JPWO2021070494A1 - - Google Patents
Info
- Publication number
- JPWO2021070494A1 JPWO2021070494A1 JP2021550425A JP2021550425A JPWO2021070494A1 JP WO2021070494 A1 JPWO2021070494 A1 JP WO2021070494A1 JP 2021550425 A JP2021550425 A JP 2021550425A JP 2021550425 A JP2021550425 A JP 2021550425A JP WO2021070494 A1 JPWO2021070494 A1 JP WO2021070494A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019187930 | 2019-10-11 | ||
| JP2019187930 | 2019-10-11 | ||
| PCT/JP2020/032020 WO2021070494A1 (ja) | 2019-10-11 | 2020-08-25 | 核酸オリゴマーの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021070494A1 true JPWO2021070494A1 (https=) | 2021-04-15 |
| JPWO2021070494A5 JPWO2021070494A5 (https=) | 2023-08-04 |
| JP7640461B2 JP7640461B2 (ja) | 2025-03-05 |
Family
ID=75437077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021550425A Active JP7640461B2 (ja) | 2019-10-11 | 2020-08-25 | 核酸オリゴマーの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12509483B2 (https=) |
| EP (1) | EP4043473A4 (https=) |
| JP (1) | JP7640461B2 (https=) |
| KR (1) | KR20220079832A (https=) |
| CN (1) | CN114502566B (https=) |
| WO (1) | WO2021070494A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230312635A1 (en) * | 2020-01-29 | 2023-10-05 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
| JP7719788B2 (ja) * | 2020-09-24 | 2025-08-06 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| CN118460647B (zh) * | 2024-07-10 | 2025-01-28 | 凯莱英医药集团（天津）股份有限公司 | 一种Patisiran的制备方法 |
| WO2026048956A1 (ja) * | 2024-08-29 | 2026-03-05 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| WO2026071145A1 (ja) * | 2024-09-30 | 2026-04-02 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007099896A1 (ja) * | 2006-02-27 | 2007-09-07 | Nippon Shinyaku Co., Ltd. | 核酸保護基の脱離方法 |
| WO2011034072A1 (ja) * | 2009-09-16 | 2011-03-24 | 株式会社キラルジェン | Rna及びその誘導体合成のための新規保護基 |
| WO2013027843A1 (ja) * | 2011-08-25 | 2013-02-28 | 株式会社ボナック | 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法 |
| WO2018070543A1 (ja) * | 2016-10-14 | 2018-04-19 | 株式会社ボナック | 新規な配糖体化合物及びその製造方法 |
| WO2019208571A1 (ja) * | 2018-04-24 | 2019-10-31 | 住友化学株式会社 | アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077709A (en) | 1998-09-29 | 2000-06-20 | Isis Pharmaceuticals Inc. | Antisense modulation of Survivin expression |
| DK1149109T3 (da) | 1999-02-05 | 2010-01-11 | Ge Healthcare Bio Sciences | Fremgangsmåde til afbeskyttelse af oligonukleotider |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| WO2005007825A2 (en) * | 2003-07-12 | 2005-01-27 | Isis Pharmaceuticals, Inc. | Modulation of aminopeptidase n expression |
| ES2386709T3 (es) | 2004-08-26 | 2012-08-27 | Nippon Shinyaku Co., Ltd. | Compuesto de fosforamidita y método para producir un oligo-ARN |
| WO2008049085A1 (en) | 2006-10-18 | 2008-04-24 | Isis Pharmaceuticals, Inc. | Antisense compounds |
| HUE037500T2 (hu) | 2010-07-08 | 2018-08-28 | Bonac Corp | Egyszálú nukleinsav molekula a génexpresszió szabályozására |
| ES2527660T3 (es) | 2010-08-03 | 2015-01-28 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| JP6459852B2 (ja) | 2014-08-29 | 2019-01-30 | 住友化学株式会社 | エーテル化合物の製造方法 |
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| JP6787398B2 (ja) | 2016-04-26 | 2020-11-18 | 住友化学株式会社 | 一本鎖核酸分子用モノマーの製造方法 |
| JP6803730B2 (ja) | 2016-11-22 | 2020-12-23 | 旭サナック株式会社 | 静電塗装装置 |
| EP3604528A4 (en) | 2017-03-31 | 2021-01-13 | Bonac Corporation | CYCLIC NUCLEIC ACID MOLECULE WITH GENE EXPRESSION CONTROL FUNCTION |
| KR20250046363A (ko) | 2017-09-19 | 2025-04-02 | 알닐람 파마슈티칼스 인코포레이티드 | 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법 |
| US20210188895A1 (en) | 2017-10-13 | 2021-06-24 | Bonac Corporation | Single-stranded nucleic acid molecule, and production method therefor |
| JP7207682B2 (ja) | 2018-04-26 | 2023-01-18 | 株式会社サンセイアールアンドディ | 遊技機 |
| EP4114384A1 (en) | 2020-03-06 | 2023-01-11 | Pfizer Inc. | Methods of inhibiting sars-cov-2 replication and treating coronavirus disease 2019 |
| JP7719788B2 (ja) * | 2020-09-24 | 2025-08-06 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
-
2020
- 2020-08-25 US US17/767,825 patent/US12509483B2/en active Active
- 2020-08-25 CN CN202080070607.0A patent/CN114502566B/zh active Active
- 2020-08-25 WO PCT/JP2020/032020 patent/WO2021070494A1/ja not_active Ceased
- 2020-08-25 JP JP2021550425A patent/JP7640461B2/ja active Active
- 2020-08-25 EP EP20875506.6A patent/EP4043473A4/en active Pending
- 2020-08-25 KR KR1020227010696A patent/KR20220079832A/ko active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007099896A1 (ja) * | 2006-02-27 | 2007-09-07 | Nippon Shinyaku Co., Ltd. | 核酸保護基の脱離方法 |
| WO2011034072A1 (ja) * | 2009-09-16 | 2011-03-24 | 株式会社キラルジェン | Rna及びその誘導体合成のための新規保護基 |
| WO2013027843A1 (ja) * | 2011-08-25 | 2013-02-28 | 株式会社ボナック | 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法 |
| WO2018070543A1 (ja) * | 2016-10-14 | 2018-04-19 | 株式会社ボナック | 新規な配糖体化合物及びその製造方法 |
| WO2019208571A1 (ja) * | 2018-04-24 | 2019-10-31 | 住友化学株式会社 | アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法 |
Non-Patent Citations (1)
| Title |
|---|
| OHGI,T. ET AL.: "Synthetic Method with a 2'-O-(2-Cyanoethoxymethyl) Protecting Group", ORGANIC LETTERS, vol. 7, no. 16, JPN6020040624, 2005, pages 3477 - 3480, ISSN: 0005426162 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220079832A (ko) | 2022-06-14 |
| EP4043473A4 (en) | 2024-03-27 |
| EP4043473A1 (en) | 2022-08-17 |
| US12509483B2 (en) | 2025-12-30 |
| JP7640461B2 (ja) | 2025-03-05 |
| WO2021070494A1 (ja) | 2021-04-15 |
| US20240116977A1 (en) | 2024-04-11 |
| CN114502566A (zh) | 2022-05-13 |
| CN114502566B (zh) | 2025-02-11 |
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