JP2013505273A5 - - Google Patents
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- Publication number
- JP2013505273A5 JP2013505273A5 JP2012530106A JP2012530106A JP2013505273A5 JP 2013505273 A5 JP2013505273 A5 JP 2013505273A5 JP 2012530106 A JP2012530106 A JP 2012530106A JP 2012530106 A JP2012530106 A JP 2012530106A JP 2013505273 A5 JP2013505273 A5 JP 2013505273A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- salt
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(OC1=O)=NC1=CCc(cc1)ccc1-c1ccccc1 Chemical compound *C(OC1=O)=NC1=CCc(cc1)ccc1-c1ccccc1 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2009/074125 WO2010034236A1 (en) | 2008-09-24 | 2009-09-23 | Process for the manufacture of n-acylbiphenyl alanine |
| CNPCT/CN2009/074125 | 2009-09-23 | ||
| PCT/CN2010/071243 WO2011035569A1 (en) | 2009-09-23 | 2010-03-23 | Process for manufacture of n-acylbphenyl alanine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505273A JP2013505273A (ja) | 2013-02-14 |
| JP2013505273A5 true JP2013505273A5 (https=) | 2013-05-09 |
| JP5894531B2 JP5894531B2 (ja) | 2016-03-30 |
Family
ID=43796233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012530106A Active JP5894531B2 (ja) | 2009-09-23 | 2010-03-23 | Ｎ−アシルビフェニルアラニンを製造するための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160115118A1 (https=) |
| EP (1) | EP2480523B1 (https=) |
| JP (1) | JP5894531B2 (https=) |
| KR (2) | KR101821090B1 (https=) |
| CN (1) | CN102639486B (https=) |
| AU (1) | AU2010297892B2 (https=) |
| BR (1) | BR112012006406A2 (https=) |
| CA (1) | CA2772681C (https=) |
| IN (1) | IN2012DN01968A (https=) |
| RU (1) | RU2534619C2 (https=) |
| WO (1) | WO2011035569A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2435402B1 (en) | 2009-05-28 | 2016-04-13 | Novartis AG | Substituted aminobutyric derivatives as neprilysin inhibitors |
| CN103896796B (zh) | 2009-05-28 | 2016-04-27 | 诺华股份有限公司 | 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物 |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| CU24330B1 (es) | 2013-02-14 | 2018-03-13 | Novartis Ag | Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral) |
| US9102635B2 (en) | 2013-02-14 | 2015-08-11 | Novartis Ag | Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy |
| TW201632493A (zh) | 2015-02-13 | 2016-09-16 | 諾華公司 | 新穎方法 |
| WO2017051326A1 (en) | 2015-09-23 | 2017-03-30 | Novartis Ag | New processes and intermediates useful in synthesis of nep inhibitors |
| CA3006254A1 (en) | 2015-12-10 | 2017-06-15 | Novartis Ag | New process and intermediates |
| CN109415308B (zh) | 2016-07-05 | 2022-09-06 | 诺华股份有限公司 | 用于早期沙卡布曲中间体的新方法 |
| US10851059B2 (en) | 2016-08-17 | 2020-12-01 | Novartis Ag | Processes and intermediates for NEP inhibitor synthesis |
| CN107778192A (zh) * | 2016-08-26 | 2018-03-09 | 浙江九洲药业股份有限公司 | 一种n‑烷氧或苄氧羰基手性氨酸的制备方法 |
| JP7138106B2 (ja) | 2016-12-23 | 2022-09-15 | ノバルティス アーゲー | 初期サクビトリル中間体のための新規な方法 |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60185752A (ja) * | 1984-03-05 | 1985-09-21 | Mitsui Toatsu Chem Inc | α−アセトアミド桂皮酸類の製造法 |
| JPS60215657A (ja) * | 1984-04-10 | 1985-10-29 | Mitsui Toatsu Chem Inc | Ｎ−アシルフエニルアラニン類の製造法 |
| JPS6245554A (ja) * | 1985-08-23 | 1987-02-27 | Nippon Redarii Kk | ４−ビフエニリル酢酸の簡易製造法 |
| CA1325222C (en) * | 1985-08-23 | 1993-12-14 | Lederle (Japan), Ltd. | Process for producing 4-biphenylylacetic acid |
| FR2662440B1 (fr) * | 1990-05-22 | 1992-07-31 | Rhone Poulenc Sante | Procede de preparation stereoselective de derives de la phenylisoserine. |
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| GB2354440A (en) * | 1999-07-20 | 2001-03-28 | Merck & Co Inc | Aryl amides as cell adhesion inhibitors |
| JP4270484B2 (ja) * | 2002-03-08 | 2009-06-03 | 第一ファインケミカル株式会社 | 光学活性フェニルアラニン誘導体の製造方法 |
| BR0305426A (pt) * | 2002-07-01 | 2004-08-24 | Upjohn Co | Compostos inibidores de ns5b polimerase de hcv, bem como composição farmacêutica compreendendo os mesmos |
| US20040180943A1 (en) * | 2002-07-23 | 2004-09-16 | Augelli-Szafran Corinne Elizabeth | Oxazolone analogs as amyloid aggregation inhibitors and for the treatment of alzheimer's disease and disorders related to amyloidosis |
| PE20091364A1 (es) | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
| CN101684077B (zh) * | 2008-09-24 | 2013-01-02 | 浙江九洲药业股份有限公司 | N-酰基联苯丙氨酸的制备方法 |
| CN101774941A (zh) * | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
| CN101555211B (zh) * | 2009-05-13 | 2012-01-25 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的化学合成方法 |
-
2010
- 2010-03-23 RU RU2012116208/04A patent/RU2534619C2/ru not_active IP Right Cessation
- 2010-03-23 WO PCT/CN2010/071243 patent/WO2011035569A1/en not_active Ceased
- 2010-03-23 BR BR112012006406A patent/BR112012006406A2/pt not_active Application Discontinuation
- 2010-03-23 AU AU2010297892A patent/AU2010297892B2/en not_active Ceased
- 2010-03-23 EP EP10818263.5A patent/EP2480523B1/en active Active
- 2010-03-23 IN IN1968DEN2012 patent/IN2012DN01968A/en unknown
- 2010-03-23 CN CN201080042243.1A patent/CN102639486B/zh active Active
- 2010-03-23 KR KR1020167036201A patent/KR101821090B1/ko not_active Expired - Fee Related
- 2010-03-23 JP JP2012530106A patent/JP5894531B2/ja active Active
- 2010-03-23 KR KR1020127010180A patent/KR20120093227A/ko not_active Ceased
- 2010-03-23 CA CA2772681A patent/CA2772681C/en not_active Expired - Fee Related
-
2016
- 2016-01-08 US US14/990,832 patent/US20160115118A1/en not_active Abandoned
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