CN102639486B - 生产n-酰基联苯基丙氨酸的方法 - Google Patents
生产n-酰基联苯基丙氨酸的方法 Download PDFInfo
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- CN102639486B CN102639486B CN201080042243.1A CN201080042243A CN102639486B CN 102639486 B CN102639486 B CN 102639486B CN 201080042243 A CN201080042243 A CN 201080042243A CN 102639486 B CN102639486 B CN 102639486B
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- acid
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- 0 *[C@@](NC(C(O)=O)=*)O Chemical compound *[C@@](NC(C(O)=O)=*)O 0.000 description 5
- KHXRDBYDEUWHPC-FIOFKEMQSA-N C/C=C\C(\c1ccccc1)=C/C=C Chemical compound C/C=C\C(\c1ccccc1)=C/C=C KHXRDBYDEUWHPC-FIOFKEMQSA-N 0.000 description 1
- SIRMGTNOSKUMFS-PHPLCDBTSA-M CC(C)(C)OC(/N=C/C(Cc(cc1)ccc1O[Tl]=C)C(OC)=O)=O Chemical compound CC(C)(C)OC(/N=C/C(Cc(cc1)ccc1O[Tl]=C)C(OC)=O)=O SIRMGTNOSKUMFS-PHPLCDBTSA-M 0.000 description 1
- XRAMJHXWXCMGJM-UHFFFAOYSA-N COC(CCc(cc1)ccc1O)=O Chemical compound COC(CCc(cc1)ccc1O)=O XRAMJHXWXCMGJM-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-MRVPVSSYSA-N N[C@H](Cc(cc1)ccc1O)C(O)=O Chemical compound N[C@H](Cc(cc1)ccc1O)C(O)=O OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 description 1
- ISDBWOPVZKNQDW-UHFFFAOYSA-N O=Cc(cc1)ccc1-c1ccccc1 Chemical compound O=Cc(cc1)ccc1-c1ccccc1 ISDBWOPVZKNQDW-UHFFFAOYSA-N 0.000 description 1
- HXITXNWTGFUOAU-UHFFFAOYSA-N OB(c1ccccc1)O Chemical compound OB(c1ccccc1)O HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
Abstract
Description
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201080042243.1A CN102639486B (zh) | 2009-09-23 | 2010-03-23 | 生产n-酰基联苯基丙氨酸的方法 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2009/074125 WO2010034236A1 (en) | 2008-09-24 | 2009-09-23 | Process for the manufacture of n-acylbiphenyl alanine |
CNPCT/CN2009/074125 | 2009-09-23 | ||
PCT/CN2010/071243 WO2011035569A1 (en) | 2009-09-23 | 2010-03-23 | Process for manufacture of n-acylbphenyl alanine |
CN201080042243.1A CN102639486B (zh) | 2009-09-23 | 2010-03-23 | 生产n-酰基联苯基丙氨酸的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102639486A CN102639486A (zh) | 2012-08-15 |
CN102639486B true CN102639486B (zh) | 2014-12-31 |
Family
ID=43796233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080042243.1A Active CN102639486B (zh) | 2009-09-23 | 2010-03-23 | 生产n-酰基联苯基丙氨酸的方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20160115118A1 (zh) |
EP (1) | EP2480523B1 (zh) |
JP (1) | JP5894531B2 (zh) |
KR (2) | KR20120093227A (zh) |
CN (1) | CN102639486B (zh) |
AU (1) | AU2010297892B2 (zh) |
BR (1) | BR112012006406A2 (zh) |
CA (1) | CA2772681C (zh) |
IN (1) | IN2012DN01968A (zh) |
RU (1) | RU2534619C2 (zh) |
WO (1) | WO2011035569A1 (zh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR076707A1 (es) | 2009-05-28 | 2011-06-29 | Novartis Ag | Derivados amino-propionicos sustituidos como inhibidores de neprilisina |
EP2435402B1 (en) | 2009-05-28 | 2016-04-13 | Novartis AG | Substituted aminobutyric derivatives as neprilysin inhibitors |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
PT2956464T (pt) | 2013-02-14 | 2018-07-04 | Novartis Ag | Derivados de ácido bisfenil butanóico fosfónico substituído como inibidores de nep (endopeptidase neutra |
AU2014216417B2 (en) | 2013-02-14 | 2016-05-12 | Novartis Ag | Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy |
TW201632493A (zh) | 2015-02-13 | 2016-09-16 | 諾華公司 | 新穎方法 |
WO2017051326A1 (en) | 2015-09-23 | 2017-03-30 | Novartis Ag | New processes and intermediates useful in synthesis of nep inhibitors |
WO2017098430A1 (en) | 2015-12-10 | 2017-06-15 | Novartis Ag | New process and intermediates |
JP6944473B2 (ja) | 2016-07-05 | 2021-10-06 | ノバルティス アーゲー | 初期サクビトリル中間体のための新規な方法 |
JP6945619B2 (ja) | 2016-08-17 | 2021-10-06 | ノバルティス アーゲー | Nep阻害剤合成のための新規な方法および中間体 |
CN107778192A (zh) * | 2016-08-26 | 2018-03-09 | 浙江九洲药业股份有限公司 | 一种n‑烷氧或苄氧羰基手性氨酸的制备方法 |
CN110088079A (zh) | 2016-12-23 | 2019-08-02 | 诺华股份有限公司 | 用于早期沙卡布曲中间体的新方法 |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0212617A1 (en) * | 1985-08-23 | 1987-03-04 | Lederle (Japan) Ltd. | Process for producing 4-biphenylylacetic acid |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60185752A (ja) * | 1984-03-05 | 1985-09-21 | Mitsui Toatsu Chem Inc | α−アセトアミド桂皮酸類の製造法 |
JPS60215657A (ja) * | 1984-04-10 | 1985-10-29 | Mitsui Toatsu Chem Inc | N−アシルフエニルアラニン類の製造法 |
JPS6245554A (ja) * | 1985-08-23 | 1987-02-27 | Nippon Redarii Kk | 4−ビフエニリル酢酸の簡易製造法 |
FR2662440B1 (fr) * | 1990-05-22 | 1992-07-31 | Rhone Poulenc Sante | Procede de preparation stereoselective de derives de la phenylisoserine. |
IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
GB2354440A (en) * | 1999-07-20 | 2001-03-28 | Merck & Co Inc | Aryl amides as cell adhesion inhibitors |
JP4270484B2 (ja) * | 2002-03-08 | 2009-06-03 | 第一ファインケミカル株式会社 | 光学活性フェニルアラニン誘導体の製造方法 |
CA2489433A1 (en) * | 2002-07-01 | 2004-01-08 | Pharmacia & Upjohn Company Llc | Inhibitors of hcv ns5b polymerase |
US20040180943A1 (en) * | 2002-07-23 | 2004-09-16 | Augelli-Szafran Corinne Elizabeth | Oxazolone analogs as amyloid aggregation inhibitors and for the treatment of alzheimer's disease and disorders related to amyloidosis |
PE20091364A1 (es) | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
CN101684077B (zh) * | 2008-09-24 | 2013-01-02 | 浙江九洲药业股份有限公司 | N-酰基联苯丙氨酸的制备方法 |
CN101774941A (zh) * | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
CN101555211B (zh) * | 2009-05-13 | 2012-01-25 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的化学合成方法 |
-
2010
- 2010-03-23 IN IN1968DEN2012 patent/IN2012DN01968A/en unknown
- 2010-03-23 WO PCT/CN2010/071243 patent/WO2011035569A1/en active Application Filing
- 2010-03-23 JP JP2012530106A patent/JP5894531B2/ja active Active
- 2010-03-23 CA CA2772681A patent/CA2772681C/en not_active Expired - Fee Related
- 2010-03-23 KR KR1020127010180A patent/KR20120093227A/ko active Application Filing
- 2010-03-23 AU AU2010297892A patent/AU2010297892B2/en not_active Ceased
- 2010-03-23 CN CN201080042243.1A patent/CN102639486B/zh active Active
- 2010-03-23 BR BR112012006406A patent/BR112012006406A2/pt not_active Application Discontinuation
- 2010-03-23 KR KR1020167036201A patent/KR101821090B1/ko active IP Right Grant
- 2010-03-23 RU RU2012116208/04A patent/RU2534619C2/ru not_active IP Right Cessation
- 2010-03-23 EP EP10818263.5A patent/EP2480523B1/en active Active
-
2016
- 2016-01-08 US US14/990,832 patent/US20160115118A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0212617A1 (en) * | 1985-08-23 | 1987-03-04 | Lederle (Japan) Ltd. | Process for producing 4-biphenylylacetic acid |
Non-Patent Citations (4)
Title |
---|
Analogues of Luteinizing Hormone-Releasing Hormone with Modification in Position 3;Yuichiro Yabe,et al.;《Chem.Pharm.Bull.》;19761231;第24卷(第12期);3149-3157 * |
Dicarboxylic Acid Dipeptide Neutral Endopeptidase Inhibitors;Gary M.Ksander,et al.;《J.Med.Chem.》;19950501;第38卷(第10期);1689-1700 * |
Discovery》.2009,第6卷(第1期),69-77. * |
Khalid Mohammed Khan,et al..Synthesis and Antibacterial and Antifungal Activity of 5-Substituted Imidazolones.《Letters in Drug Design & * |
Also Published As
Publication number | Publication date |
---|---|
US20160115118A1 (en) | 2016-04-28 |
CN102639486A (zh) | 2012-08-15 |
BR112012006406A2 (pt) | 2016-04-12 |
KR20120093227A (ko) | 2012-08-22 |
CA2772681C (en) | 2017-01-03 |
EP2480523B1 (en) | 2017-03-01 |
KR101821090B1 (ko) | 2018-01-22 |
CA2772681A1 (en) | 2011-03-31 |
RU2012116208A (ru) | 2013-11-10 |
EP2480523A4 (en) | 2013-06-26 |
JP5894531B2 (ja) | 2016-03-30 |
EP2480523A1 (en) | 2012-08-01 |
AU2010297892A1 (en) | 2012-03-22 |
RU2534619C2 (ru) | 2014-11-27 |
JP2013505273A (ja) | 2013-02-14 |
IN2012DN01968A (zh) | 2015-08-21 |
AU2010297892B2 (en) | 2014-02-06 |
WO2011035569A1 (en) | 2011-03-31 |
KR20170002681A (ko) | 2017-01-06 |
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CB02 | Change of applicant information |
Address after: Jiaojiang District of Taizhou City, Zhejiang province 325000 road outside No. 99 Applicant after: ZHEJIANG JIUZHOU PHARMACEUTICAL Co.,Ltd. Applicant after: NOVARTIS AG Address before: Jiaojiang District of Taizhou City, Zhejiang province 325000 road outside No. 99 Applicant before: ZHEJIANG JIUZHOU PHARMACEUTICAL Co.,Ltd. Applicant before: Novartis AG |
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Effective date of registration: 20221018 Address after: No. 18, Tonglian Road, Bixi Street, Changshu, Suzhou, Jiangsu Patentee after: Ruibo (Suzhou) Pharmaceutical Co.,Ltd. Patentee after: NOVARTIS AG Address before: Jiaojiang District of Taizhou City, Zhejiang province 318000 road outside No. 99 Patentee before: ZHEJIANG JIUZHOU PHARMACEUTICAL Co.,Ltd. Patentee before: NOVARTIS AG |