JP2013507990A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013507990A5 JP2013507990A5 JP2012536963A JP2012536963A JP2013507990A5 JP 2013507990 A5 JP2013507990 A5 JP 2013507990A5 JP 2012536963 A JP2012536963 A JP 2012536963A JP 2012536963 A JP2012536963 A JP 2012536963A JP 2013507990 A5 JP2013507990 A5 JP 2013507990A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- polypeptide
- nos
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 description 10
- 102000004196 processed proteins & peptides Human genes 0.000 description 10
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 125000000539 amino acid group Chemical group 0.000 description 5
- 150000007523 nucleic acids Chemical group 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 241000712461 unidentified influenza virus Species 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229960000310 isoleucine Drugs 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 239000004474 valine Substances 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- BEJKOYIMCGMNRB-GRHHLOCNSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 BEJKOYIMCGMNRB-GRHHLOCNSA-N 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25479509P | 2009-10-26 | 2009-10-26 | |
| US61/254,795 | 2009-10-26 | ||
| PCT/US2010/054128 WO2011056591A1 (en) | 2009-10-26 | 2010-10-26 | High titer recombinant influenza viruses with enhanced replication in vero cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016053990A Division JP6375329B2 (ja) | 2009-10-26 | 2016-03-17 | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507990A JP2013507990A (ja) | 2013-03-07 |
| JP2013507990A5 true JP2013507990A5 (enExample) | 2013-06-20 |
Family
ID=43502620
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012536963A Pending JP2013507990A (ja) | 2009-10-26 | 2010-10-26 | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
| JP2016053990A Active JP6375329B2 (ja) | 2009-10-26 | 2016-03-17 | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016053990A Active JP6375329B2 (ja) | 2009-10-26 | 2016-03-17 | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9109013B2 (enExample) |
| EP (1) | EP2493912B1 (enExample) |
| JP (2) | JP2013507990A (enExample) |
| ES (1) | ES2813347T3 (enExample) |
| WO (1) | WO2011056591A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009532352A (ja) | 2006-03-31 | 2009-09-10 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ワクチンのための高力価組み換えインフルエンザ・ウィルス |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| ES2813347T3 (es) | 2009-10-26 | 2021-03-23 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| ES2628301T3 (es) * | 2012-03-02 | 2017-08-02 | Seqirus UK Limited | Recombinación de virus de gripe |
| AU2014290203B2 (en) * | 2013-07-15 | 2020-12-24 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2016201127A1 (en) * | 2015-06-09 | 2016-12-15 | Sanofi Pasteur, Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| AU2017221444B2 (en) | 2016-02-19 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza B virus replication for vaccine development |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| US11389523B2 (en) | 2018-08-20 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN113874496A (zh) | 2019-02-08 | 2021-12-31 | 威斯康星校友研究基金会(Warf) | 人源化细胞系 |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| WO2020247844A1 (en) * | 2019-06-07 | 2020-12-10 | Flugen, Inc. | Influenza virus backbone |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| JP2023534840A (ja) * | 2020-07-21 | 2023-08-14 | フルゲン， インコーポレイテッド | Ｍ２／ｂｍ２欠失インフルエンザベクターを使用したワクチン |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071618A (en) | 1974-09-03 | 1978-01-31 | Research Foundation For Microbial Diseases Of Osaka University | Process for preparing virus disease live vaccines |
| JPS57136528A (en) | 1981-02-09 | 1982-08-23 | Hayashibara Biochem Lab Inc | Preparation of viral vaccine |
| NZ219515A (en) | 1987-02-10 | 1989-09-27 | Wellcome Found | Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US5919676A (en) | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| EP1394259A3 (en) | 1994-07-18 | 2004-04-14 | Karl-Klaus Prof. Dr. Conzelmann | Recombinant infectious non-segmented negative strand RNA virus |
| US5716821A (en) | 1994-09-30 | 1998-02-10 | Uab Research Foundation | Prevention and treatment of respiratory tract disease |
| US5789229A (en) | 1994-09-30 | 1998-08-04 | Uab Research Foundation | Stranded RNA virus particles |
| AU3727895A (en) | 1994-09-30 | 1996-04-26 | St. Jude Children's Research Hospital | Nucleic acid encoding mutant matrix proteins useful for attenuation or enhancement of influenza a virus |
| ATE181112T1 (de) | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| US6037348A (en) * | 1996-02-09 | 2000-03-14 | Eli Lilly And Company | Inhibition of viral replication |
| DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| US5994526A (en) | 1996-06-21 | 1999-11-30 | Plant Genetic Systems | Gene expression in plants |
| ATE451451T1 (de) | 1996-07-15 | 2009-12-15 | Us Gov Health & Human Serv | Herstellung von attenuierten respiratorischen syncytialvirus-impfstoffen aus klonierten nukleotidsequenzen |
| TW570803B (en) | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
| CN1250725C (zh) | 1997-05-23 | 2006-04-12 | 美国政府健康及人类服务部 | 从克隆的核苷酸序列制备减毒副流感病毒疫苗的方法 |
| DE69832706T2 (de) | 1997-08-05 | 2006-08-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Immunschützendes influenzaantigen und dessen verwendung zur impfung |
| US6169175B1 (en) | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| KR100281676B1 (ko) | 1997-11-29 | 2001-04-02 | 신동권 | 신규한독감생백신바이러스 |
| US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
| EP1035209A1 (en) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| PT1820853E (pt) | 1999-04-06 | 2012-01-03 | Wisconsin Alumni Res Found | Vírus recombinante da gripe para vacinas e terapia genética |
| US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6686168B1 (en) | 1999-11-04 | 2004-02-03 | Zymogenetics, Inc. | Cell surface display of proteins by recombinant host cells |
| US7192759B1 (en) | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
| WO2001064846A1 (fr) | 2000-03-03 | 2001-09-07 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Cellule utilisable pour culture sans serum et culture en suspension, et procede de production de virus pour vaccin utilisant cette cellule |
| EP1276852B1 (en) | 2000-04-14 | 2010-11-17 | Wisconsin Alumni Research Foundation | Viruses comprising mutated ion channel protein |
| CN100489107C (zh) | 2000-04-28 | 2009-05-20 | 圣朱德儿童研究医院 | 用于产生感染性流感病毒的dna转染系统 |
| EP1201760A1 (en) | 2000-10-30 | 2002-05-02 | ARTEMIS Pharmaceuticals GmbH | Influenza virus vector for human dendritic cells |
| EP1364006A2 (en) | 2001-02-23 | 2003-11-26 | Wisconsin Alumni Research Foundation | Methods to identify mutant cells with altered sialic acid |
| DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
| US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
| EP3009507B1 (en) | 2002-02-13 | 2020-06-24 | Wisconsin Alumini Research Foundation | Signal for packaging of influenza virus vectors |
| WO2003076462A1 (en) | 2002-03-08 | 2003-09-18 | Crucell Holland B.V. | Use of recombinant trypsin for vaccine production |
| CN1678345A (zh) | 2002-04-26 | 2005-10-05 | 米迪缪尼疫苗股份有限公司 | 制备流感病毒的多质粒系统 |
| US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| JP2005532057A (ja) | 2002-07-09 | 2005-10-27 | バクスター・インターナショナル・インコーポレイテッド | 細胞を培養するための動物性タンパク質非含有培地 |
| MXPA05011250A (es) | 2003-04-23 | 2006-03-30 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza que mantienen una mutacion en un gen de proteina transmembranal. |
| CN1829799A (zh) | 2003-05-28 | 2006-09-06 | 威斯康星旧生研究基金会 | 含polii启动子和核酶的重组流感载体 |
| AU2004249133B2 (en) | 2003-05-28 | 2009-05-28 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines and gene therapy |
| US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US7037707B2 (en) | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
| ATE469972T1 (de) | 2003-12-23 | 2010-06-15 | Medimmune Llc | Multiplasmid-system zur erzeugung des grippevirus |
| JP2005245302A (ja) | 2004-03-04 | 2005-09-15 | Kanazawa Univ Tlo Inc | 組換えインフルエンザウイルスおよびそれを用いたワクチン |
| US20080254067A1 (en) | 2004-05-20 | 2008-10-16 | Id Biomedical Corporation | Process for the Production of an Influenza Vaccine |
| PL2236155T3 (pl) | 2004-09-09 | 2012-10-31 | Novartis Ag | Zmniejszenie potencjalnego zagrożenia jatrogennego związanego ze szczepionkami przeciwko grypie |
| EP1814990A2 (en) | 2004-11-19 | 2007-08-08 | Wisconsin Alumni Research Foundation | Recombinant influenza vectors with tandem transcription units |
| CN103555670B (zh) | 2004-12-23 | 2015-08-12 | 米迪缪尼有限公司 | 用于病毒增殖的非致瘤性mdck细胞系 |
| DK1831357T3 (da) | 2004-12-24 | 2012-12-10 | Abbott Biologicals Bv | Genvinding af influenzavirus |
| ES2527503T3 (es) | 2005-03-08 | 2015-01-26 | Medimmune, Llc | Virus influenza reordenantes |
| CA2891994A1 (en) | 2005-10-17 | 2007-04-26 | Bin Lu | Multi plasmid system for the production of influenza virus |
| KR20080089663A (ko) | 2006-01-27 | 2008-10-07 | 노바티스 백신즈 앤드 다이아그노스틱스 게엠베하 운트 콤파니 카게 | 적혈구응집소 및 기질 단백질을 함유한 인플루엔자 백신 |
| AU2014202470B2 (en) | 2006-03-31 | 2016-08-04 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| AU2012204138B2 (en) | 2006-03-31 | 2014-02-06 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| JP2009532352A (ja) | 2006-03-31 | 2009-09-10 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ワクチンのための高力価組み換えインフルエンザ・ウィルス |
| US7883844B2 (en) | 2006-05-11 | 2011-02-08 | Juridical Foundation The Chemosero-Therapeutic Research Institute | Method for propagating influenza virus |
| US7507411B2 (en) | 2006-06-23 | 2009-03-24 | University Of Saskatchewan | Attenuated influenza NS1 variants |
| AU2007286161B2 (en) | 2006-08-09 | 2013-05-02 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| EP2069480B1 (en) | 2006-09-15 | 2014-03-19 | MedImmune, LLC | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
| CN101553252A (zh) | 2006-12-06 | 2009-10-07 | 诺华有限公司 | 包含来自于四株流感病毒的抗原的疫苗 |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| EP2069484B1 (en) | 2007-06-18 | 2014-08-13 | MedImmune, LLC | Influenza B viruses having alterations in the hemaglutinin polypeptide |
| HRP20120790T1 (hr) | 2007-06-27 | 2013-01-31 | Novartis Ag | Cjepiva protiv influence sa niskom koliäśinom aditiva |
| US8591914B2 (en) | 2008-07-11 | 2013-11-26 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| PE20120571A1 (es) | 2009-07-16 | 2012-06-06 | Crucell Holland Bv | Produccion de titulos elevados de polivirus para la produccion de vacunas |
| ES2813347T3 (es) | 2009-10-26 | 2021-03-23 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero |
| GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| GB201011502D0 (en) | 2010-07-08 | 2010-08-25 | Glaxosmithkline Biolog Sa | Novel process |
| WO2012033236A1 (ko) | 2010-09-06 | 2012-03-15 | 에스케이케미칼 주식회사 | 무혈청 배양 및 부유 배양에 적응된 ｍｄｃｋ 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법 |
| MX346625B (es) | 2011-06-24 | 2017-03-27 | Flugen Inc | Mutantes de virus de influenza y usos para los mismos. |
| CN102304495A (zh) | 2011-09-08 | 2012-01-04 | 中国农业科学院上海兽医研究所 | 高效表达ha蛋白的重组流感病毒及其制备方法和应用 |
| JP2016521553A (ja) | 2013-06-06 | 2016-07-25 | ノバルティス アーゲー | インフルエンザウイルス再集合 |
| AU2014290203B2 (en) | 2013-07-15 | 2020-12-24 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| AU2017221444B2 (en) | 2016-02-19 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza B virus replication for vaccine development |
-
2010
- 2010-10-26 ES ES10777154T patent/ES2813347T3/es active Active
- 2010-10-26 WO PCT/US2010/054128 patent/WO2011056591A1/en not_active Ceased
- 2010-10-26 US US12/912,411 patent/US9109013B2/en active Active
- 2010-10-26 JP JP2012536963A patent/JP2013507990A/ja active Pending
- 2010-10-26 EP EP10777154.5A patent/EP2493912B1/en active Active
-
2015
- 2015-08-03 US US14/816,807 patent/US10059925B2/en active Active
-
2016
- 2016-03-17 JP JP2016053990A patent/JP6375329B2/ja active Active
-
2018
- 2018-07-26 US US16/046,250 patent/US10808229B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013507990A5 (enExample) | ||
| EP3792348A3 (en) | Mutated rep encoding sequences for use in aav production | |
| JP2014224126A5 (enExample) | ||
| HK1199211A1 (en) | Influenza virus vaccines and uses thereof | |
| CO6220904A2 (es) | Acidos nucleicos que codifican mutantes de acetohidroxiacido-sintasa (ahas) | |
| JP2006149395A5 (enExample) | ||
| JP2012095652A5 (enExample) | ||
| ES2691539T3 (es) | Luciferasas de Oplophorus sintéticas con mayor emisión de luz | |
| MX358725B (es) | Antigenos prostaticos de consenso, molecula de acido nucleico que los codifica y vacuna y usos que los comprenden. | |
| JP2012525819A5 (enExample) | ||
| JP2015513533A5 (enExample) | ||
| JP2007175057A5 (enExample) | ||
| WO2012031243A3 (en) | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS | |
| BR112015013387B8 (pt) | Proteínas tipo coiled-coil modificadas possuindo propriedades melhoradas | |
| JP2019505521A5 (enExample) | ||
| JP2014525439A5 (enExample) | ||
| NZ629843A (en) | Identification of channelrhodopsin-2 (chop2) mutations and methods of use | |
| ECSP10010082A (es) | Udp-glucuronil transferasa y polinucleotido de codificacion | |
| MX346019B (es) | Kit para detectar el virus de la leucemia bovina (blv), y uso del mismo. | |
| MX2017007105A (es) | Variantes de lipasa y polinucleotidos que las codifican. | |
| JP2010265269A5 (enExample) | ||
| EA201300057A1 (ru) | Полипептид, обладающий углеводдеградирующей активностью, и его применения | |
| JP2018511344A5 (enExample) | ||
| AR081866A1 (es) | Variantes de peptidos antimicrobianos y polinucleotidos que las codifican | |
| WO2011135222A3 (fr) | Utilisation de peptides comme transporteurs destines a l'internalisation de molecules d'interet dans des cellules cibles |