IN2012DN02358A - - Google Patents
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- Publication number
- IN2012DN02358A IN2012DN02358A IN2358DEN2012A IN2012DN02358A IN 2012DN02358 A IN2012DN02358 A IN 2012DN02358A IN 2358DEN2012 A IN2358DEN2012 A IN 2358DEN2012A IN 2012DN02358 A IN2012DN02358 A IN 2012DN02358A
- Authority
- IN
- India
- Prior art keywords
- silk
- active agents
- microparticles
- present
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Abstract
The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped. The silk nano- and microparticles of the present invention are thus suitable for a variety of biomedical and pharmaceutical applications, such as drug delivery or tissue engineering.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24667609P | 2009-09-29 | 2009-09-29 | |
PCT/US2010/050698 WO2011041395A2 (en) | 2009-09-29 | 2010-09-29 | Silk nanospheres and microspheres and methods of making same |
Publications (1)
Publication Number | Publication Date |
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IN2012DN02358A true IN2012DN02358A (en) | 2015-08-21 |
Family
ID=43826861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2358DEN2012 IN2012DN02358A (en) | 2009-09-29 | 2010-09-29 |
Country Status (7)
Country | Link |
---|---|
US (2) | US8715740B2 (en) |
EP (1) | EP2483199B1 (en) |
JP (1) | JP5730317B2 (en) |
CA (1) | CA2774643A1 (en) |
IL (1) | IL218654A (en) |
IN (1) | IN2012DN02358A (en) |
WO (1) | WO2011041395A2 (en) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6092337A (en) * | 1983-10-26 | 1985-05-23 | Sekisui Plastics Co Ltd | Preparation of foamed phenolic resin molding |
EP2650907A3 (en) | 2004-06-04 | 2014-10-08 | The Board of Trustees of the University of Illinois | Methods and devices for fabricating and assembling printable semiconductor elements |
JP2010509645A (en) | 2006-11-03 | 2010-03-25 | トラスティーズ オブ タフツ カレッジ | Biopolymer optical device having nano pattern formed thereon and method for producing the same |
WO2008127402A2 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer sensor and method of manufacturing the same |
WO2008140562A2 (en) * | 2006-11-03 | 2008-11-20 | Trustees Of Tufts College | Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same |
WO2010042653A1 (en) | 2008-10-07 | 2010-04-15 | Mc10, Inc. | Catheter balloon having stretchable integrated circuitry and sensor array |
US8389862B2 (en) | 2008-10-07 | 2013-03-05 | Mc10, Inc. | Extremely stretchable electronics |
US8886334B2 (en) | 2008-10-07 | 2014-11-11 | Mc10, Inc. | Systems, methods, and devices using stretchable or flexible electronics for medical applications |
JP2013506058A (en) | 2009-09-28 | 2013-02-21 | タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ | Stretched silk egel fiber and method for producing the same |
CA2774643A1 (en) * | 2009-09-29 | 2011-04-07 | Trustees Of Tufts College | Silk nanospheres and microspheres and methods of making same |
WO2011041727A1 (en) | 2009-10-01 | 2011-04-07 | Mc10, Inc. | Protective cases with integrated electronics |
US9936574B2 (en) | 2009-12-16 | 2018-04-03 | The Board Of Trustees Of The University Of Illinois | Waterproof stretchable optoelectronics |
US10441185B2 (en) | 2009-12-16 | 2019-10-15 | The Board Of Trustees Of The University Of Illinois | Flexible and stretchable electronic systems for epidermal electronics |
JP6046491B2 (en) | 2009-12-16 | 2016-12-21 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | In vivo electrophysiology using conformal electronics |
US8666471B2 (en) | 2010-03-17 | 2014-03-04 | The Board Of Trustees Of The University Of Illinois | Implantable biomedical devices on bioresorbable substrates |
JP2013542181A (en) | 2010-09-03 | 2013-11-21 | タフツ ユニバーシティー/トラスティーズ オブ タフツ カレッジ | Plasmon nanoparticle-doped silk material |
CA2833879C (en) * | 2011-04-21 | 2023-03-14 | David L. Kaplan | Compositions and methods for stabilization of active agents |
US9765934B2 (en) | 2011-05-16 | 2017-09-19 | The Board Of Trustees Of The University Of Illinois | Thermally managed LED arrays assembled by printing |
WO2012166686A2 (en) | 2011-05-27 | 2012-12-06 | Mc10, Inc. | Electronic, optical and/or mechanical apparatus and systems and methods for fabricating same |
WO2012167096A2 (en) | 2011-06-03 | 2012-12-06 | The Board Of Trustees Of The University Of Illinois | Conformable actively multiplexed high-density surface electrode array for brain interfacing |
CN102344686A (en) * | 2011-08-02 | 2012-02-08 | 北京汇亨创管理咨询有限公司 | Method for preparing fibroin nanoparticles taking polyvinyl alcohol as stabilizer |
KR101979354B1 (en) | 2011-12-01 | 2019-08-29 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | Transient devices designed to undergo programmable transformations |
EP3884931A3 (en) | 2012-02-06 | 2021-12-01 | Children's Medical Center, Corp. | Multi-layer biomaterial for tissue regeneration and wound healing |
CA2867464A1 (en) | 2012-03-20 | 2013-09-26 | Trustees Of Tufts College | Silk reservoirs for drug delivery |
US9554484B2 (en) | 2012-03-30 | 2017-01-24 | The Board Of Trustees Of The University Of Illinois | Appendage mountable electronic devices conformable to surfaces |
WO2013152265A1 (en) | 2012-04-06 | 2013-10-10 | Trustees Of Tufts College | Methods of producing and using silk microfibers |
WO2014021954A2 (en) * | 2012-04-13 | 2014-02-06 | Trustees Of Tufts College | Magneto-sensitive silk fibroin-based materials |
WO2013155404A1 (en) * | 2012-04-13 | 2013-10-17 | Trustees Of Tufts College | Methods and compositions for preparing a silk microsphere |
EP2841108A4 (en) * | 2012-04-25 | 2015-11-25 | Tufts College | Silk microspheres and methods for surface lubrication |
EP2872115A4 (en) * | 2012-07-13 | 2016-04-06 | Univ Tufts | Encapsulation of immiscible phases in silk fibroin biomaterials |
WO2014012101A1 (en) | 2012-07-13 | 2014-01-16 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
US9171794B2 (en) | 2012-10-09 | 2015-10-27 | Mc10, Inc. | Embedding thin chips in polymer |
US11376329B2 (en) | 2013-03-15 | 2022-07-05 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
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WO2014176458A2 (en) | 2013-04-24 | 2014-10-30 | Trustees Of Tufts College | Bioresorbable biopolymer anastomosis devices |
EP3016634A2 (en) * | 2013-07-05 | 2016-05-11 | Therakine Biodelivery GmbH | Drug-delivery composition for topical applications and injections and ophtalmic formulations, method for manufacturing thereof, and methods for delivery a drug-delivery composition |
WO2015009246A1 (en) * | 2013-07-19 | 2015-01-22 | National University Of Singapore | Tissue interface augmentation device for ligament/tendon reconstruction |
WO2015048527A1 (en) * | 2013-09-27 | 2015-04-02 | Tufts University | Optically transparent silk hydrogels |
WO2015048433A1 (en) * | 2013-09-27 | 2015-04-02 | Tufts University | Synthesis of silk fibroin micro- and submicron spheres using a co-flow method |
MX2016003961A (en) | 2013-09-30 | 2018-02-19 | Silk Therapeutics Inc | Silk potein fragment compositions and articles manufactured therefrom. |
JP6135486B2 (en) * | 2013-12-06 | 2017-05-31 | 豊田合成株式会社 | Resin molded body |
CN107405277B (en) | 2014-12-02 | 2021-08-10 | 丝绸医疗公司 | Silk performance garments and products and methods of making same |
WO2016115159A1 (en) * | 2015-01-12 | 2016-07-21 | Silk Therapeutics, Inc. | Preserved silk protein fragment compositions and articles |
WO2016196673A1 (en) | 2015-06-01 | 2016-12-08 | The Board Of Trustees Of The University Of Illinois | Alternative approach to uv sensing |
KR20180033468A (en) | 2015-06-01 | 2018-04-03 | 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 | Miniaturized electronic systems with wireless power and local communication capabilities |
US11512425B2 (en) | 2015-07-14 | 2022-11-29 | Evolved By Nature, Inc. | Silk performance apparel and products and methods of preparing the same |
US10925543B2 (en) | 2015-11-11 | 2021-02-23 | The Board Of Trustees Of The University Of Illinois | Bioresorbable silicon electronics for transient implants |
CN105297289B (en) * | 2015-12-07 | 2017-10-31 | 清华大学深圳研究生院 | A kind of fibroin albumen energy-saving and temperature-regulating fiber membrane preparation method |
CN105963275B (en) * | 2016-05-31 | 2019-05-17 | 中国医学科学院生物医学工程研究所 | The controllable fibroin albumen micro-capsule of shell and preparation method |
US11413319B2 (en) | 2016-06-23 | 2022-08-16 | Phagelux (Canada) Inc. | Microencapsulation of bacteriophages and related products |
EP3474898A4 (en) | 2016-06-23 | 2020-04-15 | Phagelux (Canada) Inc. | Microencapsulation of bacteriophages and related products |
US11248313B2 (en) | 2016-08-01 | 2022-02-15 | Trustees Of Tufts College | Biomimetic mechanical tension driven fabrication of nanofibrillar architecture |
US11617815B2 (en) | 2016-10-31 | 2023-04-04 | Sofregen Medical, Inc. | Compositions comprising silk fibroin particles and uses thereof |
KR101957013B1 (en) * | 2017-04-04 | 2019-03-11 | 서울대학교산학협력단 | Drug delivery system comprising bone morphogenetic protein and method for preparing the same |
US11390988B2 (en) | 2017-09-27 | 2022-07-19 | Evolved By Nature, Inc. | Silk coated fabrics and products and methods of preparing the same |
US11794161B1 (en) | 2018-11-21 | 2023-10-24 | Trucapsol, Llc | Reduced permeability microcapsules |
US11571674B1 (en) | 2019-03-28 | 2023-02-07 | Trucapsol Llc | Environmentally biodegradable microcapsules |
US11542392B1 (en) | 2019-04-18 | 2023-01-03 | Trucapsol Llc | Multifunctional particle additive for enhancement of toughness and degradation in biodegradable polymers |
CN110327307B (en) * | 2019-06-26 | 2020-06-23 | 浙江大学 | Preparation method and product of fibroin drug-loaded nano-microcapsule |
CN110483830B (en) * | 2019-07-31 | 2021-08-17 | 武汉纺织大学 | Ultra-light high-elasticity fibroin micro-nano fiber aerogel and preparation method and application thereof |
WO2021076798A1 (en) | 2019-10-15 | 2021-04-22 | Sofregen Medical, Inc. | Delivery devices for delivering and methods of delivering compositions |
US11484857B2 (en) | 2020-01-30 | 2022-11-01 | Trucapsol Llc | Environmentally biodegradable microcapsules |
CN111454468B (en) * | 2020-03-27 | 2021-04-20 | 西安交通大学 | Shape-controllable intelligent response microsphere and preparation method thereof |
EP4188417A1 (en) * | 2020-07-28 | 2023-06-07 | University of Georgia Research Foundation, Inc. | Antimicrobial silk nanoparticles and methods for making and using the same |
US11878280B2 (en) | 2022-04-19 | 2024-01-23 | Trucapsol Llc | Microcapsules comprising natural materials |
CN115414533B (en) * | 2022-09-20 | 2024-02-23 | 中国人民解放军总医院第一医学中心 | Tissue engineering scaffold simulating physiological structure of bladder wall and preparation method thereof |
US11904288B1 (en) | 2023-02-13 | 2024-02-20 | Trucapsol Llc | Environmentally biodegradable microcapsules |
Family Cites Families (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE380083A (en) | 1929-12-23 | |||
US3424164A (en) | 1966-05-20 | 1969-01-28 | Ethicon Inc | Silk suture |
JPS5838449B2 (en) | 1979-04-17 | 1983-08-23 | カネボウ株式会社 | Manufacturing method of finely powdered silk fiproin |
JPS56166235A (en) | 1980-05-24 | 1981-12-21 | Kanebo Ltd | Hydrophilic porous body and its preparation |
JPS5838449A (en) | 1981-08-31 | 1983-03-05 | Matsushita Electronics Corp | High pressure sodium lamp |
JPS60142259A (en) | 1983-12-29 | 1985-07-27 | Kanebo Ltd | Immobilized antibody |
JPS60259677A (en) | 1984-05-31 | 1985-12-21 | 水島 繁三郎 | Raw yarn, fabric and knitted fabric comprising animal protein adsorbed regeneration fiber and its production |
CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
JPS63190604A (en) | 1987-02-03 | 1988-08-08 | Agency Of Ind Science & Technol | Novel water-alcohol separating membrane |
US5606019A (en) | 1987-10-29 | 1997-02-25 | Protien Polymer Technologies, Inc. | Synthetic protein as implantables |
JPH0694518B2 (en) | 1987-11-02 | 1994-11-24 | 工業技術院長 | Method for producing silk fibroin porous body |
GB8800078D0 (en) | 1988-01-05 | 1988-02-10 | Ciba Geigy Ag | Novel antibodies |
JPH0669485B2 (en) * | 1988-10-19 | 1994-09-07 | 住江織物株式会社 | Molded product containing silk fibroin |
US5290494A (en) | 1990-03-05 | 1994-03-01 | Board Of Regents, The University Of Texas System | Process of making a resorbable implantation device |
US5989894A (en) | 1990-04-20 | 1999-11-23 | University Of Wyoming | Isolated DNA coding for spider silk protein, a replicable vector and a transformed cell containing the DNA |
JPH04263611A (en) | 1991-02-16 | 1992-09-18 | Pola Chem Ind Inc | Water-insoluble solid fibroin formed article and its production |
JPH06346314A (en) | 1993-06-02 | 1994-12-20 | Toyobo Co Ltd | Regenerated silk fibroin yarn and its production |
JPH08295697A (en) | 1995-04-26 | 1996-11-12 | Kanebo Ltd | Production of aqueous solution of silk fibroin at high concentration |
JPH1036676A (en) | 1996-07-26 | 1998-02-10 | Kanebo Ltd | Method for concentrating aqueous protein solution |
JP2990239B2 (en) | 1997-06-18 | 1999-12-13 | 農林水産省蚕糸・昆虫農業技術研究所長 | Wound dressing material containing silk fibroin and silk sericin as main components and method for producing the same |
WO1999001089A1 (en) | 1997-07-01 | 1999-01-14 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
US6123819A (en) | 1997-11-12 | 2000-09-26 | Protiveris, Inc. | Nanoelectrode arrays |
US5994099A (en) | 1997-12-31 | 1999-11-30 | The University Of Wyoming | Extremely elastic spider silk protein and DNA coding therefor |
US6110590A (en) | 1998-04-15 | 2000-08-29 | The University Of Akron | Synthetically spun silk nanofibers and a process for making the same |
US6196358B1 (en) | 1998-07-08 | 2001-03-06 | Shimano Inc. | Detachable fluid cooling system for bicycle disc brake |
US20030007991A1 (en) | 1998-09-25 | 2003-01-09 | Masters David B. | Devices including protein matrix materials and methods of making and using thereof |
US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
US6592623B1 (en) | 1999-08-31 | 2003-07-15 | Virginia Commonwealth University Intellectual Property Foundation | Engineered muscle |
JP3151665B2 (en) | 1999-03-23 | 2001-04-03 | 農林水産省蚕糸・昆虫農業技術研究所長 | Biopolymer / polyallylamine complex and method for producing the same |
WO2001036531A1 (en) | 1999-11-15 | 2001-05-25 | Zaidan-Houjin Ueda Sen-I Kagaku Shinkoukai | Molecularly composite polymeric material of fibroin/cellulose and process for producing the same |
JP2003521350A (en) | 2000-02-03 | 2003-07-15 | ネクシア バイオテクノロジーズ, インコーポレイテッド | Surgical sutures containing spider silk |
IT1316885B1 (en) | 2000-10-02 | 2003-05-13 | Consorzio Per Gli Studi Uni | PROCEDURE FOR THE PREPARATION OF A NON-WOVEN FABRIC IN SILK FIBER. |
JP2002128691A (en) | 2000-10-24 | 2002-05-09 | National Institute Of Agrobiological Sciences | Sericin-containing raw material, method for producing the same and method for using the same |
JPWO2002072931A1 (en) | 2001-03-14 | 2004-07-02 | 東京農工大学長 | Method for producing fiber and film of silk and silk-like material |
ITVR20010098A1 (en) | 2001-09-11 | 2003-03-11 | Consorzio Per Gli Studi Uni | PROCEDURE FOR OBTAINING SILK FIBROIN HYDROGELS. |
EP1461605A4 (en) | 2001-10-02 | 2009-10-21 | Univ Northwestern | Protein and peptide nanoarrays |
GB0126118D0 (en) | 2001-10-31 | 2002-01-02 | Vollrath Friedrich W L | Precursor feedstock for forming filaments |
US6902932B2 (en) | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
AU2002365734A1 (en) | 2001-12-07 | 2003-06-17 | Lumileds Lighting U.S., Llc | Compact lighting system and display device |
JP3803962B2 (en) | 2001-12-28 | 2006-08-02 | 独立行政法人科学技術振興機構 | Silk protein film and production method thereof |
US7057023B2 (en) | 2002-01-11 | 2006-06-06 | Nexia Biotechnologies Inc. | Methods and apparatus for spinning spider silk protein |
JP3772207B2 (en) | 2002-06-19 | 2006-05-10 | 独立行政法人農業生物資源研究所 | Biodegradable biopolymer material, production method thereof, and functional material comprising the polymer material |
JP4638735B2 (en) | 2002-06-24 | 2011-02-23 | タフツ ユニバーシティー | Silk biomaterial and method of using the same |
JP4800622B2 (en) | 2002-11-01 | 2011-10-26 | トラスティーズ オブ タフツ カレッジ | Templated natural silk smectic gel |
US7842780B2 (en) | 2003-01-07 | 2010-11-30 | Trustees Of Tufts College | Silk fibroin materials and use thereof |
EP1613796B1 (en) | 2003-04-10 | 2017-03-22 | Tufts University | Concentrated aqueous silk fibroin solution and use thereof |
WO2005000483A1 (en) | 2003-06-06 | 2005-01-06 | Tufts University | Method for forming inorganic coatings |
WO2005123114A2 (en) | 2004-06-11 | 2005-12-29 | Trustees Of Tufts College | Silk-based drug delivery system |
WO2006076711A2 (en) | 2005-01-14 | 2006-07-20 | Trustees Of Tufts College | Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials |
US9290579B2 (en) | 2005-04-20 | 2016-03-22 | Trustees Of Tufts College | Covalently immobilized protein gradients in three-dimensional porous scaffolds |
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CA2774643A1 (en) | 2009-09-29 | 2011-04-07 | Trustees Of Tufts College | Silk nanospheres and microspheres and methods of making same |
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2010
- 2010-09-29 CA CA2774643A patent/CA2774643A1/en not_active Abandoned
- 2010-09-29 WO PCT/US2010/050698 patent/WO2011041395A2/en active Application Filing
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US9381164B2 (en) | 2016-07-05 |
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CA2774643A1 (en) | 2011-04-07 |
US20120187591A1 (en) | 2012-07-26 |
JP5730317B2 (en) | 2015-06-10 |
WO2011041395A3 (en) | 2011-08-25 |
US20150056293A1 (en) | 2015-02-26 |
JP2013506007A (en) | 2013-02-21 |
IL218654A0 (en) | 2012-05-31 |
EP2483199B1 (en) | 2017-04-26 |
US8715740B2 (en) | 2014-05-06 |
EP2483199A2 (en) | 2012-08-08 |
IL218654A (en) | 2015-08-31 |
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