=C1C(C=C1)=CC=C1C1=NN=CN1 ZSMPGGSXRQZDSI-UHFFFAOYSA-N 0.000 claims description 2
• IJPDTFGHINPMDZ-UHFFFAOYSA-N 8-ethyl-2-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)CC(=O)NC2=NC=C1C(C=N1)=CC=C1C=1N=CNN=1 IJPDTFGHINPMDZ-UHFFFAOYSA-N 0.000 claims description 2
• SPXZOEYWZLMLNF-UHFFFAOYSA-N 8-propan-2-yl-2-[6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)CC(=O)NC2=NC=C1C(C=N1)=CC=C1C=1N=CNN=1 SPXZOEYWZLMLNF-UHFFFAOYSA-N 0.000 claims description 2
• DWLJVUMDUSLYKR-HDJSIYSDSA-N C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2[C@@H]3CC[C@@H](O)CC3)C2=N1 Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2[C@@H]3CC[C@@H](O)CC3)C2=N1 DWLJVUMDUSLYKR-HDJSIYSDSA-N 0.000 claims description 2
• DWLJVUMDUSLYKR-OKILXGFUSA-N C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2[C@H]3CC[C@@H](O)CC3)C2=N1 Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NC(=O)CN2[C@H]3CC[C@@H](O)CC3)C2=N1 DWLJVUMDUSLYKR-OKILXGFUSA-N 0.000 claims description 2
• KTLFTPMXQQIXMP-HDJSIYSDSA-N C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2[C@@H]3CC[C@@H](O)CC3)C2=N1 Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2[C@@H]3CC[C@@H](O)CC3)C2=N1 KTLFTPMXQQIXMP-HDJSIYSDSA-N 0.000 claims description 2
• KTLFTPMXQQIXMP-OKILXGFUSA-N C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2[C@H]3CC[C@@H](O)CC3)C2=N1 Chemical compound C1=NC(C(C)(O)C)=CC=C1C1=CN=C(NCC(=O)N2[C@H]3CC[C@@H](O)CC3)C2=N1 KTLFTPMXQQIXMP-OKILXGFUSA-N 0.000 claims description 2
• TZHUXNWOSOSEOU-MQMHXKEQSA-N C1C[C@@H](O)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](O)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 TZHUXNWOSOSEOU-MQMHXKEQSA-N 0.000 claims description 2
• HNRUHUMESXAVSX-MQMHXKEQSA-N C1C[C@@H](O)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O Chemical compound C1C[C@@H](O)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O HNRUHUMESXAVSX-MQMHXKEQSA-N 0.000 claims description 2
• ABLFRLHGLALIJS-JOCQHMNTSA-N C1C[C@@H](O)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](O)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 ABLFRLHGLALIJS-JOCQHMNTSA-N 0.000 claims description 2
• ZADHRFJEWSWHTM-JOCQHMNTSA-N C1C[C@@H](O)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O Chemical compound C1C[C@@H](O)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O ZADHRFJEWSWHTM-JOCQHMNTSA-N 0.000 claims description 2
• TZHUXNWOSOSEOU-XBXGTLAGSA-N C1C[C@@H](O)CC[C@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](O)CC[C@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 TZHUXNWOSOSEOU-XBXGTLAGSA-N 0.000 claims description 2
• HNRUHUMESXAVSX-XBXGTLAGSA-N C1C[C@@H](O)CC[C@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O Chemical compound C1C[C@@H](O)CC[C@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O HNRUHUMESXAVSX-XBXGTLAGSA-N 0.000 claims description 2
• ABLFRLHGLALIJS-BETUJISGSA-N C1C[C@@H](O)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](O)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 ABLFRLHGLALIJS-BETUJISGSA-N 0.000 claims description 2
• ZADHRFJEWSWHTM-BETUJISGSA-N C1C[C@@H](O)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O Chemical compound C1C[C@@H](O)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O ZADHRFJEWSWHTM-BETUJISGSA-N 0.000 claims description 2
• SPGRJRJDZVPGOT-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NC(=O)C1 SPGRJRJDZVPGOT-SHTZXODSSA-N 0.000 claims description 2
• ZNYMSBFVLLHDJP-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NCC1=O ZNYMSBFVLLHDJP-SHTZXODSSA-N 0.000 claims description 2
• NRKHRXABMIBGEW-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=NC=3)C3=NNC=N3)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=NC=3)C3=NNC=N3)C)=CN=C2NCC1=O NRKHRXABMIBGEW-SHTZXODSSA-N 0.000 claims description 2
• KVEPKTYZFVUHKX-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=NC(=CC=3)C3=NNC=N3)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=NC(=CC=3)C3=NNC=N3)C)=CN=C2NCC1=O KVEPKTYZFVUHKX-SHTZXODSSA-N 0.000 claims description 2
• CXTSHKNYOVLEJT-RZDIXWSQSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=CC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=CC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 CXTSHKNYOVLEJT-RZDIXWSQSA-N 0.000 claims description 2
• NPBANVRWVVVQJV-KOMQPUFPSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 NPBANVRWVVVQJV-KOMQPUFPSA-N 0.000 claims description 2
• KXDXRGGNJRTDPF-KOMQPUFPSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O KXDXRGGNJRTDPF-KOMQPUFPSA-N 0.000 claims description 2
• IEJOOKMBLTZCSH-CTYIDZIISA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 IEJOOKMBLTZCSH-CTYIDZIISA-N 0.000 claims description 2
• ZNBIWMFZTYSTHE-CTYIDZIISA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O ZNBIWMFZTYSTHE-CTYIDZIISA-N 0.000 claims description 2
• LWEANEUUPMFOAV-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=C(F)C(C4=NNC=N4)=CC=3)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=C(F)C(C4=NNC=N4)=CC=3)C)=CN=C2NC(=O)C1 LWEANEUUPMFOAV-HDJSIYSDSA-N 0.000 claims description 2
• PEQCVXULHGVULI-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NC(=O)C1 PEQCVXULHGVULI-HDJSIYSDSA-N 0.000 claims description 2
• IQBLMUACDDUKHT-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NCC1=O IQBLMUACDDUKHT-HDJSIYSDSA-N 0.000 claims description 2
• OKXFJZPFOWVLJA-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=NC=3)C(C)(C)O)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=NC=3)C(C)(C)O)C)=CN=C2NC(=O)C1 OKXFJZPFOWVLJA-SHTZXODSSA-N 0.000 claims description 2
• OCSPQJXVGHARNB-JOCQHMNTSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=NC=3)C(N)=O)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=NC=3)C(N)=O)C)=CN=C2NC(=O)C1 OCSPQJXVGHARNB-JOCQHMNTSA-N 0.000 claims description 2
• FUXWSETYLSIMOM-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=NC=3)C3=NNC=N3)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=CC(=NC=3)C3=NNC=N3)C)=CN=C2NCC1=O FUXWSETYLSIMOM-HDJSIYSDSA-N 0.000 claims description 2
• JKTYSPNFRTWOKB-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C(C)(C)O)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C(C)(C)O)C)=CN=C2NC(=O)C1 JKTYSPNFRTWOKB-SHTZXODSSA-N 0.000 claims description 2
• AHTXWEHJMLNLGH-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 AHTXWEHJMLNLGH-HDJSIYSDSA-N 0.000 claims description 2
• DXYGEHPPAYSYLJ-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NCC1=O DXYGEHPPAYSYLJ-HDJSIYSDSA-N 0.000 claims description 2
• ZDJQARYZMONTRY-QAQDUYKDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=CC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=CC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 ZDJQARYZMONTRY-QAQDUYKDSA-N 0.000 claims description 2
• ZGLONRFJOSBXER-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 ZGLONRFJOSBXER-SHTZXODSSA-N 0.000 claims description 2
• ZEGQEBXPUDXWGO-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 ZEGQEBXPUDXWGO-HDJSIYSDSA-N 0.000 claims description 2
• MVBGDSJVWDIFQJ-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O MVBGDSJVWDIFQJ-HDJSIYSDSA-N 0.000 claims description 2
• XTQFYGUDDGJCCH-SHTZXODSSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=[N+]([O-])C(=CC=3)C(C)(C)O)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(C=3C=[N+]([O-])C(=CC=3)C(C)(C)O)=CN=C2NCC1=O XTQFYGUDDGJCCH-SHTZXODSSA-N 0.000 claims description 2
• LWEANEUUPMFOAV-OKILXGFUSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=C(F)C(C4=NNC=N4)=CC=3)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=C(F)C(C4=NNC=N4)=CC=3)C)=CN=C2NC(=O)C1 LWEANEUUPMFOAV-OKILXGFUSA-N 0.000 claims description 2
• PEQCVXULHGVULI-OKILXGFUSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NC(=O)C1 PEQCVXULHGVULI-OKILXGFUSA-N 0.000 claims description 2
• OQVFHGHNGHEBQU-GASCZTMLSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=NC(=CC=3)C#N)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=NC(=CC=3)C#N)C)=CN=C2NC(=O)C1 OQVFHGHNGHEBQU-GASCZTMLSA-N 0.000 claims description 2
• AHTXWEHJMLNLGH-OKILXGFUSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C(=NC(=CC=3)C=3NC=NN=3)C)=CN=C2NC(=O)C1 AHTXWEHJMLNLGH-OKILXGFUSA-N 0.000 claims description 2
• ZGLONRFJOSBXER-GASCZTMLSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 ZGLONRFJOSBXER-GASCZTMLSA-N 0.000 claims description 2
• ZEGQEBXPUDXWGO-OKILXGFUSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 ZEGQEBXPUDXWGO-OKILXGFUSA-N 0.000 claims description 2
• MVBGDSJVWDIFQJ-OKILXGFUSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O MVBGDSJVWDIFQJ-OKILXGFUSA-N 0.000 claims description 2
• SPGRJRJDZVPGOT-GASCZTMLSA-N C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NC(=O)C1 SPGRJRJDZVPGOT-GASCZTMLSA-N 0.000 claims description 2
• ZNYMSBFVLLHDJP-GASCZTMLSA-N C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NCC1=O Chemical compound C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=C(F)C=3)C3=NNC=N3)C)=CN=C2NCC1=O ZNYMSBFVLLHDJP-GASCZTMLSA-N 0.000 claims description 2
• KVEPKTYZFVUHKX-GASCZTMLSA-N C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=NC(=CC=3)C3=NNC=N3)C)=CN=C2NCC1=O Chemical compound C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=NC(=CC=3)C3=NNC=N3)C)=CN=C2NCC1=O KVEPKTYZFVUHKX-GASCZTMLSA-N 0.000 claims description 2
• NPBANVRWVVVQJV-FZNQNYSPSA-N C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 Chemical compound C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NC(=O)C1 NPBANVRWVVVQJV-FZNQNYSPSA-N 0.000 claims description 2
• KXDXRGGNJRTDPF-FZNQNYSPSA-N C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O Chemical compound C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O KXDXRGGNJRTDPF-FZNQNYSPSA-N 0.000 claims description 2
• IEJOOKMBLTZCSH-OTVXOJSOSA-N C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 Chemical compound C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NC(=O)C1 IEJOOKMBLTZCSH-OTVXOJSOSA-N 0.000 claims description 2
• ZNBIWMFZTYSTHE-OTVXOJSOSA-N C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O Chemical compound C1C[C@H](OC)CC[C@@H]1CN1C2=NC(C=3C=NC(=CC=3)C3=NNC=N3)=CN=C2NCC1=O ZNBIWMFZTYSTHE-OTVXOJSOSA-N 0.000 claims description 2
• OSSHUTSYXCKZMN-WKILWMFISA-N CC(C=CN=C1C)=C1C1=NC(N(C[C@H](CC2)CC[C@@H]2OC)C(CN2)=O)=C2N=C1 Chemical compound CC(C=CN=C1C)=C1C1=NC(N(C[C@H](CC2)CC[C@@H]2OC)C(CN2)=O)=C2N=C1 OSSHUTSYXCKZMN-WKILWMFISA-N 0.000 claims description 2
• BIYXBMJPSRSLCH-BETUJISGSA-N CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2[C@@H]1CC[C@H](O)CC1 Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2[C@@H]1CC[C@H](O)CC1 BIYXBMJPSRSLCH-BETUJISGSA-N 0.000 claims description 2
• BIYXBMJPSRSLCH-JOCQHMNTSA-N CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2[C@H]1CC[C@H](O)CC1 Chemical compound CC1=NC(C=2NC=NN=2)=CC=C1C(N=C12)=CN=C1NCC(=O)N2[C@H]1CC[C@H](O)CC1 BIYXBMJPSRSLCH-JOCQHMNTSA-N 0.000 claims description 2
• UWCDGUGMIIBSNZ-IYBDPMFKSA-N CO[C@H]1CC[C@H](CC1)CN1C2=C(NCC1=O)N=CC(=N2)C=2C(=CC(=NC2)C)C Chemical compound CO[C@H]1CC[C@H](CC1)CN1C2=C(NCC1=O)N=CC(=N2)C=2C(=CC(=NC2)C)C UWCDGUGMIIBSNZ-IYBDPMFKSA-N 0.000 claims description 2
• DFHJIYKBSFMGTL-HDJSIYSDSA-N FC=1C=C(C=2N=C3N(C[C@@H]4CC[C@@H](O)CC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 Chemical compound FC=1C=C(C=2N=C3N(C[C@@H]4CC[C@@H](O)CC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 DFHJIYKBSFMGTL-HDJSIYSDSA-N 0.000 claims description 2
• PDWFKNLSEZQKMO-HDJSIYSDSA-N FC=1C=C(C=2N=C3N(C[C@@H]4CC[C@@H](O)CC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 Chemical compound FC=1C=C(C=2N=C3N(C[C@@H]4CC[C@@H](O)CC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 PDWFKNLSEZQKMO-HDJSIYSDSA-N 0.000 claims description 2
• DFHJIYKBSFMGTL-OKILXGFUSA-N FC=1C=C(C=2N=C3N(C[C@H]4CC[C@@H](O)CC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 Chemical compound FC=1C=C(C=2N=C3N(C[C@H]4CC[C@@H](O)CC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 DFHJIYKBSFMGTL-OKILXGFUSA-N 0.000 claims description 2
• PDWFKNLSEZQKMO-OKILXGFUSA-N FC=1C=C(C=2N=C3N(C[C@H]4CC[C@@H](O)CC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 Chemical compound FC=1C=C(C=2N=C3N(C[C@H]4CC[C@@H](O)CC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 PDWFKNLSEZQKMO-OKILXGFUSA-N 0.000 claims description 2
• BVPODDRJFGBSDV-JOCQHMNTSA-N FC=1C=C(C=2N=C3N([C@@H]4CC[C@@H](O)CC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 Chemical compound FC=1C=C(C=2N=C3N([C@@H]4CC[C@@H](O)CC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 BVPODDRJFGBSDV-JOCQHMNTSA-N 0.000 claims description 2
• NCYPXMZZCBFOHU-JOCQHMNTSA-N FC=1C=C(C=2N=C3N([C@@H]4CC[C@@H](O)CC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 Chemical compound FC=1C=C(C=2N=C3N([C@@H]4CC[C@@H](O)CC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 NCYPXMZZCBFOHU-JOCQHMNTSA-N 0.000 claims description 2
• BVPODDRJFGBSDV-BETUJISGSA-N FC=1C=C(C=2N=C3N([C@H]4CC[C@@H](O)CC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 Chemical compound FC=1C=C(C=2N=C3N([C@H]4CC[C@@H](O)CC4)C(=O)CNC3=NC=2)C(C)=CC=1C=1N=CNN=1 BVPODDRJFGBSDV-BETUJISGSA-N 0.000 claims description 2
• NCYPXMZZCBFOHU-BETUJISGSA-N FC=1C=C(C=2N=C3N([C@H]4CC[C@@H](O)CC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 Chemical compound FC=1C=C(C=2N=C3N([C@H]4CC[C@@H](O)CC4)CC(=O)NC3=NC=2)C(C)=CC=1C=1N=CNN=1 NCYPXMZZCBFOHU-BETUJISGSA-N 0.000 claims description 2
• GNKOTIZUHONTHK-JHJOSGQCSA-N OC(C)(C)C1=CC=C(C=C1)C1NC=2C(=NC=CN2)N(C1=O)[C@@H]1CC[C@H](CC1)OC Chemical compound OC(C)(C)C1=CC=C(C=C1)C1NC=2C(=NC=CN2)N(C1=O)[C@@H]1CC[C@H](CC1)OC GNKOTIZUHONTHK-JHJOSGQCSA-N 0.000 claims description 2
• CUQOHAYJWVTKDE-UHFFFAOYSA-N potassium;butan-1-olate Chemical group [K+].CCCC[O-] CUQOHAYJWVTKDE-UHFFFAOYSA-N 0.000 claims description 2
• 125000005843 halogen group Chemical group 0.000 claims 13
• HAKVNWBUOCSHTR-UHFFFAOYSA-N (9,9-dimethylxanthen-1-yl)-diphenylphosphane Chemical compound C=12C(C)(C)C3=CC=CC=C3OC2=CC=CC=1P(C=1C=CC=CC=1)C1=CC=CC=C1 HAKVNWBUOCSHTR-UHFFFAOYSA-N 0.000 claims 2
• KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims 1
• XUUDRYNLHCRUEM-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-5-[(3-methoxyphenyl)methyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound COC1=CC=CC(CN2C3=NC(=CN=C3NCC2=O)C=2C=CC(O)=CC=2)=C1 XUUDRYNLHCRUEM-UHFFFAOYSA-N 0.000 claims 1
• PVPHLPKWACCKHK-UHFFFAOYSA-N 8-[2-(oxan-4-yl)ethyl]-2-(1h-pyrrolo[2,3-b]pyridin-3-yl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C4=CC=CN=C4NC=3)=CN=C2NC(=O)CN1CCC1CCOCC1 PVPHLPKWACCKHK-UHFFFAOYSA-N 0.000 claims 1
• IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims 1
• 150000002366 halogen compounds Chemical class 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 43
• 206010028980 Neoplasm Diseases 0.000 abstract description 37
• 201000010099 disease Diseases 0.000 abstract description 32
• 201000011510 cancer Diseases 0.000 abstract description 21
• 208000024891 symptom Diseases 0.000 abstract description 20
• 230000002757 inflammatory effect Effects 0.000 abstract description 9
• 206010012601 diabetes mellitus Diseases 0.000 abstract description 7
• 208000008589 Obesity Diseases 0.000 abstract description 6
• 230000004770 neurodegeneration Effects 0.000 abstract description 6
• 235000020824 obesity Nutrition 0.000 abstract description 6
• 230000001900 immune effect Effects 0.000 abstract description 5
• 208000015122 neurodegenerative disease Diseases 0.000 abstract description 5
• 208000012902 Nervous system disease Diseases 0.000 abstract description 4
• 208000025966 Neurological disease Diseases 0.000 abstract description 4
• 230000002526 effect on cardiovascular system Effects 0.000 abstract description 4
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 504
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 256
• 239000007787 solid Substances 0.000 description 177
• 239000000243 solution Substances 0.000 description 176
• 230000002829 reductive effect Effects 0.000 description 151
• 239000011259 mixed solution Substances 0.000 description 147
• 239000000047 product Substances 0.000 description 129
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 125
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 118
• 238000006243 chemical reaction Methods 0.000 description 101
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 79
• 229910052757 nitrogen Inorganic materials 0.000 description 57
• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 53
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 41
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 38
• 239000012044 organic layer Substances 0.000 description 36
• 239000011541 reaction mixture Substances 0.000 description 35
• 238000003756 stirring Methods 0.000 description 35
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
• 239000000706 filtrate Substances 0.000 description 33
• 125000001424 substituent group Chemical group 0.000 description 33
• 238000005481 NMR spectroscopy Methods 0.000 description 32
• 239000000203 mixture Substances 0.000 description 31
• 239000003921 oil Substances 0.000 description 29
• 238000003818 flash chromatography Methods 0.000 description 28
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 26
• 235000019341 magnesium sulphate Nutrition 0.000 description 26
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 24
• 229920006395 saturated elastomer Polymers 0.000 description 22
• 239000012267 brine Substances 0.000 description 20
• SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 20
• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 20
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 19
• 108091000080 Phosphotransferase Proteins 0.000 description 19
• 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 description 19
• 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 description 19
• NXQGGXCHGDYOHB-UHFFFAOYSA-L cyclopenta-1,4-dien-1-yl(diphenyl)phosphane;dichloropalladium;iron(2+) Chemical compound [Fe+2].Cl[Pd]Cl.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 NXQGGXCHGDYOHB-UHFFFAOYSA-L 0.000 description 19
• 238000001914 filtration Methods 0.000 description 19
• 239000000543 intermediate Substances 0.000 description 19
• 239000010410 layer Substances 0.000 description 19
• 102000020233 phosphotransferase Human genes 0.000 description 19
• 239000000741 silica gel Substances 0.000 description 19
• 229910002027 silica gel Inorganic materials 0.000 description 19
• 239000003039 volatile agent Substances 0.000 description 19
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 18
• 125000004093 cyano group Chemical group *C#N 0.000 description 18
• 239000012071 phase Substances 0.000 description 18
• 238000010898 silica gel chromatography Methods 0.000 description 18
• 238000011282 treatment Methods 0.000 description 18
• 238000010992 reflux Methods 0.000 description 17
• VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 16
• 239000000908 ammonium hydroxide Substances 0.000 description 16
• 238000000746 purification Methods 0.000 description 16
• 238000003828 vacuum filtration Methods 0.000 description 16
• 108091007960 PI3Ks Proteins 0.000 description 15
• 102000038030 PI3Ks Human genes 0.000 description 15
• 230000037361 pathway Effects 0.000 description 15
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 14
• 239000000463 material Substances 0.000 description 14
• 238000002953 preparative HPLC Methods 0.000 description 14
• 230000002441 reversible effect Effects 0.000 description 14
• 229910052938 sodium sulfate Inorganic materials 0.000 description 14
• 235000011152 sodium sulphate Nutrition 0.000 description 14
• ZLTDABKISAGHGQ-UHFFFAOYSA-N ethyl 2-[(3,5-dibromopyrazin-2-yl)amino]acetate Chemical compound CCOC(=O)CNC1=NC=C(Br)N=C1Br ZLTDABKISAGHGQ-UHFFFAOYSA-N 0.000 description 13
• 239000012299 nitrogen atmosphere Substances 0.000 description 13
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 13
• 125000004076 pyridyl group Chemical group 0.000 description 13
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 12
• PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 12
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 12
• 229910000027 potassium carbonate Inorganic materials 0.000 description 12
• 230000002265 prevention Effects 0.000 description 12
• LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 12
• BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 description 11
• 108091008611 Protein Kinase B Proteins 0.000 description 11
• 239000007864 aqueous solution Substances 0.000 description 11
• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 11
• 229910001873 dinitrogen Inorganic materials 0.000 description 11
• 208000035475 disorder Diseases 0.000 description 11
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 11
• 239000002002 slurry Substances 0.000 description 11
• BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 10
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 10
• 102000001253 Protein Kinase Human genes 0.000 description 10
• 210000004027 cell Anatomy 0.000 description 10
• 238000001816 cooling Methods 0.000 description 10
• 239000012065 filter cake Substances 0.000 description 10
• IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine hydrate Chemical compound O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 10
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 10
• 239000003208 petroleum Substances 0.000 description 10
• 235000011056 potassium acetate Nutrition 0.000 description 10
• 108060006633 protein kinase Proteins 0.000 description 10
• 150000003254 radicals Chemical group 0.000 description 10
• CYPYTURSJDMMMP-WVCUSYJESA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].[Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 CYPYTURSJDMMMP-WVCUSYJESA-N 0.000 description 9
• YQBWUEBSDRAFNZ-UHFFFAOYSA-N 3-bromo-2-methyl-6-[1-(oxan-2-yl)-1,2,4-triazol-3-yl]pyridine Chemical compound C1=C(Br)C(C)=NC(C2=NN(C=N2)C2OCCCC2)=C1 YQBWUEBSDRAFNZ-UHFFFAOYSA-N 0.000 description 9
• NFJCCSONEBUNGR-UHFFFAOYSA-N 5-bromo-6-methylpyridine-2-carbonitrile Chemical compound CC1=NC(C#N)=CC=C1Br NFJCCSONEBUNGR-UHFFFAOYSA-N 0.000 description 9
• 238000006619 Stille reaction Methods 0.000 description 9
• 125000004432 carbon atom Chemical group C* 0.000 description 9
• 239000012043 crude product Substances 0.000 description 9
• 125000002768 hydroxyalkyl group Chemical group 0.000 description 9
• 229940098779 methanesulfonic acid Drugs 0.000 description 9
• 239000002244 precipitate Substances 0.000 description 9
• 125000003226 pyrazolyl group Chemical group 0.000 description 9
• FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 9
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 9
• DJWLQUUYOPIWAO-UHFFFAOYSA-N 3-bromo-2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridine Chemical compound C1=C(Br)C(C)=NC(C2=NNC=N2)=C1 DJWLQUUYOPIWAO-UHFFFAOYSA-N 0.000 description 8
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 8
• 238000006069 Suzuki reaction reaction Methods 0.000 description 8
• IPWKHHSGDUIRAH-UHFFFAOYSA-N bis(pinacolato)diboron Chemical compound O1C(C)(C)C(C)(C)OB1B1OC(C)(C)C(C)(C)O1 IPWKHHSGDUIRAH-UHFFFAOYSA-N 0.000 description 8
• 230000005764 inhibitory process Effects 0.000 description 8
• 208000011580 syndromic disease Diseases 0.000 description 8
• 125000001425 triazolyl group Chemical group 0.000 description 8
• 238000005406 washing Methods 0.000 description 8
• 150000001412 amines Chemical class 0.000 description 7
• 230000015572 biosynthetic process Effects 0.000 description 7
• 239000004327 boric acid Substances 0.000 description 7
• 206010009887 colitis Diseases 0.000 description 7
• 238000004440 column chromatography Methods 0.000 description 7
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
• 125000001041 indolyl group Chemical group 0.000 description 7
• 210000003734 kidney Anatomy 0.000 description 7
• 210000004185 liver Anatomy 0.000 description 7
• 210000004072 lung Anatomy 0.000 description 7
• 125000000714 pyrimidinyl group Chemical group 0.000 description 7
• 238000006798 ring closing metathesis reaction Methods 0.000 description 7
• 210000003491 skin Anatomy 0.000 description 7
• 229910000080 stannane Inorganic materials 0.000 description 7
• KXCAEQNNTZANTK-UHFFFAOYSA-N stannane Chemical compound [SnH4] KXCAEQNNTZANTK-UHFFFAOYSA-N 0.000 description 7
• 238000003786 synthesis reaction Methods 0.000 description 7
• 238000004809 thin layer chromatography Methods 0.000 description 7
• DTLBKXRFWUERQN-UHFFFAOYSA-N 3,5-dibromopyrazin-2-amine Chemical compound NC1=NC=C(Br)N=C1Br DTLBKXRFWUERQN-UHFFFAOYSA-N 0.000 description 6
• IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 6
• 238000013459 approach Methods 0.000 description 6
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 6
• PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 6
• DOBRDRYODQBAMW-UHFFFAOYSA-N copper(i) cyanide Chemical compound [Cu+].N#[C-] DOBRDRYODQBAMW-UHFFFAOYSA-N 0.000 description 6
• 238000010438 heat treatment Methods 0.000 description 6
• 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 description 6
• 208000014674 injury Diseases 0.000 description 6
• 210000000496 pancreas Anatomy 0.000 description 6
• 229910000160 potassium phosphate Inorganic materials 0.000 description 6
• 235000011009 potassium phosphates Nutrition 0.000 description 6
• 239000011780 sodium chloride Substances 0.000 description 6
• 239000007858 starting material Substances 0.000 description 6
• 239000000725 suspension Substances 0.000 description 6
• 208000006542 von Hippel-Lindau disease Diseases 0.000 description 6
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 5
• WJMJWMSWJSACSN-UHFFFAOYSA-N 3,5-dibromopyridin-2-amine Chemical compound NC1=NC=C(Br)C=C1Br WJMJWMSWJSACSN-UHFFFAOYSA-N 0.000 description 5
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 5
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 5
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 5
• 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 description 5
• UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 5
• 210000000988 bone and bone Anatomy 0.000 description 5
• 210000004556 brain Anatomy 0.000 description 5
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 5
• FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 5
• 229910000024 caesium carbonate Inorganic materials 0.000 description 5
• 239000000460 chlorine Substances 0.000 description 5
• 229910052801 chlorine Inorganic materials 0.000 description 5
• 238000004587 chromatography analysis Methods 0.000 description 5
• 239000011737 fluorine Substances 0.000 description 5
• 229910052731 fluorine Inorganic materials 0.000 description 5
• 235000019253 formic acid Nutrition 0.000 description 5
• 125000005842 heteroatom Chemical group 0.000 description 5
• 238000004128 high performance liquid chromatography Methods 0.000 description 5
• 239000005457 ice water Substances 0.000 description 5
• 125000002883 imidazolyl group Chemical group 0.000 description 5
• 125000001412 tetrahydropyranyl group Chemical group 0.000 description 5
• CCRMAATUKBYMPA-UHFFFAOYSA-N trimethyltin Chemical compound C[Sn](C)C.C[Sn](C)C CCRMAATUKBYMPA-UHFFFAOYSA-N 0.000 description 5
• KYDBSZOYSKYICM-UHFFFAOYSA-N 2-(5-trimethylstannylpyridin-2-yl)propan-2-ol Chemical compound CC(C)(O)C1=CC=C([Sn](C)(C)C)C=N1 KYDBSZOYSKYICM-UHFFFAOYSA-N 0.000 description 4
• UCHKRHGVKYVGTC-UHFFFAOYSA-N 3,6-dibromo-2-methylpyridine Chemical compound CC1=NC(Br)=CC=C1Br UCHKRHGVKYVGTC-UHFFFAOYSA-N 0.000 description 4
• NJTBQTUBDFATFP-UHFFFAOYSA-N 3-bromo-5-ethyl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C(Br)N=C2N(CC)C(=O)CNC2=N1 NJTBQTUBDFATFP-UHFFFAOYSA-N 0.000 description 4
• TWZYAXSENRULCZ-UHFFFAOYSA-N 3-bromo-5-propan-2-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C(Br)N=C2N(C(C)C)C(=O)CNC2=N1 TWZYAXSENRULCZ-UHFFFAOYSA-N 0.000 description 4
• NCGLRIMMNYDKIO-UHFFFAOYSA-N 3-bromo-6-iodo-2-methylpyridine Chemical compound CC1=NC(I)=CC=C1Br NCGLRIMMNYDKIO-UHFFFAOYSA-N 0.000 description 4
• DWOZNANUEDYIOF-UHFFFAOYSA-L 4-ditert-butylphosphanyl-n,n-dimethylaniline;dichloropalladium Chemical compound Cl[Pd]Cl.CN(C)C1=CC=C(P(C(C)(C)C)C(C)(C)C)C=C1.CN(C)C1=CC=C(P(C(C)(C)C)C(C)(C)C)C=C1 DWOZNANUEDYIOF-UHFFFAOYSA-L 0.000 description 4
• PPKQKRUNGRLNPE-UHFFFAOYSA-N 5-propan-2-yl-3-trimethylstannyl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C([Sn](C)(C)C)N=C2N(C(C)C)C(=O)CNC2=N1 PPKQKRUNGRLNPE-UHFFFAOYSA-N 0.000 description 4
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
• CBNCYSPEZRQDAU-KYZUINATSA-N C1C[C@@H](OC)CC[C@@H]1N1C2=NC(Br)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1N1C2=NC(Br)=CN=C2NCC1=O CBNCYSPEZRQDAU-KYZUINATSA-N 0.000 description 4
• 208000012609 Cowden disease Diseases 0.000 description 4
• 201000002847 Cowden syndrome Diseases 0.000 description 4
• 201000003883 Cystic fibrosis Diseases 0.000 description 4
• 201000004624 Dermatitis Diseases 0.000 description 4
• 206010014733 Endometrial cancer Diseases 0.000 description 4
• 206010014759 Endometrial neoplasm Diseases 0.000 description 4
• ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 4
• 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 description 4
• 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 description 4
• 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 description 4
• ZSXGLVDWWRXATF-UHFFFAOYSA-N N,N-dimethylformamide dimethyl acetal Chemical compound COC(OC)N(C)C ZSXGLVDWWRXATF-UHFFFAOYSA-N 0.000 description 4
• MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 4
• AHVYPIQETPWLSZ-UHFFFAOYSA-N N-methyl-pyrrolidine Natural products CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 description 4
• 102000007530 Neurofibromin 1 Human genes 0.000 description 4
• 108010085793 Neurofibromin 1 Proteins 0.000 description 4
• 102100036143 Polycystin-1 Human genes 0.000 description 4
• 206010052779 Transplant rejections Diseases 0.000 description 4
• HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 4
• 108050009309 Tuberin Proteins 0.000 description 4
• 102000044633 Tuberous Sclerosis Complex 2 Human genes 0.000 description 4
• 208000027418 Wounds and injury Diseases 0.000 description 4
• 235000001014 amino acid Nutrition 0.000 description 4
• YNHIGQDRGKUECZ-UHFFFAOYSA-L bis(triphenylphosphine)palladium(ii) dichloride Chemical compound [Cl-].[Cl-].[Pd+2].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 YNHIGQDRGKUECZ-UHFFFAOYSA-L 0.000 description 4
• 210000000621 bronchi Anatomy 0.000 description 4
• 208000035269 cancer or benign tumor Diseases 0.000 description 4
• KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 4
• 239000003795 chemical substances by application Substances 0.000 description 4
• 210000001072 colon Anatomy 0.000 description 4
• 239000012141 concentrate Substances 0.000 description 4
• 125000004122 cyclic group Chemical group 0.000 description 4
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 4
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
• 230000000694 effects Effects 0.000 description 4
• DQYBDCGIPTYXML-UHFFFAOYSA-N ethoxyethane;hydrate Chemical compound O.CCOCC DQYBDCGIPTYXML-UHFFFAOYSA-N 0.000 description 4
• 229910000041 hydrogen chloride Inorganic materials 0.000 description 4
• 125000002950 monocyclic group Chemical group 0.000 description 4
• LURCCLXOEMMYBM-UHFFFAOYSA-N n-(3,5-dibromopyrazin-2-yl)-2-iodoacetamide Chemical compound BrC1=CN=C(NC(=O)CI)C(Br)=N1 LURCCLXOEMMYBM-UHFFFAOYSA-N 0.000 description 4
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 4
• 229910052760 oxygen Inorganic materials 0.000 description 4
• 239000008194 pharmaceutical composition Substances 0.000 description 4
• 210000003800 pharynx Anatomy 0.000 description 4
• 210000002307 prostate Anatomy 0.000 description 4
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 4
• 239000011734 sodium Substances 0.000 description 4
• 210000002784 stomach Anatomy 0.000 description 4
• 150000003573 thiols Chemical class 0.000 description 4
• 210000001519 tissue Anatomy 0.000 description 4
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
• 210000003462 vein Anatomy 0.000 description 4
• 238000010626 work up procedure Methods 0.000 description 4
• FUKOTTQGWQVMQB-UHFFFAOYSA-N (2-bromoacetyl) 2-bromoacetate Chemical compound BrCC(=O)OC(=O)CBr FUKOTTQGWQVMQB-UHFFFAOYSA-N 0.000 description 3
• BMBKKFNREYWHLR-UHFFFAOYSA-N 2-(5-bromo-4-methylpyridin-2-yl)propan-2-ol Chemical compound CC1=CC(C(C)(C)O)=NC=C1Br BMBKKFNREYWHLR-UHFFFAOYSA-N 0.000 description 3
• KCXHWKVIHRVLDF-UHFFFAOYSA-N 2-bromo-n-(3,5-dibromopyrazin-2-yl)acetamide Chemical compound BrCC(=O)NC1=NC=C(Br)N=C1Br KCXHWKVIHRVLDF-UHFFFAOYSA-N 0.000 description 3
• DABFZABFCKLOBL-UHFFFAOYSA-N 3-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(oxan-2-yl)-1,2,4-triazole Chemical compound CC1=CC(C=2N(C=NN=2)C2OCCCC2)=CC=C1B1OC(C)(C)C(C)(C)O1 DABFZABFCKLOBL-UHFFFAOYSA-N 0.000 description 3
• AVWURNFAFWROHV-UHFFFAOYSA-N 3-bromo-5-(2-methoxyethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C(Br)N=C2N(CCOC)C(=O)CNC2=N1 AVWURNFAFWROHV-UHFFFAOYSA-N 0.000 description 3
• REBLJUKAMOBCBL-UHFFFAOYSA-N 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1,2-diamine Chemical compound NC1=C(N)C(C)=CC(B2OC(C)(C)C(C)(C)O2)=C1 REBLJUKAMOBCBL-UHFFFAOYSA-N 0.000 description 3
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
• OGHYZWOLLIVBLK-UHFFFAOYSA-N 4-(oxan-2-yl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,2,4-triazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CC=C(C=2N(C=NN=2)C2OCCCC2)C=C1 OGHYZWOLLIVBLK-UHFFFAOYSA-N 0.000 description 3
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 3
• MJDRFCPNHLHNON-UHFFFAOYSA-N 4-bromo-2-fluorobenzamide Chemical compound NC(=O)C1=CC=C(Br)C=C1F MJDRFCPNHLHNON-UHFFFAOYSA-N 0.000 description 3
• FQSYBFNJHBTTTD-UHFFFAOYSA-N 5-(4-bromo-2-fluorophenyl)-1h-1,2,4-triazole Chemical compound FC1=CC(Br)=CC=C1C1=NN=CN1 FQSYBFNJHBTTTD-UHFFFAOYSA-N 0.000 description 3
• XZGBRNYIIHOXIN-UHFFFAOYSA-N 5-bromo-2-[1-(oxan-2-yl)-1,2,4-triazol-3-yl]pyridine Chemical compound N1=CC(Br)=CC=C1C1=NN(C2OCCCC2)C=N1 XZGBRNYIIHOXIN-UHFFFAOYSA-N 0.000 description 3
• WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
• 208000024827 Alzheimer disease Diseases 0.000 description 3
• 206010002556 Ankylosing Spondylitis Diseases 0.000 description 3
• 206010006187 Breast cancer Diseases 0.000 description 3
• 208000026310 Breast neoplasm Diseases 0.000 description 3
• OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 3
• 206010009900 Colitis ulcerative Diseases 0.000 description 3
• 208000011231 Crohn disease Diseases 0.000 description 3
• OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 3
• 208000009329 Graft vs Host Disease Diseases 0.000 description 3
• 102100031561 Hamartin Human genes 0.000 description 3
• 101710175981 Hamartin Proteins 0.000 description 3
• 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 description 3
• 208000023105 Huntington disease Diseases 0.000 description 3
• 208000008839 Kidney Neoplasms Diseases 0.000 description 3
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 3
• 102000009308 Mechanistic Target of Rapamycin Complex 2 Human genes 0.000 description 3
• 108010034057 Mechanistic Target of Rapamycin Complex 2 Proteins 0.000 description 3
• 206010027476 Metastases Diseases 0.000 description 3
• 241001465754 Metazoa Species 0.000 description 3
• 206010033128 Ovarian cancer Diseases 0.000 description 3
• 206010061535 Ovarian neoplasm Diseases 0.000 description 3
• 208000018737 Parkinson disease Diseases 0.000 description 3
• KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
• 206010060862 Prostate cancer Diseases 0.000 description 3
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
• 201000004681 Psoriasis Diseases 0.000 description 3
• 206010038389 Renal cancer Diseases 0.000 description 3
• 208000006265 Renal cell carcinoma Diseases 0.000 description 3
• 206010039085 Rhinitis allergic Diseases 0.000 description 3
• 206010039491 Sarcoma Diseases 0.000 description 3
• 208000006011 Stroke Diseases 0.000 description 3
• 208000026911 Tuberous sclerosis complex Diseases 0.000 description 3
• 201000006704 Ulcerative Colitis Diseases 0.000 description 3
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
• 150000007513 acids Chemical class 0.000 description 3
• UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 3
• 125000004183 alkoxy alkyl group Chemical group 0.000 description 3
• 125000003545 alkoxy group Chemical group 0.000 description 3
• 125000003282 alkyl amino group Chemical group 0.000 description 3
• 201000010105 allergic rhinitis Diseases 0.000 description 3
• 208000006673 asthma Diseases 0.000 description 3
• 239000012298 atmosphere Substances 0.000 description 3
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 3
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 3
• 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 description 3
• 210000004369 blood Anatomy 0.000 description 3
• 239000008280 blood Substances 0.000 description 3
• 210000000481 breast Anatomy 0.000 description 3
• 206010006451 bronchitis Diseases 0.000 description 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
• 230000001684 chronic effect Effects 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 230000006378 damage Effects 0.000 description 3
• WMKGGPCROCCUDY-PHEQNACWSA-N dibenzylideneacetone Chemical compound C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 WMKGGPCROCCUDY-PHEQNACWSA-N 0.000 description 3
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 3
• 239000003814 drug Substances 0.000 description 3
• 150000002148 esters Chemical class 0.000 description 3
• 125000002541 furyl group Chemical group 0.000 description 3
• 208000024908 graft versus host disease Diseases 0.000 description 3
• 210000003128 head Anatomy 0.000 description 3
• 208000014829 head and neck neoplasm Diseases 0.000 description 3
• 210000002216 heart Anatomy 0.000 description 3
• 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 3
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
• 239000003112 inhibitor Substances 0.000 description 3
• QWXYZCJEXYQNEI-OSZHWHEXSA-N intermediate I Chemical compound COC(=O)[C@@]1(C=O)[C@H]2CC=[N+](C\C2=C\C)CCc2c1[nH]c1ccccc21 QWXYZCJEXYQNEI-OSZHWHEXSA-N 0.000 description 3
• 210000000936 intestine Anatomy 0.000 description 3
• 238000005342 ion exchange Methods 0.000 description 3
• 208000002551 irritable bowel syndrome Diseases 0.000 description 3
• 230000000302 ischemic effect Effects 0.000 description 3
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 3
• 125000000842 isoxazolyl group Chemical group 0.000 description 3
• 201000010982 kidney cancer Diseases 0.000 description 3
• 208000017169 kidney disease Diseases 0.000 description 3
• 210000000867 larynx Anatomy 0.000 description 3
• 201000005202 lung cancer Diseases 0.000 description 3
• 208000020816 lung neoplasm Diseases 0.000 description 3
• 206010025135 lupus erythematosus Diseases 0.000 description 3
• 229910052751 metal Inorganic materials 0.000 description 3
• 239000002184 metal Substances 0.000 description 3
• 230000009401 metastasis Effects 0.000 description 3
• 125000002757 morpholinyl group Chemical group 0.000 description 3
• 210000000214 mouth Anatomy 0.000 description 3
• 208000010125 myocardial infarction Diseases 0.000 description 3
• 125000001624 naphthyl group Chemical group 0.000 description 3
• 210000003739 neck Anatomy 0.000 description 3
• 231100000252 nontoxic Toxicity 0.000 description 3
• 230000003000 nontoxic effect Effects 0.000 description 3
• 210000000056 organ Anatomy 0.000 description 3
• 239000003960 organic solvent Substances 0.000 description 3
• 210000001672 ovary Anatomy 0.000 description 3
• 125000002971 oxazolyl group Chemical group 0.000 description 3
• 239000001301 oxygen Substances 0.000 description 3
• NXJCBFBQEVOTOW-UHFFFAOYSA-L palladium(2+);dihydroxide Chemical compound O[Pd]O NXJCBFBQEVOTOW-UHFFFAOYSA-L 0.000 description 3
• 125000003367 polycyclic group Chemical group 0.000 description 3
• 239000000843 powder Substances 0.000 description 3
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
• 238000011321 prophylaxis Methods 0.000 description 3
• 235000018102 proteins Nutrition 0.000 description 3
• 102000004169 proteins and genes Human genes 0.000 description 3
• 108090000623 proteins and genes Proteins 0.000 description 3
• 125000003373 pyrazinyl group Chemical group 0.000 description 3
• 125000002098 pyridazinyl group Chemical group 0.000 description 3
• 125000000168 pyrrolyl group Chemical group 0.000 description 3
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 3
• 230000002285 radioactive effect Effects 0.000 description 3
• 210000000664 rectum Anatomy 0.000 description 3
• 238000011160 research Methods 0.000 description 3
• 208000037803 restenosis Diseases 0.000 description 3
• 206010039073 rheumatoid arthritis Diseases 0.000 description 3
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 3
• 235000009518 sodium iodide Nutrition 0.000 description 3
• 239000012321 sodium triacetoxyborohydride Substances 0.000 description 3
• 210000000952 spleen Anatomy 0.000 description 3
• DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 3
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 3
• 125000003831 tetrazolyl group Chemical group 0.000 description 3
• 125000000335 thiazolyl group Chemical group 0.000 description 3
• 125000001544 thienyl group Chemical group 0.000 description 3
• 238000002054 transplantation Methods 0.000 description 3
• 230000008733 trauma Effects 0.000 description 3
• 208000009999 tuberous sclerosis Diseases 0.000 description 3
• 210000003932 urinary bladder Anatomy 0.000 description 3
• 210000004291 uterus Anatomy 0.000 description 3
• PNVPNXKRAUBJGW-UHFFFAOYSA-N (2-chloroacetyl) 2-chloroacetate Chemical compound ClCC(=O)OC(=O)CCl PNVPNXKRAUBJGW-UHFFFAOYSA-N 0.000 description 2
• GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
• KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 2
• KEXFRBIOHPDZQM-UHFFFAOYSA-N 1,1-bis(2,2-dimethylpropoxy)-n,n-dimethylmethanamine Chemical compound CC(C)(C)COC(N(C)C)OCC(C)(C)C KEXFRBIOHPDZQM-UHFFFAOYSA-N 0.000 description 2
• SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 2
• NWAGHQGLQLEDIZ-UHFFFAOYSA-N 1-(oxan-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CC=CC2=C1C=NN2C1OCCCC1 NWAGHQGLQLEDIZ-UHFFFAOYSA-N 0.000 description 2
• OKRROXQXGNEUSS-UHFFFAOYSA-N 1h-imidazol-1-ium-1-carboxylate Chemical compound OC(=O)N1C=CN=C1 OKRROXQXGNEUSS-UHFFFAOYSA-N 0.000 description 2
• WWJLJUAHQHXDGM-UHFFFAOYSA-N 2,5-dibromo-4-methylpyridine Chemical compound CC1=CC(Br)=NC=C1Br WWJLJUAHQHXDGM-UHFFFAOYSA-N 0.000 description 2
• LSEAAPGIZCDEEH-UHFFFAOYSA-N 2,6-dichloropyrazine Chemical compound ClC1=CN=CC(Cl)=N1 LSEAAPGIZCDEEH-UHFFFAOYSA-N 0.000 description 2
• AOGYBHJTXLXRSM-UHFFFAOYSA-N 2-(4-bromophenyl)propan-2-ol Chemical compound CC(C)(O)C1=CC=C(Br)C=C1 AOGYBHJTXLXRSM-UHFFFAOYSA-N 0.000 description 2
• AASMWJPVSZLZCE-UHFFFAOYSA-N 2-(4-methyl-5-trimethylstannylpyridin-2-yl)propan-2-ol Chemical compound CC1=CC(C(C)(C)O)=NC=C1[Sn](C)(C)C AASMWJPVSZLZCE-UHFFFAOYSA-N 0.000 description 2
• RDQCATQYMZDJLU-UHFFFAOYSA-N 2-(5-bromopyridin-2-yl)propan-2-ol Chemical compound CC(C)(O)C1=CC=C(Br)C=N1 RDQCATQYMZDJLU-UHFFFAOYSA-N 0.000 description 2
• AUCJQPPZTFKDHI-UHFFFAOYSA-N 2-(oxan-4-yl)acetaldehyde Chemical compound O=CCC1CCOCC1 AUCJQPPZTFKDHI-UHFFFAOYSA-N 0.000 description 2
• UVVBTHYPMAWWCK-UHFFFAOYSA-N 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propan-2-ol Chemical compound C1=CC(C(C)(O)C)=CC=C1B1OC(C)(C)C(C)(C)O1 UVVBTHYPMAWWCK-UHFFFAOYSA-N 0.000 description 2
• XGKFKGKAWKAJOW-UHFFFAOYSA-N 2-bromo-8-(2-morpholin-4-ylethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(Br)=CN=C2NC(=O)CN1CCN1CCOCC1 XGKFKGKAWKAJOW-UHFFFAOYSA-N 0.000 description 2
• UGNVJEFFXOAVDT-UHFFFAOYSA-N 2-bromo-8-(oxan-4-yl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(Br)=CN=C2NC(=O)CN1C1CCOCC1 UGNVJEFFXOAVDT-UHFFFAOYSA-N 0.000 description 2
• QDVDHIVRAQKVLS-UHFFFAOYSA-N 2-bromo-8-(oxan-4-ylmethyl)-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(Br)=CN=C2NC(=O)CN1CC1CCOCC1 QDVDHIVRAQKVLS-UHFFFAOYSA-N 0.000 description 2
• XHIYPVIUDQOFBN-UHFFFAOYSA-N 2-bromo-8-[2-(oxan-4-yl)ethyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(Br)=CN=C2NC(=O)CN1CCC1CCOCC1 XHIYPVIUDQOFBN-UHFFFAOYSA-N 0.000 description 2
• VVSQPQYAGIIZDS-UHFFFAOYSA-N 2-bromo-8-ethyl-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C(Br)N=C2N(CC)CC(=O)NC2=N1 VVSQPQYAGIIZDS-UHFFFAOYSA-N 0.000 description 2
• GCHRYFWQAYDDPP-UHFFFAOYSA-N 2-chloro-n-(3,5-dibromopyrazin-2-yl)acetamide Chemical compound ClCC(=O)NC1=NC=C(Br)N=C1Br GCHRYFWQAYDDPP-UHFFFAOYSA-N 0.000 description 2
• FFNVQNRYTPFDDP-UHFFFAOYSA-N 2-cyanopyridine Chemical compound N#CC1=CC=CC=N1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 description 2
• MXSKEFVXKIIMNX-UHFFFAOYSA-N 2-methyl-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline Chemical compound [O-][N+](=O)C1=C(N)C(C)=CC(B2OC(C)(C)C(C)(C)O2)=C1 MXSKEFVXKIIMNX-UHFFFAOYSA-N 0.000 description 2
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 2
• JMFIMWNEVPCCRM-UHFFFAOYSA-N 3-(4-bromo-2-fluoro-3-methylphenyl)-4-(oxan-2-yl)-1,2,4-triazole Chemical compound CC1=C(Br)C=CC(C=2N(C=NN=2)C2OCCCC2)=C1F JMFIMWNEVPCCRM-UHFFFAOYSA-N 0.000 description 2
• CPVSMTAHLBFNRD-UHFFFAOYSA-N 3-(4-bromo-2-fluoro-5-methylphenyl)-1-(oxan-2-yl)-1,2,4-triazole Chemical compound C1=C(Br)C(C)=CC(C2=NN(C=N2)C2OCCCC2)=C1F CPVSMTAHLBFNRD-UHFFFAOYSA-N 0.000 description 2
• VEWXIPUUQVLOKQ-UHFFFAOYSA-N 3-(4-bromo-3-methylphenyl)-4-(oxan-2-yl)-1,2,4-triazole Chemical compound C1=C(Br)C(C)=CC(C=2N(C=NN=2)C2OCCCC2)=C1 VEWXIPUUQVLOKQ-UHFFFAOYSA-N 0.000 description 2
• UYPMQMXICOOQLK-UHFFFAOYSA-N 3-(4-bromophenyl)-4-(oxan-2-yl)-1,2,4-triazole Chemical compound C1=CC(Br)=CC=C1C1=NN=CN1C1OCCCC1 UYPMQMXICOOQLK-UHFFFAOYSA-N 0.000 description 2
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 2
• DYWQEAIELCVSMZ-UHFFFAOYSA-N 3-bromo-5-(oxan-4-ylmethyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(Br)=CN=C2NCC(=O)N1CC1CCOCC1 DYWQEAIELCVSMZ-UHFFFAOYSA-N 0.000 description 2
• PFFKLYJCSGCBHD-UHFFFAOYSA-N 3-bromo-5-[2-(oxan-4-yl)ethyl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(Br)=CN=C2NCC(=O)N1CCC1CCOCC1 PFFKLYJCSGCBHD-UHFFFAOYSA-N 0.000 description 2
• GTAKXKONKSMWLZ-UHFFFAOYSA-N 4-amino-2-fluoro-3-methylbenzonitrile Chemical compound CC1=C(N)C=CC(C#N)=C1F GTAKXKONKSMWLZ-UHFFFAOYSA-N 0.000 description 2
• HVBSAKJJOYLTQU-UHFFFAOYSA-N 4-aminobenzenesulfonic acid Chemical compound NC1=CC=C(S(O)(=O)=O)C=C1 HVBSAKJJOYLTQU-UHFFFAOYSA-N 0.000 description 2
• SSJAOWRBTUOVMD-UHFFFAOYSA-N 4-bromo-1-(oxan-2-yl)indazole Chemical compound N1=CC=2C(Br)=CC=CC=2N1C1CCCCO1 SSJAOWRBTUOVMD-UHFFFAOYSA-N 0.000 description 2
• KJIODOACRIRBPB-UHFFFAOYSA-N 4-bromo-1h-indazole Chemical compound BrC1=CC=CC2=C1C=NN2 KJIODOACRIRBPB-UHFFFAOYSA-N 0.000 description 2
• LEZHTYOQWQEBLH-UHFFFAOYSA-N 4-bromo-1h-pyrrolo[2,3-b]pyridine Chemical compound BrC1=CC=NC2=C1C=CN2 LEZHTYOQWQEBLH-UHFFFAOYSA-N 0.000 description 2
• VOQXEDVIDBQYNA-UHFFFAOYSA-N 4-bromo-2-fluoro-3-methylbenzamide Chemical compound CC1=C(Br)C=CC(C(N)=O)=C1F VOQXEDVIDBQYNA-UHFFFAOYSA-N 0.000 description 2
• PWISOHRBGSJIPW-UHFFFAOYSA-N 4-bromo-2-fluoro-3-methylbenzonitrile Chemical compound CC1=C(Br)C=CC(C#N)=C1F PWISOHRBGSJIPW-UHFFFAOYSA-N 0.000 description 2
• CDIILNNLSWGFCF-UHFFFAOYSA-N 4-bromo-2-fluoro-5-methylbenzamide Chemical compound CC1=CC(C(N)=O)=C(F)C=C1Br CDIILNNLSWGFCF-UHFFFAOYSA-N 0.000 description 2
• HOFKRNFFIGAFNE-UHFFFAOYSA-N 4-bromo-3-fluoro-2-methylaniline Chemical compound CC1=C(N)C=CC(Br)=C1F HOFKRNFFIGAFNE-UHFFFAOYSA-N 0.000 description 2
• QQIMLHFOAXATBR-UHFFFAOYSA-N 4-bromo-n-(dimethylaminomethylidene)-2-fluoro-5-methylbenzamide Chemical compound CN(C)C=NC(=O)C1=CC(C)=C(Br)C=C1F QQIMLHFOAXATBR-UHFFFAOYSA-N 0.000 description 2
• DZBUBOOTUOGPHI-UHFFFAOYSA-N 4-methyl-1-(oxan-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzimidazole Chemical compound C1=NC=2C(C)=CC(B3OC(C)(C)C(C)(C)O3)=CC=2N1C1CCCCO1 DZBUBOOTUOGPHI-UHFFFAOYSA-N 0.000 description 2
• KENZNDNQGUCNQQ-UHFFFAOYSA-N 4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-benzimidazol-2-amine Chemical compound C=1C=2N=C(N)NC=2C(C)=CC=1B1OC(C)(C)C(C)(C)O1 KENZNDNQGUCNQQ-UHFFFAOYSA-N 0.000 description 2
• RUZASAYTXQUUCN-UHFFFAOYSA-N 5-(2-methoxyethyl)-3-trimethylstannyl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1=C([Sn](C)(C)C)N=C2N(CCOC)C(=O)CNC2=N1 RUZASAYTXQUUCN-UHFFFAOYSA-N 0.000 description 2
• YKXZEDABKYNUHG-UHFFFAOYSA-N 5-(4-bromo-2-fluoro-3-methylphenyl)-1h-1,2,4-triazole Chemical compound CC1=C(Br)C=CC(C2=NNC=N2)=C1F YKXZEDABKYNUHG-UHFFFAOYSA-N 0.000 description 2
• XDFGQSVERBDTAA-UHFFFAOYSA-N 5-(4-bromo-2-fluoro-5-methylphenyl)-1h-1,2,4-triazole Chemical compound C1=C(Br)C(C)=CC(C2=NNC=N2)=C1F XDFGQSVERBDTAA-UHFFFAOYSA-N 0.000 description 2
• FDERMDFQPSEUMV-UHFFFAOYSA-N 5-(4-bromo-3-methylphenyl)-1h-1,2,4-triazole Chemical compound C1=C(Br)C(C)=CC(C2=NNC=N2)=C1 FDERMDFQPSEUMV-UHFFFAOYSA-N 0.000 description 2
• XJSPWQRTWATLKK-UHFFFAOYSA-N 5-(4-bromophenyl)-1h-1,2,4-triazole Chemical compound C1=CC(Br)=CC=C1C1=NN=CN1 XJSPWQRTWATLKK-UHFFFAOYSA-N 0.000 description 2
• PFKSZLBCUGBMCY-UHFFFAOYSA-N 5-[2-(oxan-4-yl)ethyl]-3-trimethylstannyl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC([Sn](C)(C)C)=CN=C2NCC(=O)N1CCC1CCOCC1 PFKSZLBCUGBMCY-UHFFFAOYSA-N 0.000 description 2
• WUPMXGZPJNFYJG-UHFFFAOYSA-N 5-bromo-2-(1h-1,2,4-triazol-5-yl)pyridine Chemical compound N1=CC(Br)=CC=C1C1=NNC=N1 WUPMXGZPJNFYJG-UHFFFAOYSA-N 0.000 description 2
• JAQLBGDFALXUMV-UHFFFAOYSA-N 5-bromo-4-methylpyridine-2-carbonitrile Chemical compound CC1=CC(C#N)=NC=C1Br JAQLBGDFALXUMV-UHFFFAOYSA-N 0.000 description 2
• RVLQAJVSZQBQCT-UHFFFAOYSA-N 5-bromo-6-methylpyridine-2-carboxamide Chemical compound CC1=NC(C(N)=O)=CC=C1Br RVLQAJVSZQBQCT-UHFFFAOYSA-N 0.000 description 2
• TZEFGHLONAEWQU-UHFFFAOYSA-N 6-bromo-3,3-dimethyl-4-[2-(oxan-4-yl)ethyl]-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound C12=NC(Br)=CN=C2NC(=O)C(C)(C)N1CCC1CCOCC1 TZEFGHLONAEWQU-UHFFFAOYSA-N 0.000 description 2
• MVVLEVCUXDYCAK-UHFFFAOYSA-N 6-bromo-4-methyl-1-(oxan-2-yl)benzimidazole Chemical compound C1=NC=2C(C)=CC(Br)=CC=2N1C1CCCCO1 MVVLEVCUXDYCAK-UHFFFAOYSA-N 0.000 description 2
• HCLQDFPYGSBULF-UHFFFAOYSA-N 6-bromo-n,4-dimethyl-1h-benzimidazol-2-amine Chemical compound BrC1=CC(C)=C2NC(NC)=NC2=C1 HCLQDFPYGSBULF-UHFFFAOYSA-N 0.000 description 2
• WSVPGDYMTHTTGX-UHFFFAOYSA-N 6-bromospiro[1,4-dihydropyrazino[2,3-b]pyrazine-3,1'-cyclopropane]-2-one Chemical compound N1C2=NC(Br)=CN=C2NC(=O)C21CC2 WSVPGDYMTHTTGX-UHFFFAOYSA-N 0.000 description 2
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
• AHTXWEHJMLNLGH-UHFFFAOYSA-N 8-(4-methoxycyclohexyl)-2-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1CC(OC)CCC1N1C2=NC(C=3C(=NC(=CC=3)C=3NN=CN=3)C)=CN=C2NC(=O)C1 AHTXWEHJMLNLGH-UHFFFAOYSA-N 0.000 description 2
• IYEQCLQQDHXALY-UHFFFAOYSA-N 8-(oxan-4-yl)-2-trimethylstannyl-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC([Sn](C)(C)C)=CN=C2NC(=O)CN1C1CCOCC1 IYEQCLQQDHXALY-UHFFFAOYSA-N 0.000 description 2
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
• QGZKDVFQNNGYKY-OUBTZVSYSA-N Ammonia-15N Chemical compound [15NH3] QGZKDVFQNNGYKY-OUBTZVSYSA-N 0.000 description 2
• 201000001320 Atherosclerosis Diseases 0.000 description 2
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 2
• 208000035143 Bacterial infection Diseases 0.000 description 2
• 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
• NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
• 206010006895 Cachexia Diseases 0.000 description 2
• 201000009030 Carcinoma Diseases 0.000 description 2
• 208000024172 Cardiovascular disease Diseases 0.000 description 2
• 206010008342 Cervix carcinoma Diseases 0.000 description 2
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
• 208000000668 Chronic Pancreatitis Diseases 0.000 description 2
• 208000034656 Contusions Diseases 0.000 description 2
• RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
• YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 2
• XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
• QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
• 201000005569 Gout Diseases 0.000 description 2
• AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
• 208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 2
• 206010049459 Lymphangioleiomyomatosis Diseases 0.000 description 2
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
• 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 2
• XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
• 208000034486 Multi-organ failure Diseases 0.000 description 2
• 208000010718 Multiple Organ Failure Diseases 0.000 description 2
• 208000034578 Multiple myelomas Diseases 0.000 description 2
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 2
• CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 2
• MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 2
• 206010052399 Neuroendocrine tumour Diseases 0.000 description 2
• 208000003019 Neurofibromatosis 1 Diseases 0.000 description 2
• 208000024834 Neurofibromatosis type 1 Diseases 0.000 description 2
• 206010030216 Oesophagitis Diseases 0.000 description 2
• 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 2
• 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 2
• 206010033649 Pancreatitis chronic Diseases 0.000 description 2
• 241000286209 Phasianidae Species 0.000 description 2
• 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 2
• 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 2
• 206010035226 Plasma cell myeloma Diseases 0.000 description 2
• 101710146367 Polycystin-1 Proteins 0.000 description 2
• 102000001708 Protein Isoforms Human genes 0.000 description 2
• 108010029485 Protein Isoforms Proteins 0.000 description 2
• 208000007531 Proteus syndrome Diseases 0.000 description 2
• 208000015634 Rectal Neoplasms Diseases 0.000 description 2
• 206010040070 Septic Shock Diseases 0.000 description 2
• 101710181599 Serine/threonine-protein kinase STK11 Proteins 0.000 description 2
• 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 description 2
• 208000005718 Stomach Neoplasms Diseases 0.000 description 2
• 108010004408 TRPP Cation Channels Proteins 0.000 description 2
• 206010060872 Transplant failure Diseases 0.000 description 2
• DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 2
• 239000007983 Tris buffer Substances 0.000 description 2
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
• 208000036142 Viral infection Diseases 0.000 description 2
• AZFNGPAYDKGCRB-XCPIVNJJSA-M [(1s,2s)-2-amino-1,2-diphenylethyl]-(4-methylphenyl)sulfonylazanide;chlororuthenium(1+);1-methyl-4-propan-2-ylbenzene Chemical compound [Ru+]Cl.CC(C)C1=CC=C(C)C=C1.C1=CC(C)=CC=C1S(=O)(=O)[N-][C@@H](C=1C=CC=CC=1)[C@@H](N)C1=CC=CC=C1 AZFNGPAYDKGCRB-XCPIVNJJSA-M 0.000 description 2
• 230000002159 abnormal effect Effects 0.000 description 2
• 230000005856 abnormality Effects 0.000 description 2
• 230000001154 acute effect Effects 0.000 description 2
• 125000002877 alkyl aryl group Chemical group 0.000 description 2
• 125000005119 alkyl cycloalkyl group Chemical group 0.000 description 2
• 150000001409 amidines Chemical class 0.000 description 2
• 150000001413 amino acids Chemical class 0.000 description 2
• 238000004458 analytical method Methods 0.000 description 2
• 230000033115 angiogenesis Effects 0.000 description 2
• RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
• 208000010668 atopic eczema Diseases 0.000 description 2
• 125000005602 azabenzimidazolyl group Chemical group 0.000 description 2
• 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 description 2
• 150000001540 azides Chemical class 0.000 description 2
• 230000001580 bacterial effect Effects 0.000 description 2
• 208000022362 bacterial infectious disease Diseases 0.000 description 2
• 125000005605 benzo group Chemical group 0.000 description 2
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• 125000005874 benzothiadiazolyl group Chemical group 0.000 description 2
• 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 2
• 230000037396 body weight Effects 0.000 description 2
• 230000031709 bromination Effects 0.000 description 2
• 238000005893 bromination reaction Methods 0.000 description 2
• 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
• 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
• 230000010261 cell growth Effects 0.000 description 2
• 201000010881 cervical cancer Diseases 0.000 description 2
• 239000003610 charcoal Substances 0.000 description 2
• 239000003153 chemical reaction reagent Substances 0.000 description 2
• 210000000349 chromosome Anatomy 0.000 description 2
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 2
• 210000002808 connective tissue Anatomy 0.000 description 2
• 230000009519 contusion Effects 0.000 description 2
• 239000007819 coupling partner Substances 0.000 description 2
• 239000013058 crude material Substances 0.000 description 2
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
• JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000010511 deprotection reaction Methods 0.000 description 2
• 229910052805 deuterium Inorganic materials 0.000 description 2
• SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
• WDUDHEOUGWAKFD-UHFFFAOYSA-N ditert-butyl(cyclopenta-2,4-dien-1-yl)phosphane;iron(2+) Chemical compound [Fe+2].CC(C)(C)P(C(C)(C)C)C1=CC=C[CH-]1.CC(C)(C)P(C(C)(C)C)C1=CC=C[CH-]1 WDUDHEOUGWAKFD-UHFFFAOYSA-N 0.000 description 2
• 229940079593 drug Drugs 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 239000003480 eluent Substances 0.000 description 2
• 206010015037 epilepsy Diseases 0.000 description 2
• 208000006881 esophagitis Diseases 0.000 description 2
• 210000003238 esophagus Anatomy 0.000 description 2
• XWBDWHCCBGMXKG-UHFFFAOYSA-N ethanamine;hydron;chloride Chemical compound Cl.CCN XWBDWHCCBGMXKG-UHFFFAOYSA-N 0.000 description 2
• ZNVZPCFHWHRPRC-UHFFFAOYSA-N ethyl 2-(pyrazin-2-ylamino)acetate Chemical compound CCOC(=O)CNC1=CN=CC=N1 ZNVZPCFHWHRPRC-UHFFFAOYSA-N 0.000 description 2
• FDAXWQMNHQXETK-UHFFFAOYSA-N ethyl 2-[(6-chloropyrazin-2-yl)amino]acetate Chemical compound CCOC(=O)CNC1=CN=CC(Cl)=N1 FDAXWQMNHQXETK-UHFFFAOYSA-N 0.000 description 2
• IFTPOAIAIUKDIR-UHFFFAOYSA-N ethyl 2-[[5-bromo-3-(oxan-4-ylmethylamino)pyrazin-2-yl]amino]acetate Chemical compound CCOC(=O)CNC1=NC=C(Br)N=C1NCC1CCOCC1 IFTPOAIAIUKDIR-UHFFFAOYSA-N 0.000 description 2
• LPUANPBEPNFXPT-UHFFFAOYSA-N ethyl 2-[[5-bromo-3-(propan-2-ylamino)pyrazin-2-yl]amino]acetate Chemical compound CCOC(=O)CNC1=NC=C(Br)N=C1NC(C)C LPUANPBEPNFXPT-UHFFFAOYSA-N 0.000 description 2
• AYZZDJJEFIICHJ-UHFFFAOYSA-N ethyl 2-[[5-bromo-3-[(2,4-dimethoxyphenyl)methylamino]pyrazin-2-yl]amino]acetate Chemical compound CCOC(=O)CNC1=NC=C(Br)N=C1NCC1=CC=C(OC)C=C1OC AYZZDJJEFIICHJ-UHFFFAOYSA-N 0.000 description 2
• ZFQIZBFOPBXMKH-UHFFFAOYSA-N ethyl 2-[[5-bromo-3-[2-(oxan-4-yl)ethylamino]pyrazin-2-yl]amino]acetate Chemical compound CCOC(=O)CNC1=NC=C(Br)N=C1NCCC1CCOCC1 ZFQIZBFOPBXMKH-UHFFFAOYSA-N 0.000 description 2
• 201000003444 follicular lymphoma Diseases 0.000 description 2
• XZBIXDPGRMLSTC-UHFFFAOYSA-N formohydrazide Chemical compound NNC=O XZBIXDPGRMLSTC-UHFFFAOYSA-N 0.000 description 2
• 239000012458 free base Substances 0.000 description 2
• 239000007789 gas Substances 0.000 description 2
• 206010017758 gastric cancer Diseases 0.000 description 2
• 230000002068 genetic effect Effects 0.000 description 2
• 208000005017 glioblastoma Diseases 0.000 description 2
• 208000013210 hematogenous Diseases 0.000 description 2
• 201000005787 hematologic cancer Diseases 0.000 description 2
• 208000006454 hepatitis Diseases 0.000 description 2
• 231100000283 hepatitis Toxicity 0.000 description 2
• 150000004677 hydrates Chemical class 0.000 description 2
• 150000007857 hydrazones Chemical class 0.000 description 2
• 229910000042 hydrogen bromide Inorganic materials 0.000 description 2
• 125000002632 imidazolidinyl group Chemical group 0.000 description 2
• 125000002636 imidazolinyl group Chemical group 0.000 description 2
• 125000005945 imidazopyridyl group Chemical group 0.000 description 2
• 150000003949 imides Chemical class 0.000 description 2
• 150000002466 imines Chemical class 0.000 description 2
• 230000003834 intracellular effect Effects 0.000 description 2
• 239000011630 iodine Substances 0.000 description 2
• INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 2
• 208000028867 ischemia Diseases 0.000 description 2
• 208000023589 ischemic disease Diseases 0.000 description 2
• SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
• 239000012948 isocyanate Substances 0.000 description 2
• 150000002513 isocyanates Chemical class 0.000 description 2
• 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 2
• JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 2
• 229940011051 isopropyl acetate Drugs 0.000 description 2
• 150000002540 isothiocyanates Chemical class 0.000 description 2
• GWYFCOCPABKNJV-UHFFFAOYSA-M isovalerate Chemical compound CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 2
• 150000002576 ketones Chemical class 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 229940124302 mTOR inhibitor Drugs 0.000 description 2
• 230000003211 malignant effect Effects 0.000 description 2
• 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 description 2
• 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 2
• 150000007522 mineralic acids Chemical class 0.000 description 2
• 208000029744 multiple organ dysfunction syndrome Diseases 0.000 description 2
• 201000006417 multiple sclerosis Diseases 0.000 description 2
• 230000035772 mutation Effects 0.000 description 2
• JMLIKPVZZKAIKO-UHFFFAOYSA-N n'-amino-5-bromo-6-methylpyridine-2-carboximidamide Chemical compound CC1=NC(C(=N)NN)=CC=C1Br JMLIKPVZZKAIKO-UHFFFAOYSA-N 0.000 description 2
• JTSLALYXYSRPGW-UHFFFAOYSA-N n-[5-(4-cyanophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C1=C2)=CNC1=NC=C2C1=CC=C(C#N)C=C1 JTSLALYXYSRPGW-UHFFFAOYSA-N 0.000 description 2
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
• 230000009826 neoplastic cell growth Effects 0.000 description 2
• 208000029522 neoplastic syndrome Diseases 0.000 description 2
• 201000008383 nephritis Diseases 0.000 description 2
• 208000016065 neuroendocrine neoplasm Diseases 0.000 description 2
• 201000011519 neuroendocrine tumor Diseases 0.000 description 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
• 238000000238 one-dimensional nuclear magnetic resonance spectroscopy Methods 0.000 description 2
• 239000000082 organ preservation Substances 0.000 description 2
• 150000007524 organic acids Chemical class 0.000 description 2
• 235000005985 organic acids Nutrition 0.000 description 2
• 201000008482 osteoarthritis Diseases 0.000 description 2
• IPBPLHNLRKRLPJ-UHFFFAOYSA-N oxan-4-ylmethanamine Chemical compound NCC1CCOCC1 IPBPLHNLRKRLPJ-UHFFFAOYSA-N 0.000 description 2
• UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 2
• 125000004193 piperazinyl group Chemical group 0.000 description 2
• 125000005936 piperidyl group Chemical group 0.000 description 2
• 239000004304 potassium nitrite Substances 0.000 description 2
• 235000010289 potassium nitrite Nutrition 0.000 description 2
• 230000002062 proliferating effect Effects 0.000 description 2
• 235000019260 propionic acid Nutrition 0.000 description 2
• FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 2
• 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 2
• 125000006085 pyrrolopyridyl group Chemical group 0.000 description 2
• 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 2
• 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 2
• 239000002516 radical scavenger Substances 0.000 description 2
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
• 239000012066 reaction slurry Substances 0.000 description 2
• 230000009257 reactivity Effects 0.000 description 2
• 206010038038 rectal cancer Diseases 0.000 description 2
• 201000001275 rectum cancer Diseases 0.000 description 2
• 125000006413 ring segment Chemical group 0.000 description 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
• 238000000926 separation method Methods 0.000 description 2
• 229960002930 sirolimus Drugs 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
• 235000019345 sodium thiosulphate Nutrition 0.000 description 2
• WYHZYTFAZXPIGR-UHFFFAOYSA-M sodium;2-[(3,5-dibromopyrazin-2-yl)amino]acetate Chemical compound [Na+].[O-]C(=O)CNC1=NC=C(Br)N=C1Br WYHZYTFAZXPIGR-UHFFFAOYSA-M 0.000 description 2
• 239000012453 solvate Substances 0.000 description 2
• 238000000527 sonication Methods 0.000 description 2
• 201000011549 stomach cancer Diseases 0.000 description 2
• 125000005346 substituted cycloalkyl group Chemical group 0.000 description 2
• 150000003457 sulfones Chemical class 0.000 description 2
• 229910052717 sulfur Inorganic materials 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 2
• 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 2
• 150000003568 thioethers Chemical class 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• CSRZQMIRAZTJOY-UHFFFAOYSA-N trimethylsilyl iodide Chemical compound C[Si](C)(C)I CSRZQMIRAZTJOY-UHFFFAOYSA-N 0.000 description 2
• RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
• 230000004614 tumor growth Effects 0.000 description 2
• 238000005292 vacuum distillation Methods 0.000 description 2
• 230000009385 viral infection Effects 0.000 description 2
• QOWBXWFYRXSBAS-UHFFFAOYSA-N (2,4-dimethoxyphenyl)methanamine Chemical compound COC1=CC=C(CN)C(OC)=C1 QOWBXWFYRXSBAS-UHFFFAOYSA-N 0.000 description 1
• QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
• XUHRVZXFBWDCFB-QRTDKPMLSA-N (3R)-4-[[(3S,6S,9S,12R,15S,18R,21R,24R,27R,28R)-12-(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-3-(2-carboxyethyl)-18-(hydroxymethyl)-28-methyl-9,15,21,24-tetrakis(2-methylpropyl)-2,5,8,11,14,17,20,23,26-nonaoxo-1-oxa-4,7,10,13,16,19,22,25-octazacyclooctacos-27-yl]amino]-3-[[(2R)-2-[[(3S)-3-hydroxydecanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid Chemical compound CCCCCCC[C@H](O)CC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H]1[C@@H](C)OC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC1=O)[C@@H](C)CC XUHRVZXFBWDCFB-QRTDKPMLSA-N 0.000 description 1
• VBAPKBJGWWZEDK-UHFFFAOYSA-N (4-methoxycyclohexyl)methanamine Chemical compound COC1CCC(CN)CC1 VBAPKBJGWWZEDK-UHFFFAOYSA-N 0.000 description 1
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 1
• MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 description 1
• BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
• WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
• NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
• WYECURVXVYPVAT-UHFFFAOYSA-N 1-(4-bromophenyl)ethanone Chemical compound CC(=O)C1=CC=C(Br)C=C1 WYECURVXVYPVAT-UHFFFAOYSA-N 0.000 description 1
• DSKCOVBHIFAJRI-UHFFFAOYSA-N 1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopropane-1-carboxylic acid Chemical compound CC(C)(C)OC(=O)NC1(C(O)=O)CC1 DSKCOVBHIFAJRI-UHFFFAOYSA-N 0.000 description 1
• 125000006432 1-methyl cyclopropyl group Chemical group [H]C([H])([H])C1(*)C([H])([H])C1([H])[H] 0.000 description 1
• AVFZOVWCLRSYKC-UHFFFAOYSA-N 1-methylpyrrolidine Chemical compound CN1CCCC1 AVFZOVWCLRSYKC-UHFFFAOYSA-N 0.000 description 1
• HSDTUSZAFUYLCB-UHFFFAOYSA-N 1h-pyrazin-2-one;hydrochloride Chemical compound Cl.O=C1C=NC=CN1 HSDTUSZAFUYLCB-UHFFFAOYSA-N 0.000 description 1
• ZHXUWDPHUQHFOV-UHFFFAOYSA-N 2,5-dibromopyridine Chemical compound BrC1=CC=C(Br)N=C1 ZHXUWDPHUQHFOV-UHFFFAOYSA-N 0.000 description 1
• BZMADPOGYCRPAI-UHFFFAOYSA-N 2-(oxan-4-yl)ethanamine Chemical compound NCCC1CCOCC1 BZMADPOGYCRPAI-UHFFFAOYSA-N 0.000 description 1
• PWGRVAAEDDBHCT-UHFFFAOYSA-N 2-(oxan-4-yl)ethanamine;hydrochloride Chemical compound [Cl-].[NH3+]CCC1CCOCC1 PWGRVAAEDDBHCT-UHFFFAOYSA-N 0.000 description 1
• PPDPUIRKDSCCFN-UHFFFAOYSA-N 2-benzofuran-1,3-diimine Chemical compound C1=CC=C2C(=N)OC(=N)C2=C1 PPDPUIRKDSCCFN-UHFFFAOYSA-N 0.000 description 1
• RVBUZBPJAGZHSQ-UHFFFAOYSA-N 2-chlorobutanoic acid Chemical compound CCC(Cl)C(O)=O RVBUZBPJAGZHSQ-UHFFFAOYSA-N 0.000 description 1
• KZVDFULOZMEUAR-UHFFFAOYSA-N 2-diphenylphosphanylethyl(trimethyl)azanium Chemical compound C=1C=CC=CC=1P(CC[N+](C)(C)C)C1=CC=CC=C1 KZVDFULOZMEUAR-UHFFFAOYSA-N 0.000 description 1
• ASUDFOJKTJLAIK-UHFFFAOYSA-N 2-methoxyethanamine Chemical compound COCCN ASUDFOJKTJLAIK-UHFFFAOYSA-N 0.000 description 1
• 125000005916 2-methylpentyl group Chemical group 0.000 description 1
• WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 description 1
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
• XXQOEIWENZGLAB-UHFFFAOYSA-N 3,3-dimethyl-6-[2-methyl-4-[4-(oxan-2-yl)-1,2,4-triazol-3-yl]phenyl]-4-[2-(oxan-4-yl)ethyl]-1h-pyrazino[2,3-b]pyrazin-2-one Chemical compound CC1=CC(C=2N(C=NN=2)C2OCCCC2)=CC=C1C(N=C12)=CN=C1NC(=O)C(C)(C)N2CCC1CCOCC1 XXQOEIWENZGLAB-UHFFFAOYSA-N 0.000 description 1
• QDVGIDHOLUSPGM-UHFFFAOYSA-N 3-(5-bromo-6-methylpyridin-2-yl)-5-tert-butyl-1,2,4-triazole-1-carboxylic acid Chemical compound C1=C(Br)C(C)=NC(C2=NN(C(=N2)C(C)(C)C)C(O)=O)=C1 QDVGIDHOLUSPGM-UHFFFAOYSA-N 0.000 description 1
• FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
• LNXFFHLUUUIHNR-UHFFFAOYSA-N 3-[2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-7,8-dihydro-5h-pyrazino[2,3-b]pyrazin-6-one;hydrochloride Chemical compound Cl.C=1C=C(C=2N=C3NC(=O)CNC3=NC=2)C(C)=CC=1C1=NN=CN1 LNXFFHLUUUIHNR-UHFFFAOYSA-N 0.000 description 1
• MFGREXSVPPGQKE-UHFFFAOYSA-N 3-[2-methyl-6-[4-(oxan-2-yl)-1,2,4-triazol-3-yl]pyridin-3-yl]-5-propan-2-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)C(=O)CNC2=NC=C1C(C(=N1)C)=CC=C1C1=NN=CN1C1CCCCO1 MFGREXSVPPGQKE-UHFFFAOYSA-N 0.000 description 1
• YFZUHPBRXXHHHX-UHFFFAOYSA-N 3-[5-fluoro-2-methyl-4-(1h-1,2,4-triazol-5-yl)phenyl]-5-propan-2-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)C(=O)CNC2=NC=C1C(C(=C1)C)=CC(F)=C1C=1N=CNN=1 YFZUHPBRXXHHHX-UHFFFAOYSA-N 0.000 description 1
• FQHFWOWTLUKYPW-UHFFFAOYSA-N 3-[5-fluoro-2-methyl-4-[1-(oxan-2-yl)-1,2,4-triazol-3-yl]phenyl]-5-propan-2-yl-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)C(=O)CNC2=NC=C1C(C(=C1)C)=CC(F)=C1C(=N1)N=CN1C1CCCCO1 FQHFWOWTLUKYPW-UHFFFAOYSA-N 0.000 description 1
• UFKLYTOEMRFKAD-UHFFFAOYSA-N 3-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-5-(4-methoxycyclohexyl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C1CC(OC)CCC1N1C2=NC(C=3C=NC(=CC=3)C(C)(C)O)=CN=C2NCC1=O UFKLYTOEMRFKAD-UHFFFAOYSA-N 0.000 description 1
• IILVSKMKMOJHMA-UHFFFAOYSA-N 3-bromo-2-methylaniline Chemical compound CC1=C(N)C=CC=C1Br IILVSKMKMOJHMA-UHFFFAOYSA-N 0.000 description 1
• POSGDJSZCUYKBF-UHFFFAOYSA-N 3-bromo-7,8-dihydro-5h-pyrazino[2,3-b]pyrazin-6-one Chemical compound N1CC(=O)NC2=NC(Br)=CN=C21 POSGDJSZCUYKBF-UHFFFAOYSA-N 0.000 description 1
• SLDLVGFPFFLYBM-UHFFFAOYSA-N 3-fluoro-2-methyl-aniline Chemical compound CC1=C(N)C=CC=C1F SLDLVGFPFFLYBM-UHFFFAOYSA-N 0.000 description 1
• 125000006497 3-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])* 0.000 description 1
• AXNUJYHFQHQZBE-UHFFFAOYSA-N 3-methylbenzene-1,2-diamine Chemical compound CC1=CC=CC(N)=C1N AXNUJYHFQHQZBE-UHFFFAOYSA-N 0.000 description 1
• 125000005917 3-methylpentyl group Chemical group 0.000 description 1
• NGJCUJZBSJGQPY-UHFFFAOYSA-N 3-pyrimidin-2-yl-1,2-oxazole Chemical class O1C=CC(C=2N=CC=CN=2)=N1 NGJCUJZBSJGQPY-UHFFFAOYSA-N 0.000 description 1
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 1
• KVXXEKIGMOEPSA-UHFFFAOYSA-N 4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-3-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1CCOCC1C(O)=O KVXXEKIGMOEPSA-UHFFFAOYSA-N 0.000 description 1
• GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 description 1
• AVBKISZUVMWQIA-UHFFFAOYSA-N 4-bromo-2-fluoro-5-methylbenzonitrile Chemical compound CC1=CC(C#N)=C(F)C=C1Br AVBKISZUVMWQIA-UHFFFAOYSA-N 0.000 description 1
• HGXWRDPQFZKOLZ-UHFFFAOYSA-N 4-bromo-2-fluorobenzonitrile Chemical compound FC1=CC(Br)=CC=C1C#N HGXWRDPQFZKOLZ-UHFFFAOYSA-N 0.000 description 1
• ZXFVKFUXKFPUQJ-UHFFFAOYSA-N 4-bromo-2-methyl-6-nitroaniline Chemical compound CC1=CC(Br)=CC([N+]([O-])=O)=C1N ZXFVKFUXKFPUQJ-UHFFFAOYSA-N 0.000 description 1
• SKXUZFJOLNNWIG-UHFFFAOYSA-N 4-bromo-3-methylbenzonitrile Chemical compound CC1=CC(C#N)=CC=C1Br SKXUZFJOLNNWIG-UHFFFAOYSA-N 0.000 description 1
• HQSCPPCMBMFJJN-UHFFFAOYSA-N 4-bromobenzonitrile Chemical compound BrC1=CC=C(C#N)C=C1 HQSCPPCMBMFJJN-UHFFFAOYSA-N 0.000 description 1
• 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
• 125000001572 5'-adenylyl group Chemical group C=12N=C([H])N=C(N([H])[H])C=1N=C([H])N2[C@@]1([H])[C@@](O[H])([H])[C@@](O[H])([H])[C@](C(OP(=O)(O[H])[*])([H])[H])([H])O1 0.000 description 1
• FTQZASSPTVRUKQ-UHFFFAOYSA-N 5-(2-hydroxyethyl)-3-[2-methyl-6-(1h-1,2,4-triazol-5-yl)pyridin-3-yl]-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C=1C=C(C=2N=C3N(CCO)C(=O)CNC3=NC=2)C(C)=NC=1C=1N=CNN=1 FTQZASSPTVRUKQ-UHFFFAOYSA-N 0.000 description 1
• AEZQGSHUZONAFR-UHFFFAOYSA-N 5-(oxan-2-yl)-1h-1,2,4-triazole Chemical compound O1CCCCC1C1=NC=NN1 AEZQGSHUZONAFR-UHFFFAOYSA-N 0.000 description 1
• LPTVWZSQAIDCEB-UHFFFAOYSA-N 5-bromo-1h-pyrrolo[2,3-b]pyridine Chemical compound BrC1=CN=C2NC=CC2=C1 LPTVWZSQAIDCEB-UHFFFAOYSA-N 0.000 description 1
• WGOLHUGPTDEKCF-UHFFFAOYSA-N 5-bromopyridin-2-amine Chemical compound NC1=CC=C(Br)C=N1 WGOLHUGPTDEKCF-UHFFFAOYSA-N 0.000 description 1
• IPWPEOLXILHOLV-UHFFFAOYSA-N 5-bromopyridine-2-carboxamide Chemical compound NC(=O)C1=CC=C(Br)C=N1 IPWPEOLXILHOLV-UHFFFAOYSA-N 0.000 description 1
• NVVHMPDIQNAGLB-UHFFFAOYSA-N 5-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)C(=O)CNC2=NC=C1B1OC(C)(C)C(C)(C)O1 NVVHMPDIQNAGLB-UHFFFAOYSA-N 0.000 description 1
• PNMGBOZHKHCBCZ-UHFFFAOYSA-N 5-propan-2-yl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(C(C)C)C(=O)CNC2=NC=C1B1OC(C)(C)C(C)(C)O1 PNMGBOZHKHCBCZ-UHFFFAOYSA-N 0.000 description 1
• WPTOSLNWOXGYRI-UHFFFAOYSA-N 6-bromo-4-methyl-1h-benzimidazole Chemical compound CC1=CC(Br)=CC2=C1N=CN2 WPTOSLNWOXGYRI-UHFFFAOYSA-N 0.000 description 1
• BHHMPZQRVWVAAR-UHFFFAOYSA-N 7-bromo-8-methylpyrido[2,3-b]pyrazine Chemical compound C1=CN=C2C(C)=C(Br)C=NC2=N1 BHHMPZQRVWVAAR-UHFFFAOYSA-N 0.000 description 1
• FAVRAFCMCYLLEI-UHFFFAOYSA-N 7-hydroxypyrrolo[2,3-b]pyridine Chemical compound ON1C=CC=C2C=CN=C12 FAVRAFCMCYLLEI-UHFFFAOYSA-N 0.000 description 1
• MFUYFRNAVHGXAQ-UHFFFAOYSA-N 8-(oxan-4-yl)-2-[6-[1-(oxan-2-yl)-1,2,4-triazol-3-yl]pyridin-3-yl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=NC(=CC=3)C3=NN(C=N3)C3OCCCC3)=CN=C2NC(=O)CN1C1CCOCC1 MFUYFRNAVHGXAQ-UHFFFAOYSA-N 0.000 description 1
• MLNSAGOBCFMEKI-UHFFFAOYSA-N 8-[2-(oxan-4-yl)ethyl]-2-[4-(1h-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound C12=NC(C=3C=CC(=CC=3)C=3NN=CN=3)=CN=C2NC(=O)CN1CCC1CCOCC1 MLNSAGOBCFMEKI-UHFFFAOYSA-N 0.000 description 1
• YYPTYWAHHWBUPG-UHFFFAOYSA-N 8-ethyl-2-[4-(1h-1,2,4-triazol-5-yl)phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one;hydrochloride Chemical compound Cl.N1=C2N(CC)CC(=O)NC2=NC=C1C(C=C1)=CC=C1C1=NN=CN1 YYPTYWAHHWBUPG-UHFFFAOYSA-N 0.000 description 1
• BBLMVARYKUXDPA-UHFFFAOYSA-N 8-ethyl-2-[4-[4-(oxan-2-yl)-1,2,4-triazol-3-yl]phenyl]-5,7-dihydropyrazino[2,3-b]pyrazin-6-one Chemical compound N1=C2N(CC)CC(=O)NC2=NC=C1C(C=C1)=CC=C1C1=NN=CN1C1CCCCO1 BBLMVARYKUXDPA-UHFFFAOYSA-N 0.000 description 1
• 241000251169 Alopias vulpinus Species 0.000 description 1
• 208000031277 Amaurotic familial idiocy Diseases 0.000 description 1
• BMFMQGXDDJALKQ-BYPYZUCNSA-N Argininic acid Chemical compound NC(N)=NCCC[C@H](O)C(O)=O BMFMQGXDDJALKQ-BYPYZUCNSA-N 0.000 description 1
• 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 description 1
• 208000023275 Autoimmune disease Diseases 0.000 description 1
• 208000003950 B-cell lymphoma Diseases 0.000 description 1
• 208000023328 Basedow disease Diseases 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 208000003174 Brain Neoplasms Diseases 0.000 description 1
• 208000014644 Brain disease Diseases 0.000 description 1
• YDQJIRKVDFZBLV-UHFFFAOYSA-L C([O-])([O-])=O.[Cs+].N1=CC=CC=C1.[Cs+] Chemical compound C([O-])([O-])=O.[Cs+].N1=CC=CC=C1.[Cs+] YDQJIRKVDFZBLV-UHFFFAOYSA-L 0.000 description 1
• VYWKDMVLPNBJCV-UHFFFAOYSA-N C.N=C=S Chemical compound C.N=C=S VYWKDMVLPNBJCV-UHFFFAOYSA-N 0.000 description 1
• RBCIZFTUWNECGB-MGCOHNPYSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(Br)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(Br)=CN=C2NCC1=O RBCIZFTUWNECGB-MGCOHNPYSA-N 0.000 description 1
• MOIOCRUIRQIERC-KOMQPUFPSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=NC=3)C#N)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=NC=3)C#N)C)=CN=C2NCC1=O MOIOCRUIRQIERC-KOMQPUFPSA-N 0.000 description 1
• BWBUIDPWOFWMHH-QRMDTYOQSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=NC=3)C(=O)\N=C/N(C)C)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=NC=3)C(=O)\N=C/N(C)C)C)=CN=C2NCC1=O BWBUIDPWOFWMHH-QRMDTYOQSA-N 0.000 description 1
• KTKQRDMDJDFELL-HDJSIYSDSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=NC=3)C(N)=O)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC(C=3C(=CC(=NC=3)C(N)=O)C)=CN=C2NCC1=O KTKQRDMDJDFELL-HDJSIYSDSA-N 0.000 description 1
• DQAKONKAKBTMPV-ORHQCAHMSA-N C1C[C@@H](OC)CC[C@@H]1CN1C2=NC([Sn](C)(C)C)=CN=C2NCC1=O Chemical compound C1C[C@@H](OC)CC[C@@H]1CN1C2=NC([Sn](C)(C)C)=CN=C2NCC1=O DQAKONKAKBTMPV-ORHQCAHMSA-N 0.000 description 1
• FYVYOLIUEIUYBG-DTORHVGOSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC(Br)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC(Br)=CN=C2NC(=O)C1 FYVYOLIUEIUYBG-DTORHVGOSA-N 0.000 description 1
• IYUQTUZPPFFOHF-GUQANJBTSA-N C1C[C@@H](OC)CC[C@H]1N1C2=NC([Sn](C)(C)C)=CN=C2NC(=O)C1 Chemical compound C1C[C@@H](OC)CC[C@H]1N1C2=NC([Sn](C)(C)C)=CN=C2NC(=O)C1 IYUQTUZPPFFOHF-GUQANJBTSA-N 0.000 description 1
• MSFZUPMEZBMFRP-UHFFFAOYSA-N CC(C)(C)C(COCC1)(C(C(C(Br)=N2)=NC=C2Br)=O)N1C(O)=O Chemical compound CC(C)(C)C(COCC1)(C(C(C(Br)=N2)=NC=C2Br)=O)N1C(O)=O MSFZUPMEZBMFRP-UHFFFAOYSA-N 0.000 description 1
• PVYICKKCIKRBKB-UHFFFAOYSA-N CC(C)(C)C(N(C(O)=O)C1=NC=C2)=CC1=C2C1=NC(N(CCC2CCOCC2)C(CN2)=O)=C2N=C1 Chemical compound CC(C)(C)C(N(C(O)=O)C1=NC=C2)=CC1=C2C1=NC(N(CCC2CCOCC2)C(CN2)=O)=C2N=C1 PVYICKKCIKRBKB-UHFFFAOYSA-N 0.000 description 1
• JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• OKTJSMMVPCPJKN-NJFSPNSNSA-N Carbon-14 Chemical compound [14C] OKTJSMMVPCPJKN-NJFSPNSNSA-N 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
• 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
• 241000700198 Cavia Species 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• 206010010904 Convulsion Diseases 0.000 description 1
• 229910021591 Copper(I) chloride Inorganic materials 0.000 description 1
• LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 1
• RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
• 206010012289 Dementia Diseases 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
• JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
• PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
• HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 1
• 208000004930 Fatty Liver Diseases 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 208000007882 Gastritis Diseases 0.000 description 1
• 101001114134 Gloydius halys Neutral phospholipase A2 agkistrodotoxin Proteins 0.000 description 1
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
• 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 description 1
• 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 description 1
• 208000015023 Graves' disease Diseases 0.000 description 1
• 101150113453 Gsk3a gene Proteins 0.000 description 1
• 208000023329 Gun shot wound Diseases 0.000 description 1
• 101000897035 Homo sapiens Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 description 1
• 101000864057 Homo sapiens Serine/threonine-protein kinase SMG1 Proteins 0.000 description 1
• 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 206010023439 Kidney transplant rejection Diseases 0.000 description 1
• 239000005909 Kieselgur Substances 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
• 125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 description 1
• 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 description 1
• WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
• 208000019693 Lung disease Diseases 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 208000002569 Machado-Joseph Disease Diseases 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 102100040243 Microtubule-associated protein tau Human genes 0.000 description 1
• 208000026072 Motor neurone disease Diseases 0.000 description 1
• 208000003445 Mouth Neoplasms Diseases 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• SUAKHGWARZSWIH-UHFFFAOYSA-N N,N‐diethylformamide Chemical compound CCN(CC)C=O SUAKHGWARZSWIH-UHFFFAOYSA-N 0.000 description 1
• 150000001204 N-oxides Chemical class 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• 102000007399 Nuclear hormone receptor Human genes 0.000 description 1
• 108020005497 Nuclear hormone receptor Proteins 0.000 description 1
• MFGBFQUUPISRBX-UHFFFAOYSA-N O=C(C1)NC2=NC=CN=C2N1C1CCOCC1 Chemical compound O=C(C1)NC2=NC=CN=C2N1C1CCOCC1 MFGBFQUUPISRBX-UHFFFAOYSA-N 0.000 description 1
• 208000011623 Obstructive Lung disease Diseases 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
• KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 description 1
• WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
• IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 206010063837 Reperfusion injury Diseases 0.000 description 1
• 208000007014 Retinitis pigmentosa Diseases 0.000 description 1
• 206010039710 Scleroderma Diseases 0.000 description 1
• 101710142052 Serine/threonine-protein kinase mTOR Proteins 0.000 description 1
• KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• NINIDFKCEFEMDL-AKLPVKDBSA-N Sulfur-35 Chemical compound [35S] NINIDFKCEFEMDL-AKLPVKDBSA-N 0.000 description 1
• 108010021188 Superoxide Dismutase-1 Proteins 0.000 description 1
• 102100038836 Superoxide dismutase [Cu-Zn] Human genes 0.000 description 1
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
• 101710173511 Tensin homolog Proteins 0.000 description 1
• 102100024547 Tensin-1 Human genes 0.000 description 1
• 108010088950 Tensins Proteins 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
• YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
• 208000002495 Uterine Neoplasms Diseases 0.000 description 1
• 229940127538 Vascular Endothelial Growth Factor Receptor Inhibitors Drugs 0.000 description 1
• 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 1
• 201000008803 Wolff-Parkinson-white syndrome Diseases 0.000 description 1
• 206010052428 Wound Diseases 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• PNDPGZBMCMUPRI-XXSWNUTMSA-N [125I][125I] Chemical compound [125I][125I] PNDPGZBMCMUPRI-XXSWNUTMSA-N 0.000 description 1
• 150000003869 acetamides Chemical class 0.000 description 1
• 239000003377 acid catalyst Substances 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 125000004442 acylamino group Chemical group 0.000 description 1
• 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 1
• 208000009956 adenocarcinoma Diseases 0.000 description 1
• 230000011759 adipose tissue development Effects 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
• 125000005262 alkoxyamine group Chemical group 0.000 description 1
• 125000004656 alkyl sulfonylamino group Chemical group 0.000 description 1
• 230000000735 allogeneic effect Effects 0.000 description 1
• 125000005336 allyloxy group Chemical group 0.000 description 1
• BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 229910021529 ammonia Inorganic materials 0.000 description 1
• 235000019270 ammonium chloride Nutrition 0.000 description 1
• 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 description 1
• 230000001093 anti-cancer Effects 0.000 description 1
• 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 description 1
• 150000001491 aromatic compounds Chemical class 0.000 description 1
• 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
• 206010003246 arthritis Diseases 0.000 description 1
• 125000002102 aryl alkyloxo group Chemical group 0.000 description 1
• 125000002393 azetidinyl group Chemical group 0.000 description 1
• 125000004069 aziridinyl group Chemical group 0.000 description 1
• 230000009286 beneficial effect Effects 0.000 description 1
• JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
• SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
• 229940092714 benzenesulfonic acid Drugs 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• 229960004365 benzoic acid Drugs 0.000 description 1
• 125000004622 benzoxazinyl group Chemical group O1NC(=CC2=C1C=CC=C2)* 0.000 description 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
• 125000002619 bicyclic group Chemical group 0.000 description 1
• 239000004305 biphenyl Substances 0.000 description 1
• 235000010290 biphenyl Nutrition 0.000 description 1
• 238000010322 bone marrow transplantation Methods 0.000 description 1
• 125000001246 bromo group Chemical group Br* 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 125000002837 carbocyclic group Chemical group 0.000 description 1
• 150000001721 carbon Chemical group 0.000 description 1
• 150000001728 carbonyl compounds Chemical class 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 208000025188 carcinoma of pharynx Diseases 0.000 description 1
• 230000002612 cardiopulmonary effect Effects 0.000 description 1
• 210000000845 cartilage Anatomy 0.000 description 1
• 238000006555 catalytic reaction Methods 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 210000003169 central nervous system Anatomy 0.000 description 1
• 201000007455 central nervous system cancer Diseases 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• 239000003638 chemical reducing agent Substances 0.000 description 1
• 230000002113 chemopreventative effect Effects 0.000 description 1
• 235000013330 chicken meat Nutrition 0.000 description 1
• VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 description 1
• 229960002023 chloroprocaine Drugs 0.000 description 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• 208000037976 chronic inflammation Diseases 0.000 description 1
• 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
• 208000019425 cirrhosis of liver Diseases 0.000 description 1
• 239000012230 colorless oil Substances 0.000 description 1
• OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 1
• 238000012937 correction Methods 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 239000010779 crude oil Substances 0.000 description 1
• XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 description 1
• ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
• 125000006165 cyclic alkyl group Chemical group 0.000 description 1
• 125000004367 cycloalkylaryl group Chemical group 0.000 description 1
• 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
• 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 description 1
• 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 1
• 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
• 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 description 1
• 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 1
• BSEXNZMHLUMQKR-UHFFFAOYSA-N cyclopropanecarboxamide Chemical compound NC(=O)C1CC1.NC(=O)C1CC1 BSEXNZMHLUMQKR-UHFFFAOYSA-N 0.000 description 1
• RZZFOJKGQIYSBE-UHFFFAOYSA-N cyclopropyl carbamate Chemical compound NC(=O)OC1CC1 RZZFOJKGQIYSBE-UHFFFAOYSA-N 0.000 description 1
• 230000007850 degeneration Effects 0.000 description 1
• 238000005695 dehalogenation reaction Methods 0.000 description 1
• 230000003111 delayed effect Effects 0.000 description 1
• 229940075894 denatured ethanol Drugs 0.000 description 1
• 201000001981 dermatomyositis Diseases 0.000 description 1
• 238000011161 development Methods 0.000 description 1
• 230000018109 developmental process Effects 0.000 description 1
• 125000000950 dibromo group Chemical group Br* 0.000 description 1
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
• 229940043237 diethanolamine Drugs 0.000 description 1
• 206010012818 diffuse large B-cell lymphoma Diseases 0.000 description 1
• 125000005433 dihydrobenzodioxinyl group Chemical group O1C(COC2=C1C=CC=C2)* 0.000 description 1
• 125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 description 1
• 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
• 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 125000000597 dioxinyl group Chemical group 0.000 description 1
• 208000037765 diseases and disorders Diseases 0.000 description 1
• 238000004821 distillation Methods 0.000 description 1
• 125000005883 dithianyl group Chemical group 0.000 description 1
• 239000003596 drug target Substances 0.000 description 1
• 238000000132 electrospray ionisation Methods 0.000 description 1
• 239000000839 emulsion Substances 0.000 description 1
• 150000002081 enamines Chemical class 0.000 description 1
• 206010014599 encephalitis Diseases 0.000 description 1
• 201000002491 encephalomyelitis Diseases 0.000 description 1
• 210000000981 epithelium Anatomy 0.000 description 1
• PVQYIZJADZBWRR-UHFFFAOYSA-N ethyl 2-[[5-bromo-3-(ethylamino)pyrazin-2-yl]amino]acetate Chemical compound CCNC1=NC(Br)=CN=C1NCC(=O)OCC PVQYIZJADZBWRR-UHFFFAOYSA-N 0.000 description 1
• NTNZTEQNFHNYBC-UHFFFAOYSA-N ethyl 2-aminoacetate Chemical compound CCOC(=O)CN NTNZTEQNFHNYBC-UHFFFAOYSA-N 0.000 description 1
• SWJFEVFZCZJOOE-UHFFFAOYSA-N ethyl 4-bromobenzenecarboximidate;hydrochloride Chemical compound Cl.CCOC(=N)C1=CC=C(Br)C=C1 SWJFEVFZCZJOOE-UHFFFAOYSA-N 0.000 description 1
• VEUUMBGHMNQHGO-UHFFFAOYSA-N ethyl chloroacetate Chemical compound CCOC(=O)CCl VEUUMBGHMNQHGO-UHFFFAOYSA-N 0.000 description 1
• 125000004494 ethyl ester group Chemical group 0.000 description 1
• 229940012017 ethylenediamine Drugs 0.000 description 1
• 229960005167 everolimus Drugs 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 210000001508 eye Anatomy 0.000 description 1
• 206010016629 fibroma Diseases 0.000 description 1
• 230000003176 fibrotic effect Effects 0.000 description 1
• 238000002376 fluorescence recovery after photobleaching Methods 0.000 description 1
• 125000001153 fluoro group Chemical group F* 0.000 description 1
• 239000001530 fumaric acid Substances 0.000 description 1
• 125000000524 functional group Chemical group 0.000 description 1
• 230000009395 genetic defect Effects 0.000 description 1
• 230000000762 glandular Effects 0.000 description 1
• 239000000174 gluconic acid Substances 0.000 description 1
• 235000012208 gluconic acid Nutrition 0.000 description 1
• 229940097043 glucuronic acid Drugs 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 230000012010 growth Effects 0.000 description 1
• 208000019622 heart disease Diseases 0.000 description 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
• 210000003494 hepatocyte Anatomy 0.000 description 1
• 125000000592 heterocycloalkyl group Chemical group 0.000 description 1
• 125000005844 heterocyclyloxy group Chemical group 0.000 description 1
• 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 description 1
• 229960000443 hydrochloric acid Drugs 0.000 description 1
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
• 239000012216 imaging agent Substances 0.000 description 1
• 230000028993 immune response Effects 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 238000001727 in vivo Methods 0.000 description 1
• 238000011503 in vivo imaging Methods 0.000 description 1
• 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 1
• 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 1
• 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 description 1
• 230000004968 inflammatory condition Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 150000007529 inorganic bases Chemical class 0.000 description 1
• 230000003993 interaction Effects 0.000 description 1
• 208000036971 interstitial lung disease 2 Diseases 0.000 description 1
• 208000028774 intestinal disease Diseases 0.000 description 1
• 229940044173 iodine-125 Drugs 0.000 description 1
• 239000003456 ion exchange resin Substances 0.000 description 1
• 229920003303 ion-exchange polymer Polymers 0.000 description 1
• 208000037906 ischaemic injury Diseases 0.000 description 1
• 208000012947 ischemia reperfusion injury Diseases 0.000 description 1
• 229940045996 isethionic acid Drugs 0.000 description 1
• OWFXIOWLTKNBAP-UHFFFAOYSA-N isoamyl nitrite Chemical compound CC(C)CCON=O OWFXIOWLTKNBAP-UHFFFAOYSA-N 0.000 description 1
• 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
• 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 description 1
• JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
• 125000001786 isothiazolyl group Chemical group 0.000 description 1
• 230000000155 isotopic effect Effects 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 229960000448 lactic acid Drugs 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 210000000265 leukocyte Anatomy 0.000 description 1
• 230000000670 limiting effect Effects 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 229910052744 lithium Inorganic materials 0.000 description 1
• 208000019423 liver disease Diseases 0.000 description 1
• 210000003141 lower extremity Anatomy 0.000 description 1
• 210000001165 lymph node Anatomy 0.000 description 1
• 210000003563 lymphoid tissue Anatomy 0.000 description 1
• 125000001288 lysyl group Chemical group 0.000 description 1
• 239000011777 magnesium Substances 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• NXPHGHWWQRMDIA-UHFFFAOYSA-M magnesium;carbanide;bromide Chemical compound [CH3-].[Mg+2].[Br-] NXPHGHWWQRMDIA-UHFFFAOYSA-M 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 239000011976 maleic acid Substances 0.000 description 1
• 229940098895 maleic acid Drugs 0.000 description 1
• 239000001630 malic acid Substances 0.000 description 1
• 235000011090 malic acid Nutrition 0.000 description 1
• 229940099690 malic acid Drugs 0.000 description 1
• 208000026037 malignant tumor of neck Diseases 0.000 description 1
• 229960002510 mandelic acid Drugs 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 229960003194 meglumine Drugs 0.000 description 1
• 201000001441 melanoma Diseases 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 208000030159 metabolic disease Diseases 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 239000002808 molecular sieve Substances 0.000 description 1
• 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
• 235000019796 monopotassium phosphate Nutrition 0.000 description 1
• STUHQDIOZQUPGP-UHFFFAOYSA-N morpholin-4-ium-4-carboxylate Chemical compound OC(=O)N1CCOCC1 STUHQDIOZQUPGP-UHFFFAOYSA-N 0.000 description 1
• 239000012452 mother liquor Substances 0.000 description 1
• 208000005264 motor neuron disease Diseases 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 206010028417 myasthenia gravis Diseases 0.000 description 1
• 206010028537 myelofibrosis Diseases 0.000 description 1
• DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
• RWIVICVCHVMHMU-UHFFFAOYSA-N n-aminoethylmorpholine Chemical compound NCCN1CCOCC1 RWIVICVCHVMHMU-UHFFFAOYSA-N 0.000 description 1
• 125000004593 naphthyridinyl group Chemical group N1=C(C=CC2=CC=CN=C12)* 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 230000000626 neurodegenerative effect Effects 0.000 description 1
• 229910017604 nitric acid Inorganic materials 0.000 description 1
• 238000002414 normal-phase solid-phase extraction Methods 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 150000007530 organic bases Chemical class 0.000 description 1
• 125000001715 oxadiazolyl group Chemical group 0.000 description 1
• AHVQYHFYQWKUKB-UHFFFAOYSA-N oxan-4-amine Chemical compound NC1CCOCC1 AHVQYHFYQWKUKB-UHFFFAOYSA-N 0.000 description 1
• IVMHDOBGNQOUHO-UHFFFAOYSA-N oxathiane Chemical compound C1CCSOC1 IVMHDOBGNQOUHO-UHFFFAOYSA-N 0.000 description 1
• 150000002923 oximes Chemical class 0.000 description 1
• PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
• WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
• 208000024691 pancreas disease Diseases 0.000 description 1
• 239000011713 pantothenic acid Substances 0.000 description 1
• 229940055726 pantothenic acid Drugs 0.000 description 1
• 235000019161 pantothenic acid Nutrition 0.000 description 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
• 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
• 238000012746 preparative thin layer chromatography Methods 0.000 description 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
• 229960004919 procaine Drugs 0.000 description 1
• QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
• 239000003909 protein kinase inhibitor Substances 0.000 description 1
• 230000009822 protein phosphorylation Effects 0.000 description 1
• 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
• 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
• XFTQRUTUGRCSGO-UHFFFAOYSA-N pyrazin-2-amine Chemical compound NC1=CN=CC=N1 XFTQRUTUGRCSGO-UHFFFAOYSA-N 0.000 description 1
• IPEHBUMCGVEMRF-UHFFFAOYSA-N pyrazinecarboxamide Chemical compound NC(=O)C1=CN=CC=N1 IPEHBUMCGVEMRF-UHFFFAOYSA-N 0.000 description 1
• 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
• 125000002755 pyrazolinyl group Chemical group 0.000 description 1
• 125000001422 pyrrolinyl group Chemical group 0.000 description 1
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
• 239000002994 raw material Substances 0.000 description 1
• 238000001953 recrystallisation Methods 0.000 description 1
• 238000006268 reductive amination reaction Methods 0.000 description 1
• 201000002793 renal fibrosis Diseases 0.000 description 1
• 230000010410 reperfusion Effects 0.000 description 1
• 230000001850 reproductive effect Effects 0.000 description 1
• 239000000790 retinal pigment Substances 0.000 description 1
• 229960004889 salicylic acid Drugs 0.000 description 1
• 230000009291 secondary effect Effects 0.000 description 1
• 230000007781 signaling event Effects 0.000 description 1
• URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
• 239000012279 sodium borohydride Substances 0.000 description 1
• 229910000033 sodium borohydride Inorganic materials 0.000 description 1
• 239000012312 sodium hydride Substances 0.000 description 1
• 229910000104 sodium hydride Inorganic materials 0.000 description 1
• KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
• 229910001948 sodium oxide Inorganic materials 0.000 description 1
• 159000000000 sodium salts Chemical class 0.000 description 1
• 239000012265 solid product Substances 0.000 description 1
• 239000011877 solvent mixture Substances 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 208000027140 splenic disease Diseases 0.000 description 1
• 238000010561 standard procedure Methods 0.000 description 1
• 125000003638 stannyl group Chemical group [H][Sn]([H])([H])* 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 239000012258 stirred mixture Substances 0.000 description 1
• 125000000547 substituted alkyl group Chemical group 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 229950000244 sulfanilic acid Drugs 0.000 description 1
• 229940124530 sulfonamide Drugs 0.000 description 1
• 150000003456 sulfonamides Chemical class 0.000 description 1
• 239000011593 sulfur Substances 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 239000011975 tartaric acid Substances 0.000 description 1
• 235000002906 tartaric acid Nutrition 0.000 description 1
• 238000003419 tautomerization reaction Methods 0.000 description 1
• TUNXVHVCLTYSCQ-UHFFFAOYSA-N tert-butyl n-[1-[(3,5-dibromopyrazin-2-yl)amino]-2-methyl-1-oxopropan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)NC(C)(C)C(=O)NC1=NC=C(Br)N=C1Br TUNXVHVCLTYSCQ-UHFFFAOYSA-N 0.000 description 1
• 238000012360 testing method Methods 0.000 description 1
• 210000001550 testis Anatomy 0.000 description 1
• JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
• 125000005944 tetrahydroimidazopyridyl group Chemical group 0.000 description 1
• 125000005888 tetrahydroindolyl group Chemical group 0.000 description 1
• 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
• 125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 125000001113 thiadiazolyl group Chemical group 0.000 description 1
• 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 description 1
• 125000001984 thiazolidinyl group Chemical group 0.000 description 1
• 125000002769 thiazolinyl group Chemical group 0.000 description 1
• 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
• 210000001685 thyroid gland Anatomy 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000007704 transition Effects 0.000 description 1
• 125000004306 triazinyl group Chemical group 0.000 description 1
• 150000003852 triazoles Chemical class 0.000 description 1
• WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 1
• GQSLZAFZAPLKEY-UHFFFAOYSA-N trimethyl-[2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]propan-2-yloxy]silane Chemical compound C1=NC(C(C)(O[Si](C)(C)C)C)=CC=C1B1OC(C)(C)C(C)(C)O1 GQSLZAFZAPLKEY-UHFFFAOYSA-N 0.000 description 1
• AALUTIYNYXEFNT-UHFFFAOYSA-N trimethylsilane hydroiodide Chemical compound C[SiH](C)C.I AALUTIYNYXEFNT-UHFFFAOYSA-N 0.000 description 1
• 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 229910052722 tritium Inorganic materials 0.000 description 1
• 238000001665 trituration Methods 0.000 description 1
• 210000004881 tumor cell Anatomy 0.000 description 1
• 230000004565 tumor cell growth Effects 0.000 description 1
• 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
• 206010046766 uterine cancer Diseases 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• 229920002554 vinyl polymer Polymers 0.000 description 1
• NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
• 238000010792 warming Methods 0.000 description 1
• 229910052725 zinc Inorganic materials 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1