JP2012528184A5 - - Google Patents
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- JP2012528184A5 JP2012528184A5 JP2012513237A JP2012513237A JP2012528184A5 JP 2012528184 A5 JP2012528184 A5 JP 2012528184A5 JP 2012513237 A JP2012513237 A JP 2012513237A JP 2012513237 A JP2012513237 A JP 2012513237A JP 2012528184 A5 JP2012528184 A5 JP 2012528184A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- composition according
- dose
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 25
- 238000012423 maintenance Methods 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- -1 3,4-dimethylphenyl Chemical group 0.000 claims 7
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 claims 6
- 206010043554 thrombocytopenia Diseases 0.000 claims 6
- 229940126214 compound 3 Drugs 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 208000004235 neutropenia Diseases 0.000 claims 4
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims 2
- 108010092408 Eosinophil Peroxidase Proteins 0.000 claims 2
- 102100028471 Eosinophil peroxidase Human genes 0.000 claims 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 claims 2
- 108090001007 Interleukin-8 Proteins 0.000 claims 2
- 102000004890 Interleukin-8 Human genes 0.000 claims 2
- PLILLUUXAVKBPY-SBIAVEDLSA-N NCCO.NCCO.CC1=NN(C=2C=C(C)C(C)=CC=2)C(=O)\C1=N/NC(C=1O)=CC=CC=1C1=CC=CC(C(O)=O)=C1 Chemical compound NCCO.NCCO.CC1=NN(C=2C=C(C)C(C)=CC=2)C(=O)\C1=N/NC(C=1O)=CC=CC=1C1=CC=CC(C(O)=O)=C1 PLILLUUXAVKBPY-SBIAVEDLSA-N 0.000 claims 2
- 102100027188 Thyroid peroxidase Human genes 0.000 claims 2
- 101710113649 Thyroid peroxidase Proteins 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000001483 mobilizing effect Effects 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- SVOQIEJWJCQGDQ-UHFFFAOYSA-N 3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid Chemical compound CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C SVOQIEJWJCQGDQ-UHFFFAOYSA-N 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims 1
- 229940124184 Interleukin receptor agonist Drugs 0.000 claims 1
- 101710177504 Kit ligand Proteins 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000409 cytokine receptor agonist Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 108700014844 flt3 ligand Proteins 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18214809P | 2009-05-29 | 2009-05-29 | |
| US61/182,148 | 2009-05-29 | ||
| PCT/US2010/036294 WO2010138656A1 (en) | 2009-05-29 | 2010-05-27 | Methods of administration of thrombopoietin agonist compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015158039A Division JP2016020360A (ja) | 2009-05-29 | 2015-08-10 | トロンボポエチンアゴニスト化合物の投与の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012528184A JP2012528184A (ja) | 2012-11-12 |
| JP2012528184A5 true JP2012528184A5 (enExample) | 2013-07-11 |
Family
ID=43223061
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513237A Withdrawn JP2012528184A (ja) | 2009-05-29 | 2010-05-27 | トロンボポエチンアゴニスト化合物の投与の方法 |
| JP2015158039A Withdrawn JP2016020360A (ja) | 2009-05-29 | 2015-08-10 | トロンボポエチンアゴニスト化合物の投与の方法 |
| JP2017132914A Pending JP2017226668A (ja) | 2009-05-29 | 2017-07-06 | トロンボポエチンアゴニスト化合物の投与の方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015158039A Withdrawn JP2016020360A (ja) | 2009-05-29 | 2015-08-10 | トロンボポエチンアゴニスト化合物の投与の方法 |
| JP2017132914A Pending JP2017226668A (ja) | 2009-05-29 | 2017-07-06 | トロンボポエチンアゴニスト化合物の投与の方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8609693B2 (enExample) |
| EP (2) | EP2434894B1 (enExample) |
| JP (3) | JP2012528184A (enExample) |
| KR (1) | KR20120015355A (enExample) |
| CN (2) | CN104173337A (enExample) |
| AU (1) | AU2010254046C1 (enExample) |
| BR (1) | BRPI1014548A2 (enExample) |
| CA (1) | CA2763768A1 (enExample) |
| DK (1) | DK3127427T3 (enExample) |
| EA (2) | EA201690401A1 (enExample) |
| ES (2) | ES2782898T3 (enExample) |
| HU (1) | HUE049075T2 (enExample) |
| IL (1) | IL216365A (enExample) |
| MX (1) | MX2011012668A (enExample) |
| PL (2) | PL3127427T3 (enExample) |
| PT (2) | PT2434894T (enExample) |
| SG (1) | SG176088A1 (enExample) |
| SI (1) | SI3127427T1 (enExample) |
| WO (1) | WO2010138656A1 (enExample) |
| ZA (1) | ZA201108374B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045310A1 (en) * | 2008-10-16 | 2010-04-22 | Glaxosmithkline Llc | Method of treating thrombocytopenia |
| PT2434894T (pt) | 2009-05-29 | 2016-11-29 | Novartis Ag | Métodos de administração de compostos agonistas de trombopoietina |
Family Cites Families (68)
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|---|---|---|---|---|
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| US2809963A (en) | 1954-10-26 | 1957-10-15 | Ciba Ltd | Azo-dyestuffs |
| DE1046220B (de) | 1956-04-21 | 1958-12-11 | Bayer Ag | Verfahren zur Herstellung von Monoazofarbstoffen und deren Metallkomplexverbindungen |
| GB826207A (en) | 1956-07-23 | 1959-12-31 | Bayer Ag | ú´-ú´-dihydroxy-monoazo dyestuffs containing pyrrolidonyl residues and their metal complex compounds |
| US2950273A (en) | 1956-11-20 | 1960-08-23 | Agfa Ag | Process for the production of symmetrical and unsymmetrical azo compounds |
| US3366619A (en) | 1965-04-09 | 1968-01-30 | Interchem Corp | Disazo pyrazolone pigments |
| US4435417A (en) | 1981-02-20 | 1984-03-06 | Gruppo Lepetit S.P.A. | Antiinflammatory 3H-naphtho[1,2-d]imidazoles |
| ES523609A0 (es) | 1982-07-05 | 1985-03-01 | Erba Farmitalia | Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. |
| FR2559483B1 (fr) | 1984-02-10 | 1986-12-05 | Sandoz Sa | Composes heterocycliques contenant des groupes basiques et/ou cationiques, leur preparation et leur utilisation comme colorants |
| US4582831A (en) | 1984-11-16 | 1986-04-15 | Pfizer Inc. | Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor |
| FI91869C (fi) | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
| US4880788A (en) | 1987-10-30 | 1989-11-14 | Baylor College Of Medicine | Method for preventing and treating thrombosis |
| US5326776A (en) | 1992-03-02 | 1994-07-05 | Abbott Laboratories | Angiotensin II receptor antagonists |
| IL109570A0 (en) | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
| EP0638617A1 (de) | 1993-08-13 | 1995-02-15 | Ciba-Geigy Ag | Pigmentsalze |
| EP0661170B1 (en) | 1993-12-28 | 1998-09-02 | Dai Nippon Printing Co., Ltd. | Thermal transfer sheet |
| US5482546A (en) | 1994-03-30 | 1996-01-09 | Canon Kabushiki Kaisha | Dye, ink containing the same, and ink-jet recording method and instrument using the ink |
| TW496870B (en) | 1994-03-31 | 2002-08-01 | Amgen Inc | Compositions methods for stimulating megakaryocyte growth and differentiation |
| US5760038A (en) | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
| US5746821A (en) | 1995-02-13 | 1998-05-05 | Engelhard Corporation | Pigment compositions |
| PT885242E (pt) | 1995-06-07 | 2008-06-18 | Glaxo Group Ltd | Péptidos e compostos que se ligam a um receptor de trombopoietina |
| US5622818A (en) | 1995-11-29 | 1997-04-22 | Eastman Kodak Company | Color photographic elements containing yellow colored magenta dye forming masking couplers |
| US5669967A (en) | 1996-05-30 | 1997-09-23 | Engelhard Corporation | Pigment compositions |
| US5932546A (en) | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
| SE9701398D0 (sv) | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
| GB9715830D0 (en) | 1997-07-25 | 1997-10-01 | Basf Ag | Reactive dyes containing piperazine |
| WO1999011262A1 (en) | 1997-09-02 | 1999-03-11 | Roche Diagnostics Gmbh | Mpl-receptor ligands, process for their preparation, medicaments containing them and their use for the treatment and prevention of thrombocytopaenia and anaemia |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| CA2308317A1 (en) | 1997-10-31 | 1999-05-14 | Smithkline Beecham Corporation | Novel metal complexes |
| DE19851389A1 (de) | 1998-11-07 | 2000-05-11 | Dystar Textilfarben Gmbh & Co | Gelbe Farbstoffmischungen von wasserlöslichen faserreaktiven Azofarbstoffen und ihre Verwendung |
| GC0000177A (en) | 1998-12-17 | 2006-03-29 | Smithkline Beecham | Thrombopoietin mimetics |
| CO5210907A1 (es) | 1999-05-12 | 2002-10-30 | Novartis Ag | Solvatos de pometrozina, insecticidamente activos, composiciones que contienen estos compuestos y metodos tanto para producir dichos compuestos y composiciones como para controlar plagas animales con estas composiciones |
| KR20020069183A (ko) | 1999-07-26 | 2002-08-29 | 시오노기세이야쿠가부시키가이샤 | 트롬보포이에틴 작동성을 나타내는 의약 조성물 |
| WO2001017349A1 (en) | 1999-09-10 | 2001-03-15 | Smithkline Beckman Corporation | Thrombopoietin mimetics |
| DE60032783T2 (de) | 1999-09-24 | 2007-12-06 | Smithkline Beecham Corp. | Thrombopoietinmimetika |
| AU1462201A (en) | 1999-11-05 | 2001-06-06 | Smithkline Beecham Corporation | Semicarbazone derivatives and their use as thrombopoietin mimetics |
| ES2160560T1 (es) | 1999-11-10 | 2001-11-16 | Curacyte Ag | Colorantes o,o'-dihidroxi-azoicos como constituyentes de medicamentos para el tratamiento de trombopenias. |
| TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
| US6436915B1 (en) | 2000-04-07 | 2002-08-20 | Kinetek Pharmaceuticals, Inc. | Pyrazole compounds |
| HUP0001417A2 (hu) | 2000-04-07 | 2002-12-28 | Sanofi-Synthelabo | Gyógyászatilag alkalmazható új sók, eljárás előállításukra és azokat tartalmazó gyógyászati készítmények |
| US6214813B1 (en) | 2000-04-07 | 2001-04-10 | Kinetek Pharmaceuticals, Inc. | Pyrazole compounds |
| CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
| WO2002049413A2 (en) | 2000-12-19 | 2002-06-27 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
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| WO2002059099A1 (en) | 2001-01-26 | 2002-08-01 | Shionogi & Co., Ltd. | Cyclic compounds having thrombopoietin receptor agonism |
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| JP3927001B2 (ja) | 2001-06-15 | 2007-06-06 | 三菱化学株式会社 | 色素セット、インクセット並びに記録方法 |
| CN1671379A (zh) | 2001-11-30 | 2005-09-21 | Qlt公司 | 亚肼基吡唑衍生物和它们作为治疗剂的用途 |
| WO2003074550A2 (en) | 2002-03-01 | 2003-09-12 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
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| AU2003248630A1 (en) | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| JP4317818B2 (ja) | 2002-09-30 | 2009-08-19 | アステラス製薬株式会社 | ２−アシルアミノチアゾール誘導体の新規な塩 |
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| JP4895807B2 (ja) | 2003-04-29 | 2012-03-14 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 変性疾患／損傷の治療方法 |
| TW200526638A (en) | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
| JP2009508476A (ja) * | 2005-08-31 | 2009-03-05 | セントカー・インコーポレーテツド | 高められたエフェクター機能をもつ抗体定常領域の製造用の宿主細胞株 |
| US20070202140A1 (en) * | 2005-12-22 | 2007-08-30 | Veltri Enrico P | Thrombin receptor antagonists as prophylaxis to complications from cardiopulmonary surgery |
| US20090304634A1 (en) | 2006-12-12 | 2009-12-10 | Smithkline Beecham Corporation | Novel Combinations |
| UY30915A1 (es) | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
| ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
| WO2009151862A1 (en) | 2008-05-15 | 2009-12-17 | Smithkline Beecham Corporation | Method of treatment |
| WO2010045310A1 (en) | 2008-10-16 | 2010-04-22 | Glaxosmithkline Llc | Method of treating thrombocytopenia |
| EP2427053A4 (en) | 2009-05-07 | 2012-12-05 | Glaxosmithkline Llc | METHOD FOR TREATING THROMBOCYTOPENIA |
| PT2434894T (pt) | 2009-05-29 | 2016-11-29 | Novartis Ag | Métodos de administração de compostos agonistas de trombopoietina |
| CN111399357A (zh) | 2015-04-11 | 2020-07-10 | 安田斯研究所有限公司 | 影像识别方法及记录媒介 |
-
2010
- 2010-05-27 PT PT107811762T patent/PT2434894T/pt unknown
- 2010-05-27 AU AU2010254046A patent/AU2010254046C1/en not_active Ceased
- 2010-05-27 BR BRPI1014548-6A patent/BRPI1014548A2/pt not_active Application Discontinuation
- 2010-05-27 CA CA2763768A patent/CA2763768A1/en not_active Abandoned
- 2010-05-27 EP EP10781176.2A patent/EP2434894B1/en active Active
- 2010-05-27 CN CN201410340066.5A patent/CN104173337A/zh active Pending
- 2010-05-27 KR KR1020117031236A patent/KR20120015355A/ko not_active Ceased
- 2010-05-27 EP EP16183711.7A patent/EP3127427B1/en not_active Revoked
- 2010-05-27 PL PL16183711T patent/PL3127427T3/pl unknown
- 2010-05-27 HU HUE16183711A patent/HUE049075T2/hu unknown
- 2010-05-27 JP JP2012513237A patent/JP2012528184A/ja not_active Withdrawn
- 2010-05-27 EA EA201690401A patent/EA201690401A1/ru unknown
- 2010-05-27 WO PCT/US2010/036294 patent/WO2010138656A1/en not_active Ceased
- 2010-05-27 US US13/321,577 patent/US8609693B2/en active Active
- 2010-05-27 ES ES16183711T patent/ES2782898T3/es active Active
- 2010-05-27 PL PL10781176T patent/PL2434894T3/pl unknown
- 2010-05-27 SG SG2011084191A patent/SG176088A1/en unknown
- 2010-05-27 EA EA201171462A patent/EA024557B1/ru not_active IP Right Cessation
- 2010-05-27 MX MX2011012668A patent/MX2011012668A/es active IP Right Grant
- 2010-05-27 PT PT161837117T patent/PT3127427T/pt unknown
- 2010-05-27 ES ES10781176.2T patent/ES2605593T3/es active Active
- 2010-05-27 CN CN2010800335467A patent/CN102458120A/zh active Pending
- 2010-05-27 DK DK16183711.7T patent/DK3127427T3/da active
- 2010-05-27 SI SI201031994T patent/SI3127427T1/sl unknown
-
2011
- 2011-11-14 IL IL216365A patent/IL216365A/en not_active IP Right Cessation
- 2011-11-15 ZA ZA2011/08374A patent/ZA201108374B/en unknown
-
2015
- 2015-08-10 JP JP2015158039A patent/JP2016020360A/ja not_active Withdrawn
-
2017
- 2017-07-06 JP JP2017132914A patent/JP2017226668A/ja active Pending
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