CN116209668A - 核酸寡聚物的制造方法 - Google Patents

核酸寡聚物的制造方法 Download PDF

Info

Publication number
CN116209668A
CN116209668A CN202180064903.4A CN202180064903A CN116209668A CN 116209668 A CN116209668 A CN 116209668A CN 202180064903 A CN202180064903 A CN 202180064903A CN 116209668 A CN116209668 A CN 116209668A
Authority
CN
China
Prior art keywords
formula
nucleic acid
group
production method
acid oligomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180064903.4A
Other languages
English (en)
Chinese (zh)
Inventor
宫川卓也
奥村英贵
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of CN116209668A publication Critical patent/CN116209668A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN202180064903.4A 2020-09-24 2021-08-19 核酸寡聚物的制造方法 Pending CN116209668A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-159460 2020-09-24
JP2020159460 2020-09-24
PCT/JP2021/030423 WO2022064908A1 (ja) 2020-09-24 2021-08-19 核酸オリゴマーの製造方法

Publications (1)

Publication Number Publication Date
CN116209668A true CN116209668A (zh) 2023-06-02

Family

ID=80845119

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180064903.4A Pending CN116209668A (zh) 2020-09-24 2021-08-19 核酸寡聚物的制造方法

Country Status (6)

Country Link
US (1) US20240051986A1 (https=)
EP (1) EP4219520A4 (https=)
JP (1) JP7719788B2 (https=)
KR (1) KR20230074205A (https=)
CN (1) CN116209668A (https=)
WO (1) WO2022064908A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114502566A (zh) * 2019-10-11 2022-05-13 住友化学株式会社 核酸寡聚物的制造方法
CN115003682A (zh) * 2020-01-29 2022-09-02 住友化学株式会社 核酸寡聚物的制造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240162536A (ko) * 2022-03-23 2024-11-15 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60105692A (ja) * 1983-11-14 1985-06-11 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
US20070282097A1 (en) * 2004-08-26 2007-12-06 Nippon Shinyaku Co., Ltd. Phosphoramidite Compound And Method For Producing Oligo-Rna
US20090149645A1 (en) * 2006-02-27 2009-06-11 Nippon Shinyaku Co., Ltd. Method for detaching protecting group on nucleic acid
US20110178284A1 (en) * 2009-09-16 2011-07-21 Chiralgen, Ltd. Novel protective group for synthesis of RNA and derivative
CN102918052A (zh) * 2010-03-05 2013-02-06 国立大学法人东京大学 硫代磷酸核糖核苷的制造方法
CN103052711A (zh) * 2010-08-03 2013-04-17 株式会社博纳克 具有含氮脂环式骨架的单链核酸分子
CN103906758A (zh) * 2011-08-25 2014-07-02 株式会社博纳克 配糖体化合物、硫醚的制造方法、醚、醚的制造方法、配糖体化合物的制造方法及核酸的制造方法
CN104039961A (zh) * 2012-01-07 2014-09-10 株式会社博纳克 具有氨基酸骨架的单链核酸分子
CN114502566A (zh) * 2019-10-11 2022-05-13 住友化学株式会社 核酸寡聚物的制造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111095A (en) * 1995-06-07 2000-08-29 Merck & Co., Inc. Capped synthetic RNA, analogs, and aptamers
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
DK1149109T3 (da) 1999-02-05 2010-01-11 Ge Healthcare Bio Sciences Fremgangsmåde til afbeskyttelse af oligonukleotider
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
WO2008049085A1 (en) 2006-10-18 2008-04-24 Isis Pharmaceuticals, Inc. Antisense compounds
HUE037500T2 (hu) 2010-07-08 2018-08-28 Bonac Corp Egyszálú nukleinsav molekula a génexpresszió szabályozására
US8691782B2 (en) 2010-08-03 2014-04-08 Bonac Corporation Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
EP3241902B1 (en) 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
US10900034B2 (en) 2014-12-03 2021-01-26 Agilent Technologies, Inc. Guide RNA with chemical modifications
JP6787398B2 (ja) 2016-04-26 2020-11-18 住友化学株式会社 一本鎖核酸分子用モノマーの製造方法
EP3604528A4 (en) 2017-03-31 2021-01-13 Bonac Corporation CYCLIC NUCLEIC ACID MOLECULE WITH GENE EXPRESSION CONTROL FUNCTION
KR20250046363A (ko) 2017-09-19 2025-04-02 알닐람 파마슈티칼스 인코포레이티드 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
JP7412890B2 (ja) 2019-03-26 2024-01-15 株式会社小松製作所 油圧機器の検査装置、油圧機器の検査システム、作業車両および油圧機器の検査方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60105692A (ja) * 1983-11-14 1985-06-11 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
US20070282097A1 (en) * 2004-08-26 2007-12-06 Nippon Shinyaku Co., Ltd. Phosphoramidite Compound And Method For Producing Oligo-Rna
US20090149645A1 (en) * 2006-02-27 2009-06-11 Nippon Shinyaku Co., Ltd. Method for detaching protecting group on nucleic acid
US20110178284A1 (en) * 2009-09-16 2011-07-21 Chiralgen, Ltd. Novel protective group for synthesis of RNA and derivative
CN102918052A (zh) * 2010-03-05 2013-02-06 国立大学法人东京大学 硫代磷酸核糖核苷的制造方法
CN103052711A (zh) * 2010-08-03 2013-04-17 株式会社博纳克 具有含氮脂环式骨架的单链核酸分子
CN103906758A (zh) * 2011-08-25 2014-07-02 株式会社博纳克 配糖体化合物、硫醚的制造方法、醚、醚的制造方法、配糖体化合物的制造方法及核酸的制造方法
CN104039961A (zh) * 2012-01-07 2014-09-10 株式会社博纳克 具有氨基酸骨架的单链核酸分子
CN114502566A (zh) * 2019-10-11 2022-05-13 住友化学株式会社 核酸寡聚物的制造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
公益社团法人: "《化学便览 应用化学编》", vol. 7, 31 December 2014, 丸善出版株式会社, pages: 504 - 505 *
张军良 等: "《有机化学合成方法》", vol. 2011, 31 January 2011, 中国医药科技出版社, pages: 86 *
黄恩才 等: "《化学反应工程》", vol. 1996, 30 June 1996, 化学工业出版社, pages: 85 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114502566A (zh) * 2019-10-11 2022-05-13 住友化学株式会社 核酸寡聚物的制造方法
CN114502566B (zh) * 2019-10-11 2025-02-11 住友化学株式会社 核酸寡聚物的制造方法
US12509483B2 (en) 2019-10-11 2025-12-30 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomers
CN115003682A (zh) * 2020-01-29 2022-09-02 住友化学株式会社 核酸寡聚物的制造方法

Also Published As

Publication number Publication date
KR20230074205A (ko) 2023-05-26
JP7719788B2 (ja) 2025-08-06
US20240051986A1 (en) 2024-02-15
EP4219520A4 (en) 2024-09-18
WO2022064908A1 (ja) 2022-03-31
EP4219520A1 (en) 2023-08-02
JPWO2022064908A1 (https=) 2022-03-31

Similar Documents

Publication Publication Date Title
CN103068834B (zh) 用于反向合成rna的亚磷酰胺
US5449769A (en) Method and reagent for sulfurization of organophosphorous compounds
CN114502566B (zh) 核酸寡聚物的制造方法
US11400161B2 (en) Method of conjugating oligomeric compounds
KR102190852B1 (ko) 변형된 커플링 프로토콜을 이용하는 올리고머 화합물의 제조 방법
CN116209668A (zh) 核酸寡聚物的制造方法
JP7698631B2 (ja) 核酸オリゴマーの製造方法
JP7759323B2 (ja) 核酸オリゴマーの製造方法
US7002006B2 (en) Protection of nucleosides
EP4563559A1 (en) Thionizing solution
EP4559925A1 (en) Production method of oligonucleotide
CN117980285A (zh) 纯化二氯乙酸的制造方法
WO2026071145A1 (ja) 核酸オリゴマーの製造方法
CN120418262A (zh) 寡核苷酸的制造方法
CN119948043A (zh) 寡核苷酸的制造方法
WO2026048956A1 (ja) 核酸オリゴマーの製造方法
Thorpe Reviving H-phosphonate Chemistry: Novel Methods for Sustainable Oligonucleotide Synthesis
KR20250122396A (ko) 올리고뉴클레오티드 합성을 위한 개선된 방법
CN118891269A (zh) 核酸寡聚物的制造方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination