JP7719788B2 - 核酸オリゴマーの製造方法 - Google Patents

核酸オリゴマーの製造方法

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Publication number
JP7719788B2
JP7719788B2 JP2022551198A JP2022551198A JP7719788B2 JP 7719788 B2 JP7719788 B2 JP 7719788B2 JP 2022551198 A JP2022551198 A JP 2022551198A JP 2022551198 A JP2022551198 A JP 2022551198A JP 7719788 B2 JP7719788 B2 JP 7719788B2
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JP
Japan
Prior art keywords
formula
nucleic acid
method described
group
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2022551198A
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English (en)
Japanese (ja)
Other versions
JPWO2022064908A1 (https=
JPWO2022064908A5 (https=
Inventor
卓也 宮川
英貴 奥村
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
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Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of JPWO2022064908A1 publication Critical patent/JPWO2022064908A1/ja
Publication of JPWO2022064908A5 publication Critical patent/JPWO2022064908A5/ja
Application granted granted Critical
Publication of JP7719788B2 publication Critical patent/JP7719788B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
JP2022551198A 2020-09-24 2021-08-19 核酸オリゴマーの製造方法 Active JP7719788B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020159460 2020-09-24
JP2020159460 2020-09-24
PCT/JP2021/030423 WO2022064908A1 (ja) 2020-09-24 2021-08-19 核酸オリゴマーの製造方法

Publications (3)

Publication Number Publication Date
JPWO2022064908A1 JPWO2022064908A1 (https=) 2022-03-31
JPWO2022064908A5 JPWO2022064908A5 (https=) 2024-08-19
JP7719788B2 true JP7719788B2 (ja) 2025-08-06

Family

ID=80845119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022551198A Active JP7719788B2 (ja) 2020-09-24 2021-08-19 核酸オリゴマーの製造方法

Country Status (6)

Country Link
US (1) US20240051986A1 (https=)
EP (1) EP4219520A4 (https=)
JP (1) JP7719788B2 (https=)
KR (1) KR20230074205A (https=)
CN (1) CN116209668A (https=)
WO (1) WO2022064908A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7640461B2 (ja) * 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法
EP4098655A4 (en) * 2020-01-29 2024-02-28 Sumitomo Chemical Company, Limited METHOD FOR PRODUCING NUCLEIC ACID OLIGOMERS
US12509485B2 (en) * 2022-03-23 2025-12-30 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
JP5555346B2 (ja) 2010-08-03 2014-07-23 株式会社ボナック 含窒素脂環式骨格を有する一本鎖核酸分子
JP5876890B2 (ja) 2012-01-07 2016-03-02 株式会社ボナック アミノ酸骨格を有する一本鎖核酸分子
JP7640461B2 (ja) 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法

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JPS60105692A (ja) * 1983-11-14 1985-06-11 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
US6111095A (en) * 1995-06-07 2000-08-29 Merck & Co., Inc. Capped synthetic RNA, analogs, and aptamers
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
US8158775B2 (en) * 2006-02-27 2012-04-17 Nippon Shinyaku Co., Ltd. Method for detaching protecting group on nucleic acid
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
ES2586683T3 (es) * 2009-09-16 2016-10-18 Wave Life Sciences Japan, Inc. Grupo protector novedoso para sintetizar ARN y derivados del mismo
JP5847700B2 (ja) * 2010-03-05 2016-01-27 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ リボヌクレオシドホスホロチオエートの製造方法
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
EP3450439B8 (en) 2016-04-26 2021-06-30 Sumitomo Chemical Company, Limited Method for producing monomer for single-stranded nucleic acid molecule
JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
JP7412890B2 (ja) 2019-03-26 2024-01-15 株式会社小松製作所 油圧機器の検査装置、油圧機器の検査システム、作業車両および油圧機器の検査方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5555346B2 (ja) 2010-08-03 2014-07-23 株式会社ボナック 含窒素脂環式骨格を有する一本鎖核酸分子
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
JP5876890B2 (ja) 2012-01-07 2016-03-02 株式会社ボナック アミノ酸骨格を有する一本鎖核酸分子
JP7640461B2 (ja) 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
公益社団法人 日本化学会，化学便覧 応用化学編 第７版，丸善出版株式会社，2014年，第５０４，５０５頁

Also Published As

Publication number Publication date
CN116209668A (zh) 2023-06-02
JPWO2022064908A1 (https=) 2022-03-31
WO2022064908A1 (ja) 2022-03-31
KR20230074205A (ko) 2023-05-26
EP4219520A4 (en) 2024-09-18
US20240051986A1 (en) 2024-02-15
EP4219520A1 (en) 2023-08-02

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