JP7640461B2 - 核酸オリゴマーの製造方法 - Google Patents

核酸オリゴマーの製造方法 Download PDF

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Publication number
JP7640461B2
JP7640461B2 JP2021550425A JP2021550425A JP7640461B2 JP 7640461 B2 JP7640461 B2 JP 7640461B2 JP 2021550425 A JP2021550425 A JP 2021550425A JP 2021550425 A JP2021550425 A JP 2021550425A JP 7640461 B2 JP7640461 B2 JP 7640461B2
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Prior art keywords
formula
group
nucleic acid
acid oligomer
protecting group
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Japanese (ja)
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JPWO2021070494A5 (https=
JPWO2021070494A1 (https=
Inventor
卓也 宮川
英貴 奥村
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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
JP2021550425A 2019-10-11 2020-08-25 核酸オリゴマーの製造方法 Active JP7640461B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019187930 2019-10-11
JP2019187930 2019-10-11
PCT/JP2020/032020 WO2021070494A1 (ja) 2019-10-11 2020-08-25 核酸オリゴマーの製造方法

Publications (3)

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JPWO2021070494A1 JPWO2021070494A1 (https=) 2021-04-15
JPWO2021070494A5 JPWO2021070494A5 (https=) 2023-08-04
JP7640461B2 true JP7640461B2 (ja) 2025-03-05

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Family Applications (1)

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JP2021550425A Active JP7640461B2 (ja) 2019-10-11 2020-08-25 核酸オリゴマーの製造方法

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US (1) US12509483B2 (https=)
EP (1) EP4043473A4 (https=)
JP (1) JP7640461B2 (https=)
KR (1) KR20220079832A (https=)
CN (1) CN114502566B (https=)
WO (1) WO2021070494A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022064908A1 (https=) * 2020-09-24 2022-03-31

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230312635A1 (en) * 2020-01-29 2023-10-05 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
CN118460647B (zh) * 2024-07-10 2025-01-28 凯莱英医药集团（天津）股份有限公司 一种Patisiran的制备方法
WO2026048956A1 (ja) * 2024-08-29 2026-03-05 住友化学株式会社 核酸オリゴマーの製造方法
WO2026071145A1 (ja) * 2024-09-30 2026-04-02 住友化学株式会社 核酸オリゴマーの製造方法

Citations (5)

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WO2007099896A1 (ja) 2006-02-27 2007-09-07 Nippon Shinyaku Co., Ltd. 核酸保護基の脱離方法
WO2011034072A1 (ja) 2009-09-16 2011-03-24 株式会社キラルジェン Rna及びその誘導体合成のための新規保護基
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
WO2018070543A1 (ja) 2016-10-14 2018-04-19 株式会社ボナック 新規な配糖体化合物及びその製造方法
WO2019208571A1 (ja) 2018-04-24 2019-10-31 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法

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US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
DK1149109T3 (da) 1999-02-05 2010-01-11 Ge Healthcare Bio Sciences Fremgangsmåde til afbeskyttelse af oligonukleotider
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
WO2005007825A2 (en) * 2003-07-12 2005-01-27 Isis Pharmaceuticals, Inc. Modulation of aminopeptidase n expression
ES2386709T3 (es) 2004-08-26 2012-08-27 Nippon Shinyaku Co., Ltd. Compuesto de fosforamidita y método para producir un oligo-ARN
WO2008049085A1 (en) 2006-10-18 2008-04-24 Isis Pharmaceuticals, Inc. Antisense compounds
HUE037500T2 (hu) 2010-07-08 2018-08-28 Bonac Corp Egyszálú nukleinsav molekula a génexpresszió szabályozására
ES2527660T3 (es) 2010-08-03 2015-01-28 Bonac Corporation Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno
EP3241902B1 (en) 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
JP6459852B2 (ja) 2014-08-29 2019-01-30 住友化学株式会社 エーテル化合物の製造方法
US10900034B2 (en) 2014-12-03 2021-01-26 Agilent Technologies, Inc. Guide RNA with chemical modifications
JP6787398B2 (ja) 2016-04-26 2020-11-18 住友化学株式会社 一本鎖核酸分子用モノマーの製造方法
JP6803730B2 (ja) 2016-11-22 2020-12-23 旭サナック株式会社 静電塗装装置
EP3604528A4 (en) 2017-03-31 2021-01-13 Bonac Corporation CYCLIC NUCLEIC ACID MOLECULE WITH GENE EXPRESSION CONTROL FUNCTION
KR20250046363A (ko) 2017-09-19 2025-04-02 알닐람 파마슈티칼스 인코포레이티드 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099896A1 (ja) 2006-02-27 2007-09-07 Nippon Shinyaku Co., Ltd. 核酸保護基の脱離方法
WO2011034072A1 (ja) 2009-09-16 2011-03-24 株式会社キラルジェン Rna及びその誘導体合成のための新規保護基
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
WO2018070543A1 (ja) 2016-10-14 2018-04-19 株式会社ボナック 新規な配糖体化合物及びその製造方法
WO2019208571A1 (ja) 2018-04-24 2019-10-31 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法

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OHGI,T. et al.，Synthetic Method with a 2'-O-(2-Cyanoethoxymethyl) Protecting Group，Organic Letters，2005年，Vol.7, No.16，pp.3477-3480，DOI 10.1021/ol051151f

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022064908A1 (https=) * 2020-09-24 2022-03-31
JP7719788B2 (ja) 2020-09-24 2025-08-06 住友化学株式会社 核酸オリゴマーの製造方法

Also Published As

Publication number Publication date
KR20220079832A (ko) 2022-06-14
EP4043473A4 (en) 2024-03-27
JPWO2021070494A1 (https=) 2021-04-15
EP4043473A1 (en) 2022-08-17
US12509483B2 (en) 2025-12-30
WO2021070494A1 (ja) 2021-04-15
US20240116977A1 (en) 2024-04-11
CN114502566A (zh) 2022-05-13
CN114502566B (zh) 2025-02-11

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