JP2013199502A5 - - Google Patents
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- Publication number
- JP2013199502A5 JP2013199502A5 JP2013144711A JP2013144711A JP2013199502A5 JP 2013199502 A5 JP2013199502 A5 JP 2013199502A5 JP 2013144711 A JP2013144711 A JP 2013144711A JP 2013144711 A JP2013144711 A JP 2013144711A JP 2013199502 A5 JP2013199502 A5 JP 2013199502A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- bronsted
- lidocaine
- equimolar
- room temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 7
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 6
- -1 amine compound Chemical class 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 5
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 150000001735 carboxylic acids Chemical class 0.000 claims 3
- 229960004194 lidocaine Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical class CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 claims 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- SLINHMUFWFWBMU-UHFFFAOYSA-N Triisopropanolamine Chemical compound CC(O)CN(CC(C)O)CC(C)O SLINHMUFWFWBMU-UHFFFAOYSA-N 0.000 claims 2
- 238000000862 absorption spectrum Methods 0.000 claims 2
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 claims 2
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 229960005293 etodolac Drugs 0.000 claims 1
- 229960002390 flurbiprofen Drugs 0.000 claims 1
- 229960000991 ketoprofen Drugs 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013144711A JP2013199502A (ja) | 2007-01-29 | 2013-07-10 | 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007018005 | 2007-01-29 | ||
| JP2007018005 | 2007-01-29 | ||
| JP2007031188 | 2007-02-09 | ||
| JP2007031188 | 2007-02-09 | ||
| JP2007069620 | 2007-03-16 | ||
| JP2007069620 | 2007-03-16 | ||
| JP2013144711A JP2013199502A (ja) | 2007-01-29 | 2013-07-10 | 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556118A Division JP5360751B2 (ja) | 2007-01-29 | 2008-01-29 | 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013199502A JP2013199502A (ja) | 2013-10-03 |
| JP2013199502A5 true JP2013199502A5 (https=) | 2014-01-16 |
Family
ID=39673995
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556118A Expired - Fee Related JP5360751B2 (ja) | 2007-01-29 | 2008-01-29 | 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 |
| JP2013144711A Pending JP2013199502A (ja) | 2007-01-29 | 2013-07-10 | 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556118A Expired - Fee Related JP5360751B2 (ja) | 2007-01-29 | 2008-01-29 | 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100029704A1 (https=) |
| EP (1) | EP2128123A4 (https=) |
| JP (2) | JP5360751B2 (https=) |
| WO (1) | WO2008093686A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2867194C (en) | 2005-10-07 | 2016-10-04 | The University Of Alabama | Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients |
| US8920843B2 (en) | 2007-11-07 | 2014-12-30 | Svip5 Llc | Slow release of organic salts of local anesthetics for pain relief |
| EP2311498A4 (en) * | 2008-08-05 | 2013-07-24 | Medrx Co Ltd | EXTERNAL PREPARATION COMPRISING A FATTY ACID SALT OR A BENZOIC ACID SALT OF A PHARMACOLOGICALLY ACTIVE BASIC COMPONENT, AND PROCESS FOR PRODUCTION THEREOF |
| RU2397975C1 (ru) * | 2008-11-27 | 2010-08-27 | Андрей Александрович Иващенко | Замещенные 2-(5-гидрокси-2-метил-1н-индол-3-ил)уксусные кислоты и их эфиры, противовирусное активное начало, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний |
| WO2010103845A1 (ja) * | 2009-03-11 | 2010-09-16 | 興和株式会社 | 鎮痛・抗炎症剤含有外用剤 |
| JPWO2010103844A1 (ja) * | 2009-03-11 | 2012-09-13 | 興和株式会社 | 鎮痛・抗炎症剤含有外用剤 |
| JP2012158521A (ja) * | 2009-04-17 | 2012-08-23 | Kureha Corp | 外用剤 |
| EP2463263B1 (en) * | 2009-08-03 | 2014-04-23 | Riken | Isotope labeled 2-arylpropionic acid compounds and process for production of same, and molecular probe for positron emission tomography and method for imaging of cyclooxygenase and the like using same |
| JP5897804B2 (ja) * | 2010-02-26 | 2016-03-30 | 興和株式会社 | ロキソプロフェン含有の医薬組成物 |
| JP5622410B2 (ja) * | 2010-03-12 | 2014-11-12 | 帝國製薬株式会社 | ケトプロフェン含有水性貼付剤 |
| EP2593096A4 (en) * | 2010-07-12 | 2014-02-26 | Yung Shin Pharm Ind Co Ltd | DICLOFENAC SALT OF TRAMADOL |
| ES3034911T3 (en) | 2011-05-10 | 2025-08-26 | Itochu Chemical Frontier Corp | Non-aqueous patch |
| BR112013028802B1 (pt) | 2011-05-10 | 2021-10-26 | Itochu Chemical Frontier Corporation | Curativo adesivo não-aquoso |
| US11786455B2 (en) | 2011-05-10 | 2023-10-17 | Itochu Chemical Frontier Corporation | Non-aqueous patch |
| WO2012172413A1 (en) | 2011-06-16 | 2012-12-20 | Abbott Healthcare Pvt. Ltd. | Pharmaceutical composition comprising a combination of eperisone and diclofenac and process for preparing thereof |
| LT2823815T (lt) | 2011-09-27 | 2018-08-27 | Itochu Chemical Frontier Corporation | Nevandeninis pleistras |
| CN102526001B (zh) * | 2011-12-30 | 2013-09-25 | 沈阳药科大学 | 吲哚美辛盐透皮贴剂及其制备方法 |
| CN102940618A (zh) * | 2012-11-29 | 2013-02-27 | 沈阳药科大学 | 洛索洛芬有机胺盐透皮贴剂及其制备方法 |
| EP3395763B1 (en) * | 2013-04-30 | 2020-06-17 | Merck Patent GmbH | Uses of alumina flakes |
| WO2015013772A1 (en) * | 2013-08-01 | 2015-02-05 | Monash University | Compositions and preparation methods of low melting ionic salts of poorly- water soluble drugs |
| EP3251697A4 (en) * | 2015-01-27 | 2018-08-22 | Ajinomoto Co., Inc. | Method for controlling skin penetration |
| ES2863500T3 (es) | 2015-04-10 | 2021-10-11 | Capsugel Belgium Nv | Formulaciones lipídicas de acetato de abiraterona |
| CN107613961B (zh) * | 2015-05-19 | 2021-07-13 | 美德阿利克斯株式会社 | 经皮吸收型液体制剂 |
| US10064795B2 (en) * | 2015-05-22 | 2018-09-04 | Grip Tight Sport Llc | Atomizing spray for grip enhancement |
| WO2017027474A1 (en) * | 2015-08-10 | 2017-02-16 | The Trustees Of Princetion University | Nano-encapsulation using gras materials and applications thereof |
| WO2017111167A1 (ja) * | 2015-12-25 | 2017-06-29 | 興和株式会社 | ロキソプロフェンを含有する医薬製剤 |
| WO2020086046A2 (en) * | 2018-10-26 | 2020-04-30 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Topical compositions comprising tolperisone and flurbiprofen combination |
| CN111494308A (zh) * | 2019-01-30 | 2020-08-07 | 北京蓝丹医药科技有限公司 | 一种稳定的氟比洛芬注射液 |
| AU2020362643B2 (en) * | 2019-10-11 | 2024-12-12 | Toray Industries, Inc. | Pharmaceutical composition containing temperature-responsive ionic liquid |
| CN112755196B (zh) * | 2019-11-01 | 2024-02-27 | 华东理工大学 | 多奈哌齐离子液体 |
| CN110907583B (zh) * | 2019-11-13 | 2021-03-02 | 湖南九典制药股份有限公司 | 一种洛索洛芬或其钠盐中有关物质的分离方法 |
| CN111807985A (zh) * | 2020-06-17 | 2020-10-23 | 西安医学院 | 一种利多卡因非甾体抗炎药离子液体及其制备方法 |
| JP7525095B2 (ja) * | 2020-08-14 | 2024-07-30 | 森田薬品工業株式会社 | ｐ－ボロノフェニルアラニンを構成成分とするイオン液体 |
| CN112079842A (zh) * | 2020-09-18 | 2020-12-15 | 哈尔滨工业大学（深圳） | 一种依托度酸离子盐及其制备方法与应用 |
| EP4292583A4 (en) * | 2021-02-12 | 2024-12-18 | MEDRx Co., Ltd. | COMPOSITION WITH IMPROVED ABSORBABILITY OF A POORLY ABSORBABLE MEDICINAL PRODUCT |
| CN116350577B (zh) * | 2023-03-29 | 2024-09-20 | 西安医学院 | 一种非甾体抗炎药离子液体凝胶的制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2104684A1 (en) * | 1991-03-04 | 1992-09-05 | Mahdi B. Fawzi | Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms |
| CA2200068C (en) | 1994-09-16 | 2005-01-11 | Munehiko Hirano | A preparation for external use and a patch having the preparation attached thereto |
| US6191285B1 (en) * | 1997-07-03 | 2001-02-20 | Abbott Laboratories | Process for the preparation of ketorolac tromethamine |
| EP1043031A4 (en) * | 1997-12-26 | 2007-05-02 | Astellas Pharma Inc | MEDICINAL COMPOSITIONS WITH PROLONGED RELEASE |
| US6211246B1 (en) * | 1999-06-10 | 2001-04-03 | Mcneil-Ppc, Inc. | Rapidly absorbed liquid compositions |
| JP4684404B2 (ja) * | 2000-10-26 | 2011-05-18 | 第一三共株式会社 | 消炎鎮痛外用剤組成物 |
| DE10059020A1 (de) * | 2000-11-28 | 2002-05-29 | Gruenenthal Gmbh | Parenteral applizierbare Darreichungsformen |
| DE10100455A1 (de) * | 2001-01-08 | 2002-07-11 | Creavis Tech & Innovation Gmbh | Neuartige Polymerbindersysteme mit ionischen Flüssigkeiten |
| ATE348712T1 (de) | 2001-03-16 | 2007-01-15 | Datalase Ltd | Laser markierbare zusammensetzungen und verfahren zur erzeugung eines bildes durch laser |
| US7166641B2 (en) | 2002-10-02 | 2007-01-23 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same |
| US20080026077A1 (en) * | 2002-11-12 | 2008-01-31 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
| JP2007018005A (ja) | 2003-02-17 | 2007-01-25 | Matsushita Electric Ind Co Ltd | フォトマスク |
| JP2005068035A (ja) * | 2003-08-20 | 2005-03-17 | Medorekkusu:Kk | 慢性疼痛治療用外用剤 |
| JP2005082512A (ja) | 2003-09-05 | 2005-03-31 | Medorekkusu:Kk | イオン性の薬物の経皮吸収性を高めた外用剤 |
| JP2005145930A (ja) * | 2003-11-19 | 2005-06-09 | Medorekkusu:Kk | 非ステロイド系消炎鎮痛剤を含む消炎鎮痛外用剤および組成物の製造方法 |
| JP2005145932A (ja) * | 2003-11-19 | 2005-06-09 | Medorekkusu:Kk | 消炎鎮痛外用剤 |
| KR20060124724A (ko) * | 2004-01-26 | 2006-12-05 | 유니버시티 오브 사우스 앨라배마 | 음이온성―스위트너를 기반으로 하는 이온성 액체 및그것의 사용 방법 |
| ATE534405T1 (de) * | 2004-01-29 | 2011-12-15 | Medrx Co Ltd | Entzündungshemmendes analgetikum für die äussere anwendung |
| JP4807721B2 (ja) * | 2004-01-29 | 2011-11-02 | 株式会社 メドレックス | 消炎鎮痛外用剤 |
| JP4584620B2 (ja) | 2004-04-30 | 2010-11-24 | 久光製薬株式会社 | 消炎鎮痛外用剤 |
| US7592371B2 (en) * | 2004-08-18 | 2009-09-22 | Medrx Co., Ltd. | External preparation |
| WO2006018987A1 (ja) | 2004-08-18 | 2006-02-23 | Konica Minolta Medical & Graphic, Inc. | 画像記録方法及び画像記録装置 |
| US20060210613A1 (en) * | 2005-03-15 | 2006-09-21 | Carliss Richard D | Therapeutic wound care product |
| JP4823596B2 (ja) | 2005-07-25 | 2011-11-24 | 住友大阪セメント株式会社 | セメント焼成設備における排ガスの処理方法及び処理装置 |
| CA2867194C (en) * | 2005-10-07 | 2016-10-04 | The University Of Alabama | Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients |
-
2008
- 2008-01-29 US US12/524,828 patent/US20100029704A1/en not_active Abandoned
- 2008-01-29 EP EP08704108A patent/EP2128123A4/en not_active Withdrawn
- 2008-01-29 JP JP2008556118A patent/JP5360751B2/ja not_active Expired - Fee Related
- 2008-01-29 WO PCT/JP2008/051326 patent/WO2008093686A1/ja not_active Ceased
-
2013
- 2013-07-10 JP JP2013144711A patent/JP2013199502A/ja active Pending
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