SG11202106124UA - Modified rhodamine dye and use thereof in biological assays - Google Patents
Modified rhodamine dye and use thereof in biological assaysInfo
- Publication number
- SG11202106124UA SG11202106124UA SG11202106124UA SG11202106124UA SG11202106124UA SG 11202106124U A SG11202106124U A SG 11202106124UA SG 11202106124U A SG11202106124U A SG 11202106124UA SG 11202106124U A SG11202106124U A SG 11202106124UA SG 11202106124U A SG11202106124U A SG 11202106124UA
- Authority
- SG
- Singapore
- Prior art keywords
- biological assays
- rhodamine dye
- modified rhodamine
- modified
- dye
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/10—Amino derivatives of triarylmethanes
- C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6846—Common amplification features
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862782465P | 2018-12-20 | 2018-12-20 | |
PCT/US2019/067925 WO2020132487A1 (en) | 2018-12-20 | 2019-12-20 | Modified rhodamine dye and use thereof in biological assays |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202106124UA true SG11202106124UA (en) | 2021-07-29 |
Family
ID=69326668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202106124UA SG11202106124UA (en) | 2018-12-20 | 2019-12-20 | Modified rhodamine dye and use thereof in biological assays |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220056041A1 (en) |
EP (1) | EP3898842A1 (en) |
JP (1) | JP2022514397A (en) |
KR (1) | KR20210107737A (en) |
CN (1) | CN113614182A (en) |
AU (1) | AU2019403406A1 (en) |
BR (1) | BR112021012146A2 (en) |
CA (1) | CA3124333A1 (en) |
MX (1) | MX2021007494A (en) |
SG (1) | SG11202106124UA (en) |
WO (1) | WO2020132487A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4185858A2 (en) | 2020-07-23 | 2023-05-31 | Life Technologies Corporation | Compositions, systems and methods for biological analysis using dyes |
CA3186955A1 (en) | 2020-07-23 | 2022-01-27 | Scott Benson | Energy transfer dye conjugates for use in biological assays |
KR20230082741A (en) | 2021-12-01 | 2023-06-09 | 한국생산기술연구원 | Rodamine dye for detecting acid gas capable of radical polymerization and manufacturing method of the same |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
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US191A (en) | 1837-05-08 | Machine for facing and dressing stone | ||
US5231A (en) | 1847-08-07 | Improvement in combining a rocking-chair and fan | ||
US162A (en) | 1837-04-17 | Island | ||
US5847A (en) | 1848-10-10 | Wheel for spinning | ||
US4481136A (en) | 1979-09-07 | 1984-11-06 | Syva Company | Alkyl substituted fluorescent compounds and conjugates |
DE3071373D1 (en) | 1980-10-27 | 1986-03-06 | Syva Co | Novel ether substituted fluorescein compounds as fluorescers and quenchers |
US4439356A (en) | 1981-03-03 | 1984-03-27 | Syva Company | Unsymmetrical fluorescein derivatives |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5151507A (en) | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
US5066580A (en) | 1988-08-31 | 1991-11-19 | Becton Dickinson And Company | Xanthene dyes that emit to the red of fluorescein |
US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
US5227487A (en) | 1990-04-16 | 1993-07-13 | Molecular Probes, Inc. | Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes |
US5750409A (en) | 1991-11-18 | 1998-05-12 | Boehringer Mannheim Gmbh | Pentacyclic compounds and their use as absorption or fluorescent dyes |
US5599666A (en) | 1994-03-28 | 1997-02-04 | Promega Corporation | Allelic ladders for short tandem repeat loci |
US7008771B1 (en) | 1994-09-30 | 2006-03-07 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
US5654441A (en) | 1995-09-14 | 1997-08-05 | Uniroyal Chemical Ltd./Ltee | Synthesis of 1,3-oxathiolane sulfoxide compounds |
US6020481A (en) | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
US5863727A (en) | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US6017712A (en) | 1996-06-27 | 2000-01-25 | Lee; Linda | 4,7-dichlororhodamine dyes |
US6080852A (en) | 1996-06-27 | 2000-06-27 | The Perkin-Elmer Corporation | 4,7-dichlororhodamine dyes |
US5821356A (en) | 1996-08-12 | 1998-10-13 | The Perkin Elmer Corporation | Propargylethoxyamino nucleotides |
US6008379A (en) | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
US5936087A (en) | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
US5948648A (en) | 1998-05-29 | 1999-09-07 | Khan; Shaheer H. | Nucleotide compounds including a rigid linker |
US6605434B1 (en) * | 1999-03-16 | 2003-08-12 | Human Genome Sciences, Inc. | Direct bacterial lysate sequencing |
US6248884B1 (en) | 1999-06-03 | 2001-06-19 | The Perkin-Elmer Corporation | Extended rhodamine compounds useful as fluorescent labels |
US6358684B1 (en) | 1999-08-27 | 2002-03-19 | Pe Corporation | UV excitable fluorescent energy transfer dyes |
US6221604B1 (en) | 2000-02-07 | 2001-04-24 | Pe Corporation | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes |
EP1317464B1 (en) | 2000-10-11 | 2009-05-13 | Applera Corporation | Fluorescent nucleobase conjugates having anionic linkers |
US6780588B2 (en) | 2001-05-07 | 2004-08-24 | Applera Corporation | Methods for the reduction of stutter in microsatellite amplification |
BR0307905A (en) | 2002-02-22 | 2006-04-04 | Bayer Pharmaceuticals Corp | benzothiophene and benzofuran derivatives useful in the treatment of hyperproliferative disorders |
WO2006132588A1 (en) * | 2005-06-10 | 2006-12-14 | Quiatech Ab | Method for the purification of synthetic oligonucleotides containing one or several labels |
EP2640848A1 (en) | 2010-11-15 | 2013-09-25 | Life Technologies Corporation | Methods and kits for multiplex amplification of short tandem repeat loci |
US8828678B2 (en) * | 2010-11-16 | 2014-09-09 | Enzo Life Sciences, Inc. | Self-immolative probes for enzyme activity detection |
EP3670523B1 (en) * | 2011-09-13 | 2021-08-11 | Agilent Technologies, Inc. | 3'-oh unblocked, fast photocleavable terminating nucleotides and their use in methods for nucleic acid sequencing |
CN104220438B (en) * | 2012-01-30 | 2017-03-08 | 香港大学 | For detecting the diaryl amine base fluorescent probe of peroxynitrite |
JP2017532348A (en) * | 2014-10-17 | 2017-11-02 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション | Novel small molecule anticancer agent |
CN107459482B (en) * | 2016-06-03 | 2020-11-17 | 华东理工大学 | Nitric oxide donors, their preparation and use |
-
2019
- 2019-12-20 EP EP19842961.5A patent/EP3898842A1/en active Pending
- 2019-12-20 JP JP2021535711A patent/JP2022514397A/en active Pending
- 2019-12-20 AU AU2019403406A patent/AU2019403406A1/en active Pending
- 2019-12-20 US US17/299,706 patent/US20220056041A1/en active Pending
- 2019-12-20 SG SG11202106124UA patent/SG11202106124UA/en unknown
- 2019-12-20 BR BR112021012146-3A patent/BR112021012146A2/en not_active Application Discontinuation
- 2019-12-20 CA CA3124333A patent/CA3124333A1/en active Pending
- 2019-12-20 WO PCT/US2019/067925 patent/WO2020132487A1/en unknown
- 2019-12-20 MX MX2021007494A patent/MX2021007494A/en unknown
- 2019-12-20 CN CN201980084874.0A patent/CN113614182A/en active Pending
- 2019-12-20 KR KR1020217022585A patent/KR20210107737A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA3124333A1 (en) | 2020-06-25 |
EP3898842A1 (en) | 2021-10-27 |
JP2022514397A (en) | 2022-02-10 |
CN113614182A (en) | 2021-11-05 |
MX2021007494A (en) | 2021-10-13 |
US20220056041A1 (en) | 2022-02-24 |
AU2019403406A1 (en) | 2021-07-01 |
WO2020132487A1 (en) | 2020-06-25 |
KR20210107737A (en) | 2021-09-01 |
BR112021012146A2 (en) | 2021-08-31 |
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