JP2013508456A5 - - Google Patents
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- Publication number
- JP2013508456A5 JP2013508456A5 JP2012536897A JP2012536897A JP2013508456A5 JP 2013508456 A5 JP2013508456 A5 JP 2013508456A5 JP 2012536897 A JP2012536897 A JP 2012536897A JP 2012536897 A JP2012536897 A JP 2012536897A JP 2013508456 A5 JP2013508456 A5 JP 2013508456A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydropyrazino
- pyrazin
- methyl
- triazol
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25491709P | 2009-10-26 | 2009-10-26 | |
| US61/254,917 | 2009-10-26 | ||
| US32848010P | 2010-04-27 | 2010-04-27 | |
| US61/328,480 | 2010-04-27 | ||
| PCT/US2010/053678 WO2011053518A1 (en) | 2009-10-26 | 2010-10-22 | Methods of synthesis and purification of heteroaryl compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148782A Division JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013508456A JP2013508456A (ja) | 2013-03-07 |
| JP2013508456A5 true JP2013508456A5 (https=) | 2013-11-07 |
Family
ID=43922466
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012536897A Pending JP2013508456A (ja) | 2009-10-26 | 2010-10-22 | ヘテロアリール化合物の合成方法および精製方法 |
| JP2016148782A Active JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016148782A Active JP6338622B2 (ja) | 2009-10-26 | 2016-07-28 | ヘテロアリール化合物の合成方法および精製方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8569494B2 (https=) |
| EP (2) | EP3091021B1 (https=) |
| JP (2) | JP2013508456A (https=) |
| KR (2) | KR20120091240A (https=) |
| CN (2) | CN106117213B (https=) |
| AR (1) | AR078788A1 (https=) |
| AU (1) | AU2010313585B2 (https=) |
| BR (1) | BR112012009751A2 (https=) |
| CA (1) | CA2778615C (https=) |
| CO (1) | CO6541598A2 (https=) |
| CR (1) | CR20120211A (https=) |
| EC (1) | ECSP12011831A (https=) |
| ES (2) | ES2613664T3 (https=) |
| IL (1) | IL219368A (https=) |
| MX (1) | MX341704B (https=) |
| MY (1) | MY177695A (https=) |
| NI (1) | NI201200066A (https=) |
| NZ (2) | NZ599549A (https=) |
| PH (2) | PH12012500825A1 (https=) |
| RU (1) | RU2557242C2 (https=) |
| SG (1) | SG10201500511TA (https=) |
| WO (1) | WO2011053518A1 (https=) |
| ZA (1) | ZA201202959B (https=) |
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| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
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| KR102040997B1 (ko) * | 2011-12-02 | 2019-11-27 | 시그날 파마소티칼 엘엘씨 | 7-(6-(2-히드록시프로판-2-일)피리딘-3-일)-1-((트랜스)-4-메톡시시클로헥실)-3,4-디히드로피라지노[2,3-b]피라진-2(1H)-온, 그의 고체 형태의 제약 조성물 및 그의 사용 방법 |
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| BR112014022703A2 (pt) | 2012-03-15 | 2021-05-04 | Signal Pharmaceuticals, Llc | método para o tratamento de carcinoma de células escamosas de cabeça e de pescoço, método para melhorar os critérios de avaliação, método para inibição da fosforilação, método para inibição de dna, método para a medição da inibição da fosforilação, kit |
| MY178012A (en) | 2012-03-15 | 2020-09-29 | Signal Pharm Llc | Treatment of cancer with tor kinase inhibitors |
| TWI664968B (zh) | 2012-03-15 | 2019-07-11 | 標誌製藥公司 | 使用tor激酶抑制劑之癌症治療 |
| BR112014022700A2 (pt) | 2012-03-15 | 2020-06-30 | Signal Pharmaceuticals, Llc | uso de uma quantidade eficaz de um inibidor da quinase tor, método para melhorar o critério do grupo de trabalho 2 do antígeno prostático específico (psawg2), método para a inibição da fosforilação de s6rp, 4e-bp1 e/ou de akt, método para a inibição da atividade da proteína quinase dependente do dna (dna-pk), método para a medição da inibição da fosforilação de s6rp, 4e-bp1 ou akt, método para a medição da inibição da fosforilação de dna-pk s2056 e kit |
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| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
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| US9505764B2 (en) * | 2013-04-17 | 2016-11-29 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
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| NZ714742A (en) * | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| ES2823756T3 (es) | 2014-04-16 | 2021-05-10 | Signal Pharm Llc | Métodos para tratar el cáncer usando terapia de combinación de inhibidores de quinasa TOR |
| US9512129B2 (en) | 2014-04-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer |
| WO2016010886A1 (en) | 2014-07-14 | 2016-01-21 | Signal Pharmaceuticals, Llc | Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
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| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
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| TWI787284B (zh) | 2017-06-22 | 2022-12-21 | 美商西建公司 | 以b型肝炎病毒感染表徵之肝細胞癌之治療 |
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| JP7832891B2 (ja) | 2019-12-04 | 2026-03-18 | インサイト・コーポレイション | Fgfr阻害剤の誘導体 |
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| CN115135636B (zh) * | 2020-04-29 | 2024-08-23 | 北京泰德制药股份有限公司 | 喹喔啉酮衍生物作为kras g12c突变蛋白的不可逆抑制剂 |
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