JP2013506007A5 - - Google Patents
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- Publication number
- JP2013506007A5 JP2013506007A5 JP2012532269A JP2012532269A JP2013506007A5 JP 2013506007 A5 JP2013506007 A5 JP 2013506007A5 JP 2012532269 A JP2012532269 A JP 2012532269A JP 2012532269 A JP2012532269 A JP 2012532269A JP 2013506007 A5 JP2013506007 A5 JP 2013506007A5
- Authority
- JP
- Japan
- Prior art keywords
- silk
- pva
- solution
- blend
- spheres
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 72
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 56
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 56
- 239000000203 mixture Substances 0.000 claims description 46
- 108010022355 Fibroins Proteins 0.000 claims description 21
- 239000013543 active substance Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000001035 drying Methods 0.000 claims description 11
- 239000002077 nanosphere Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 8
- 238000000527 sonication Methods 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 150000003384 small molecules Chemical class 0.000 claims description 3
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 239000003667 hormone antagonist Substances 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 229940002612 prodrug Drugs 0.000 claims description 2
- 239000000651 prodrug Substances 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 238000009210 therapy by ultrasound Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 31
- 239000007864 aqueous solution Substances 0.000 description 10
- 239000004005 microsphere Substances 0.000 description 5
- -1 antibody Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24667609P | 2009-09-29 | 2009-09-29 | |
| US61/246,676 | 2009-09-29 | ||
| PCT/US2010/050698 WO2011041395A2 (en) | 2009-09-29 | 2010-09-29 | Silk nanospheres and microspheres and methods of making same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506007A JP2013506007A (ja) | 2013-02-21 |
| JP2013506007A5 true JP2013506007A5 (enExample) | 2013-11-14 |
| JP5730317B2 JP5730317B2 (ja) | 2015-06-10 |
Family
ID=43826861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532269A Active JP5730317B2 (ja) | 2009-09-29 | 2010-09-29 | 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8715740B2 (enExample) |
| EP (1) | EP2483199B1 (enExample) |
| JP (1) | JP5730317B2 (enExample) |
| CA (1) | CA2774643A1 (enExample) |
| IL (1) | IL218654A (enExample) |
| IN (1) | IN2012DN02358A (enExample) |
| WO (1) | WO2011041395A2 (enExample) |
Families Citing this family (72)
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| JPS6092337A (ja) * | 1983-10-26 | 1985-05-23 | Sekisui Plastics Co Ltd | 発泡フエノ−ル樹脂成形物の製造方法 |
| KR101368748B1 (ko) | 2004-06-04 | 2014-03-05 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 인쇄가능한 반도체소자들의 제조 및 조립방법과 장치 |
| EP2650112B1 (en) | 2006-11-03 | 2016-08-24 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| US20100096763A1 (en) | 2006-11-03 | 2010-04-22 | Trustees Of Tufts College | Biopolymer optofluidic device and method of manufacturing the same |
| CA2704768A1 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer sensor and method of manufacturing the same |
| US8389862B2 (en) | 2008-10-07 | 2013-03-05 | Mc10, Inc. | Extremely stretchable electronics |
| EP2349440B1 (en) | 2008-10-07 | 2019-08-21 | Mc10, Inc. | Catheter balloon having stretchable integrated circuitry and sensor array |
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| CA2775706A1 (en) | 2009-09-28 | 2011-03-31 | Trustees Of Tufts College | Drawn silk egel fibers and methods of making same |
| JP5730317B2 (ja) | 2009-09-29 | 2015-06-10 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法 |
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| US10441185B2 (en) | 2009-12-16 | 2019-10-15 | The Board Of Trustees Of The University Of Illinois | Flexible and stretchable electronic systems for epidermal electronics |
| WO2011084450A1 (en) | 2009-12-16 | 2011-07-14 | The Board Of Trustees Of The University Of Illinois | Electrophysiology in-vivo using conformal electronics |
| US9936574B2 (en) | 2009-12-16 | 2018-04-03 | The Board Of Trustees Of The University Of Illinois | Waterproof stretchable optoelectronics |
| EP2974673B1 (en) | 2010-03-17 | 2017-03-22 | The Board of Trustees of the University of Illionis | Implantable biomedical devices on bioresorbable substrates |
| WO2012031282A2 (en) | 2010-09-03 | 2012-03-08 | Tufts University/Trustees Of Tufts College | Plasmonic nanoparticle-doped silk materials |
| BR112013027057A2 (pt) * | 2011-04-21 | 2020-08-11 | Trustees Of Tufts College | composições e métodos para a estabilização de agentes ativos |
| WO2012158709A1 (en) | 2011-05-16 | 2012-11-22 | The Board Of Trustees Of The University Of Illinois | Thermally managed led arrays assembled by printing |
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| EP2713863B1 (en) | 2011-06-03 | 2020-01-15 | The Board of Trustees of the University of Illionis | Conformable actively multiplexed high-density surface electrode array for brain interfacing |
| CN102344686A (zh) * | 2011-08-02 | 2012-02-08 | 北京汇亨创管理咨询有限公司 | 一种以聚乙烯醇为稳定剂的丝素蛋白纳米颗粒的制备方法 |
| HK1204205A1 (en) | 2011-12-01 | 2015-11-06 | The Board Of Trustees Of The University Of Illinois | Transient devices designed to undergo programmable transformations |
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| EP2830492B1 (en) | 2012-03-30 | 2021-05-19 | The Board of Trustees of the University of Illinois | Appendage mountable electronic devices conformable to surfaces and method of making the same |
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| KR20210153142A (ko) | 2013-09-30 | 2021-12-16 | 실크 테라퓨틱스, 인코퍼레이티드 | 실크 단백질 단편 조성물 및 이로부터 제작된 물품 |
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| US11029198B2 (en) | 2015-06-01 | 2021-06-08 | The Board Of Trustees Of The University Of Illinois | Alternative approach for UV sensing |
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| US10925543B2 (en) | 2015-11-11 | 2021-02-23 | The Board Of Trustees Of The University Of Illinois | Bioresorbable silicon electronics for transient implants |
| CN105297289B (zh) * | 2015-12-07 | 2017-10-31 | 清华大学深圳研究生院 | 一种丝素蛋白储能调温纤维膜制备方法 |
| CN105963275B (zh) * | 2016-05-31 | 2019-05-17 | 中国医学科学院生物医学工程研究所 | 壳层可控的丝素蛋白微囊及制备方法 |
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| CN109789218A (zh) | 2016-06-23 | 2019-05-21 | 菲吉乐科(加拿大)有限公司 | 噬菌体的微囊化和相关产品 |
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| US9290579B2 (en) | 2005-04-20 | 2016-03-22 | Trustees Of Tufts College | Covalently immobilized protein gradients in three-dimensional porous scaffolds |
| ES2374428T3 (es) | 2005-08-02 | 2012-02-16 | Trustees Of Tufts College | Métodos para la deposición progresiva de recubrimientos de fibroína de seda. |
| GB0516846D0 (en) | 2005-08-17 | 2005-09-21 | Knight David P | Meniscal repair device |
| DE102005043609A1 (de) * | 2005-09-13 | 2007-03-22 | Technische Universität München | Verfahren und Vorrichtung zur Herstellung eines Fadens aus Seidenproteinen |
| US20100028451A1 (en) | 2006-09-26 | 2010-02-04 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
| US20110121485A1 (en) | 2006-10-30 | 2011-05-26 | Spintec Engineering Gmbh | Method and apparatus for the manufacture of a fiber |
| EP2650112B1 (en) | 2006-11-03 | 2016-08-24 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| US20100096763A1 (en) | 2006-11-03 | 2010-04-22 | Trustees Of Tufts College | Biopolymer optofluidic device and method of manufacturing the same |
| US20100068740A1 (en) | 2006-11-03 | 2010-03-18 | Trustees Of Tufts College | Microfluidic device with a cylindrical microchannel and a method for fabricating same |
| US20100046902A1 (en) | 2006-11-03 | 2010-02-25 | Trustees Of Tufts College | Biopolymer photonic crystals and method of manufacturing the same |
| CA2704768A1 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer sensor and method of manufacturing the same |
| WO2008106485A2 (en) | 2007-02-27 | 2008-09-04 | Trustees Of Tufts College | Tissue-engineered silk organs |
| US8187616B2 (en) | 2007-05-29 | 2012-05-29 | Trustees Of Tufts College | Method for silk fibroin gelation using sonication |
| US9808557B2 (en) | 2007-08-10 | 2017-11-07 | Trustees Of Tufts College | Tubular silk compositions and methods of use thereof |
| EP2206017B1 (en) | 2007-11-05 | 2019-02-20 | Trustees Of Tufts College | Fabrication of silk fibroin photonic structures by nanocontact imprinting |
| CN101970023A (zh) | 2008-02-07 | 2011-02-09 | 塔夫茨大学信托人 | 三维的丝羟基磷灰石组合物 |
| US8206774B2 (en) | 2008-03-13 | 2012-06-26 | Trustees Of Tufts College | Diazonium salt modification of silk polymer |
| WO2009126689A2 (en) | 2008-04-08 | 2009-10-15 | Trustees Of Tufts College | System and method for making biomaterial structures |
| CA2721961A1 (en) | 2008-05-15 | 2009-11-19 | Trustees Of Tufts College | Silk polymer-based adenosine release: therapeutic potential for epilepsy |
| US20090297588A1 (en) | 2008-05-28 | 2009-12-03 | Spin'tec Engineering Gmbh | Antibiotic dressing for the treatment of infected wounds |
| EP2307054A4 (en) | 2008-06-18 | 2013-02-06 | Tufts College | EDIBLE HOLOGRAPHIC SILK PRODUCTS |
| GB2461125A (en) | 2008-06-25 | 2009-12-30 | Spintec Engineering Gmbh | A silk membrane for bone graft material |
| US8501172B2 (en) | 2008-09-26 | 2013-08-06 | Trustees Of Tufts College | pH-induced silk gels and uses thereof |
| GB2464348A (en) | 2008-10-17 | 2010-04-21 | Spintec Engineering Gmbh | Applying a liquid protein onto a permeable surface, and silk mono-filament having specific properties |
| EP2253336A1 (en) | 2009-05-15 | 2010-11-24 | Spintec Engineering GmbH | A silk medical device with antimicrobial properties and a method of manufacture thereof |
| JP2012532614A (ja) | 2009-07-10 | 2012-12-20 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | バイオ絹糸タンパク質ベース核酸送達システム |
| JP5730317B2 (ja) * | 2009-09-29 | 2015-06-10 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法 |
-
2010
- 2010-09-29 JP JP2012532269A patent/JP5730317B2/ja active Active
- 2010-09-29 EP EP10821161.6A patent/EP2483199B1/en active Active
- 2010-09-29 US US13/496,227 patent/US8715740B2/en active Active
- 2010-09-29 CA CA2774643A patent/CA2774643A1/en not_active Abandoned
- 2010-09-29 WO PCT/US2010/050698 patent/WO2011041395A2/en not_active Ceased
- 2010-09-29 IN IN2358DEN2012 patent/IN2012DN02358A/en unknown
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2012
- 2012-03-15 IL IL218654A patent/IL218654A/en active IP Right Grant
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2014
- 2014-03-17 US US14/216,756 patent/US9381164B2/en active Active
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