JP2013048635A5 - - Google Patents

Download PDF

Info

Publication number
JP2013048635A5
JP2013048635A5 JP2012259617A JP2012259617A JP2013048635A5 JP 2013048635 A5 JP2013048635 A5 JP 2013048635A5 JP 2012259617 A JP2012259617 A JP 2012259617A JP 2012259617 A JP2012259617 A JP 2012259617A JP 2013048635 A5 JP2013048635 A5 JP 2013048635A5
Authority
JP
Japan
Prior art keywords
group
oligonucleotide
carbon atoms
lower alkyl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012259617A
Other languages
English (en)
Japanese (ja)
Other versions
JP5698206B2 (ja
JP2013048635A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2013048635A publication Critical patent/JP2013048635A/ja
Publication of JP2013048635A5 publication Critical patent/JP2013048635A5/ja
Application granted granted Critical
Publication of JP5698206B2 publication Critical patent/JP5698206B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012259617A 2006-03-31 2012-11-28 ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬 Active JP5698206B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78777706P 2006-03-31 2006-03-31
US60/787,777 2006-03-31

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2009503336A Division JP2009533022A (ja) 2006-03-31 2007-04-02 ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014011166A Division JP2014079254A (ja) 2006-03-31 2014-01-24 ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬

Publications (3)

Publication Number Publication Date
JP2013048635A JP2013048635A (ja) 2013-03-14
JP2013048635A5 true JP2013048635A5 (https=) 2014-03-13
JP5698206B2 JP5698206B2 (ja) 2015-04-08

Family

ID=38564295

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009503336A Pending JP2009533022A (ja) 2006-03-31 2007-04-02 ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬
JP2012259617A Active JP5698206B2 (ja) 2006-03-31 2012-11-28 ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬
JP2014011166A Withdrawn JP2014079254A (ja) 2006-03-31 2014-01-24 ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2009503336A Pending JP2009533022A (ja) 2006-03-31 2007-04-02 ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014011166A Withdrawn JP2014079254A (ja) 2006-03-31 2014-01-24 ローダミン標識されたオリゴヌクレオチドを合成するために有用な試薬

Country Status (7)

Country Link
US (5) US9040674B2 (https=)
EP (1) EP2001871B1 (https=)
JP (3) JP2009533022A (https=)
CN (1) CN101454315B (https=)
AU (1) AU2007234451A1 (https=)
CA (1) CA2647827A1 (https=)
WO (1) WO2007115265A2 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
CA2767253A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc. Novel nucleic acid prodrugs and methods of use thereof
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
CN107326073A (zh) * 2010-12-29 2017-11-07 生命技术公司 作为荧光参考标准品的 ddao 化合物
AU2012284265B2 (en) 2011-07-19 2017-08-17 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
WO2013134686A1 (en) * 2012-03-09 2013-09-12 Promega Corporation pH SENSORS
JP6453212B2 (ja) 2012-07-13 2019-01-16 ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. キラル制御
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
CN104684923B (zh) 2012-07-13 2018-09-28 株式会社新日本科学 手性核酸佐剂
CN103122379A (zh) * 2012-12-24 2013-05-29 深圳先进技术研究院 基因转染实时监测的方法
CN103232489B (zh) * 2013-02-18 2016-09-28 常州津坛生物科技有限公司 一种荧光探针化合物及其制备方法和用途
CA2902992C (en) * 2013-03-08 2020-08-25 Illumina Cambridge Ltd Rhodamine compounds and their use as fluorescent labels
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
ES2917473T3 (es) 2014-01-16 2022-07-08 Wave Life Sciences Ltd Diseño quiral
CN106281309B (zh) * 2016-08-03 2018-07-10 陕西师范大学 硼酸衍生物功能化荧光探针在检测5-羟甲基胞嘧啶中的应用
CN106350064B (zh) * 2016-08-30 2019-03-29 上海大学 利用微波加热法水热炭化造纸黑液制备水溶性荧光碳材料的方法
CA3099701A1 (en) * 2018-05-07 2019-11-14 Cepheid Sulforhodamine phosphoramidite dyes
EP3833715B1 (en) 2018-08-10 2026-01-07 Life Technologies Corporation Silicon-substituted rhodamine dyes and dye conjugates
SG11202106124UA (en) * 2018-12-20 2021-07-29 Life Technologies Corp Modified rhodamine dye and use thereof in biological assays
KR20230034333A (ko) 2020-07-02 2023-03-09 라이프 테크놀로지스 코포레이션 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도
WO2022020731A2 (en) 2020-07-23 2022-01-27 Life Technologies Corporation Compositions, systems and methods for biological analysis involving energy transfer dye conjugates and analytes comprising the same
CA3186955A1 (en) 2020-07-23 2022-01-27 Scott Benson Energy transfer dye conjugates for use in biological assays
US20250092261A1 (en) 2021-07-21 2025-03-20 Life Technologies Corporation Dibenzoxanthene Quenchers, Uses, and Methods of Preparation
CN116333006A (zh) * 2023-04-07 2023-06-27 苏州欧利生物医药科技有限公司 一种带有荧光标记物的寡核苷酸的固相合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4557862A (en) 1983-10-28 1985-12-10 University Patents, Inc. Rhodamine derivatives as fluorogenic substrates for proteinases
US5231191A (en) 1987-12-24 1993-07-27 Applied Biosystems, Inc. Rhodamine phosphoramidite compounds
US4965349A (en) 1987-12-24 1990-10-23 Applied Biosystems, Inc. Method of synthesizing oligonucleotides labeled with ammonia-labile groups on solid phase supports
US5451463A (en) 1989-08-28 1995-09-19 Clontech Laboratories, Inc. Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
US5366860A (en) * 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US6028190A (en) * 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US6020481A (en) * 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
US6080852A (en) * 1996-06-27 2000-06-27 The Perkin-Elmer Corporation 4,7-dichlororhodamine dyes
US6583168B1 (en) * 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US6255476B1 (en) * 1999-02-22 2001-07-03 Pe Corporation (Ny) Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports
US6248884B1 (en) * 1999-06-03 2001-06-19 The Perkin-Elmer Corporation Extended rhodamine compounds useful as fluorescent labels
US7183405B2 (en) 1999-06-25 2007-02-27 Syn Gen, Inc. Compositions and methods for labeling oligonucleotides
US6750357B1 (en) 1999-06-25 2004-06-15 Syngen, Inc. Rhodamine-based fluorophores useful as labeling reagents
US20040014131A1 (en) * 2002-07-09 2004-01-22 Pfizer Inc. Assay methods
WO2005007678A2 (en) * 2003-07-14 2005-01-27 Irm Llc Methods for the preparation of rhodamine
EP1781675B1 (en) * 2004-08-13 2014-03-26 Epoch Biosciences, Inc. Phosphonate fluorescent dyes and conjugates

Similar Documents

Publication Publication Date Title
JP2013048635A5 (https=)
JP2025037925A5 (https=)
DE69229149T2 (de) Modifizierte, Phosphor enthaltende Zwischenprodukte zur Erzeugung von funktionalen Gruppen am 5' Ende von Oligonucleotiden
JP2010529034A5 (https=)
RU2013132683A (ru) Ингибиторы репликации вирусов гриппа
RU2014107430A (ru) Моногидрат мезилата n-[5-(аминосульфонил)-4-метил-1,3-тиазол-2-ил]-n-метил-2-[4-(2-пиридинил)фенил]ацетамида
JP2010525122A5 (https=)
RU2017144050A (ru) Способ синтеза производных рапамицина
RU2015100197A (ru) Асимметричная вспомогательная группа
RU2014134380A (ru) Модифицированные олигонуклеотиды и способ их получения
EA201591277A1 (ru) Пирролобензодиазепины и их конъюгаты
JP2010529036A5 (https=)
JP2009523146A5 (https=)
JP2014514920A (ja) キャプチャータグを用いた、三リン酸化オリゴヌクレオチドの精製
RU2010136996A (ru) Реакции сочетания, которые могут быть использованы при получении производных (1н-тетразол-5-ил)бифенила
WO2020196890A1 (ja) ホスホロチオエート化部位を有するオリゴヌクレオチドの製造方法
RU2008153041A (ru) Производные фторалкоксикомбретастатина, способы их производства и использования
JP2013521268A5 (https=)
RU2493150C2 (ru) Соединения 2,4-пиримидиндиаминов и их применение
JP2019514982A (ja) 芳香族フッ素化方法
RU2012106074A (ru) Новые алкоксиеноны и енаминокетоны и способ их получения
RU2011142308A (ru) Способ получения трийодированных карбоксильных ароматических производных
ES8304975A1 (es) "procedimiento para la preparacion de derivados triptaminicos sustituidos de tieniloxipropanolaminas, racemicos y opticamente activos".
JP2010512392A5 (https=)
JP2013216653A5 (https=)