JP2013048635A5 - - Google Patents
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- Publication number
- JP2013048635A5 JP2013048635A5 JP2012259617A JP2012259617A JP2013048635A5 JP 2013048635 A5 JP2013048635 A5 JP 2013048635A5 JP 2012259617 A JP2012259617 A JP 2012259617A JP 2012259617 A JP2012259617 A JP 2012259617A JP 2013048635 A5 JP2013048635 A5 JP 2013048635A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- oligonucleotide
- carbon atoms
- lower alkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78777706P | 2006-03-31 | 2006-03-31 | |
| US60/787,777 | 2006-03-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503336A Division JP2009533022A (ja) | 2006-03-31 | 2007-04-02 | ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014011166A Division JP2014079254A (ja) | 2006-03-31 | 2014-01-24 | ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013048635A JP2013048635A (ja) | 2013-03-14 |
| JP2013048635A5 true JP2013048635A5 (https=) | 2014-03-13 |
| JP5698206B2 JP5698206B2 (ja) | 2015-04-08 |
Family
ID=38564295
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503336A Pending JP2009533022A (ja) | 2006-03-31 | 2007-04-02 | ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬 |
| JP2012259617A Active JP5698206B2 (ja) | 2006-03-31 | 2012-11-28 | ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬 |
| JP2014011166A Withdrawn JP2014079254A (ja) | 2006-03-31 | 2014-01-24 | ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503336A Pending JP2009533022A (ja) | 2006-03-31 | 2007-04-02 | ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014011166A Withdrawn JP2014079254A (ja) | 2006-03-31 | 2014-01-24 | ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US9040674B2 (https=) |
| EP (1) | EP2001871B1 (https=) |
| JP (3) | JP2009533022A (https=) |
| CN (1) | CN101454315B (https=) |
| AU (1) | AU2007234451A1 (https=) |
| CA (1) | CA2647827A1 (https=) |
| WO (1) | WO2007115265A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2572826C2 (ru) | 2008-12-02 | 2016-01-20 | Чиралджен, Лтд. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| CN107326073A (zh) * | 2010-12-29 | 2017-11-07 | 生命技术公司 | 作为荧光参考标准品的 ddao 化合物 |
| AU2012284265B2 (en) | 2011-07-19 | 2017-08-17 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| WO2013134686A1 (en) * | 2012-03-09 | 2013-09-12 | Promega Corporation | pH SENSORS |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | キラル制御 |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| CN104684923B (zh) | 2012-07-13 | 2018-09-28 | 株式会社新日本科学 | 手性核酸佐剂 |
| CN103122379A (zh) * | 2012-12-24 | 2013-05-29 | 深圳先进技术研究院 | 基因转染实时监测的方法 |
| CN103232489B (zh) * | 2013-02-18 | 2016-09-28 | 常州津坛生物科技有限公司 | 一种荧光探针化合物及其制备方法和用途 |
| CA2902992C (en) * | 2013-03-08 | 2020-08-25 | Illumina Cambridge Ltd | Rhodamine compounds and their use as fluorescent labels |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| CN106281309B (zh) * | 2016-08-03 | 2018-07-10 | 陕西师范大学 | 硼酸衍生物功能化荧光探针在检测5-羟甲基胞嘧啶中的应用 |
| CN106350064B (zh) * | 2016-08-30 | 2019-03-29 | 上海大学 | 利用微波加热法水热炭化造纸黑液制备水溶性荧光碳材料的方法 |
| CA3099701A1 (en) * | 2018-05-07 | 2019-11-14 | Cepheid | Sulforhodamine phosphoramidite dyes |
| EP3833715B1 (en) | 2018-08-10 | 2026-01-07 | Life Technologies Corporation | Silicon-substituted rhodamine dyes and dye conjugates |
| SG11202106124UA (en) * | 2018-12-20 | 2021-07-29 | Life Technologies Corp | Modified rhodamine dye and use thereof in biological assays |
| KR20230034333A (ko) | 2020-07-02 | 2023-03-09 | 라이프 테크놀로지스 코포레이션 | 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도 |
| WO2022020731A2 (en) | 2020-07-23 | 2022-01-27 | Life Technologies Corporation | Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same |
| CA3186955A1 (en) | 2020-07-23 | 2022-01-27 | Scott Benson | Energy transfer dye conjugates for use in biological assays |
| US20250092261A1 (en) | 2021-07-21 | 2025-03-20 | Life Technologies Corporation | Dibenzoxanthene Quenchers, Uses, and Methods of Preparation |
| CN116333006A (zh) * | 2023-04-07 | 2023-06-27 | 苏州欧利生物医药科技有限公司 | 一种带有荧光标记物的寡核苷酸的固相合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4557862A (en) | 1983-10-28 | 1985-12-10 | University Patents, Inc. | Rhodamine derivatives as fluorogenic substrates for proteinases |
| US5231191A (en) | 1987-12-24 | 1993-07-27 | Applied Biosystems, Inc. | Rhodamine phosphoramidite compounds |
| US4965349A (en) | 1987-12-24 | 1990-10-23 | Applied Biosystems, Inc. | Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports |
| US5451463A (en) | 1989-08-28 | 1995-09-19 | Clontech Laboratories, Inc. | Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides |
| US5366860A (en) * | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
| US6028190A (en) * | 1994-02-01 | 2000-02-22 | The Regents Of The University Of California | Probes labeled with energy transfer coupled dyes |
| US6020481A (en) * | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
| US6080852A (en) * | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
| US6583168B1 (en) * | 1997-11-25 | 2003-06-24 | Applera Corporation | Sulfonated diarylrhodamine dyes |
| US6255476B1 (en) * | 1999-02-22 | 2001-07-03 | Pe Corporation (Ny) | Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports |
| US6248884B1 (en) * | 1999-06-03 | 2001-06-19 | The Perkin-Elmer Corporation | Extended rhodamine compounds useful as fluorescent labels |
| US7183405B2 (en) | 1999-06-25 | 2007-02-27 | Syn Gen, Inc. | Compositions and methods for labeling oligonucleotides |
| US6750357B1 (en) | 1999-06-25 | 2004-06-15 | Syngen, Inc. | Rhodamine-based fluorophores useful as labeling reagents |
| US20040014131A1 (en) * | 2002-07-09 | 2004-01-22 | Pfizer Inc. | Assay methods |
| WO2005007678A2 (en) * | 2003-07-14 | 2005-01-27 | Irm Llc | Methods for the preparation of rhodamine |
| EP1781675B1 (en) * | 2004-08-13 | 2014-03-26 | Epoch Biosciences, Inc. | Phosphonate fluorescent dyes and conjugates |
-
2007
- 2007-04-02 CN CN200780019599.1A patent/CN101454315B/zh not_active Expired - Fee Related
- 2007-04-02 CA CA002647827A patent/CA2647827A1/en not_active Abandoned
- 2007-04-02 WO PCT/US2007/065798 patent/WO2007115265A2/en not_active Ceased
- 2007-04-02 AU AU2007234451A patent/AU2007234451A1/en not_active Abandoned
- 2007-04-02 US US11/695,548 patent/US9040674B2/en active Active
- 2007-04-02 JP JP2009503336A patent/JP2009533022A/ja active Pending
- 2007-04-02 EP EP07759970.2A patent/EP2001871B1/en active Active
-
2012
- 2012-11-28 JP JP2012259617A patent/JP5698206B2/ja active Active
-
2014
- 2014-01-24 JP JP2014011166A patent/JP2014079254A/ja not_active Withdrawn
-
2015
- 2015-05-01 US US14/702,499 patent/US9783560B2/en active Active
-
2017
- 2017-09-01 US US15/694,279 patent/US20180057516A1/en not_active Abandoned
-
2020
- 2020-01-30 US US16/776,682 patent/US11407773B2/en active Active
-
2022
- 2022-06-30 US US17/854,220 patent/US20230096149A1/en not_active Abandoned
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