JP7640461B2 - 核酸オリゴマーの製造方法 - Google Patents

核酸オリゴマーの製造方法 Download PDF

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Publication number
JP7640461B2
JP7640461B2 JP2021550425A JP2021550425A JP7640461B2 JP 7640461 B2 JP7640461 B2 JP 7640461B2 JP 2021550425 A JP2021550425 A JP 2021550425A JP 2021550425 A JP2021550425 A JP 2021550425A JP 7640461 B2 JP7640461 B2 JP 7640461B2
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Japan
Prior art keywords
formula
group
nucleic acid
acid oligomer
protecting group
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Japanese (ja)
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JPWO2021070494A1 (https=
JPWO2021070494A5 (https=
Inventor
卓也 宮川
英貴 奥村
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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
JP2021550425A 2019-10-11 2020-08-25 核酸オリゴマーの製造方法 Active JP7640461B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019187930 2019-10-11
JP2019187930 2019-10-11
PCT/JP2020/032020 WO2021070494A1 (ja) 2019-10-11 2020-08-25 核酸オリゴマーの製造方法

Publications (3)

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JPWO2021070494A1 JPWO2021070494A1 (https=) 2021-04-15
JPWO2021070494A5 JPWO2021070494A5 (https=) 2023-08-04
JP7640461B2 true JP7640461B2 (ja) 2025-03-05

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Family Applications (1)

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JP2021550425A Active JP7640461B2 (ja) 2019-10-11 2020-08-25 核酸オリゴマーの製造方法

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US (1) US12509483B2 (https=)
EP (1) EP4043473A4 (https=)
JP (1) JP7640461B2 (https=)
KR (1) KR20220079832A (https=)
CN (1) CN114502566B (https=)
WO (1) WO2021070494A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022064908A1 (https=) * 2020-09-24 2022-03-31

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4098655A4 (en) * 2020-01-29 2024-02-28 Sumitomo Chemical Company, Limited METHOD FOR PRODUCING NUCLEIC ACID OLIGOMERS
CN118460647B (zh) * 2024-07-10 2025-01-28 凯莱英医药集团（天津）股份有限公司 一种Patisiran的制备方法
WO2026048956A1 (ja) * 2024-08-29 2026-03-05 住友化学株式会社 核酸オリゴマーの製造方法
WO2026071145A1 (ja) * 2024-09-30 2026-04-02 住友化学株式会社 核酸オリゴマーの製造方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099896A1 (ja) 2006-02-27 2007-09-07 Nippon Shinyaku Co., Ltd. 核酸保護基の脱離方法
WO2011034072A1 (ja) 2009-09-16 2011-03-24 株式会社キラルジェン Rna及びその誘導体合成のための新規保護基
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
WO2018070543A1 (ja) 2016-10-14 2018-04-19 株式会社ボナック 新規な配糖体化合物及びその製造方法
WO2019208571A1 (ja) 2018-04-24 2019-10-31 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
US20050075307A1 (en) * 2003-07-12 2005-04-07 Bennett C. Frank Modulation of aminopeptidase N expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
EP2639307B1 (en) 2010-08-03 2015-03-04 Bonac Corporation Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
CN105384668B (zh) 2014-08-29 2018-10-09 住友化学株式会社 用于制备醚化合物的方法
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
EP3450439B8 (en) 2016-04-26 2021-06-30 Sumitomo Chemical Company, Limited Method for producing monomer for single-stranded nucleic acid molecule
JP6803730B2 (ja) 2016-11-22 2020-12-23 旭サナック株式会社 静電塗装装置
JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
JP7207682B2 (ja) 2018-04-26 2023-01-18 株式会社サンセイアールアンドディ 遊技機
US20230157998A1 (en) * 2020-03-06 2023-05-25 Pfizer Inc. Methods of Inhibiting SARS-CoV-2 Replication and Treating Corona Virus Disease 2019
KR20230074205A (ko) * 2020-09-24 2023-05-26 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099896A1 (ja) 2006-02-27 2007-09-07 Nippon Shinyaku Co., Ltd. 核酸保護基の脱離方法
WO2011034072A1 (ja) 2009-09-16 2011-03-24 株式会社キラルジェン Rna及びその誘導体合成のための新規保護基
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
WO2018070543A1 (ja) 2016-10-14 2018-04-19 株式会社ボナック 新規な配糖体化合物及びその製造方法
WO2019208571A1 (ja) 2018-04-24 2019-10-31 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
OHGI,T. et al.，Synthetic Method with a 2'-O-(2-Cyanoethoxymethyl) Protecting Group，Organic Letters，2005年，Vol.7, No.16，pp.3477-3480，DOI 10.1021/ol051151f

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022064908A1 (https=) * 2020-09-24 2022-03-31
JP7719788B2 (ja) 2020-09-24 2025-08-06 住友化学株式会社 核酸オリゴマーの製造方法

Also Published As

Publication number Publication date
JPWO2021070494A1 (https=) 2021-04-15
CN114502566A (zh) 2022-05-13
EP4043473A4 (en) 2024-03-27
US12509483B2 (en) 2025-12-30
CN114502566B (zh) 2025-02-11
KR20220079832A (ko) 2022-06-14
EP4043473A1 (en) 2022-08-17
WO2021070494A1 (ja) 2021-04-15
US20240116977A1 (en) 2024-04-11

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