JPWO2022064908A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2022064908A5
JPWO2022064908A5 JP2022551198A JP2022551198A JPWO2022064908A5 JP WO2022064908 A5 JPWO2022064908 A5 JP WO2022064908A5 JP 2022551198 A JP2022551198 A JP 2022551198A JP 2022551198 A JP2022551198 A JP 2022551198A JP WO2022064908 A5 JPWO2022064908 A5 JP WO2022064908A5
Authority
JP
Japan
Prior art keywords
formula
oligonucleotide
argon
method described
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022551198A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2022064908A1 (https=
JP7719788B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2021/030423 external-priority patent/WO2022064908A1/ja
Publication of JPWO2022064908A1 publication Critical patent/JPWO2022064908A1/ja
Publication of JPWO2022064908A5 publication Critical patent/JPWO2022064908A5/ja
Application granted granted Critical
Publication of JP7719788B2 publication Critical patent/JP7719788B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022551198A 2020-09-24 2021-08-19 核酸オリゴマーの製造方法 Active JP7719788B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020159460 2020-09-24
JP2020159460 2020-09-24
PCT/JP2021/030423 WO2022064908A1 (ja) 2020-09-24 2021-08-19 核酸オリゴマーの製造方法

Publications (3)

Publication Number Publication Date
JPWO2022064908A1 JPWO2022064908A1 (https=) 2022-03-31
JPWO2022064908A5 true JPWO2022064908A5 (https=) 2024-08-19
JP7719788B2 JP7719788B2 (ja) 2025-08-06

Family

ID=80845119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022551198A Active JP7719788B2 (ja) 2020-09-24 2021-08-19 核酸オリゴマーの製造方法

Country Status (6)

Country Link
US (1) US20240051986A1 (https=)
EP (1) EP4219520A4 (https=)
JP (1) JP7719788B2 (https=)
KR (1) KR20230074205A (https=)
CN (1) CN116209668A (https=)
WO (1) WO2022064908A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7640461B2 (ja) * 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法
EP4098655A4 (en) * 2020-01-29 2024-02-28 Sumitomo Chemical Company, Limited METHOD FOR PRODUCING NUCLEIC ACID OLIGOMERS
US12509485B2 (en) * 2022-03-23 2025-12-30 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60105692A (ja) * 1983-11-14 1985-06-11 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
US6111095A (en) * 1995-06-07 2000-08-29 Merck & Co., Inc. Capped synthetic RNA, analogs, and aptamers
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
US8158775B2 (en) * 2006-02-27 2012-04-17 Nippon Shinyaku Co., Ltd. Method for detaching protecting group on nucleic acid
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
ES2586683T3 (es) * 2009-09-16 2016-10-18 Wave Life Sciences Japan, Inc. Grupo protector novedoso para sintetizar ARN y derivados del mismo
JP5847700B2 (ja) * 2010-03-05 2016-01-27 株式会社Wave Life Sciences Japan リボヌクレオシドホスホロチオエートの製造方法
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
EP2639307B1 (en) 2010-08-03 2015-03-04 Bonac Corporation Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
MX370398B (es) * 2011-08-25 2019-12-11 Bonac Corp Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico.
CN104039961A (zh) * 2012-01-07 2014-09-10 株式会社博纳克 具有氨基酸骨架的单链核酸分子
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
EP3450439B8 (en) 2016-04-26 2021-06-30 Sumitomo Chemical Company, Limited Method for producing monomer for single-stranded nucleic acid molecule
JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
JP7412890B2 (ja) 2019-03-26 2024-01-15 株式会社小松製作所 油圧機器の検査装置、油圧機器の検査システム、作業車両および油圧機器の検査方法
JP7640461B2 (ja) * 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法

Similar Documents

Publication Publication Date Title
JP6292631B2 (ja) 含窒素複素環構造を有するヌクレオシド及びヌクレオチド
JP3186795B2 (ja) 末端3′−3′または5′−5′ヌクレオチド間結合を有するオリゴヌクレオチド類似体
JP4731324B2 (ja) N−o結合性架橋構造型新規人工核酸
JP3535519B2 (ja) N−2置換プリン類
JP3530218B2 (ja) ▲n4▼−アシル−5’−デオキシ−5−フルオロシチジン誘導体の新規製造法
EP3040340B1 (en) Chemical compounds
ES2244957T3 (es) Oligonucleotidos modificados, su preparacion, asi como su empleo.
CA2106819C (en) Oligoribonucleotide and ribozyme analogs with terminal 3'-3' and/or 5'-5' linkages
JPWO2022064908A5 (https=)
JPH072889A (ja) 2’−エーテル基を有するヌクレオシド及びオリゴヌクレオチド
JPH07300493A (ja) 2′−エーテル基を有する、ヌクレオシド及びオリゴヌクレオチド
WO2001002423A9 (en) 2'-guanidinyl-substituted oligonucleotides and gene expression modulation therewith
JPWO2014112463A1 (ja) スルホンアミド構造を有するヌクレオシドおよびヌクレオチド
EP0316017A2 (en) 2',3'-Dideoxy-2'-fluoronucleosides
AU2013234303A1 (en) Tricyclic nucleosides and oligomeric compounds prepared therefrom
JP7719788B2 (ja) 核酸オリゴマーの製造方法
JP3675847B2 (ja) ヌクレオチド又はオリゴヌクレオチドホスホロアミダイトの合成方法
Hunziker et al. Nucleic acid analogues: synthesis and properties
EP4098655A1 (en) Method for producing nucleic acid oligomer
US20040033967A1 (en) Alkylated hexitol nucleoside analogues and oligomers thereof
US8680262B2 (en) Purification of oligonucleotides
WO2024024873A1 (ja) チオ化溶液
EP4265627A1 (en) Cytosine-type crosslinked nucleoside amidite crystals and method for producing same
Seio et al. Synthesis of LNA gapmers that replace a phosphorothioate linkage with a sulfonamide in the gap region, and their ability to form duplexes with complementary RNA targets
RU2088588C1 (ru) Олигонуклеотиды и способ их получения