ES2160560T1 - Colorantes o,o'-dihidroxi-azoicos como constituyentes de medicamentos para el tratamiento de trombopenias. - Google Patents

Colorantes o,o'-dihidroxi-azoicos como constituyentes de medicamentos para el tratamiento de trombopenias.

Info

Publication number
ES2160560T1
ES2160560T1 ES99122346T ES99122346T ES2160560T1 ES 2160560 T1 ES2160560 T1 ES 2160560T1 ES 99122346 T ES99122346 T ES 99122346T ES 99122346 T ES99122346 T ES 99122346T ES 2160560 T1 ES2160560 T1 ES 2160560T1
Authority
ES
Spain
Prior art keywords
halogen
group
means hydrogen
alkyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES99122346T
Other languages
English (en)
Inventor
Edgar Dr Voss
Michael Dr Brandt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curacyte AG
Original Assignee
Curacyte AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curacyte AG filed Critical Curacyte AG
Publication of ES2160560T1 publication Critical patent/ES2160560T1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/49—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C309/50—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms having at least one of the sulfo groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Utilización de compuestos de la Fórmula general I X-N=N-Y (I) *** (Fórmula) *** en la que R1 significa hidroxi o un enlace con el grupo azo, R2 significa hidroxi o un enlace con el grupo azo cuando R1 corresponde a un grupo hidroxi, R3 significa hidrógeno, halógeno, alquilo C1-C4, alcoxi C1-C4 o una amida de ácido carboxílico que en el nitrógeno está sustituida con un grupo fenilo, el cual puede estar eventualmente sustituido, R4 significa hidrógeno, halógeno o un grupo de ácido sulfónico, R5 significa hidrógeno, halógeno, alquilo C1-C4, alcoxi C1-C4, o un grupo de ácido sulfónico, R6, R7 significan hidrógeno, halógeno, alquilo C1-C4, alcoxi C1-C4, R8 significa hidrógeno, halógeno, alquilo C1-C4, alcoxiC1-C4 o acetamido, R9 significa hidroxi o un enlace con el grupo azo, R10 significa hidroxi o un enlace con el grupo azo cuando R9 corresponde a un grupo hidroxi, R11 significa hidrógeno, halógeno, metoxi o un grupo carboxilo, R12 significa hidrógeno, halógeno, alcoxi C1-C4 o un grupo de ácido sulfónico, R13 significa hidrógeno, halógeno, alquilo C1-C4, alcoxi C1-C4 o un grupo de ácido sulfónico, R14 significa hidrógeno, halógeno, alquilo C1-C4, alcoxi C1-C4 o un grupo nitro, R15 significa hidrógeno, halógeno, alquilo C1-C4, alcoxi C1-C4 o un grupo de ácido sulfónico, R16 significa hidrógeno o halógeno, R17 significa hidrógeno, halógeno o un grupo de ácido sulfónico, R18 significa hidrógeno, halógeno, hidroxi o un grupo de ácido sulfónico, R19 significa hidrógeno, halógeno, metilo, metoxi o un grupo de ácido sulfónico, R20 significa hidrógeno, halógeno o alquilo C1-C4 y R21 significa un enlace con el grupo azo, correspondiendo alquilo C1-C4 en tales casos a metilo, etilo, propilo, butilo, isopropilo, isobutilo o terc.-butilo, así como sus tautómeros, sales fisiológicamente compatibles y profármacos de estos compuestos para la preparación de medicamentos destinados al tratamiento y la prevención de trombopenias y anemias.
ES99122346T 1999-11-10 1999-11-10 Colorantes o,o'-dihidroxi-azoicos como constituyentes de medicamentos para el tratamiento de trombopenias. Pending ES2160560T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99122346A EP1104674A1 (de) 1999-11-10 1999-11-10 O,o'-Dihydroxyazofarbstoffe als Bestandteile von Arzneimitteln mit TPO-Agonistischer oder -Synergetischer Wirkung

Publications (1)

Publication Number Publication Date
ES2160560T1 true ES2160560T1 (es) 2001-11-16

Family

ID=8239360

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99122346T Pending ES2160560T1 (es) 1999-11-10 1999-11-10 Colorantes o,o'-dihidroxi-azoicos como constituyentes de medicamentos para el tratamiento de trombopenias.

Country Status (3)

Country Link
EP (1) EP1104674A1 (es)
ES (1) ES2160560T1 (es)
GR (1) GR20010300055T1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GC0000177A (en) 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
CY2010012I2 (el) 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
JP2004527541A (ja) 2001-03-01 2004-09-09 スミスクライン・ビーチャム・コーポレイション トロンボポエチン模倣物
AR040083A1 (es) 2002-05-22 2005-03-16 Smithkline Beecham Corp Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac
JP4895807B2 (ja) 2003-04-29 2012-03-14 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 変性疾患／損傷の治療方法
TW200526638A (en) 2003-10-22 2005-08-16 Smithkline Beecham Corp 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline
US20110129550A1 (en) 2007-02-16 2011-06-02 Connie Erickson-Miller Cancer treatment method
UY30915A1 (es) 2007-02-16 2008-09-02 Smithkline Beecham Corp Método de tratamiento de canceres
ECSP077628A (es) 2007-05-03 2008-12-30 Smithkline Beechman Corp Nueva composición farmacéutica
JP5393691B2 (ja) 2007-10-09 2014-01-22 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 急性ヒト骨髄性白血病細胞を死滅させるトロンボポエチン受容体作用薬（ＴｐｏＲＡ）
US8476249B2 (en) 2009-05-07 2013-07-02 Glaxosmithkline Llc Method of treating thrombocytopenia
SI3127427T1 (sl) 2009-05-29 2020-07-31 Novartis Ag Postopki dajanja spojin agonista trombopoetina

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE177925C (es) *
GB779880A (en) * 1953-02-27 1957-07-24 Ciba Ltd Functional derivatives of azo-dyestuffs containing sulphonic acid groups and processfor making them
GB789025A (en) * 1955-07-15 1958-01-15 Ici Ltd New dyestuffs of the benzotrifluoride-monoazo-benzene series
FR1171642A (fr) * 1957-04-15 1959-01-28 Cfmc Nouveaux colorants monoazoïques et leurs applications
US2987513A (en) * 1958-01-31 1961-06-06 Bayer Ag Azo dyestuffs and process for their manufacture
US4880788A (en) * 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
GC0000177A (en) * 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics

Also Published As

Publication number Publication date
GR20010300055T1 (en) 2001-10-31
EP1104674A1 (de) 2001-06-06

Similar Documents

Publication Publication Date Title
ES2160560T1 (es) Colorantes o,o&#39;-dihidroxi-azoicos como constituyentes de medicamentos para el tratamiento de trombopenias.
HRP20090162T1 (en) Quinolinone-carboxamide compounds as 5-ht4 receptor agonists
SE8800949L (sv) Aromatiska karboxylsyraderivat och anvendning av dessa som mellanprodukter for framstellning av aromatiska heterocykliska derivat med terapeutiska och kosmetiska egenskaper
NO943165L (no) Heterocykliske karbonsyrederivater som binder til retinoid-reseptorer (RAR)
TW200800938A (en) Indole carboxylic acid derivatives exhibiting PGD2 receptor antagonism
CO5031241A1 (es) Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos
EP1566380A4 (en) ISOQUINOLINONE COMPOUNDS AND THEIR USE FOR MEDICINAL PURPOSES
EP1340755A4 (en) AGENT WITH EFFECT AGAINST HELICOBACTER
PE20040907A1 (es) Derivados de anilinopirazol
IL79462A (en) Bactericidal formulations containing quinolonecarboxylic acids and derivatives thereof for use in veterinary medicine
IL104869A0 (en) Substituted indole,azaindole and tetrahydro-1h-pyrrolo-(2,3-c)pyridine-7-one derivatives,their preparation and pharmaceutical compositions containing them
DE3561814D1 (en) Substituted bis-(4-aminophenyl)-sulphones, their preparation and their use as medicines
IL160082A0 (en) Quinoline derivatives and use thereof as antitumor agents
MXPA02003952A (es) Derivados de imidazol como inhibidores de la fosfodieterasa vii.
CO5170535A1 (es) Derivados de n-[2-(4-aminofenil)etil]2,3-dihidro-1,4- benzodioxin-2-metanamina, su preparacion y su aplciacion en terapeutica
CR6503A (es) Derivados de- 1-trifluorometil-4-hidroxi-7-piperidinil-aminometiclcromano
RS20050954A (en) Use of bycyclo/2.2.1/heptane derivatives for the preparation of neuroprotective pharmaceutical compositions
DE69409734D1 (de) Neue Derivate des 2-(1H)-Chinolinones, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
AR046212A1 (es) Derivados de 2-fenilbenzofurano, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
AR026241A1 (es) Empleo de carbinoles 2-imidazolil substituidos para la preparacion de un medicamento para el tratamiento o profilaxis de enfermedades provocadas porestados isquemicos
WO2003104189A3 (en) COMPOUNDS
AR045994A1 (es) Farmaco activo para el dolor neuropatico
ATE134607T1 (de) Tetrahydronaphtalenderivate, ihre herstellung und ihre therapeutische verwendung
DOP2001000182A (es) 2-aminocarbonil-9h-derivados de purina
CO4950518A1 (es) Procedimiento para la preparacion de piperacina, 1 [[3- (4,7-dihidro-1-metil-7-oxo-3-propil-1h-pirazolo[4,3-d] pirimidin-5-il)-4-etoxifenil]-sulfonil]-4-metil y sus sales