CN114502566B - 核酸寡聚物的制造方法 - Google Patents

核酸寡聚物的制造方法 Download PDF

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Publication number
CN114502566B
CN114502566B CN202080070607.0A CN202080070607A CN114502566B CN 114502566 B CN114502566 B CN 114502566B CN 202080070607 A CN202080070607 A CN 202080070607A CN 114502566 B CN114502566 B CN 114502566B
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Prior art keywords
formula
group
nucleic acid
acid oligomer
protecting group
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CN202080070607.0A
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Chinese (zh)
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CN114502566A (zh
Inventor
宫川卓也
奥村英贵
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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN202080070607.0A 2019-10-11 2020-08-25 核酸寡聚物的制造方法 Active CN114502566B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019-187930 2019-10-11
JP2019187930 2019-10-11
PCT/JP2020/032020 WO2021070494A1 (ja) 2019-10-11 2020-08-25 核酸オリゴマーの製造方法

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CN114502566A CN114502566A (zh) 2022-05-13
CN114502566B true CN114502566B (zh) 2025-02-11

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CN202080070607.0A Active CN114502566B (zh) 2019-10-11 2020-08-25 核酸寡聚物的制造方法

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US (1) US12509483B2 (https=)
EP (1) EP4043473A4 (https=)
JP (1) JP7640461B2 (https=)
KR (1) KR20220079832A (https=)
CN (1) CN114502566B (https=)
WO (1) WO2021070494A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230312635A1 (en) * 2020-01-29 2023-10-05 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
JP7719788B2 (ja) * 2020-09-24 2025-08-06 住友化学株式会社 核酸オリゴマーの製造方法
CN118460647B (zh) * 2024-07-10 2025-01-28 凯莱英医药集团（天津）股份有限公司 一种Patisiran的制备方法
WO2026048956A1 (ja) * 2024-08-29 2026-03-05 住友化学株式会社 核酸オリゴマーの製造方法
WO2026071145A1 (ja) * 2024-09-30 2026-04-02 住友化学株式会社 核酸オリゴマーの製造方法

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CN112020507A (zh) * 2018-04-24 2020-12-01 住友化学株式会社 酰胺化合物及使用该化合物的多核苷酸的制造方法
TW202146012A (zh) * 2020-03-06 2021-12-16 美商輝瑞股份有限公司 抑制ＳＡＲＳ－ＣｏＶ－２複製和治療冠狀病毒疾病２０１９之方法
CN116209668A (zh) * 2020-09-24 2023-06-02 住友化学株式会社 核酸寡聚物的制造方法

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US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
WO2005007825A2 (en) * 2003-07-12 2005-01-27 Isis Pharmaceuticals, Inc. Modulation of aminopeptidase n expression
ES2386709T3 (es) 2004-08-26 2012-08-27 Nippon Shinyaku Co., Ltd. Compuesto de fosforamidita y método para producir un oligo-ARN
US8158775B2 (en) 2006-02-27 2012-04-17 Nippon Shinyaku Co., Ltd. Method for detaching protecting group on nucleic acid
WO2008049085A1 (en) 2006-10-18 2008-04-24 Isis Pharmaceuticals, Inc. Antisense compounds
EP2479182B8 (en) * 2009-09-16 2016-07-13 Wave Life Sciences Japan, Inc. Novel protecting group for synthesizing rna and derivative thereof
HUE037500T2 (hu) 2010-07-08 2018-08-28 Bonac Corp Egyszálú nukleinsav molekula a génexpresszió szabályozására
ES2527660T3 (es) 2010-08-03 2015-01-28 Bonac Corporation Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
EP3241902B1 (en) 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
JP6459852B2 (ja) 2014-08-29 2019-01-30 住友化学株式会社 エーテル化合物の製造方法
US10900034B2 (en) 2014-12-03 2021-01-26 Agilent Technologies, Inc. Guide RNA with chemical modifications
JP6787398B2 (ja) 2016-04-26 2020-11-18 住友化学株式会社 一本鎖核酸分子用モノマーの製造方法
EP3527578A4 (en) 2016-10-14 2020-07-15 Bonac Corporation NOVEL GLYCOSIDE COMPOUND AND PROCESS FOR PRODUCING THE SAME
JP6803730B2 (ja) 2016-11-22 2020-12-23 旭サナック株式会社 静電塗装装置
EP3604528A4 (en) 2017-03-31 2021-01-13 Bonac Corporation CYCLIC NUCLEIC ACID MOLECULE WITH GENE EXPRESSION CONTROL FUNCTION
KR20250046363A (ko) 2017-09-19 2025-04-02 알닐람 파마슈티칼스 인코포레이티드 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
JP7207682B2 (ja) 2018-04-26 2023-01-18 株式会社サンセイアールアンドディ 遊技機

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112020507A (zh) * 2018-04-24 2020-12-01 住友化学株式会社 酰胺化合物及使用该化合物的多核苷酸的制造方法
TW202146012A (zh) * 2020-03-06 2021-12-16 美商輝瑞股份有限公司 抑制ＳＡＲＳ－ＣｏＶ－２複製和治療冠狀病毒疾病２０１９之方法
CN116209668A (zh) * 2020-09-24 2023-06-02 住友化学株式会社 核酸寡聚物的制造方法

Also Published As

Publication number Publication date
KR20220079832A (ko) 2022-06-14
EP4043473A4 (en) 2024-03-27
JPWO2021070494A1 (https=) 2021-04-15
EP4043473A1 (en) 2022-08-17
US12509483B2 (en) 2025-12-30
JP7640461B2 (ja) 2025-03-05
WO2021070494A1 (ja) 2021-04-15
US20240116977A1 (en) 2024-04-11
CN114502566A (zh) 2022-05-13

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