JPWO2021070494A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021070494A5 JPWO2021070494A5 JP2021550425A JP2021550425A JPWO2021070494A5 JP WO2021070494 A5 JPWO2021070494 A5 JP WO2021070494A5 JP 2021550425 A JP2021550425 A JP 2021550425A JP 2021550425 A JP2021550425 A JP 2021550425A JP WO2021070494 A5 JPWO2021070494 A5 JP WO2021070494A5
- Authority
- JP
- Japan
- Prior art keywords
- ion
- solution
- linkers
- pmm
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019187930 | 2019-10-11 | ||
| JP2019187930 | 2019-10-11 | ||
| PCT/JP2020/032020 WO2021070494A1 (ja) | 2019-10-11 | 2020-08-25 | 核酸オリゴマーの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021070494A1 JPWO2021070494A1 (https=) | 2021-04-15 |
| JPWO2021070494A5 true JPWO2021070494A5 (https=) | 2023-08-04 |
| JP7640461B2 JP7640461B2 (ja) | 2025-03-05 |
Family
ID=75437077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021550425A Active JP7640461B2 (ja) | 2019-10-11 | 2020-08-25 | 核酸オリゴマーの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12509483B2 (https=) |
| EP (1) | EP4043473A4 (https=) |
| JP (1) | JP7640461B2 (https=) |
| KR (1) | KR20220079832A (https=) |
| CN (1) | CN114502566B (https=) |
| WO (1) | WO2021070494A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230312635A1 (en) * | 2020-01-29 | 2023-10-05 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
| JP7719788B2 (ja) * | 2020-09-24 | 2025-08-06 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| CN118460647B (zh) * | 2024-07-10 | 2025-01-28 | 凯莱英医药集团(天津)股份有限公司 | 一种Patisiran的制备方法 |
| WO2026048956A1 (ja) * | 2024-08-29 | 2026-03-05 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| WO2026071145A1 (ja) * | 2024-09-30 | 2026-04-02 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077709A (en) | 1998-09-29 | 2000-06-20 | Isis Pharmaceuticals Inc. | Antisense modulation of Survivin expression |
| DK1149109T3 (da) | 1999-02-05 | 2010-01-11 | Ge Healthcare Bio Sciences | Fremgangsmåde til afbeskyttelse af oligonukleotider |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| WO2005007825A2 (en) * | 2003-07-12 | 2005-01-27 | Isis Pharmaceuticals, Inc. | Modulation of aminopeptidase n expression |
| ES2386709T3 (es) | 2004-08-26 | 2012-08-27 | Nippon Shinyaku Co., Ltd. | Compuesto de fosforamidita y método para producir un oligo-ARN |
| US8158775B2 (en) | 2006-02-27 | 2012-04-17 | Nippon Shinyaku Co., Ltd. | Method for detaching protecting group on nucleic acid |
| WO2008049085A1 (en) | 2006-10-18 | 2008-04-24 | Isis Pharmaceuticals, Inc. | Antisense compounds |
| EP2479182B8 (en) * | 2009-09-16 | 2016-07-13 | Wave Life Sciences Japan, Inc. | Novel protecting group for synthesizing rna and derivative thereof |
| HUE037500T2 (hu) | 2010-07-08 | 2018-08-28 | Bonac Corp | Egyszálú nukleinsav molekula a génexpresszió szabályozására |
| ES2527660T3 (es) | 2010-08-03 | 2015-01-28 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| WO2013027843A1 (ja) | 2011-08-25 | 2013-02-28 | 株式会社ボナック | 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法 |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| JP6459852B2 (ja) | 2014-08-29 | 2019-01-30 | 住友化学株式会社 | エーテル化合物の製造方法 |
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| JP6787398B2 (ja) | 2016-04-26 | 2020-11-18 | 住友化学株式会社 | 一本鎖核酸分子用モノマーの製造方法 |
| EP3527578A4 (en) | 2016-10-14 | 2020-07-15 | Bonac Corporation | NOVEL GLYCOSIDE COMPOUND AND PROCESS FOR PRODUCING THE SAME |
| JP6803730B2 (ja) | 2016-11-22 | 2020-12-23 | 旭サナック株式会社 | 静電塗装装置 |
| EP3604528A4 (en) | 2017-03-31 | 2021-01-13 | Bonac Corporation | CYCLIC NUCLEIC ACID MOLECULE WITH GENE EXPRESSION CONTROL FUNCTION |
| KR20250046363A (ko) | 2017-09-19 | 2025-04-02 | 알닐람 파마슈티칼스 인코포레이티드 | 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법 |
| US20210188895A1 (en) | 2017-10-13 | 2021-06-24 | Bonac Corporation | Single-stranded nucleic acid molecule, and production method therefor |
| KR102670605B1 (ko) | 2018-04-24 | 2024-05-29 | 스미또모 가가꾸 가부시끼가이샤 | 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법 |
| JP7207682B2 (ja) | 2018-04-26 | 2023-01-18 | 株式会社サンセイアールアンドディ | 遊技機 |
| EP4114384A1 (en) | 2020-03-06 | 2023-01-11 | Pfizer Inc. | Methods of inhibiting sars-cov-2 replication and treating coronavirus disease 2019 |
| JP7719788B2 (ja) * | 2020-09-24 | 2025-08-06 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
-
2020
- 2020-08-25 US US17/767,825 patent/US12509483B2/en active Active
- 2020-08-25 CN CN202080070607.0A patent/CN114502566B/zh active Active
- 2020-08-25 WO PCT/JP2020/032020 patent/WO2021070494A1/ja not_active Ceased
- 2020-08-25 JP JP2021550425A patent/JP7640461B2/ja active Active
- 2020-08-25 EP EP20875506.6A patent/EP4043473A4/en active Pending
- 2020-08-25 KR KR1020227010696A patent/KR20220079832A/ko active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2021070494A5 (https=) | ||
| US8541569B2 (en) | Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA | |
| JP7492829B2 (ja) | 多重カップリングおよび酸化の方法 | |
| JP7164540B2 (ja) | 立体的に規定されたホスホロチオエートオリゴヌクレオチドの調製のための直交保護基 | |
| JP2011088935A (ja) | リン原子修飾ヌクレオチド類縁体の製造のための光学活性ヌクレオシド3’−ホスホロアミダイト | |
| JP7719788B2 (ja) | 核酸オリゴマーの製造方法 | |
| JP7777452B2 (ja) | 核酸オリゴマーの製造方法 | |
| JPWO2007102581A1 (ja) | 2’水酸基修飾リボヌクレオシド誘導体 | |
| JPWO2022064908A5 (https=) | ||
| JP7759323B2 (ja) | 核酸オリゴマーの製造方法 | |
| US11542294B2 (en) | Rapid unylinker cleavage | |
| JP7698631B2 (ja) | 核酸オリゴマーの製造方法 | |
| US20130066061A1 (en) | Purification of oligonucleotides | |
| EP3154996B1 (en) | Protecting groups for "z nucleotide" and methods thereof | |
| WO2024019137A1 (ja) | オリゴヌクレオチドの製造方法 | |
| WO2023054350A1 (ja) | 精製ジクロロ酢酸の製造方法 | |
| JP7657736B2 (ja) | セグメント型アミダイトを用いた核酸合成法 | |
| WO2006095739A1 (ja) | リボヌクレオシドの2’水酸基の脱保護方法 | |
| US20250340585A1 (en) | Amidite monomer | |
| WO2025229953A1 (ja) | オリゴヌクレオチドの製造方法 | |
| WO2025244124A1 (ja) | 核酸オリゴマーの製造方法 | |
| JP2023503985A (ja) | 3’-rnaオリゴヌクレオチドの合成 |